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chr5:128,541,597-132,839,137

Best TWAS P=1.34e-25 · Best GWAS P=7.2e-24 conditioned to 9.82e-20

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	LOC553103	0.05	0.02	bslmm	433	0.03	3.2e-04	-7.32	6.0	2.7e-09	-0.04	0.78	0.04	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PDLIM4	0.11	0.18	lasso	5	0.18	8.0e-21	-7.18	-7.4	1.1e-13	0.07	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	SLC22A5	0.05	0.04	lasso	4	0.04	4.2e-04	9.75	-8.5	1.4e-17	0.05	0.03	0.96	FALSE
4	GTEx	Adipose Subcutaneous	AC034220.3	0.11	0.11	lasso	10	0.09	4.8e-08	-8.04	8.0	9.0e-16	-0.06	0.51	0.49	FALSE
5	GTEx	Adipose Visceral Omentum	AC034220.3	0.10	0.09	lasso	7	0.08	7.3e-05	-8.08	8.1	6.4e-16	-0.07	0.27	0.55	FALSE
6	GTEx	Adrenal Gland	AC034220.3	0.12	0.11	lasso	16	0.08	7.7e-04	-8.05	8.2	2.9e-16	-0.07	0.28	0.63	FALSE
7	GTEx	Artery Aorta	P4HA2	0.12	0.14	lasso	2	0.11	1.2e-06	9.88	9.9	4.4e-23	-0.06	0.01	0.99	FALSE
8	GTEx	Artery Aorta	AC034220.3	0.08	0.06	lasso	3	0.05	1.1e-03	-8.18	9.1	6.7e-20	-0.07	0.23	0.65	FALSE
9	GTEx	Artery Aorta	P4HA2-AS1	0.08	0.03	lasso	3	0.01	6.6e-02	9.80	9.9	3.2e-23	-0.08	0.03	0.94	FALSE
10	GTEx	Artery Tibial	P4HA2	0.12	0.15	lasso	6	0.14	3.2e-11	9.88	10.0	1.6e-23	-0.08	0.01	0.99	FALSE
11	GTEx	Artery Tibial	HINT1	0.11	0.04	enet	18	0.06	1.0e-05	-2.61	-5.4	5.4e-08	0.06	0.24	0.53	FALSE
12	GTEx	Artery Tibial	SLC22A5	0.18	0.12	enet	8	0.12	2.5e-09	9.75	-8.7	3.0e-18	0.05	0.02	0.98	FALSE
13	GTEx	Artery Tibial	P4HA2-AS1	0.10	0.09	lasso	4	0.11	1.0e-08	9.87	9.8	1.4e-22	-0.07	0.02	0.98	FALSE
14	GTEx	Brain Caudate basal ganglia	AC034220.3	0.41	0.45	enet	19	0.46	8.8e-15	-8.08	8.4	3.3e-17	-0.06	0.32	0.68	FALSE
15	GTEx	Brain Cortex	AC034220.3	0.43	0.39	lasso	15	0.17	2.4e-05	-8.08	8.1	4.8e-16	-0.07	0.39	0.61	FALSE
16	GTEx	Brain Frontal Cortex BA9	AC034220.3	0.31	0.20	lasso	14	0.21	3.3e-06	-8.26	7.1	1.5e-12	-0.05	0.31	0.63	FALSE
17	GTEx	Brain Hippocampus	AC034220.3	0.21	0.15	lasso	14	0.18	5.8e-05	-8.26	8.5	2.4e-17	-0.05	0.06	0.89	FALSE
18	GTEx	Brain Hypothalamus	AC034220.3	0.38	0.14	enet	33	0.28	3.2e-07	-4.52	5.4	5.4e-08	-0.05	0.26	0.56	FALSE
19	GTEx	Brain Nucleus accumbens basal ganglia	AC034220.3	0.24	0.24	enet	34	0.24	3.7e-07	-8.07	8.2	2.2e-16	-0.06	0.25	0.73	FALSE
20	GTEx	Breast Mammary Tissue	SLC22A5	0.10	0.02	enet	16	0.06	4.5e-04	9.91	-6.7	1.8e-11	0.07	0.06	0.92	FALSE
21	GTEx	Breast Mammary Tissue (Female)	SLC22A5	0.04	-0.01	lasso	3	0.01	1.3e-01	-3.53	-6.5	1.1e-10	0.06	0.05	0.19	FALSE
22	GTEx	Cells EBV-transformed lymphocytes	SLC22A5	0.37	0.05	lasso	13	0.10	2.8e-04	9.91	-8.7	5.1e-18	0.06	0.03	0.94	FALSE
23	GTEx	Cells Transformed fibroblasts	PDLIM4	0.08	0.09	lasso	1	0.07	6.4e-06	-7.37	-7.4	1.7e-13	0.06	0.50	0.42	FALSE
24	GTEx	Cells Transformed fibroblasts	SLC22A5	0.32	0.28	lasso	7	0.35	1.6e-27	-8.69	-9.4	5.9e-21	0.06	0.12	0.88	FALSE
25	GTEx	Colon Sigmoid	AC034220.3	0.18	0.11	lasso	12	0.06	3.7e-03	-8.25	8.0	1.2e-15	-0.05	0.19	0.35	FALSE
26	GTEx	Colon Transverse	SLC22A5	0.12	0.07	enet	8	0.07	2.5e-04	9.91	-8.4	4.2e-17	0.01	0.04	0.94	FALSE
27	GTEx	Colon Transverse	AC034220.3	0.30	0.15	lasso	3	0.11	8.4e-06	-8.18	8.6	9.7e-18	-0.07	0.63	0.34	FALSE
28	GTEx	Esophagus Gastroesophageal Junction	SEPT8	0.22	0.08	lasso	12	0.10	2.2e-04	-7.47	8.1	6.2e-16	-0.04	0.33	0.51	FALSE
29	GTEx	Esophagus Mucosa	P4HA2	0.23	0.10	lasso	6	0.14	6.1e-10	9.88	9.8	7.4e-23	-0.06	0.01	0.99	FALSE
30	GTEx	Esophagus Mucosa	SLC22A5	0.16	0.16	enet	8	0.16	6.3e-11	9.91	-9.5	2.0e-21	0.06	0.01	0.99	FALSE
31	GTEx	Esophagus Mucosa	AC034220.3	0.08	0.03	lasso	3	0.05	4.7e-04	-8.26	8.2	3.3e-16	-0.06	0.45	0.54	FALSE
32	GTEx	Esophagus Mucosa	P4HA2-AS1	0.09	0.06	lasso	6	0.08	5.4e-06	9.88	9.6	1.1e-21	-0.07	0.02	0.98	FALSE
33	GTEx	Esophagus Muscularis	AC034220.3	0.12	0.08	enet	20	0.07	3.8e-05	-8.18	7.5	6.5e-14	-0.07	0.12	0.86	FALSE
34	GTEx	Heart Atrial Appendage	AC034220.3	0.16	0.09	enet	17	0.18	1.7e-08	-8.05	8.8	8.8e-19	-0.07	0.06	0.94	FALSE
35	GTEx	Heart Left Ventricle	AC034220.3	0.25	0.22	lasso	6	0.25	8.6e-14	-8.18	8.9	6.3e-19	-0.06	0.22	0.78	FALSE
36	GTEx	Liver	AC034220.3	0.30	0.16	lasso	6	0.16	3.9e-05	-8.05	6.9	6.3e-12	-0.06	0.42	0.32	FALSE
37	GTEx	Lung	SLC22A5	0.10	0.15	enet	11	0.13	3.4e-10	9.91	-9.3	2.0e-20	0.07	0.01	0.99	FALSE
38	GTEx	Muscle Skeletal	SLC22A5	0.10	0.01	lasso	3	0.02	6.6e-03	-4.94	-5.3	1.3e-07	0.07	0.26	0.06	FALSE
39	GTEx	Muscle Skeletal	AC034220.3	0.27	0.23	lasso	9	0.24	9.1e-24	-8.08	8.6	7.3e-18	-0.07	1.00	0.00	FALSE
40	GTEx	Muscle Skeletal	MIR3936	0.04	0.01	lasso	4	0.00	9.9e-02	-7.37	8.9	3.6e-19	-0.07	0.08	0.69	FALSE
41	GTEx	Nerve Tibial	P4HA2	0.19	0.12	enet	26	0.14	6.2e-10	-8.05	8.7	3.2e-18	-0.07	0.02	0.98	FALSE
42	GTEx	Nerve Tibial	AC034220.3	0.15	0.11	lasso	5	0.10	1.9e-07	-8.05	8.1	4.7e-16	-0.06	0.55	0.45	FALSE
43	GTEx	Nerve Tibial	P4HA2-AS1	0.14	0.05	lasso	8	0.08	3.8e-06	9.07	9.1	7.8e-20	-0.11	0.04	0.96	FALSE
44	GTEx	Ovary	AC004041.2	0.21	-0.01	lasso	2	-0.01	7.7e-01	-6.56	7.8	7.7e-15	-0.07	0.07	0.22	FALSE
45	GTEx	Pituitary	AC034220.3	0.25	0.22	lasso	12	0.18	3.1e-05	-7.36	8.1	8.5e-16	-0.05	0.50	0.32	FALSE
46	GTEx	Prostate	AC034220.3	0.38	0.37	lasso	5	0.37	3.0e-10	-8.18	7.8	4.7e-15	-0.05	0.37	0.63	FALSE
47	GTEx	Skin Not Sun Exposed Suprapubic	PDLIM4	0.13	0.08	lasso	2	0.06	2.6e-04	9.91	-8.8	1.8e-18	0.07	0.03	0.95	FALSE
48	GTEx	Skin Not Sun Exposed Suprapubic	SLC22A4	0.13	0.00	lasso	4	0.01	7.1e-02	-2.49	-5.8	6.4e-09	0.03	0.15	0.11	FALSE
49	GTEx	Skin Not Sun Exposed Suprapubic	SLC22A5	0.13	0.05	lasso	8	0.05	8.3e-04	-8.07	-9.2	2.6e-20	0.07	0.09	0.91	FALSE
50	GTEx	Skin Sun Exposed Lower leg	PDLIM4	0.09	0.08	lasso	8	0.09	1.0e-07	9.88	-10.2	3.0e-24	0.06	0.02	0.98	FALSE
51	GTEx	Skin Sun Exposed Lower leg	SLC22A5	0.25	0.21	lasso	3	0.20	1.4e-16	9.75	-9.8	1.3e-22	0.06	0.02	0.98	FALSE
52	GTEx	Spleen	SLC22A5	0.26	0.28	lasso	4	0.28	6.6e-08	9.91	10.0	1.5e-23	-0.08	0.01	0.96	FALSE
53	GTEx	Stomach	SLC22A5	0.09	0.04	lasso	4	0.01	9.0e-02	-8.30	-8.9	5.7e-19	0.04	0.07	0.61	FALSE
54	GTEx	Stomach	AC034220.3	0.17	0.15	enet	21	0.16	4.2e-08	-7.42	8.4	5.6e-17	-0.05	0.64	0.36	FALSE
55	GTEx	Testis	P4HA2	0.14	0.13	lasso	5	0.11	1.4e-05	9.88	10.0	9.2e-24	-0.06	0.02	0.98	FALSE
56	GTEx	Testis	PDLIM4	0.15	0.07	enet	8	0.05	2.5e-03	-8.26	8.4	4.6e-17	-0.05	0.12	0.57	FALSE
57	GTEx	Testis	RAPGEF6	0.50	0.35	lasso	4	0.32	6.5e-15	-5.18	-5.4	7.7e-08	0.01	1.00	0.00	FALSE
58	GTEx	Testis	CHSY3	0.20	0.27	enet	7	0.25	2.8e-11	5.22	6.2	4.2e-10	0.64	0.77	0.23	TRUE
59	GTEx	Testis	AC034220.3	0.15	0.12	lasso	9	0.12	4.4e-06	-8.08	8.1	7.4e-16	-0.07	0.65	0.28	FALSE
60	GTEx	Thyroid	P4HA2	0.08	0.07	enet	9	0.06	3.5e-05	9.88	9.7	4.5e-22	-0.06	0.01	0.98	FALSE
61	GTEx	Thyroid	PDLIM4	0.05	0.02	enet	5	0.01	3.1e-02	9.07	-9.5	2.6e-21	0.08	0.04	0.90	FALSE
62	GTEx	Thyroid	SLC22A4	0.06	0.02	lasso	4	0.02	2.3e-02	-7.42	5.7	1.2e-08	-0.02	0.22	0.50	FALSE
63	GTEx	Thyroid	SLC22A5	0.17	0.07	lasso	5	0.13	4.8e-10	-0.32	-5.8	5.2e-09	0.02	0.04	0.96	FALSE
64	GTEx	Thyroid	AC034220.3	0.29	0.29	lasso	5	0.31	4.8e-24	-7.36	6.6	3.7e-11	-0.05	1.00	0.00	FALSE
65	GTEx	Thyroid	P4HA2-AS1	0.08	0.06	enet	14	0.05	1.6e-04	9.88	9.7	2.0e-22	-0.05	0.01	0.98	FALSE
66	GTEx	Uterus	P4HA2	0.58	-0.01	lasso	5	0.02	1.6e-01	-3.74	6.0	1.6e-09	-0.03	0.05	0.36	FALSE
67	GTEx	Whole Blood	SLC22A4	0.07	0.05	enet	16	0.05	4.6e-05	-8.69	-8.7	3.0e-18	0.05	0.06	0.90	FALSE
68	GTEx	Whole Blood	SLC22A5	0.09	0.12	lasso	2	0.10	1.7e-09	9.91	-9.9	3.7e-23	0.07	0.01	0.99	FALSE
69	GTEx	Whole Blood	AC034220.3	0.08	0.05	enet	31	0.06	4.0e-06	9.75	-9.6	5.3e-22	0.05	0.03	0.97	FALSE
70	GTEx	Whole Blood	AC116366.6	0.05	0.04	lasso	17	0.03	5.7e-04	-4.72	6.3	2.1e-10	-0.08	0.27	0.52	FALSE
71	METSIM	Adipose	P4HA2	0.09	0.08	lasso	12	0.09	2.4e-13	9.87	8.3	8.0e-17	-0.09	0.01	0.99	FALSE
72	METSIM	Adipose	PDLIM4	0.05	0.04	lasso	4	0.02	2.8e-04	9.12	-9.1	9.6e-20	0.10	0.68	0.27	FALSE
73	METSIM	Adipose	SLC22A4	0.05	0.02	lasso	3	0.03	8.4e-06	5.68	-6.4	1.8e-10	0.05	0.72	0.24	FALSE
74	METSIM	Adipose	SLC22A5	0.05	0.08	lasso	1	0.08	1.0e-11	9.91	-9.9	3.6e-23	0.07	0.01	0.99	FALSE
75	NTR	Blood	IRF1	0.03	0.02	blup	424	0.01	5.7e-05	-4.72	5.3	1.4e-07	-0.04	1.00	0.00	FALSE
76	NTR	Blood	SLC22A4	0.02	0.00	blup	423	0.01	5.2e-04	5.68	-7.1	9.4e-13	0.07	0.07	0.92	FALSE
77	ROSMAP	Brain Pre-frontal Cortex	PDLIM4	0.25	0.27	lasso	4	0.26	2.7e-33	-7.32	-8.0	1.3e-15	0.07	1.00	0.00	FALSE
78	ROSMAP	Brain Pre-frontal Cortex	SLC22A4	0.03	0.05	lasso	2	0.04	1.2e-05	-9.97	-10.1	6.3e-24	0.09	0.01	0.99	FALSE
79	ROSMAP	Brain Pre-frontal Cortex	AC034220.3	0.04	0.02	blup	415	0.04	1.3e-05	-4.82	6.4	1.2e-10	-0.06	0.36	0.63	FALSE
80	YFS	Blood	SLC22A4	0.10	0.12	enet	47	0.14	5.1e-42	-8.04	-7.6	3.0e-14	0.06	1.00	0.00	FALSE
81	YFS	Blood	SLC22A5	0.38	0.36	bslmm	430	0.37	3.0e-128	9.91	-10.5	1.3e-25	0.08	0.01	0.99	TRUE
82	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PDLIM4	0.05	0.01	enet	4	0.02	1.2e-02	-6.56	-6.1	8.8e-10	0.08	0.08	0.07	FALSE
83	The Cancer Genome Atlas	Breast Invasive Carcinoma	P4HA2	0.03	0.02	blup	47	0.03	3.1e-06	9.87	7.6	2.4e-14	-0.10	0.00	0.99	FALSE
84	The Cancer Genome Atlas	Breast Invasive Carcinoma	PDLIM4	0.05	0.05	lasso	4	0.05	9.0e-11	-7.32	-7.4	1.3e-13	0.05	0.99	0.01	FALSE
85	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC22A4	0.05	0.01	enet	7	0.02	1.6e-05	9.91	-8.3	7.5e-17	0.04	0.01	0.97	FALSE
86	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC22A5	0.05	0.07	enet	11	0.09	5.3e-17	-7.42	-8.3	7.5e-17	0.05	1.00	0.00	FALSE
87	The Cancer Genome Atlas	Colon Adenocarcinoma	SLC22A5	0.08	0.04	blup	92	0.07	1.2e-04	-8.69	-8.5	2.1e-17	0.05	0.04	0.88	FALSE
88	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC22A4	0.02	0.02	lasso	1	0.02	3.0e-03	-7.47	-7.5	8.1e-14	0.04	0.15	0.41	FALSE
89	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC22A5	0.06	0.05	blup	93	0.08	1.2e-09	-8.04	-8.9	7.6e-19	0.05	0.04	0.96	FALSE
90	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PDLIM4	0.09	0.02	lasso	6	0.05	4.5e-06	-6.56	-8.3	1.2e-16	0.08	0.15	0.73	FALSE
91	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC22A4	0.03	0.03	lasso	1	0.02	3.5e-03	-8.07	-8.1	6.8e-16	0.06	0.20	0.58	FALSE
92	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SLC22A4	0.04	0.03	blup	108	0.01	7.1e-02	-7.42	-7.6	2.6e-14	0.05	0.10	0.29	FALSE
93	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PDLIM4	0.08	0.03	blup	67	0.05	2.4e-03	-7.38	-6.6	4.5e-11	0.06	0.04	0.36	FALSE
94	The Cancer Genome Atlas	Lung Adenocarcinoma	SLC22A5	0.06	0.03	lasso	4	0.02	9.3e-04	-8.69	-8.5	1.9e-17	0.05	0.08	0.64	FALSE
95	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C5orf56	0.07	0.01	blup	98	0.03	3.2e-04	-4.93	5.7	1.4e-08	-0.07	0.19	0.28	FALSE
96	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC22A4	0.04	0.01	blup	111	0.03	3.0e-04	-3.41	-7.0	2.7e-12	0.04	0.05	0.75	FALSE
97	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC22A5	0.05	0.03	blup	93	0.05	1.9e-06	-7.42	-8.7	2.4e-18	0.05	0.06	0.94	FALSE
98	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SLC22A5	0.12	0.04	blup	92	0.07	2.2e-05	-8.69	-5.2	1.6e-07	0.02	0.14	0.52	FALSE
99	The Cancer Genome Atlas	Prostate Adenocarcinoma	PDLIM4	0.32	0.36	enet	13	0.37	3.8e-40	-6.56	-7.9	2.9e-15	0.07	1.00	0.00	FALSE
100	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC22A4	0.09	0.07	blup	108	0.09	3.0e-09	-8.05	-8.4	2.8e-17	0.03	0.11	0.89	FALSE
101	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC22A5	0.12	0.05	lasso	4	0.08	1.8e-08	-4.11	-6.3	3.2e-10	0.04	0.96	0.01	FALSE
102	The Cancer Genome Atlas	Stomach Adenocarcinoma	SLC22A5	0.05	0.01	blup	92	0.02	1.1e-02	-4.98	-6.4	1.9e-10	0.02	0.09	0.15	FALSE
103	The Cancer Genome Atlas	Thyroid Carcinoma	C5orf56	0.06	0.04	blup	98	0.03	1.3e-03	-5.03	8.6	6.1e-18	-0.10	0.64	0.28	FALSE
104	The Cancer Genome Atlas	Thyroid Carcinoma	IRF1	0.05	0.02	blup	83	0.03	1.5e-03	7.68	8.3	7.0e-17	-0.05	0.01	0.81	FALSE
105	The Cancer Genome Atlas	Thyroid Carcinoma	P4HA2	0.21	0.35	enet	10	0.35	4.7e-35	9.87	9.3	8.9e-21	-0.07	0.00	1.00	FALSE
106	The Cancer Genome Atlas	Thyroid Carcinoma	SLC22A5	0.03	0.02	lasso	1	0.01	2.6e-02	-8.69	-8.7	3.6e-18	0.05	0.02	0.60	FALSE