Hub : Genes

LRRC14B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0311	0.0175	6.3e-05	0.016	0.026	0.015	NA	0.015	0.00023	4.2e-06	0.00031	NA	0.00032
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0366	0.0248	1.8e-03	0.019	0.011	0.001	NA	0.008	0.00310	2.0e-02	0.26000	NA	0.03400
3	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0800	0.0430	1.5e-03	0.036	0.028	0.014	NA	0.031	0.00390	9.8e-03	0.05100	NA	0.00670

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.3	0.4	1.0	1.0	-0.0	0.5
Bipolar Disorder or Schizophrenia	0.2	0.5	1.0	0.1	-1.0	-0.8
Depressed Affect (Nagel 2018)	0.2	0.5	0.9	-0.9	0.8	0.1
Depression (Nagel 2018)	0.0	0.0	0.1	-0.1	0.2	-0.1
Intelligence (Savage-Jansen 2018)	0.0	0.1	0.1	-0.2	0.4	0.0
Neuroticism (Nagel 2018)	1.2	2.7	4.0	-1.9	2.0	0.7
Schizophrenia (2018)	0.6	1.3	1.9	-0.7	-1.2	-1.4
Schizophrenia vs Biploar Disorder	0.6	0.8	2.3	0.4	-1.5	-0.2
Worry (Nagel 2018)	0.6	1.2	1.6	-1.1	1.3	0.8
Alzheimer’s Disease (in mother)	0.4	0.5	0.8	-0.9	0.6	0.5
Alzheimer’s Disease (in father)	0.4	0.5	1.2	0.3	-1.1	0.1
Alzheimer’s Disease (including proxy)	0.4	0.6	1.1	-1.1	0.4	0.7
Crohns Disease (2017)	0.7	1.5	2.9	1.7	-1.0	0.7
Irritable Bowel Disease (IBD)	0.5	1.2	2.5	1.6	0.1	1.1
Ulcerative Colitis (UC)	0.5	1.0	1.8	0.7	1.4	0.8
Major Depression (MDD)	0.1	0.1	0.1	-0.3	-0.1	-0.3
Reaction Time	1.1	2.1	4.5	2.1	-1.4	0.1
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.6	0.3	-0.7	-0.8
Breast Cancer	2.5	6.1	12.3	0.8	-2.3	-3.5
Ovarian Cancer	1.9	2.5	5.5	-1.4	-0.3	-2.3
Prostate Cancer	0.3	0.4	0.7	-0.4	0.9	0.4
Age at First Birth	1.5	2.1	2.7	-1.6	1.5	1.2
Bipolar Disorder (2011)	0.2	0.2	0.3	-0.2	-0.4	-0.5
Body Mass Index (BMI) (2010)	0.2	0.3	0.5	0.3	-0.7	-0.6
Coronary Artery Disease (CAD)	0.1	0.1	0.2	0.2	-0.2	0.4
Crohns Disease (2012)	1.2	1.9	3.5	1.9	-0.2	1.5
Mean Putamen Volume	0.6	0.6	1.7	-1.3	0.2	-0.5
Fasting Glucose	0.9	1.1	1.9	1.4	-1.1	0.2
HbA1C	1.3	1.4	3.3	1.0	-0.1	1.8
HDL Cholesterol	0.5	0.8	2.2	-0.3	-0.4	-1.5
LDL Cholesterol	0.1	0.2	0.4	-0.4	0.7	-0.0
Lupus	0.7	1.0	1.4	-1.2	1.0	0.8
Neuroticism (2016)	0.4	0.6	0.7	-0.8	0.6	0.7
Primary Biliary Cirrhosis	0.9	1.3	2.5	-0.5	1.0	1.6
Rheumatoid Arthritis	2.8	3.8	7.9	2.8	-1.9	-0.1
Schizophrenia (2014)	0.2	0.4	0.9	0.5	-0.9	-0.4
Triglycerides	0.3	0.5	1.0	-0.6	1.0	-0.4
Type 2 Diabetes (T2D) (2012)	0.5	0.5	0.9	0.9	-0.1	0.9
Ulcerative Colitis	0.1	0.1	0.2	-0.2	0.4	0.1
Blood Eosinophil Count	0.1	0.7	1.4	-1.2	0.4	-0.7
Blood Platelet Count	0.6	7.4	11.9	-0.1	3.2	3.5
Blood Red Count	0.1	0.6	1.0	1.0	-0.3	0.9
Blood White Count	0.5	3.4	5.8	-0.9	2.4	1.9
Heel T-Score	0.3	2.2	5.5	-0.1	-1.1	-2.3
BMI	1.3	7.7	13.2	-0.9	3.0	3.6
Height	2.0	39.1	79.9	0.9	6.0	8.9
Waist Hip Ratio (WHR)	0.4	1.6	3.1	0.1	1.3	1.8
Systolic Blood Pressure	1.1	5.6	12.4	-0.9	3.5	1.9
Smoking Status	0.4	1.0	1.8	1.1	-1.3	-0.3
Allergy or Eczema	0.4	1.1	2.2	-1.5	0.8	-0.6
Cardiovascular Disease	2.5	8.3	13.1	-2.1	3.6	2.7
Hypothyroidism (self reported)	0.0	0.0	0.1	-0.1	-0.3	0.1
Respiratory disease	1.5	3.3	5.9	-2.4	1.5	1.2
Type 2 Diabetes (T2D) (2018)	1.1	2.0	3.3	-0.9	1.4	1.8
Lung FEV1/FVC ratio	1.5	7.7	16.9	4.1	-2.1	1.3
Lung FVC	0.1	0.7	1.3	1.1	0.1	-0.9
Neuroticism	1.4	3.3	5.1	-2.3	2.1	0.7
Chronotype (morning person)	0.9	2.1	4.8	-1.2	0.2	-2.2
Hair Pigment	0.0	1.2	2.0	-1.3	0.1	-1.4
Tanning	0.1	1.4	1.5	1.1	1.1	1.2
Hand grip strength (left)	0.8	2.1	3.8	1.6	0.1	1.9
Number of treatments/medications taken	1.5	2.6	5.0	-2.2	1.5	0.8
Average weekly spirits intake	0.3	0.4	0.7	-0.9	-0.5	-0.4
Sensitivity / hurt feelings	2.8	4.7	6.5	-1.7	2.5	2.2
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.4	0.2	0.1	0.6
Hearing difficulty/problems: Yes	0.1	0.1	0.2	0.5	0.2	-0.0
Relative age of first facial hair	1.8	3.7	5.4	-0.8	2.3	2.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	0.9	-0.7	0.9	1.0
Ever used hormone-replacement therapy (HRT)	1.7	2.1	3.5	0.5	-1.9	-1.7
Ever had hysterectomy (womb removed)	0.0	0.0	0.1	-0.0	0.2	-0.2
Systolic blood pressure, automated reading	1.4	4.0	7.8	-0.3	2.8	2.1
Eye problems/disorders: Diabetes related eye disease	4.9	5.3	7.7	-2.4	2.8	1.6
Angina	1.2	1.5	2.7	-1.3	1.6	0.2
Medication for hormone replacement therapy	0.4	0.4	0.8	0.3	-0.9	-0.6
Vitamin and mineral supplements	0.6	0.8	2.2	0.4	-0.3	-1.5
Supplements: Zinc	0.6	0.6	1.2	-0.7	0.5	1.1
Medication: Co-codamol	1.1	1.3	2.5	0.9	-1.6	-0.8
Medication: Metformin	1.4	2.0	3.6	0.0	1.5	1.9
Diabetes (father)	0.1	0.2	0.3	0.6	-0.4	0.2
Diabetes (mother)	0.5	0.6	1.8	-0.3	1.3	0.1
Severe depression (siblings)	0.5	0.6	0.8	0.5	-0.9	-0.9
Pack years adult smoking proportion	0.1	0.2	0.3	0.4	-0.4	-0.6
Impedance of leg (right)	0.0	0.1	0.3	0.3	-0.6	0.0
Leg fat-free mass (left)	2.3	12.1	22.1	-0.7	3.7	4.7
Trunk fat percentage	2.9	11.8	23.9	-0.5	3.3	4.9
Hand grip strength (right)	0.4	1.2	2.6	1.6	0.1	1.0
Townsend deprivation index at recruitment	1.4	2.0	3.5	1.4	-1.9	-0.6
Current tobacco smoking	1.2	2.0	3.8	1.0	-1.9	-1.1
Average weekly fortified wine intake	2.1	2.5	3.1	-1.1	1.8	1.7
Maternal smoking around birth	1.6	2.3	4.5	-2.1	1.4	-0.7
Fed-up feelings	0.7	1.3	2.2	-1.5	1.2	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	0.7	-0.9	0.8	0.5
Relative age voice broke	0.1	0.1	0.2	-0.1	0.4	0.4
Taking other prescription medications	1.4	2.2	2.6	-1.6	1.3	1.5
Age when periods started (menarche)	0.1	0.2	0.3	0.5	-0.5	-0.4
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	0.4	0.2	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.6	1.2	-0.7	1.1	0.1
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.4	-1.2	0.7	0.1
Qualifications: CSEs or equivalent	0.8	1.0	1.9	1.4	-1.0	0.4
Serious illness, injury or assault to yourself	3.3	4.0	7.8	-0.6	2.0	2.8
High blood pressure	0.8	2.3	3.6	-1.1	1.9	1.4
Hayfever, allergic rhinitis or eczema	0.3	0.8	1.1	-1.0	-0.3	-1.1
Multivitamins +/- minerals	0.3	0.4	1.1	-0.1	-0.3	1.1
Stomach or abdominal pain in last month	1.1	1.3	2.9	0.2	-1.0	-1.7
Supplements: Glucosamine	0.6	0.8	1.6	-1.2	0.8	0.4
Diverticular disease/diverticulitis (self-reported)	2.7	3.2	6.0	1.7	-2.4	-0.8
Medication: Atenolol	0.4	0.5	1.5	0.3	-0.0	-1.2
Medication: Levothyroxine sodium	0.4	0.7	1.2	-0.9	0.5	1.1
Sitting height	4.2	30.0	49.4	-2.0	6.1	7.0
Chronic bronchitis/emphysema (father)	0.3	0.4	0.5	-0.7	0.4	-0.7
High blood pressure (mother)	1.7	2.4	5.3	-1.0	-1.0	-2.3
Body mass index (BMI)	0.9	3.6	8.5	-0.0	1.5	2.9
Impedance of leg (left)	0.1	0.5	1.0	0.7	-1.0	-0.3
Leg predicted mass (left)	2.2	11.7	21.3	-0.7	3.6	4.6
Trunk fat mass	3.6	15.4	31.4	-0.4	3.8	5.6
Waist circumference	3.5	12.9	28.5	-0.1	3.2	5.3
Number of incorrect matches in round	1.1	1.8	3.8	-2.0	1.1	0.6
Past tobacco smoking	0.2	0.3	0.6	-0.2	0.8	0.6
Alcohol usually taken with meals	0.6	0.9	1.7	-0.9	1.3	-0.4
Nervous feelings	1.0	1.9	3.6	-1.0	1.1	1.9
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.6	-0.6	0.7	0.1
Hearing difficulty/problems with background noise	0.1	0.1	0.3	0.2	0.6	0.2
Hair/balding pattern: Pattern 2	1.6	2.0	3.3	-0.8	-1.4	-1.8
Had menopause	0.1	0.1	0.4	0.6	-0.1	-0.2
Had other major operations	0.1	0.1	0.1	0.3	-0.3	0.1
Forced vital capacity (FVC)	0.9	3.5	5.1	0.8	2.2	2.3
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.4	-0.7	0.4	0.1
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.2	0.5	-0.4	-0.3
Qualifications: None of the above	0.4	1.0	1.7	-1.3	0.8	-0.7
Financial difficulties in last 2 years	0.4	0.5	0.8	0.9	-0.3	0.8
Mouth/teeth dental problems	0.2	0.3	0.3	-0.6	0.6	0.4
Heart attack	1.2	1.5	2.4	-1.5	1.5	0.0
Allergy	0.6	1.4	2.8	1.7	-0.3	1.1
Pain all over the body in last month	0.4	0.4	1.1	0.3	0.3	1.0
Diabetes (self-reported)	1.1	1.6	2.1	-1.3	1.4	1.0
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	2.7	-1.7	0.4	-1.2
Medication: Ramipril	0.3	0.3	0.6	-0.4	0.5	0.7
Medication: Simvastatin	3.6	5.3	7.7	-1.8	2.8	2.2
Fluid intelligence score	0.0	0.1	0.2	0.3	-0.1	0.4
Illnesses of siblings	0.1	0.2	0.4	0.3	-0.3	-0.6
Neuroticism score	1.7	3.5	5.0	-1.9	2.2	1.4
Weight	2.8	13.7	28.2	-0.3	3.6	5.3
Impedance of arm (right)	0.5	2.3	3.8	-1.6	1.9	0.7
Arm fat percentage (right)	1.8	6.9	13.1	-0.8	2.7	3.6
Trunk fat-free mass	1.4	7.9	15.2	-0.7	2.8	3.9
Hip circumference	3.6	15.4	34.2	-0.1	3.4	5.8
Time employed in main current job	1.6	1.9	3.0	0.4	-1.6	-1.7
Alcohol intake versus 10 years previously	0.4	0.7	1.0	0.9	0.5	1.0
Father’s age at death	1.6	2.1	4.9	-2.2	1.0	-0.8
Worrier / anxious feelings	2.1	4.0	8.3	-2.9	1.8	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.3	-0.4	0.7	1.5
Falls in the last year	2.6	3.5	5.5	-2.0	2.4	1.1
Hair/balding pattern: Pattern 3	1.0	1.5	2.2	-1.5	1.4	0.7
Number of live births	0.3	0.5	1.0	0.6	0.2	1.0
Forced expiratory volume in 1-second (FEV1)	1.3	4.4	7.2	1.9	1.5	2.7
Pulse rate	1.3	2.2	4.9	1.1	-2.2	-0.6
Happiness	0.5	0.6	1.0	1.0	-0.8	-0.4
Noisy workplace	0.4	0.5	1.2	-1.1	0.5	0.0
Qualifications: A levels/AS levels or equivalent	0.3	0.7	1.5	-1.2	0.4	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.0	-1.0	0.2	0.1
Mouth/teeth dental problems: Dentures	1.1	1.9	4.5	2.1	-1.0	0.4
Asthma	1.5	2.9	6.0	-2.5	1.6	0.4
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	3.4	-0.2	0.2	1.9
Medication: Cholesterol lowering	0.5	0.8	1.1	-0.7	1.0	1.0
Depression (self-reported)	0.6	0.7	1.0	1.0	-0.5	0.9
Medication: Lansoprazole	0.8	0.9	1.4	0.3	-1.2	-1.2
Prospective memory result	0.8	1.0	1.8	0.1	-1.3	-1.1
Lung cancer (father)	0.7	0.8	2.2	1.5	-0.1	-0.5
Illnesses of mother	1.1	1.4	2.8	0.9	0.6	1.7
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.8	7.3	1.5	1.3	2.7
Pulse wave Arterial Stiffness index	2.2	2.5	6.3	2.5	-0.9	0.7
Impedance of arm (left)	0.5	2.2	4.3	-1.3	2.1	0.7
Arm fat mass (right)	2.4	9.9	20.2	-0.5	3.1	4.5
Trunk predicted mass	1.3	7.5	14.7	-0.6	2.7	3.8
Standing height	2.0	19.6	34.5	-0.9	4.9	5.9
Length of working week for main job	4.0	4.4	7.7	1.9	-2.8	-1.4
Exposure to tobacco smoke at home	0.6	0.7	1.1	1.0	-0.4	-0.8
Breastfed as a baby	2.5	3.2	5.1	2.3	-1.6	-1.4
Tense / ‘highly strung’	0.7	1.2	2.5	-1.0	1.6	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.6	-0.7	-0.4	-0.1
Hair/balding pattern: Pattern 4	0.4	1.1	1.7	0.4	-1.3	-1.2
Birth weight of first child	1.6	3.0	5.4	-1.9	2.3	0.3
Peak expiratory flow (PEF)	0.8	1.8	3.0	1.7	0.6	1.4
Pulse wave reflection index	0.6	0.8	2.0	1.4	0.3	0.4
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.9	-0.9	0.8	0.2
Loud music exposure frequency	0.3	0.3	0.6	-0.8	-0.4	-0.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.3	-0.0	-0.6	-0.5
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.7	-0.5	0.1	-0.8
Blood clot in the leg (DVT)	0.0	0.0	0.0	0.2	-0.1	0.2
Medication: Paracetamol	0.1	0.2	0.4	-0.6	-0.0	-0.3
Headache pain in last month	0.3	0.6	1.0	1.0	-0.2	-0.8
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	2.9	1.4	-1.7	-1.0
Glaucoma (self-reported)	1.2	1.5	2.1	-0.6	1.4	1.4
Gout (self-reported)	0.1	0.2	0.3	-0.4	0.6	-0.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.1	-1.1	0.5	0.5
Medication: Amlodipine	2.7	3.8	7.8	-2.8	1.7	-0.9
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.3	-0.3	0.1	0.6
Birth weight	1.3	2.9	4.1	-1.3	2.0	1.7
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.1	0.0	-0.4	0.4
High blood pressure (siblings)	0.1	0.2	0.5	-0.7	0.3	-0.0
Forced vital capacity (FVC), Best measure	1.0	3.7	6.7	0.6	2.0	2.6
Body fat percentage	2.4	9.5	20.7	-0.2	2.8	4.6
Leg fat percentage (right)	1.4	5.0	12.2	0.1	1.7	3.5
Arm fat-free mass (right)	1.2	6.3	14.3	0.5	2.1	3.8
Exposure to tobacco smoke outside home	1.3	1.8	2.8	-0.3	-1.6	-1.7
Comparative body size at age 10	0.2	0.5	1.5	-1.2	0.3	0.2
Number of full brothers	0.2	0.2	0.4	-0.4	0.6	0.3
Worry too long after embarrassment	1.0	1.7	3.1	-1.4	1.8	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.5	0.0	-0.5	0.7
Wheeze or whistling in the chest in last year	1.0	1.7	3.9	-2.0	1.1	-0.1
Number of children fathered	0.9	1.0	1.4	1.0	-1.2	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	3.3	-1.0	1.8	0.9
Age at first live birth	1.5	2.7	5.0	-1.5	2.2	0.9
Pulse wave peak to peak time	2.2	2.6	6.4	-2.5	1.1	-0.2
Health satisfaction	1.3	1.6	2.4	-1.5	1.2	1.1
Shortness of breath walking on level ground	0.9	1.1	1.8	-1.2	1.3	-0.2
Qualifications: College or University degree	0.1	0.3	0.7	-0.1	-0.4	0.8
Eye problems/disorders: None of the above	1.0	1.1	1.7	1.3	-1.3	-0.2
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.6	-0.2	-0.8	-0.6
Emphysema/chronic bronchitis	0.0	0.0	0.0	0.2	0.2	0.2
Medication for pain relief, constipation, heartburn	0.7	1.2	3.6	1.9	-0.2	-0.0
Neck or shoulder pain in last month	1.6	2.2	4.8	-2.2	1.4	0.0
Medication: Blood pressure	1.7	3.0	4.3	-1.3	2.1	1.7
Angina (self-reported)	1.2	1.6	2.6	-1.5	1.6	0.2
Migraine (self-reported)	0.4	0.5	0.8	-0.8	0.2	0.9
Medication: Ibuprofen	1.4	1.7	4.6	-0.3	0.6	2.2
Medication: Allopurinol	0.4	0.5	1.1	-0.6	1.1	-0.1
Medication: Omeprazole	1.4	1.6	4.4	-0.5	-0.5	-2.1
Medication: Seretide 50 evohaler	0.3	0.3	0.5	-0.7	-0.5	-0.4
Mean time to correctly identify matches	0.7	1.4	1.9	1.4	-1.4	-0.6
Heart disease (mother)	1.8	2.2	3.7	-1.9	0.9	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.1	0.1	-0.9	-1.1
Whole body fat mass	3.0	12.7	27.8	-0.2	3.2	5.3
Leg fat mass (right)	2.4	9.2	21.6	0.1	2.5	4.7
Arm predicted mass (right)	1.2	5.9	13.6	0.4	2.0	3.7
Pulse rate, automated reading	0.4	1.3	2.5	-0.7	-1.6	-1.0
Alcohol intake frequency.	0.5	1.1	1.8	1.4	-1.2	0.1
Comparative height size at age 10	1.7	9.1	13.5	-1.1	3.6	3.7
Number of full sisters	1.1	1.3	2.5	1.1	-1.6	-0.6
Suffer from ‘nerves’	0.2	0.3	0.7	-0.2	-0.8	-0.2
Overall health rating	0.2	0.4	0.7	-0.8	0.6	0.4
Chest pain or discomfort	0.1	0.2	0.6	-0.8	0.2	-0.1
Had major operations	0.4	0.4	1.2	-1.1	0.2	-0.3
Age at last live birth	0.5	0.8	1.4	-0.9	1.2	0.3
Family relationship satisfaction	0.2	0.3	0.5	-0.4	0.3	0.7
Leg pain on walking	0.8	1.0	2.5	-1.6	0.7	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.2	1.1	-0.6	0.4
Commuting to job workplace: Car/motor vehicle	1.4	1.6	2.3	1.5	-0.7	1.4
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	0.6	0.6	-0.6	-0.8
Medication: Aspirin	1.1	1.5	4.1	-2.0	0.4	0.5
Supplements: Vitamin C	0.3	0.4	0.8	0.1	0.7	0.9
Knee pain experienced in last month	1.0	1.6	2.1	-1.1	1.2	1.5
Hypertension (Self-reported)	0.7	2.0	3.2	-1.4	1.8	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	3.1	-0.8	-0.5	-1.8
Illnesses of father: Heart disease	0.3	0.5	1.0	-0.7	-0.1	-1.0
Illnesses of siblings: Diabetes	0.0	0.1	0.1	-0.3	0.2	-0.0
Smoking status: Previous	0.2	0.3	0.7	-0.8	0.5	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	2.1	4.3	7.9	-0.3	2.2	2.8
Whole body fat-free mass	1.7	9.6	18.3	-0.6	3.2	4.3
Leg fat-free mass (right)	1.9	10.2	19.1	-0.3	3.4	4.4
Arm fat percentage (left)	1.8	7.1	13.6	-0.7	2.7	3.7
Average weekly red wine intake	0.3	0.5	0.7	-0.4	0.7	0.8
Handedness (chirality/laterality): Left-handed	1.2	1.5	3.2	1.8	-0.8	0.8
Mood swings	0.3	0.5	0.9	-0.4	0.9	0.6
Loneliness, isolation	0.8	1.1	2.8	0.5	0.4	1.7
Long-standing illness, disability or infirmity	1.2	1.9	4.2	-0.9	0.9	2.0
Ever had bowel cancer screening	0.2	0.2	0.4	-0.0	0.3	-0.7
Diabetes diagnosed by doctor	1.1	1.8	3.0	-0.7	1.4	1.7
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	1.1	-1.0	1.0	0.5
Friendships satisfaction	0.7	0.9	2.0	1.4	-0.7	0.3
Qualifications: nursing, teaching	0.3	0.4	0.8	-0.9	-0.1	0.7
Commuting to job workplace: Walk	1.8	1.9	3.2	1.3	-1.0	-1.8
Eye problems/disorders: Cataract	0.5	0.6	1.2	-0.7	1.1	-0.0
Mouth/teeth dental problems: Mouth ulcers	1.3	2.0	5.1	-2.3	0.5	-0.8
Medication for cholesterol	0.1	0.1	0.3	0.1	-0.5	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.1	-0.0	-0.3	-0.2
Back pain experienced in last month	3.4	5.0	7.2	-1.2	2.5	2.7
Mineral and other dietary supplements	1.4	1.9	2.7	1.7	-1.4	-0.9
Breast cancer (self-reported)	1.3	1.6	2.1	-1.1	1.1	1.4
Asthma (self-reported)	1.6	3.3	7.6	-2.8	1.5	0.2
Osteoporosis (self-reported)	0.3	0.4	0.9	-0.0	-0.4	1.0
Osteoarthritis (self-reported)	1.4	1.8	4.6	-2.1	0.4	-0.7
Medication: Aspirin	0.9	1.1	3.0	-1.7	0.4	0.5
Medication: Gliclazide	1.2	1.3	1.5	-1.1	1.1	1.2
Illnesses of father: None of the above (group 1)	0.8	1.0	1.3	-1.1	0.8	1.1
Smoking status: Current	0.8	1.2	2.3	0.8	-1.5	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	1.9	1.3	0.6	1.4
Whole body water mass	1.7	9.8	19.0	-0.5	3.2	4.4
Leg predicted mass (right)	2.0	10.4	19.7	-0.3	3.4	4.4
Arm fat mass (left)	2.3	9.4	20.3	-0.2	2.8	4.5
Number of self-reported non-cancer illnesses	4.8	8.3	13.7	-3.7	3.1	1.1
Average weekly champagne plus white wine intake	1.1	1.5	2.8	-0.8	-1.0	-1.7
Miserableness	0.1	0.2	0.7	-0.8	0.0	0.1
Guilty feelings	3.1	4.7	8.6	-2.9	2.3	-0.3
Wears glasses or contact lenses	1.0	1.2	2.1	-0.8	-0.9	-1.4
Ever taken oral contraceptive pill	0.6	0.7	0.9	1.0	-0.6	0.9
Hearing aid user	0.6	0.7	1.9	-0.5	-0.1	-1.4
Mother’s age at death	1.0	1.2	1.9	-1.4	1.4	-0.1
Financial situation satisfaction	0.7	0.8	2.0	0.5	0.5	1.4
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	-0.5	0.2	0.2
Commuting to job workplace: Public transport	2.1	2.5	5.2	-2.3	0.5	-1.4
Eye problems/disorders: Glaucoma	0.9	1.1	1.8	-0.5	1.1	1.3
Medication: Blood pressure	0.5	0.9	1.8	-0.9	0.2	-1.4
Pain type(s) experienced in last month: Hip pain	2.0	2.6	5.0	-0.9	2.2	1.4
Supplements: Fish oil (including cod liver oil)	1.1	1.4	2.1	-0.5	1.3	1.5
High cholesterol (Self-reported)	0.9	1.6	1.9	-1.4	1.2	1.2
Medication: Bendroflumethiazide	0.2	0.3	0.7	-0.1	0.4	-0.8
Medication: Paracetamol	0.3	0.5	1.3	-1.1	0.4	-0.1
Medication: Lisinopril	0.1	0.1	0.2	-0.1	0.1	0.4
Medication: Atorvastatin	0.6	0.8	1.7	0.9	-0.1	1.3
Illnesses of father: High blood pressure	0.2	0.3	0.6	0.3	0.8	-0.5
Alcohol drinker status: Never	0.4	0.5	0.8	0.4	-0.9	-0.6
Ever smoked	1.3	2.3	3.6	1.0	-1.9	-1.5
Basal metabolic rate	2.1	11.4	23.1	-0.4	3.3	4.8
Leg fat percentage (left)	1.2	4.3	10.2	0.2	1.6	3.2
Arm fat-free mass (left)	1.3	6.5	15.1	0.4	2.1	3.9
Number of operations (self-reported)	0.4	0.6	1.0	0.4	-0.8	-1.0
Average weekly beer plus cider intake	0.2	0.4	0.9	-0.4	0.1	-0.9
Irritability	0.5	0.8	1.6	-0.1	0.9	1.3
Risk taking	0.1	0.1	0.3	-0.3	-0.0	0.5
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.3	-1.2	0.0	-0.2
Fractured/broken bones in last 5 years	0.4	0.5	0.8	-0.9	0.7	0.4
Age started oral contraceptive pill	1.5	1.8	3.0	1.5	0.5	1.7
Diastolic blood pressure, automated reading	0.4	1.4	2.5	0.4	1.6	1.2
Ever depressed for a whole week	0.5	0.6	1.7	-1.3	-0.2	-0.4
Unable to work because of sickness or disability	0.0	0.1	0.1	-0.3	-0.3	-0.1
Commuting to job workplace: Cycle	0.5	0.6	1.8	0.0	-0.1	1.3
Myopia	0.2	0.3	0.9	-0.3	0.9	-0.1
Vascular/heart problems diagnosed by doctor	0.9	2.4	4.1	1.6	-2.0	-0.9
Cholesterol lowering medication	2.8	4.1	6.1	-1.0	2.2	2.5
Medication: Omeprazole (e.g. Zanprol)	1.9	2.3	5.7	-1.0	-0.5	-2.4
Pain experienced in last month	2.0	3.4	4.9	1.9	-2.2	-1.2
Supplements: Calcium	1.3	1.4	2.2	-1.5	0.7	1.2
Basal cell carcinoma (self-reported)	2.7	3.2	6.7	2.6	-1.6	0.4
Heart attack/myocardial infarction (self-reported)	1.2	1.6	2.6	-1.6	1.5	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.5	-0.3	-0.1
Heart disease (siblings)	0.9	1.1	1.3	-1.1	1.1	0.9
Alcohol drinker status: Previous	2.4	2.8	4.8	2.2	-1.8	0.7
Pack years of smoking	0.1	0.2	0.4	0.4	-0.3	-0.6
Impedance of whole body	0.0	0.1	0.3	-0.2	0.6	0.2
Leg fat mass (left)	2.4	9.5	22.0	0.1	2.5	4.7
Arm predicted mass (left)	1.2	6.0	13.7	0.3	2.1	3.7