Best TWAS P=4.99e-31 · Best GWAS P=4.98e-42 conditioned to 2.03e-16
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SSR1 | 0.20 | 0.03 | bslmm | 635 | 0.14 | 2.3e-16 | -1.1 | -5.2 | 1.7e-07 | -0.01 | 0.92 | 0.00 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | SSR1 | 0.14 | 0.10 | lasso | 5 | 0.12 | 4.2e-09 | 6.0 | -6.4 | 2.1e-10 | -0.07 | 1.00 | 0.00 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | RP11-69L16.4 | 0.15 | 0.06 | lasso | 4 | 0.07 | 4.6e-06 | 6.0 | -6.3 | 3.1e-10 | -0.08 | 0.94 | 0.00 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | LY86-AS1 | 0.12 | 0.02 | enet | 15 | 0.08 | 1.5e-10 | -3.5 | -6.1 | 1.4e-09 | -0.04 | 0.67 | 0.27 | TRUE |
| 5 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | BMP6 | 0.29 | 0.00 | blup | 162 | 0.03 | 5.6e-02 | 3.8 | 11.6 | 5.0e-31 | 0.49 | 0.02 | 0.20 | TRUE |