[Hub]/) : Traits : Sitting height :

chr5:128,541,597-132,839,137

Best TWAS P=1.34e-25 · Best GWAS P=7.2e-24 conditioned to 9.82e-20

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex LOC553103 0.05 0.02 bslmm 433 0.03 3.2e-04 -7.32 6.0 2.7e-09 -0.04 0.78 0.04 FALSE
2 CommonMind Brain Pre-frontal Cortex PDLIM4 0.11 0.18 lasso 5 0.18 8.0e-21 -7.18 -7.4 1.1e-13 0.07 1.00 0.00 FALSE
3 GTEx Adipose Subcutaneous SLC22A5 0.05 0.04 lasso 4 0.04 4.2e-04 9.75 -8.5 1.4e-17 0.05 0.03 0.96 FALSE
4 GTEx Adipose Subcutaneous AC034220.3 0.11 0.11 lasso 10 0.09 4.8e-08 -8.04 8.0 9.0e-16 -0.06 0.51 0.49 FALSE
5 GTEx Adipose Visceral Omentum AC034220.3 0.10 0.09 lasso 7 0.08 7.3e-05 -8.08 8.1 6.4e-16 -0.07 0.27 0.55 FALSE
6 GTEx Adrenal Gland AC034220.3 0.12 0.11 lasso 16 0.08 7.7e-04 -8.05 8.2 2.9e-16 -0.07 0.28 0.63 FALSE
7 GTEx Artery Aorta P4HA2 0.12 0.14 lasso 2 0.11 1.2e-06 9.88 9.9 4.4e-23 -0.06 0.01 0.99 FALSE
8 GTEx Artery Aorta AC034220.3 0.08 0.06 lasso 3 0.05 1.1e-03 -8.18 9.1 6.7e-20 -0.07 0.23 0.65 FALSE
9 GTEx Artery Aorta P4HA2-AS1 0.08 0.03 lasso 3 0.01 6.6e-02 9.80 9.9 3.2e-23 -0.08 0.03 0.94 FALSE
10 GTEx Artery Tibial P4HA2 0.12 0.15 lasso 6 0.14 3.2e-11 9.88 10.0 1.6e-23 -0.08 0.01 0.99 FALSE
11 GTEx Artery Tibial HINT1 0.11 0.04 enet 18 0.06 1.0e-05 -2.61 -5.4 5.4e-08 0.06 0.24 0.53 FALSE
12 GTEx Artery Tibial SLC22A5 0.18 0.12 enet 8 0.12 2.5e-09 9.75 -8.7 3.0e-18 0.05 0.02 0.98 FALSE
13 GTEx Artery Tibial P4HA2-AS1 0.10 0.09 lasso 4 0.11 1.0e-08 9.87 9.8 1.4e-22 -0.07 0.02 0.98 FALSE
14 GTEx Brain Caudate basal ganglia AC034220.3 0.41 0.45 enet 19 0.46 8.8e-15 -8.08 8.4 3.3e-17 -0.06 0.32 0.68 FALSE
15 GTEx Brain Cortex AC034220.3 0.43 0.39 lasso 15 0.17 2.4e-05 -8.08 8.1 4.8e-16 -0.07 0.39 0.61 FALSE
16 GTEx Brain Frontal Cortex BA9 AC034220.3 0.31 0.20 lasso 14 0.21 3.3e-06 -8.26 7.1 1.5e-12 -0.05 0.31 0.63 FALSE
17 GTEx Brain Hippocampus AC034220.3 0.21 0.15 lasso 14 0.18 5.8e-05 -8.26 8.5 2.4e-17 -0.05 0.06 0.89 FALSE
18 GTEx Brain Hypothalamus AC034220.3 0.38 0.14 enet 33 0.28 3.2e-07 -4.52 5.4 5.4e-08 -0.05 0.26 0.56 FALSE
19 GTEx Brain Nucleus accumbens basal ganglia AC034220.3 0.24 0.24 enet 34 0.24 3.7e-07 -8.07 8.2 2.2e-16 -0.06 0.25 0.73 FALSE
20 GTEx Breast Mammary Tissue SLC22A5 0.10 0.02 enet 16 0.06 4.5e-04 9.91 -6.7 1.8e-11 0.07 0.06 0.92 FALSE
21 GTEx Breast Mammary Tissue (Female) SLC22A5 0.04 -0.01 lasso 3 0.01 1.3e-01 -3.53 -6.5 1.1e-10 0.06 0.05 0.19 FALSE
22 GTEx Cells EBV-transformed lymphocytes SLC22A5 0.37 0.05 lasso 13 0.10 2.8e-04 9.91 -8.7 5.1e-18 0.06 0.03 0.94 FALSE
23 GTEx Cells Transformed fibroblasts PDLIM4 0.08 0.09 lasso 1 0.07 6.4e-06 -7.37 -7.4 1.7e-13 0.06 0.50 0.42 FALSE
24 GTEx Cells Transformed fibroblasts SLC22A5 0.32 0.28 lasso 7 0.35 1.6e-27 -8.69 -9.4 5.9e-21 0.06 0.12 0.88 FALSE
25 GTEx Colon Sigmoid AC034220.3 0.18 0.11 lasso 12 0.06 3.7e-03 -8.25 8.0 1.2e-15 -0.05 0.19 0.35 FALSE
26 GTEx Colon Transverse SLC22A5 0.12 0.07 enet 8 0.07 2.5e-04 9.91 -8.4 4.2e-17 0.01 0.04 0.94 FALSE
27 GTEx Colon Transverse AC034220.3 0.30 0.15 lasso 3 0.11 8.4e-06 -8.18 8.6 9.7e-18 -0.07 0.63 0.34 FALSE
28 GTEx Esophagus Gastroesophageal Junction SEPT8 0.22 0.08 lasso 12 0.10 2.2e-04 -7.47 8.1 6.2e-16 -0.04 0.33 0.51 FALSE
29 GTEx Esophagus Mucosa P4HA2 0.23 0.10 lasso 6 0.14 6.1e-10 9.88 9.8 7.4e-23 -0.06 0.01 0.99 FALSE
30 GTEx Esophagus Mucosa SLC22A5 0.16 0.16 enet 8 0.16 6.3e-11 9.91 -9.5 2.0e-21 0.06 0.01 0.99 FALSE
31 GTEx Esophagus Mucosa AC034220.3 0.08 0.03 lasso 3 0.05 4.7e-04 -8.26 8.2 3.3e-16 -0.06 0.45 0.54 FALSE
32 GTEx Esophagus Mucosa P4HA2-AS1 0.09 0.06 lasso 6 0.08 5.4e-06 9.88 9.6 1.1e-21 -0.07 0.02 0.98 FALSE
33 GTEx Esophagus Muscularis AC034220.3 0.12 0.08 enet 20 0.07 3.8e-05 -8.18 7.5 6.5e-14 -0.07 0.12 0.86 FALSE
34 GTEx Heart Atrial Appendage AC034220.3 0.16 0.09 enet 17 0.18 1.7e-08 -8.05 8.8 8.8e-19 -0.07 0.06 0.94 FALSE
35 GTEx Heart Left Ventricle AC034220.3 0.25 0.22 lasso 6 0.25 8.6e-14 -8.18 8.9 6.3e-19 -0.06 0.22 0.78 FALSE
36 GTEx Liver AC034220.3 0.30 0.16 lasso 6 0.16 3.9e-05 -8.05 6.9 6.3e-12 -0.06 0.42 0.32 FALSE
37 GTEx Lung SLC22A5 0.10 0.15 enet 11 0.13 3.4e-10 9.91 -9.3 2.0e-20 0.07 0.01 0.99 FALSE
38 GTEx Muscle Skeletal SLC22A5 0.10 0.01 lasso 3 0.02 6.6e-03 -4.94 -5.3 1.3e-07 0.07 0.26 0.06 FALSE
39 GTEx Muscle Skeletal AC034220.3 0.27 0.23 lasso 9 0.24 9.1e-24 -8.08 8.6 7.3e-18 -0.07 1.00 0.00 FALSE
40 GTEx Muscle Skeletal MIR3936 0.04 0.01 lasso 4 0.00 9.9e-02 -7.37 8.9 3.6e-19 -0.07 0.08 0.69 FALSE
41 GTEx Nerve Tibial P4HA2 0.19 0.12 enet 26 0.14 6.2e-10 -8.05 8.7 3.2e-18 -0.07 0.02 0.98 FALSE
42 GTEx Nerve Tibial AC034220.3 0.15 0.11 lasso 5 0.10 1.9e-07 -8.05 8.1 4.7e-16 -0.06 0.55 0.45 FALSE
43 GTEx Nerve Tibial P4HA2-AS1 0.14 0.05 lasso 8 0.08 3.8e-06 9.07 9.1 7.8e-20 -0.11 0.04 0.96 FALSE
44 GTEx Ovary AC004041.2 0.21 -0.01 lasso 2 -0.01 7.7e-01 -6.56 7.8 7.7e-15 -0.07 0.07 0.22 FALSE
45 GTEx Pituitary AC034220.3 0.25 0.22 lasso 12 0.18 3.1e-05 -7.36 8.1 8.5e-16 -0.05 0.50 0.32 FALSE
46 GTEx Prostate AC034220.3 0.38 0.37 lasso 5 0.37 3.0e-10 -8.18 7.8 4.7e-15 -0.05 0.37 0.63 FALSE
47 GTEx Skin Not Sun Exposed Suprapubic PDLIM4 0.13 0.08 lasso 2 0.06 2.6e-04 9.91 -8.8 1.8e-18 0.07 0.03 0.95 FALSE
48 GTEx Skin Not Sun Exposed Suprapubic SLC22A4 0.13 0.00 lasso 4 0.01 7.1e-02 -2.49 -5.8 6.4e-09 0.03 0.15 0.11 FALSE
49 GTEx Skin Not Sun Exposed Suprapubic SLC22A5 0.13 0.05 lasso 8 0.05 8.3e-04 -8.07 -9.2 2.6e-20 0.07 0.09 0.91 FALSE
50 GTEx Skin Sun Exposed Lower leg PDLIM4 0.09 0.08 lasso 8 0.09 1.0e-07 9.88 -10.2 3.0e-24 0.06 0.02 0.98 FALSE
51 GTEx Skin Sun Exposed Lower leg SLC22A5 0.25 0.21 lasso 3 0.20 1.4e-16 9.75 -9.8 1.3e-22 0.06 0.02 0.98 FALSE
52 GTEx Spleen SLC22A5 0.26 0.28 lasso 4 0.28 6.6e-08 9.91 10.0 1.5e-23 -0.08 0.01 0.96 FALSE
53 GTEx Stomach SLC22A5 0.09 0.04 lasso 4 0.01 9.0e-02 -8.30 -8.9 5.7e-19 0.04 0.07 0.61 FALSE
54 GTEx Stomach AC034220.3 0.17 0.15 enet 21 0.16 4.2e-08 -7.42 8.4 5.6e-17 -0.05 0.64 0.36 FALSE
55 GTEx Testis P4HA2 0.14 0.13 lasso 5 0.11 1.4e-05 9.88 10.0 9.2e-24 -0.06 0.02 0.98 FALSE
56 GTEx Testis PDLIM4 0.15 0.07 enet 8 0.05 2.5e-03 -8.26 8.4 4.6e-17 -0.05 0.12 0.57 FALSE
57 GTEx Testis RAPGEF6 0.50 0.35 lasso 4 0.32 6.5e-15 -5.18 -5.4 7.7e-08 0.01 1.00 0.00 FALSE
58 GTEx Testis CHSY3 0.20 0.27 enet 7 0.25 2.8e-11 5.22 6.2 4.2e-10 0.64 0.77 0.23 TRUE
59 GTEx Testis AC034220.3 0.15 0.12 lasso 9 0.12 4.4e-06 -8.08 8.1 7.4e-16 -0.07 0.65 0.28 FALSE
60 GTEx Thyroid P4HA2 0.08 0.07 enet 9 0.06 3.5e-05 9.88 9.7 4.5e-22 -0.06 0.01 0.98 FALSE
61 GTEx Thyroid PDLIM4 0.05 0.02 enet 5 0.01 3.1e-02 9.07 -9.5 2.6e-21 0.08 0.04 0.90 FALSE
62 GTEx Thyroid SLC22A4 0.06 0.02 lasso 4 0.02 2.3e-02 -7.42 5.7 1.2e-08 -0.02 0.22 0.50 FALSE
63 GTEx Thyroid SLC22A5 0.17 0.07 lasso 5 0.13 4.8e-10 -0.32 -5.8 5.2e-09 0.02 0.04 0.96 FALSE
64 GTEx Thyroid AC034220.3 0.29 0.29 lasso 5 0.31 4.8e-24 -7.36 6.6 3.7e-11 -0.05 1.00 0.00 FALSE
65 GTEx Thyroid P4HA2-AS1 0.08 0.06 enet 14 0.05 1.6e-04 9.88 9.7 2.0e-22 -0.05 0.01 0.98 FALSE
66 GTEx Uterus P4HA2 0.58 -0.01 lasso 5 0.02 1.6e-01 -3.74 6.0 1.6e-09 -0.03 0.05 0.36 FALSE
67 GTEx Whole Blood SLC22A4 0.07 0.05 enet 16 0.05 4.6e-05 -8.69 -8.7 3.0e-18 0.05 0.06 0.90 FALSE
68 GTEx Whole Blood SLC22A5 0.09 0.12 lasso 2 0.10 1.7e-09 9.91 -9.9 3.7e-23 0.07 0.01 0.99 FALSE
69 GTEx Whole Blood AC034220.3 0.08 0.05 enet 31 0.06 4.0e-06 9.75 -9.6 5.3e-22 0.05 0.03 0.97 FALSE
70 GTEx Whole Blood AC116366.6 0.05 0.04 lasso 17 0.03 5.7e-04 -4.72 6.3 2.1e-10 -0.08 0.27 0.52 FALSE
71 METSIM Adipose P4HA2 0.09 0.08 lasso 12 0.09 2.4e-13 9.87 8.3 8.0e-17 -0.09 0.01 0.99 FALSE
72 METSIM Adipose PDLIM4 0.05 0.04 lasso 4 0.02 2.8e-04 9.12 -9.1 9.6e-20 0.10 0.68 0.27 FALSE
73 METSIM Adipose SLC22A4 0.05 0.02 lasso 3 0.03 8.4e-06 5.68 -6.4 1.8e-10 0.05 0.72 0.24 FALSE
74 METSIM Adipose SLC22A5 0.05 0.08 lasso 1 0.08 1.0e-11 9.91 -9.9 3.6e-23 0.07 0.01 0.99 FALSE
75 NTR Blood IRF1 0.03 0.02 blup 424 0.01 5.7e-05 -4.72 5.3 1.4e-07 -0.04 1.00 0.00 FALSE
76 NTR Blood SLC22A4 0.02 0.00 blup 423 0.01 5.2e-04 5.68 -7.1 9.4e-13 0.07 0.07 0.92 FALSE
77 ROSMAP Brain Pre-frontal Cortex PDLIM4 0.25 0.27 lasso 4 0.26 2.7e-33 -7.32 -8.0 1.3e-15 0.07 1.00 0.00 FALSE
78 ROSMAP Brain Pre-frontal Cortex SLC22A4 0.03 0.05 lasso 2 0.04 1.2e-05 -9.97 -10.1 6.3e-24 0.09 0.01 0.99 FALSE
79 ROSMAP Brain Pre-frontal Cortex AC034220.3 0.04 0.02 blup 415 0.04 1.3e-05 -4.82 6.4 1.2e-10 -0.06 0.36 0.63 FALSE
80 YFS Blood SLC22A4 0.10 0.12 enet 47 0.14 5.1e-42 -8.04 -7.6 3.0e-14 0.06 1.00 0.00 FALSE
81 YFS Blood SLC22A5 0.38 0.36 bslmm 430 0.37 3.0e-128 9.91 -10.5 1.3e-25 0.08 0.01 0.99 TRUE
82 The Cancer Genome Atlas Bladder Urothelial Carcinoma PDLIM4 0.05 0.01 enet 4 0.02 1.2e-02 -6.56 -6.1 8.8e-10 0.08 0.08 0.07 FALSE
83 The Cancer Genome Atlas Breast Invasive Carcinoma P4HA2 0.03 0.02 blup 47 0.03 3.1e-06 9.87 7.6 2.4e-14 -0.10 0.00 0.99 FALSE
84 The Cancer Genome Atlas Breast Invasive Carcinoma PDLIM4 0.05 0.05 lasso 4 0.05 9.0e-11 -7.32 -7.4 1.3e-13 0.05 0.99 0.01 FALSE
85 The Cancer Genome Atlas Breast Invasive Carcinoma SLC22A4 0.05 0.01 enet 7 0.02 1.6e-05 9.91 -8.3 7.5e-17 0.04 0.01 0.97 FALSE
86 The Cancer Genome Atlas Breast Invasive Carcinoma SLC22A5 0.05 0.07 enet 11 0.09 5.3e-17 -7.42 -8.3 7.5e-17 0.05 1.00 0.00 FALSE
87 The Cancer Genome Atlas Colon Adenocarcinoma SLC22A5 0.08 0.04 blup 92 0.07 1.2e-04 -8.69 -8.5 2.1e-17 0.05 0.04 0.88 FALSE
88 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma SLC22A4 0.02 0.02 lasso 1 0.02 3.0e-03 -7.47 -7.5 8.1e-14 0.04 0.15 0.41 FALSE
89 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma SLC22A5 0.06 0.05 blup 93 0.08 1.2e-09 -8.04 -8.9 7.6e-19 0.05 0.04 0.96 FALSE
90 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PDLIM4 0.09 0.02 lasso 6 0.05 4.5e-06 -6.56 -8.3 1.2e-16 0.08 0.15 0.73 FALSE
91 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SLC22A4 0.03 0.03 lasso 1 0.02 3.5e-03 -8.07 -8.1 6.8e-16 0.06 0.20 0.58 FALSE
92 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma SLC22A4 0.04 0.03 blup 108 0.01 7.1e-02 -7.42 -7.6 2.6e-14 0.05 0.10 0.29 FALSE
93 The Cancer Genome Atlas Liver Hepatocellular Carcinoma PDLIM4 0.08 0.03 blup 67 0.05 2.4e-03 -7.38 -6.6 4.5e-11 0.06 0.04 0.36 FALSE
94 The Cancer Genome Atlas Lung Adenocarcinoma SLC22A5 0.06 0.03 lasso 4 0.02 9.3e-04 -8.69 -8.5 1.9e-17 0.05 0.08 0.64 FALSE
95 The Cancer Genome Atlas Lung Squamous Cell Carcinoma C5orf56 0.07 0.01 blup 98 0.03 3.2e-04 -4.93 5.7 1.4e-08 -0.07 0.19 0.28 FALSE
96 The Cancer Genome Atlas Lung Squamous Cell Carcinoma SLC22A4 0.04 0.01 blup 111 0.03 3.0e-04 -3.41 -7.0 2.7e-12 0.04 0.05 0.75 FALSE
97 The Cancer Genome Atlas Lung Squamous Cell Carcinoma SLC22A5 0.05 0.03 blup 93 0.05 1.9e-06 -7.42 -8.7 2.4e-18 0.05 0.06 0.94 FALSE
98 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma SLC22A5 0.12 0.04 blup 92 0.07 2.2e-05 -8.69 -5.2 1.6e-07 0.02 0.14 0.52 FALSE
99 The Cancer Genome Atlas Prostate Adenocarcinoma PDLIM4 0.32 0.36 enet 13 0.37 3.8e-40 -6.56 -7.9 2.9e-15 0.07 1.00 0.00 FALSE
100 The Cancer Genome Atlas Prostate Adenocarcinoma SLC22A4 0.09 0.07 blup 108 0.09 3.0e-09 -8.05 -8.4 2.8e-17 0.03 0.11 0.89 FALSE
101 The Cancer Genome Atlas Prostate Adenocarcinoma SLC22A5 0.12 0.05 lasso 4 0.08 1.8e-08 -4.11 -6.3 3.2e-10 0.04 0.96 0.01 FALSE
102 The Cancer Genome Atlas Stomach Adenocarcinoma SLC22A5 0.05 0.01 blup 92 0.02 1.1e-02 -4.98 -6.4 1.9e-10 0.02 0.09 0.15 FALSE
103 The Cancer Genome Atlas Thyroid Carcinoma C5orf56 0.06 0.04 blup 98 0.03 1.3e-03 -5.03 8.6 6.1e-18 -0.10 0.64 0.28 FALSE
104 The Cancer Genome Atlas Thyroid Carcinoma IRF1 0.05 0.02 blup 83 0.03 1.5e-03 7.68 8.3 7.0e-17 -0.05 0.01 0.81 FALSE
105 The Cancer Genome Atlas Thyroid Carcinoma P4HA2 0.21 0.35 enet 10 0.35 4.7e-35 9.87 9.3 8.9e-21 -0.07 0.00 1.00 FALSE
106 The Cancer Genome Atlas Thyroid Carcinoma SLC22A5 0.03 0.02 lasso 1 0.01 2.6e-02 -8.69 -8.7 3.6e-18 0.05 0.02 0.60 FALSE