Best TWAS P=3.12e-15 · Best GWAS P=8.32e-12 conditioned to 0.025
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | MXD3 | 0.16 | 0.05 | enet | 13 | 0.06 | 1.7e-05 | 3.4 | 6.1 | 8.7e-10 | -0.15 | 0.89 | 0.02 | FALSE |
2 | GTEx | Artery Aorta | LMAN2 | 0.13 | 0.10 | lasso | 6 | 0.06 | 1.9e-04 | -5.4 | -5.5 | 3.0e-08 | 0.26 | 0.51 | 0.10 | FALSE |
3 | GTEx | Artery Aorta | MXD3 | 0.36 | 0.22 | enet | 45 | 0.29 | 2.4e-16 | 3.4 | 5.2 | 2.4e-07 | -0.27 | 1.00 | 0.00 | FALSE |
4 | GTEx | Brain Nucleus accumbens basal ganglia | MXD3 | 0.24 | 0.14 | enet | 10 | 0.25 | 2.9e-07 | 3.4 | 5.3 | 1.1e-07 | -0.06 | 0.27 | 0.06 | FALSE |
5 | GTEx | Breast Mammary Tissue | MXD3 | 0.26 | 0.08 | lasso | 5 | 0.10 | 1.3e-05 | 3.4 | 6.1 | 1.0e-09 | -0.20 | 0.20 | 0.63 | FALSE |
6 | GTEx | Breast Mammary Tissue (Female) | MXD3 | 0.23 | 0.08 | lasso | 3 | 0.09 | 1.1e-03 | 5.3 | 6.3 | 2.7e-10 | -0.17 | 0.05 | 0.38 | FALSE |
7 | GTEx | Nerve Tibial | MXD3 | 0.26 | 0.17 | lasso | 7 | 0.28 | 6.9e-20 | 3.4 | 5.3 | 1.3e-07 | -0.04 | 1.00 | 0.00 | FALSE |
8 | GTEx | Skin Sun Exposed Lower leg | MXD3 | 0.19 | 0.14 | lasso | 6 | 0.12 | 4.2e-10 | 5.3 | 5.8 | 5.5e-09 | -0.10 | 0.94 | 0.06 | FALSE |
9 | GTEx | Stomach | RGS14 | 0.11 | 0.17 | enet | 6 | 0.17 | 1.1e-08 | -4.7 | 5.2 | 2.2e-07 | -0.08 | 0.92 | 0.01 | FALSE |
10 | GTEx | Thyroid | MXD3 | 0.31 | 0.17 | lasso | 8 | 0.24 | 1.1e-18 | 3.4 | 5.7 | 1.2e-08 | -0.11 | 0.97 | 0.03 | FALSE |
11 | YFS | Blood | MXD3 | 0.04 | 0.03 | lasso | 4 | 0.04 | 5.8e-13 | -5.2 | 7.9 | 3.1e-15 | -0.65 | 0.28 | 0.72 | TRUE |
12 | The Cancer Genome Atlas | Colon Adenocarcinoma | RAB24 | 0.08 | 0.04 | enet | 7 | 0.06 | 3.4e-04 | -5.4 | 6.2 | 5.3e-10 | -0.26 | 0.01 | 0.70 | FALSE |
13 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | LMAN2 | 0.04 | 0.00 | blup | 46 | 0.00 | 1.6e-01 | 5.3 | -7.3 | 3.1e-13 | 0.53 | 0.01 | 0.41 | FALSE |
14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RGS14 | 0.05 | 0.03 | enet | 5 | 0.05 | 7.2e-06 | -4.1 | 5.2 | 1.8e-07 | -0.06 | 0.20 | 0.70 | FALSE |
15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RGS14 | 0.03 | 0.02 | blup | 39 | 0.03 | 8.1e-05 | -3.0 | 5.6 | 1.8e-08 | -0.17 | 0.03 | 0.96 | FALSE |