Best TWAS P=1.46e-10 · Best GWAS P=6.19e-18 conditioned to 6.04e-12
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SAR1B | 0.12 | 0.06 | lasso | 6 | 0.09 | 8.1e-11 | -4.5 | -5.3 | 1.4e-07 | 0.22 | 0.99 | 0.00 | FALSE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | PHF15 | 0.26 | 0.18 | lasso | 6 | 0.22 | 7.1e-08 | 5.6 | 5.9 | 3.1e-09 | -0.21 | 0.71 | 0.03 | FALSE |
| 3 | GTEx | Colon Transverse | SAR1B | 0.11 | 0.00 | enet | 17 | 0.03 | 1.2e-02 | -4.2 | -6.2 | 6.8e-10 | 0.16 | 0.07 | 0.04 | TRUE |
| 4 | GTEx | Muscle Skeletal | SAR1B | 0.10 | 0.04 | lasso | 7 | 0.04 | 6.1e-05 | 4.3 | -6.0 | 2.7e-09 | 0.22 | 0.23 | 0.14 | FALSE |
| 5 | GTEx | Pituitary | CAMLG | 0.20 | 0.07 | enet | 10 | 0.09 | 3.3e-03 | -4.6 | -5.2 | 2.6e-07 | 0.25 | 0.50 | 0.03 | FALSE |
| 6 | The Cancer Genome Atlas | Glioblastoma Multiforme | CAMLG | 0.29 | 0.18 | lasso | 3 | 0.13 | 9.6e-05 | -4.7 | -5.2 | 2.2e-07 | 0.29 | 0.00 | 0.84 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SAR1B | 0.03 | 0.00 | blup | 27 | 0.01 | 2.6e-02 | 5.6 | -6.4 | 1.5e-10 | 0.27 | 0.00 | 0.85 | TRUE |