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chr5:136,723,696-141,294,691

Best TWAS P=5.97e-13 · Best GWAS P=3.7e-16 conditioned to 0.000529

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	DNAJC18	0.09	0.10	bslmm	260	0.10	2.5e-12	4.1	5.8	7.5e-09	0.40	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FAM53C	0.05	0.02	bslmm	291	0.03	4.1e-04	6.5	5.2	2.5e-07	0.02	0.02	0.94	FALSE
3	CommonMind	Brain Pre-frontal Cortex	IK	0.03	0.02	lasso	6	0.03	6.0e-05	-4.7	-6.0	1.6e-09	-0.04	0.05	0.94	FALSE
4	CommonMind	Brain Pre-frontal Cortex	PCDHA7	0.13	0.14	lasso	8	0.14	5.1e-17	-5.0	-5.5	4.2e-08	0.02	0.24	0.76	FALSE
5	CommonMind	Brain Pre-frontal Cortex	PCDHA8	0.14	0.12	blup	460	0.15	6.6e-18	-5.0	-5.5	4.7e-08	-0.01	0.14	0.86	FALSE
6	CommonMind	Brain Pre-frontal Cortex	SPATA24	0.05	0.03	lasso	3	0.04	1.4e-05	4.7	5.4	5.2e-08	0.24	0.54	0.03	FALSE
7	CommonMind	Brain Pre-frontal Cortex	WDR55	0.12	0.05	bslmm	349	0.10	2.4e-12	-5.9	-5.8	4.8e-09	0.00	0.02	0.98	FALSE
8	GTEx	Adipose Subcutaneous	IK	0.16	0.07	lasso	5	0.07	2.7e-06	-5.7	-5.9	4.6e-09	-0.07	0.10	0.90	FALSE
9	GTEx	Artery Aorta	TMEM173	0.35	0.16	enet	5	0.15	9.8e-09	5.4	-5.2	2.3e-07	-0.41	0.99	0.00	FALSE
10	GTEx	Artery Tibial	IK	0.06	0.04	enet	13	0.05	1.3e-04	-5.7	-6.2	6.9e-10	0.01	0.06	0.94	FALSE
11	GTEx	Artery Tibial	TMEM173	0.24	0.14	lasso	3	0.13	1.2e-10	5.4	-5.7	1.0e-08	-0.39	1.00	0.00	FALSE
12	GTEx	Artery Tibial	PROB1	0.06	0.09	enet	10	0.08	5.9e-07	4.7	-5.5	3.7e-08	-0.24	0.92	0.02	FALSE
13	GTEx	Brain Cerebellum	HARS	0.11	0.17	enet	19	0.12	1.6e-04	-5.9	6.0	2.4e-09	0.03	0.03	0.95	FALSE
14	GTEx	Breast Mammary Tissue	IK	0.07	0.06	lasso	8	0.06	3.5e-04	-5.9	-5.9	3.9e-09	-0.04	0.03	0.97	FALSE
15	GTEx	Breast Mammary Tissue (Male)	SRA1	0.05	0.01	lasso	2	0.01	2.0e-01	5.2	-5.2	2.2e-07	-0.07	0.04	0.32	FALSE
16	GTEx	Cells EBV-transformed lymphocytes	DNAJC18	0.26	0.09	lasso	2	0.12	9.7e-05	4.7	6.2	6.9e-10	0.33	0.18	0.31	FALSE
17	GTEx	Cells Transformed fibroblasts	IK	0.07	0.04	lasso	4	0.02	1.0e-02	-5.3	-5.7	1.5e-08	0.02	0.05	0.94	FALSE
18	GTEx	Cells Transformed fibroblasts	WDR55	0.05	0.08	lasso	13	0.07	4.0e-06	-5.9	-6.0	2.0e-09	-0.01	0.02	0.98	FALSE
19	GTEx	Cells Transformed fibroblasts	ZMAT2	0.04	0.02	lasso	4	0.02	2.4e-02	-5.3	-5.2	1.9e-07	0.02	0.11	0.76	FALSE
20	GTEx	Cells Transformed fibroblasts	CD14	0.09	0.05	lasso	4	0.06	2.7e-05	-5.3	-6.1	1.1e-09	-0.05	0.18	0.78	FALSE
21	GTEx	Cells Transformed fibroblasts	TMEM173	0.19	0.17	lasso	1	0.17	1.7e-12	5.4	-5.4	5.4e-08	-0.42	1.00	0.00	FALSE
22	GTEx	Colon Transverse	DNAJC18	0.37	-0.01	lasso	5	0.01	1.1e-01	4.7	7.2	6.0e-13	0.55	0.02	0.66	TRUE
23	GTEx	Esophagus Gastroesophageal Junction	DNAJC18	0.17	0.01	lasso	10	0.04	2.0e-02	5.0	5.6	2.5e-08	0.12	0.17	0.12	FALSE
24	GTEx	Esophagus Mucosa	TMEM173	0.10	0.03	enet	20	0.10	1.8e-07	6.8	-6.4	1.9e-10	-0.35	0.17	0.18	TRUE
25	GTEx	Esophagus Muscularis	WDR55	0.05	0.01	lasso	4	0.03	6.6e-03	-5.1	-5.7	1.2e-08	0.03	0.06	0.81	FALSE
26	GTEx	Esophagus Muscularis	DNAJC18	0.22	0.10	lasso	6	0.13	3.2e-08	4.7	7.0	2.1e-12	0.59	0.12	0.81	FALSE
27	GTEx	Esophagus Muscularis	TMEM173	0.24	0.00	lasso	6	0.06	1.5e-04	4.7	-6.2	4.3e-10	-0.27	0.80	0.02	FALSE
28	GTEx	Nerve Tibial	IK	0.08	0.08	lasso	8	0.06	8.3e-05	-5.9	-5.9	3.6e-09	-0.02	0.02	0.98	FALSE
29	GTEx	Nerve Tibial	HARS	0.07	0.01	enet	16	0.04	1.1e-03	-5.3	5.9	3.9e-09	-0.03	0.04	0.93	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	IK	0.08	0.05	lasso	14	0.04	3.0e-03	-5.7	-6.2	7.8e-10	-0.05	0.04	0.93	FALSE
31	GTEx	Skin Sun Exposed Lower leg	WDR55	0.04	0.01	enet	10	0.01	2.8e-02	-5.7	-5.6	1.9e-08	-0.01	0.04	0.92	FALSE
32	GTEx	Skin Sun Exposed Lower leg	ZMAT2	0.12	0.12	enet	22	0.15	1.7e-12	-5.3	-5.5	4.0e-08	0.01	0.04	0.96	FALSE
33	GTEx	Testis	ZMAT2	0.09	0.12	lasso	1	0.10	2.1e-05	-5.7	-5.7	9.3e-09	-0.05	0.03	0.97	FALSE
34	GTEx	Testis	CD14	0.13	0.10	lasso	7	0.13	3.2e-06	-5.3	-5.8	4.9e-09	-0.06	0.34	0.56	FALSE
35	GTEx	Thyroid	TMEM173	0.09	0.10	lasso	1	0.09	1.8e-07	5.4	-5.4	5.4e-08	-0.42	0.92	0.01	FALSE
36	GTEx	Vagina	IK	0.27	0.09	enet	29	0.15	2.4e-04	-3.8	-5.1	3.0e-07	0.01	0.07	0.90	FALSE
37	METSIM	Adipose	DND1	0.08	0.11	lasso	5	0.10	7.3e-15	-5.3	5.7	1.0e-08	0.00	0.05	0.95	FALSE
38	METSIM	Adipose	PROB1	0.04	0.02	enet	23	0.02	2.9e-04	4.4	-5.3	1.2e-07	-0.26	0.93	0.00	FALSE
39	METSIM	Adipose	SRA1	0.08	0.06	lasso	3	0.09	8.7e-13	-5.0	5.3	1.4e-07	0.03	0.83	0.17	FALSE
40	ROSMAP	Brain Pre-frontal Cortex	WNT8A	0.05	0.01	blup	300	0.03	1.0e-04	-3.5	-5.4	8.3e-08	-0.09	0.07	0.88	TRUE
41	ROSMAP	Brain Pre-frontal Cortex	NDUFA2	0.09	0.12	enet	22	0.12	1.3e-15	-5.7	5.2	2.3e-07	0.05	0.04	0.96	FALSE
42	ROSMAP	Brain Pre-frontal Cortex	CD14	0.03	0.02	blup	206	0.01	2.0e-02	-5.0	-5.7	1.0e-08	-0.04	0.35	0.27	FALSE
43	ROSMAP	Brain Pre-frontal Cortex	PCDHB13	0.03	0.02	lasso	3	0.02	7.1e-04	-5.4	5.5	4.6e-08	0.00	0.01	0.85	FALSE
44	ROSMAP	Brain Pre-frontal Cortex	PCDHA8	0.04	0.03	enet	4	0.03	3.4e-05	-5.4	-5.4	5.2e-08	-0.03	0.04	0.96	FALSE
45	YFS	Blood	IK	0.07	0.05	blup	334	0.06	7.1e-18	-5.7	-5.4	8.1e-08	-0.01	0.07	0.93	FALSE
46	YFS	Blood	NDUFA2	0.08	0.11	lasso	6	0.11	2.0e-33	-5.7	5.8	5.2e-09	0.05	0.06	0.94	FALSE
47	YFS	Blood	TMCO6	0.01	0.00	blup	329	0.01	4.1e-03	-5.4	-5.5	4.2e-08	0.01	0.04	0.95	FALSE
48	YFS	Blood	WDR55	0.15	0.21	bslmm	337	0.21	8.6e-67	-5.9	-5.8	5.5e-09	-0.01	0.02	0.98	FALSE
49	The Cancer Genome Atlas	Breast Invasive Carcinoma	CD14	0.01	0.01	blup	38	0.00	3.5e-02	4.7	-6.5	1.1e-10	-0.04	0.01	0.45	FALSE
50	The Cancer Genome Atlas	Breast Invasive Carcinoma	PCDHA4	0.01	0.02	lasso	1	0.01	4.9e-04	-5.3	-5.3	9.6e-08	0.04	0.00	0.97	FALSE
51	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMEM173	0.02	0.03	blup	7	0.03	4.6e-07	5.1	-5.8	4.9e-09	-0.41	0.02	0.98	FALSE
52	The Cancer Genome Atlas	Breast Invasive Carcinoma	WDR55	0.10	0.03	enet	8	0.04	3.3e-09	-5.9	-5.4	5.3e-08	0.06	0.02	0.98	FALSE
53	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	WDR55	0.04	0.04	blup	44	0.03	8.2e-03	-5.9	-6.1	1.1e-09	-0.03	0.02	0.80	FALSE
54	The Cancer Genome Atlas	Colon Adenocarcinoma	CD14	0.11	0.06	enet	5	0.07	8.6e-05	-5.3	-5.6	2.1e-08	-0.03	0.14	0.24	FALSE
55	The Cancer Genome Atlas	Colon Adenocarcinoma	DND1	0.04	0.02	blup	47	0.04	3.4e-03	-4.7	-6.5	9.3e-11	-0.04	0.02	0.60	FALSE
56	The Cancer Genome Atlas	Colon Adenocarcinoma	TMCO6	0.08	0.06	enet	8	0.07	1.2e-04	-4.8	-5.3	8.9e-08	-0.05	0.24	0.40	FALSE
57	The Cancer Genome Atlas	Colon Adenocarcinoma	WDR55	0.09	0.08	enet	12	0.12	1.5e-07	-5.9	-6.6	4.2e-11	-0.02	0.02	0.98	TRUE
58	The Cancer Genome Atlas	Glioblastoma Multiforme	TMEM173	0.13	0.12	lasso	2	0.12	2.0e-04	5.4	-5.4	7.4e-08	-0.42	0.01	0.53	FALSE
59	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMEM173	0.02	0.02	lasso	2	0.02	1.5e-03	5.4	-5.4	7.4e-08	-0.42	0.01	0.40	FALSE
60	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NDUFA2	0.04	0.07	lasso	1	0.06	1.5e-07	-5.9	5.9	3.4e-09	0.02	0.01	0.99	FALSE
61	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC35A4	0.02	0.02	lasso	3	0.01	3.5e-02	-5.3	5.5	3.0e-08	0.05	0.00	0.82	FALSE
62	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SRA1	0.08	0.06	lasso	2	0.05	1.3e-06	-5.3	5.3	1.2e-07	0.04	0.00	1.00	FALSE
63	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	UBE2D2	0.05	0.02	enet	6	0.03	4.4e-04	3.6	5.8	6.3e-09	0.13	0.09	0.67	FALSE
64	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	WDR55	0.08	0.03	lasso	2	0.06	2.7e-07	-4.7	-5.1	2.9e-07	-0.05	0.10	0.89	FALSE
65	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	BRD8	0.12	0.07	lasso	4	0.05	1.2e-03	5.3	-5.3	1.2e-07	-0.04	0.00	0.96	FALSE
66	The Cancer Genome Atlas	Brain Lower Grade Glioma	WDR55	0.09	0.03	lasso	4	0.05	1.5e-06	-5.9	-6.1	9.3e-10	-0.04	0.02	0.97	FALSE
67	The Cancer Genome Atlas	Lung Adenocarcinoma	CD14	0.03	0.01	blup	38	0.02	1.6e-03	-5.0	-6.5	1.1e-10	-0.05	0.04	0.41	FALSE
68	The Cancer Genome Atlas	Lung Adenocarcinoma	WDR55	0.03	0.02	blup	44	0.03	5.2e-04	-4.8	-6.3	2.4e-10	-0.04	0.04	0.69	FALSE
69	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	WDR55	0.02	0.02	lasso	2	0.02	2.3e-03	-5.9	-5.9	3.5e-09	-0.02	0.02	0.94	FALSE
70	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	NDUFA2	0.03	0.02	blup	42	0.04	1.1e-03	3.7	6.2	5.2e-10	0.05	0.02	0.76	FALSE
71	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	WDR55	0.11	0.09	lasso	6	0.07	1.4e-05	-5.9	-5.8	7.5e-09	-0.02	0.02	0.98	FALSE
72	The Cancer Genome Atlas	Prostate Adenocarcinoma	WDR55	0.07	0.06	blup	44	0.06	1.7e-06	-5.9	-6.4	1.5e-10	-0.03	0.02	0.98	FALSE
73	The Cancer Genome Atlas	Soft Tissue Sarcoma	WDR55	0.07	0.08	lasso	5	0.08	1.8e-05	-5.9	-6.2	4.5e-10	-0.03	0.02	0.97	FALSE
74	The Cancer Genome Atlas	Stomach Adenocarcinoma	TMEM173	0.04	0.04	lasso	2	0.04	6.7e-04	5.4	-5.4	7.4e-08	-0.42	0.02	0.68	FALSE
75	The Cancer Genome Atlas	Stomach Adenocarcinoma	WDR55	0.04	0.01	blup	45	0.03	3.7e-03	4.7	-6.2	4.6e-10	-0.05	0.02	0.69	FALSE
76	The Cancer Genome Atlas	Thyroid Carcinoma	DNAJC18	0.08	0.10	blup	23	0.10	3.7e-10	4.7	5.2	2.3e-07	0.25	0.02	0.97	FALSE
77	The Cancer Genome Atlas	Thyroid Carcinoma	EIF4EBP3	0.04	0.00	enet	4	0.01	1.6e-02	-5.3	-5.4	8.4e-08	-0.01	0.00	0.89	FALSE
78	The Cancer Genome Atlas	Thyroid Carcinoma	TMEM173	0.04	0.04	lasso	3	0.04	2.1e-04	5.4	-5.4	6.0e-08	-0.44	0.02	0.91	FALSE
79	The Cancer Genome Atlas	Thyroid Carcinoma	WDR55	0.25	0.12	lasso	5	0.12	7.0e-12	-5.9	-6.2	6.4e-10	-0.02	0.02	0.98	FALSE
80	The Cancer Genome Atlas	Thyroid Carcinoma	ZMAT2	0.03	0.02	blup	38	0.03	9.6e-04	-5.9	-5.3	1.4e-07	-0.01	0.02	0.94	FALSE