TWAS hub - PHF15

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.2560	0.0760	0.00067	0.184	NA	0.207	NA	0.224	1.3e-06	NA	2.5e-07	NA	7.1e-08
2	METSIM	Adipose	0.0287	0.0154	0.00980	0.013	0.01	0.002	0.011	0.006	3.5e-03	0.01	1.3e-01	0.0065	4.3e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Age when periods started (menarche)	27.5	66.1	71.1	7.8	8.4
Relative age voice broke	12.9	19.7	23.7	4.0	4.9
Age at First Birth	11.9	17.3	27.7	2.6	5.3
Illnesses of siblings	8.3	11.6	13.2	3.6	3.2
High blood pressure (siblings)	8.3	12.0	13.4	-3.7	-3.3
Bilateral oophorectomy (both ovaries removed)	7.7	8.9	14.2	-1.9	-3.8
Age at last live birth	6.3	9.2	10.7	3.3	2.8
Illnesses of father: None of the above (group 1)	6.3	7.8	14.8	3.8	0.9
Relative age of first facial hair	5.9	12.2	12.8	3.4	3.6
Body mass index (BMI)	5.9	25.4	42.1	-2.9	-6.5
Impedance of arm (left)	5.7	26.5	35.8	4.1	6.0
Gout (self-reported)	5.6	7.7	8.9	2.6	3.0
Impedance of whole body	5.5	28.1	39.9	4.0	6.3
Impedance of arm (right)	5.2	24.1	35.0	3.6	5.9
Number of incorrect matches in round	5.1	8.5	11.6	3.4	2.3
Exposure to tobacco smoke at home	5.1	5.7	8.2	-1.8	-2.9
Birth weight of first child	5.1	9.3	14.5	3.8	2.0
Forced vital capacity (FVC)	5.0	19.2	29.1	5.4	3.1
Length of working week for main job	5.0	5.5	10.0	-3.2	-1.0
Standing height	4.8	47.9	74.3	8.6	4.6
Age at first live birth	4.7	8.4	10.8	2.5	3.3
Forced expiratory volume in 1-second (FEV1), predicted	4.7	9.7	13.3	2.5	3.6
Impedance of leg (right)	4.5	21.7	32.9	3.2	5.7
Worry too long after embarrassment	4.5	7.6	12.1	3.5	1.8
Qualifications: nursing, teaching	4.5	7.0	7.8	2.8	2.5
Prostate Cancer	4.4	6.2	8.4	2.9	2.0
Mean time to correctly identify matches	4.3	8.1	9.1	3.0	2.7
Alzheimer’s Disease (including proxy)	4.1	5.9	7.3	-2.7	-2.1
Frequency of tiredness / lethargy in last 2 weeks	4.1	6.7	10.8	-1.6	-3.3
Qualifications: College or University degree	4.1	13.0	14.6	3.4	3.8
BMI	4.0	23.0	43.2	-1.7	-6.6
Fed-up feelings	4.0	7.3	12.4	-1.5	-3.5
Bipolar Disorder (2011)	3.8	3.6	7.0	2.6	0.5
Height	3.8	73.5	135.2	11.6	3.4
Impedance of leg (left)	3.8	18.5	29.5	2.7	5.4
Forced vital capacity (FVC), Best measure	3.8	13.9	22.2	4.7	2.4
Bipolar Disorder (2018)	3.7	5.9	9.1	3.0	1.7
Unable to work because of sickness or disability	3.7	4.8	9.0	-0.7	-3.0
Alcohol drinker status: Previous	3.7	4.2	5.1	-1.8	-2.3
Reaction Time	3.5	6.6	8.0	2.8	2.3
Lupus	3.5	5.3	10.4	3.2	-0.4
Frequency of depressed mood in last 2 weeks	3.4	4.7	8.0	-1.2	-2.8
Chronic bronchitis/emphysema (mother)	3.4	4.0	4.1	-2.0	-2.0
Lung FEV1/FVC ratio	3.2	16.4	21.2	-4.6	-3.4
Eye problems/disorders: Cataract	3.2	3.8	6.6	2.6	0.9
Rheumatoid Arthritis	3.1	4.2	8.0	0.7	-2.8
Hypothyroidism/myxoedema (self-reported)	3.1	6.1	12.1	0.2	-3.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.1	3.7	7.0	0.6	2.6
HbA1C	3.0	3.3	6.0	2.4	0.8
Pain all over the body in last month	3.0	3.2	4.4	2.1	1.4
Hip circumference	3.0	12.9	25.2	0.8	-5.0
Illnesses of father: High blood pressure	3.0	3.7	6.4	-2.5	-1.0
Breastfed as a baby	2.9	3.6	5.9	2.4	1.2
Birth weight	2.9	6.4	8.4	2.9	2.1
Osteoarthritis (self-reported)	2.9	3.8	7.3	-0.5	-2.7
Arm fat mass (left)	2.9	12.0	23.4	-0.8	-4.8
Had menopause	2.8	3.4	4.5	-1.6	-2.1
Arm fat mass (right)	2.8	11.6	22.6	-0.8	-4.8
Medication: Allopurinol	2.8	3.7	5.8	2.4	1.3
Pack years adult smoking proportion	2.7	4.1	4.7	-1.8	-2.2
Chronic bronchitis/emphysema (father)	2.7	3.2	3.3	-1.7	-1.8
Glaucoma (self-reported)	2.7	3.2	4.3	2.1	1.5
Medication: Amlodipine	2.7	3.8	5.7	-2.4	-1.3
Arm fat percentage (left)	2.7	10.7	19.7	-1.3	-4.4
Supplements: Calcium	2.7	2.9	5.3	-0.7	2.3
Leg fat mass (left)	2.7	10.5	20.5	-0.7	-4.5
Body Mass Index (BMI) (2010)	2.6	3.5	4.0	-1.7	-2.0
Sitting height	2.6	18.6	35.2	5.9	1.4
Arm fat percentage (right)	2.6	10.2	18.1	-1.5	-4.3
Eye problems/disorders: None of the above	2.6	3.0	5.3	-2.3	-0.8
Age started oral contraceptive pill	2.6	3.3	3.5	1.7	1.9
Eye problems/disorders: Glaucoma	2.5	2.9	4.0	2.0	1.4
Leg fat percentage (left)	2.5	9.0	14.9	-1.8	-3.9
Commuting to job workplace: Cycle	2.5	3.0	4.1	2.0	1.3
Depressed Affect (Nagel 2018)	2.4	5.0	8.9	-1.0	-3.0
Schizophrenia vs Biploar Disorder	2.4	3.1	6.1	-2.5	0.3
Alzheimer’s Disease (in father)	2.4	2.6	4.7	-2.2	-0.7
Medication: Cholesterol lowering	2.4	3.7	3.8	1.9	1.9
Comparative body size at age 10	2.4	6.7	7.1	-2.5	-2.7
Medication: Omeprazole	2.4	2.8	3.0	-1.7	-1.6
Alcohol intake frequency.	2.4	5.7	7.9	-1.9	-2.8
Suffer from ‘nerves’	2.4	3.8	7.1	-2.7	-0.7
Medication: Blood pressure	2.4	4.6	9.0	-3.0	-0.5
Medication: Omeprazole (e.g. Zanprol)	2.4	2.9	3.9	-1.4	-2.0
Hypothyroidism (self reported)	2.3	5.3	10.1	0.7	-3.2
Heart disease (mother)	2.3	2.8	3.3	1.8	1.5
Leg fat mass (right)	2.3	8.9	17.7	-0.4	-4.2
Mood swings	2.3	4.2	6.5	-1.4	-2.6
Medication for pain relief, constipation, heartburn	2.2	3.8	7.1	0.7	2.7
Number of operations (self-reported)	2.2	3.2	5.5	-0.9	-2.4
Myopia	2.1	3.1	6.2	-2.5	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.7	4.5	-0.9	-2.1
Forced expiratory volume in 1-second (FEV1)	2.0	6.7	10.3	3.2	1.8
Pack years of smoking	2.0	2.9	3.1	-1.6	-1.8
Bipolar Disorder or Schizophrenia	1.9	4.5	5.0	2.2	2.0
Major Depression (MDD)	1.9	2.3	3.0	1.7	-1.3
Blood Platelet Count	1.9	21.8	23.8	4.9	4.5
Medication: Co-codamol	1.9	2.3	3.7	-0.9	-1.9
Current tobacco smoking	1.9	3.1	5.6	-0.8	-2.4
High blood pressure	1.9	5.3	9.4	-3.1	-1.1
Waist circumference	1.9	7.1	13.6	-0.8	-3.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.5	4.4	-0.7	-2.1
Whole body fat mass	1.9	7.8	15.5	0.1	-3.9
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	3.8	-1.9	-0.9
Hypertension (Self-reported)	1.9	5.2	10.1	-3.2	-0.5
Loneliness, isolation	1.9	2.6	5.1	0.3	-2.2
Pain type(s) experienced in last month: Hip pain	1.9	2.5	3.2	-1.3	-1.8
Depression (Nagel 2018)	1.8	2.6	5.2	-0.2	-2.3
Type 2 Diabetes (T2D) (2018)	1.8	3.4	5.1	1.3	2.3
Weight	1.8	9.0	17.0	1.0	-4.1
Leg fat percentage (right)	1.8	6.6	11.7	-1.2	-3.4
Illness, injury, bereavement, stress in last 2 years	1.8	2.2	4.2	2.0	-0.4
Smoking Status	1.7	4.0	7.0	-1.0	-2.6
Other serious medical condition/disability diagnosed by doctor	1.7	2.2	4.1	2.0	0.6
Qualifications: CSEs or equivalent	1.7	2.2	2.3	-1.4	-1.5
Father’s age at death	1.7	2.2	3.4	1.9	1.0
Body fat percentage	1.7	6.7	13.0	-0.6	-3.6
Breast cancer (self-reported)	1.7	2.0	2.1	-1.5	-1.4
Medication: Aspirin	1.7	2.2	3.3	-1.1	-1.8
Cardiovascular Disease	1.6	5.2	9.4	-3.1	-1.0
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	3.1	-1.7	-1.4
Wheeze or whistling in the chest in last year	1.6	2.8	5.6	2.4	0.2
Overall health rating	1.6	3.3	6.4	-0.5	-2.5
Knee pain experienced in last month	1.6	2.4	4.0	-0.9	-2.0
Smoking status: Current	1.6	2.5	4.6	-0.6	-2.1
Vascular/heart problems diagnosed by doctor	1.6	4.4	7.6	2.8	1.1
Type 2 Diabetes (T2D) (2012)	1.5	1.7	2.9	0.7	1.7
Hand grip strength (right)	1.5	4.0	5.0	2.2	1.8
Falls in the last year	1.5	2.0	3.9	0.1	-2.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.5	4.8	7.8	2.8	1.3
Medication: Ventolin 100micrograms inhaler	1.5	1.9	2.9	1.7	0.9
Arm fat-free mass (left)	1.5	7.7	13.7	1.3	-3.7
Hand grip strength (left)	1.4	3.6	5.4	2.3	1.3
Leg fat-free mass (left)	1.4	7.5	12.0	1.7	-3.5
Leg predicted mass (left)	1.4	7.4	12.0	1.7	-3.5
Trunk fat mass	1.4	6.0	10.6	1.2	-3.3
Arm fat-free mass (right)	1.4	6.9	10.1	1.9	-3.2
Arm predicted mass (right)	1.4	7.1	10.0	2.0	-3.2
Chest pain or discomfort	1.4	2.0	3.9	2.0	0.2
Leg fat-free mass (right)	1.4	7.7	13.4	1.4	-3.7
Medication for cholesterol	1.4	2.1	3.8	2.0	0.7
Leg predicted mass (right)	1.4	7.6	13.5	1.3	-3.7
Heart disease (siblings)	1.4	1.7	2.3	-1.5	-1.1
Arm predicted mass (left)	1.4	7.2	12.7	1.3	-3.6
Taking other prescription medications	1.3	2.0	3.4	1.8	0.8
Supplements: Glucosamine	1.3	1.7	2.7	-0.9	-1.6
Medication: Ibuprofen	1.3	1.6	2.3	1.5	-0.9
Basal metabolic rate	1.3	7.4	11.8	1.8	-3.4
Crohns Disease (2017)	1.2	2.6	5.3	0.0	2.3
Ulcerative Colitis (UC)	1.2	2.3	4.5	-2.1	0.3
Systolic Blood Pressure	1.2	5.8	11.6	-3.4	0.3
Respiratory disease	1.2	2.7	4.8	2.2	0.8
Ever had hysterectomy (womb removed)	1.2	1.4	1.6	-1.1	-1.3
Diabetes (mother)	1.2	1.5	3.0	-0.2	1.7
Hair/balding pattern: Pattern 3	1.2	1.8	3.4	0.6	-1.8
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.6	2.9	0.6	-1.7
Whole body fat-free mass	1.2	7.0	9.1	2.2	-3.0
Commuting to job workplace: Walk	1.2	1.3	2.3	1.5	0.5
Whole body water mass	1.2	7.0	9.2	2.2	-3.0
Diastolic blood pressure, automated reading	1.2	3.7	5.4	-1.4	-2.3
Irritable Bowel Disease (IBD)	1.1	2.6	2.9	-1.5	1.7
Blood Eosinophil Count	1.1	8.1	16.0	-0.5	-4.0
Medication: Lansoprazole	1.1	1.3	2.4	-0.4	-1.5
Migraine (self-reported)	1.1	1.4	2.8	0.1	-1.7
Medication: Aspirin	1.1	1.4	1.9	-0.9	-1.4
Illnesses of father: Heart disease	1.1	1.6	3.1	-1.8	0.0
Handedness (chirality/laterality): Left-handed	1.1	1.4	2.2	0.7	1.5
Medication: Bendroflumethiazide	1.1	1.7	3.2	-1.8	-0.4
Lung FVC	1.0	4.9	9.2	3.0	0.7
Systolic blood pressure, automated reading	1.0	2.8	3.9	-2.0	-1.3
Trunk fat percentage	1.0	4.1	8.0	0.5	-2.8
Trunk fat-free mass	1.0	5.7	6.2	2.5	-2.3
Happiness	1.0	1.2	1.7	1.3	0.9
Pulse wave Arterial Stiffness index	1.0	1.1	1.5	0.9	1.2
Trunk predicted mass	1.0	5.5	6.4	2.5	-2.1
Asthma (self-reported)	1.0	2.0	2.5	1.6	1.2
Ulcerative Colitis	0.9	1.3	1.6	-1.1	1.3
Waist Hip Ratio (WHR)	0.9	4.2	8.3	-0.3	2.9
Stomach or abdominal pain in last month	0.9	1.1	1.5	-1.2	-0.8
Medication: Levothyroxine sodium	0.9	1.6	1.9	1.1	-1.4
Had other major operations	0.9	1.1	1.7	-1.3	0.7
Diabetes (self-reported)	0.9	1.3	1.9	0.9	1.4
Qualifications: A levels/AS levels or equivalent	0.9	1.9	2.6	1.1	1.6
Lung cancer (father)	0.9	1.1	1.8	1.3	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.4	2.5	-0.6	-1.6
Commuting to job workplace: Car/motor vehicle	0.9	1.0	1.8	-1.4	-0.4
Cholesterol lowering medication	0.9	1.3	2.4	-1.6	-0.5
Alzheimer’s Disease (in mother)	0.8	0.9	1.2	-0.7	-1.1
Allergy or Eczema	0.8	2.2	3.9	0.7	2.0
Diabetes (father)	0.8	1.0	1.8	-1.3	-0.3
Maternal smoking around birth	0.8	1.2	1.4	-1.2	1.0
Hayfever, allergic rhinitis or eczema	0.8	1.8	2.4	1.1	1.6
High blood pressure (mother)	0.8	1.1	2.2	-1.5	-0.0
Asthma	0.8	1.6	2.2	1.5	1.0
Tense / ‘highly strung’	0.8	1.3	1.3	1.1	1.2
Loud music exposure frequency	0.8	0.8	1.0	0.8	1.0
Medication: Paracetamol	0.8	1.4	2.7	-0.3	-1.7
Neck or shoulder pain in last month	0.8	1.1	1.1	-1.1	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.0	-0.1	-1.4
Neuroticism (2016)	0.7	1.0	1.8	1.3	-0.5
Average weekly spirits intake	0.7	0.9	1.7	0.3	-1.3
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.5	-1.2	-0.4
Hearing difficulty/problems with background noise	0.7	1.1	1.8	0.6	1.4
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.6	0.3	1.3
Allergy	0.7	1.5	1.6	-1.2	-1.3
Alcohol intake versus 10 years previously	0.7	1.1	1.6	-0.7	-1.3
Noisy workplace	0.7	0.9	1.0	0.8	1.0
Depression (self-reported)	0.7	0.8	1.3	-0.5	-1.2
Number of full brothers	0.7	0.8	0.8	-0.9	-0.9
Family relationship satisfaction	0.7	0.9	1.3	0.7	1.1
Mineral and other dietary supplements	0.7	1.0	1.9	1.4	0.2
Miserableness	0.7	1.2	2.3	-0.4	-1.5
Ovarian Cancer	0.6	0.8	1.7	0.1	1.3
Townsend deprivation index at recruitment	0.6	0.8	1.6	-0.3	-1.3
Qualifications: None of the above	0.6	1.2	2.3	0.3	-1.5
Medication: Simvastatin	0.6	0.9	1.2	-1.1	0.8
Time employed in main current job	0.6	0.7	1.5	-1.2	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.0	-1.0	0.6
Pulse wave reflection index	0.6	0.7	1.1	0.6	1.0
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	1.8	-1.3	0.2
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	1.5	-0.2	-1.2
Shortness of breath walking on level ground	0.6	0.7	1.2	-1.1	-0.4
Had major operations	0.6	0.7	0.8	0.9	-0.8
Average weekly champagne plus white wine intake	0.6	0.8	1.0	1.0	0.8
Commuting to job workplace: Public transport	0.6	0.7	0.8	0.7	0.9
Medication: Atorvastatin	0.6	0.8	1.5	1.2	0.3
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.0	0.8	1.0
Worry (Nagel 2018)	0.5	1.0	1.9	0.1	1.4
Blood Red Count	0.5	4.8	6.6	-1.7	-2.6
Supplements: Zinc	0.5	0.5	1.1	-1.0	0.1
Financial difficulties in last 2 years	0.5	0.7	1.4	-1.2	0.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.2	1.1	0.0
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.2	1.1	0.3
Exposure to tobacco smoke outside home	0.5	0.7	0.9	0.9	0.7
Number of children fathered	0.5	0.6	1.1	-0.1	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	0.8	0.6	0.9
Illnesses of siblings: Diabetes	0.5	0.6	1.2	-1.1	-0.3
Long-standing illness, disability or infirmity	0.5	0.7	1.3	1.1	-0.4
Guilty feelings	0.5	0.7	0.7	0.8	-0.9
Financial situation satisfaction	0.5	0.6	0.9	-1.0	-0.6
Supplements: Fish oil (including cod liver oil)	0.5	0.6	0.6	-0.8	0.7
Schizophrenia (2018)	0.4	0.8	1.5	0.4	1.2
Coronary Artery Disease (CAD)	0.4	0.5	0.7	0.6	0.8
Crohns Disease (2012)	0.4	0.6	1.1	0.2	1.1
Primary Biliary Cirrhosis	0.4	0.5	0.8	0.9	0.5
Triglycerides	0.4	0.7	0.7	-0.8	-0.8
Tanning	0.4	4.8	7.9	-1.3	-2.8
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	0.9	0.1	-0.9
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.8	0.1	-0.9
Medication: Atenolol	0.4	0.5	0.8	-0.9	-0.5
Heart attack	0.4	0.5	0.8	0.5	0.9
Prospective memory result	0.4	0.5	0.5	-0.7	-0.7
Blood clot in the leg (DVT)	0.4	0.5	0.5	-0.7	-0.7
Headache pain in last month	0.4	0.6	1.2	1.1	-0.1
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.3	0.3	-1.1
Number of full sisters	0.4	0.5	0.9	-0.9	-0.4
Smoking status: Previous	0.4	0.6	1.2	0.1	1.1
Average weekly red wine intake	0.4	0.6	1.1	-1.1	0.1
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	0.8	0.9	0.6
Mother’s age at death	0.4	0.5	0.7	0.8	-0.6
High cholesterol (Self-reported)	0.4	0.7	1.3	0.3	1.2
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	0.7	-0.6	-0.9
Mean Putamen Volume	0.3	0.4	0.5	0.7	0.5
Neuroticism	0.3	0.8	1.3	1.1	-0.5
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.4	-0.6	-0.7
Angina	0.3	0.5	0.7	-0.5	-0.8
Severe depression (siblings)	0.3	0.3	0.5	0.7	-0.4
Average weekly fortified wine intake	0.3	0.4	0.5	0.7	-0.5
Alcohol usually taken with meals	0.3	0.4	0.5	-0.7	0.6
Hair/balding pattern: Pattern 2	0.3	0.4	0.5	-0.7	-0.6
Mouth/teeth dental problems	0.3	0.5	0.9	-0.9	0.4
Worrier / anxious feelings	0.3	0.5	0.5	0.7	0.7
Number of live births	0.3	0.4	0.7	0.8	-0.3
Pulse rate	0.3	0.4	0.9	0.0	-0.9
Pulse wave peak to peak time	0.3	0.3	0.5	-0.3	-0.7
Pulse rate, automated reading	0.3	0.9	1.1	-0.8	-1.1
Comparative height size at age 10	0.3	1.8	2.0	1.4	-1.2
Leg pain on walking	0.3	0.3	0.4	-0.5	-0.6
Diabetes diagnosed by doctor	0.3	0.6	1.0	0.4	1.0
Back pain experienced in last month	0.3	0.5	0.8	-0.4	-0.9
Ever taken oral contraceptive pill	0.3	0.3	0.4	-0.5	0.7
Hearing aid user	0.3	0.3	0.6	0.8	-0.2
Neuroticism (Nagel 2018)	0.2	0.5	0.7	0.6	-0.8
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.7	-0.8	-0.4
Breast Cancer	0.2	0.4	0.6	0.8	-0.3
Heel T-Score	0.2	1.5	3.0	-0.1	-1.7
Chronotype (morning person)	0.2	0.5	0.9	1.0	0.3
Number of treatments/medications taken	0.2	0.3	0.5	0.7	0.4
Sensitivity / hurt feelings	0.2	0.4	0.5	0.7	-0.4
Hearing difficulty/problems: Yes	0.2	0.3	0.6	0.2	0.8
Medication for hormone replacement therapy	0.2	0.3	0.5	0.0	-0.7
Vitamin and mineral supplements	0.2	0.3	0.4	0.7	-0.5
Multivitamins +/- minerals	0.2	0.3	0.5	-0.7	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.7	0.8	-0.2
Fluid intelligence score	0.2	0.5	0.9	-1.0	0.2
Neuroticism score	0.2	0.4	0.7	0.2	-0.8
Health satisfaction	0.2	0.3	0.4	-0.3	-0.6
Emphysema/chronic bronchitis	0.2	0.2	0.4	0.6	0.0
Medication: Blood pressure	0.2	0.3	0.5	-0.4	0.7
Medication: Seretide 50 evohaler	0.2	0.2	0.3	0.6	-0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.3	0.3	-0.6
Medication: Paracetamol	0.2	0.2	0.5	-0.1	-0.7
Medication: Lisinopril	0.2	0.3	0.4	-0.6	0.4
Average weekly beer plus cider intake	0.2	0.3	0.4	0.6	-0.5
Irritability	0.2	0.3	0.6	0.8	-0.2
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.4	-0.3	0.6
Pain experienced in last month	0.2	0.4	0.8	-0.1	0.9
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.3	0.5	0.6
Fasting Glucose	0.1	0.1	0.2	0.1	0.4
LDL Cholesterol	0.1	0.2	0.4	-0.1	-0.6
Schizophrenia (2014)	0.1	0.3	0.5	-0.1	0.7
Medication: Metformin	0.1	0.1	0.1	0.0	0.4
Serious illness, injury or assault to yourself	0.1	0.2	0.2	0.3	-0.5
Nervous feelings	0.1	0.3	0.5	-0.7	-0.2
Medication: Ramipril	0.1	0.2	0.2	-0.4	-0.5
Mouth/teeth dental problems: Dentures	0.1	0.1	0.3	0.5	-0.0
Illnesses of mother	0.1	0.2	0.3	0.6	-0.2
Hair/balding pattern: Pattern 4	0.1	0.2	0.3	-0.6	-0.2
Peak expiratory flow (PEF)	0.1	0.3	0.6	-0.3	0.8
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	-0.1	0.4
Angina (self-reported)	0.1	0.2	0.3	-0.2	-0.5
Supplements: Vitamin C	0.1	0.1	0.2	-0.3	0.4
Ever had bowel cancer screening	0.1	0.1	0.1	0.4	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	0.5	-0.1
Friendships satisfaction	0.1	0.1	0.2	-0.4	-0.1
Osteoporosis (self-reported)	0.1	0.1	0.1	-0.4	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.4	0.6	-0.4
Number of self-reported non-cancer illnesses	0.1	0.2	0.3	0.2	-0.5
Wears glasses or contact lenses	0.1	0.1	0.1	-0.4	0.2
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.3	-0.2	0.6
Alcohol drinker status: Never	0.1	0.1	0.1	-0.4	-0.2
Ever smoked	0.1	0.2	0.2	0.4	-0.5
Risk taking	0.1	0.1	0.1	0.3	0.4
Fractured/broken bones in last 5 years	0.1	0.1	0.3	0.5	0.1
HDL Cholesterol	0.0	0.0	0.0	0.2	0.1
Blood White Count	0.0	0.1	0.1	0.3	-0.1
Hair Pigment	0.0	0.9	1.7	-1.3	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.0	0.1	0.3	-0.2
Past tobacco smoking	0.0	0.0	0.0	0.1	0.2
Medication: Gliclazide	0.0	0.0	0.1	-0.2	-0.2
Ever depressed for a whole week	0.0	0.0	0.0	-0.0	0.0
Basal cell carcinoma (self-reported)	0.0	0.0	0.0	0.0	0.0

Hub : Genes

PHF15

Models

Trait associations