Hub : Genes

BMP6

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Nerve Tibial	0.176	0.0569	0.0015	0.124	NA	0.096	NA	0.112	4.2e-09	NA	2.6e-07	NA	2.7e-08
2	YFS	Blood	0.127	0.0204	0.0000	0.099	0.096	0.110	0.113	0.110	1.4e-30	1.3e-29	3.7e-34	6.6e-35	5.6e-34
3	TCGA	Cervical Squamous Cell Carcinoma	0.215	0.0760	0.0002	0.032	0.058	0.050	NA	0.042	1.1e-02	7.9e-04	1.7e-03	NA	3.9e-03
4	TCGA	Skin Cutaneous Melanoma	0.286	0.1110	0.0079	-0.001	0.029	-0.010	NA	-0.003	3.5e-01	5.6e-02	7.8e-01	NA	4.1e-01
5	TCGA	Thyroid Carcinoma	0.076	0.0360	0.0056	0.000	0.005	-0.003	NA	-0.002	3.5e-01	9.1e-02	8.3e-01	NA	6.4e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	1.9	3.1	7.3	-0.3	-0.7	2.7	-1.1	2.5
Bipolar Disorder or Schizophrenia	2.2	5.5	16.5	1.5	-0.8	4.1	-0.5	2.8
Depressed Affect (Nagel 2018)	0.3	0.7	1.4	0.7	1.2	-0.7	0.3	-0.9
Depression (Nagel 2018)	0.6	0.9	3.0	-0.4	1.2	0.0	-1.7	-0.4
Intelligence (Savage-Jansen 2018)	1.0	3.0	6.9	1.6	-0.3	2.3	2.6	-0.5
Neuroticism (Nagel 2018)	0.3	0.7	1.9	0.7	1.4	-0.4	0.7	-0.8
Schizophrenia (2018)	1.6	3.3	9.1	2.1	-0.5	3.0	0.2	1.6
Schizophrenia vs Biploar Disorder	0.5	0.7	1.2	0.7	0.1	-1.0	1.0	-1.1
Worry (Nagel 2018)	0.1	0.2	0.7	0.2	0.3	0.4	0.8	-0.2
Alzheimer’s Disease (in mother)	1.0	1.1	1.8	-1.0	-0.3	1.1	-1.2	1.3
Alzheimer’s Disease (in father)	1.1	1.2	3.3	-0.0	0.7	-1.8	-1.0	-1.0
Alzheimer’s Disease (including proxy)	0.4	0.5	1.7	-0.9	-0.1	-0.3	-1.3	0.3
Crohns Disease (2017)	1.2	2.6	6.9	-0.7	-2.6	1.5	0.1	1.8
Irritable Bowel Disease (IBD)	1.4	3.3	6.4	-0.2	-2.5	2.1	-0.6	2.4
Ulcerative Colitis (UC)	1.6	3.0	6.3	0.2	-1.6	2.0	-1.4	2.5
Major Depression (MDD)	0.5	0.6	1.6	-1.1	1.3	0.2	-0.6	0.1
Reaction Time	0.1	0.3	0.8	0.9	-0.2	0.6	-0.1	0.2
Verbal and Numeric Reasoning (VNR)	0.6	1.4	4.7	0.5	-0.8	2.2	1.0	0.6
Breast Cancer	0.1	0.2	0.4	-0.2	-0.6	-0.5	0.4	-0.3
Ovarian Cancer	0.4	0.6	2.1	0.0	-0.0	-0.6	0.5	-1.5
Prostate Cancer	1.3	1.8	3.1	1.2	-1.3	1.8	0.6	1.5
Age at First Birth	0.7	1.0	2.2	1.5	-0.7	-0.2	1.4	0.2
Bipolar Disorder (2011)	1.6	1.6	3.8	0.7	0.2	1.9	-0.1	1.9
Body Mass Index (BMI) (2010)	1.0	1.3	3.4	-0.5	1.4	0.2	-1.8	1.1
Coronary Artery Disease (CAD)	2.2	2.6	8.7	0.6	2.9	-1.5	-1.3	-0.2
Crohns Disease (2012)	0.7	1.1	2.6	-0.2	-1.3	1.0	0.2	1.6
Mean Putamen Volume	0.4	0.5	1.1	0.1	-0.3	0.9	-1.1	0.5
Fasting Glucose	0.6	0.7	2.3	0.3	-0.9	-0.5	0.5	-1.5
HbA1C	2.4	2.6	6.6	-1.0	2.6	-1.6	-1.7	-0.1
HDL Cholesterol	1.0	1.7	6.1	-1.1	2.5	-0.4	-0.9	0.3
LDL Cholesterol	1.1	1.8	4.2	1.8	2.0	-0.7	-0.2	-0.9
Lupus	0.2	0.3	0.5	0.5	0.7	0.7	-0.4	-0.6
Neuroticism (2016)	0.5	0.8	1.8	-0.6	0.9	-0.2	-1.4	0.8
Primary Biliary Cirrhosis	0.1	0.1	0.5	-0.1	0.2	0.1	-0.7	-0.1
Rheumatoid Arthritis	1.9	2.6	5.1	0.6	2.3	-1.8	-1.4	-1.4
Schizophrenia (2014)	2.1	4.5	13.4	1.2	-1.0	3.7	-0.1	2.6
Triglycerides	1.2	1.9	3.9	2.0	-0.6	-0.3	1.8	-1.4
Type 2 Diabetes (T2D) (2012)	1.1	1.2	2.5	-1.2	-1.6	-1.3	-0.7	0.2
Ulcerative Colitis	1.2	1.7	4.5	0.7	0.0	0.9	-2.1	1.7
Blood Eosinophil Count	0.4	2.8	7.6	1.7	2.8	-1.0	0.6	-1.4
Blood Platelet Count	0.5	5.5	11.3	3.4	3.0	1.5	2.2	-0.4
Blood Red Count	0.1	0.9	3.5	-0.4	-0.7	0.3	-1.9	0.6
Blood White Count	0.7	4.8	11.6	3.4	1.7	1.7	2.5	-0.6
Heel T-Score	1.0	7.9	19.4	-0.8	-3.5	-2.5	-4.4	-1.1
BMI	1.2	7.0	19.2	0.2	4.4	-1.1	-3.5	-1.5
Height	4.2	81.6	388.1	0.7	-2.9	1.2	19.7	-3.1
Waist Hip Ratio (WHR)	0.9	3.8	15.8	-0.5	-4.0	1.5	0.4	0.8
Systolic Blood Pressure	2.0	9.9	24.7	1.8	-1.4	3.7	5.0	2.4
Smoking Status	0.3	0.8	1.4	-1.1	-0.5	1.2	0.8	0.7
Allergy or Eczema	0.0	0.1	0.2	-0.1	0.4	0.1	0.4	0.2
Cardiovascular Disease	0.5	1.6	4.5	2.1	-1.0	1.1	0.4	1.0
Hypothyroidism (self reported)	0.9	2.0	5.7	-0.8	2.4	-0.9	-0.1	-1.7
Respiratory disease	0.1	0.3	1.1	-1.1	0.4	-0.1	-0.1	-0.1
Type 2 Diabetes (T2D) (2018)	1.5	2.8	8.9	1.2	-3.0	0.1	1.3	-1.2
Lung FEV1/FVC ratio	0.6	3.3	6.1	1.0	1.6	-2.5	-1.5	-2.1
Lung FVC	3.3	17.0	62.6	-4.1	-1.9	-1.4	-7.9	-0.1
Neuroticism	0.2	0.4	1.0	-0.4	0.6	-0.2	0.8	-1.0
Chronotype (morning person)	0.2	0.5	1.9	0.4	0.4	0.4	-1.4	0.4
Hair Pigment	0.0	0.4	1.0	0.9	-1.0	0.4	-0.4	-0.1
Tanning	0.1	1.2	2.0	-1.4	1.3	-0.9	1.1	-0.7
Hand grip strength (left)	1.6	4.1	17.1	0.5	1.3	0.4	4.1	-1.1
Number of treatments/medications taken	0.8	1.5	3.1	1.8	1.5	-1.1	-0.6	-0.9
Average weekly spirits intake	0.2	0.2	0.4	-0.0	-0.6	0.4	-0.6	0.5
Sensitivity / hurt feelings	0.4	0.7	2.4	0.1	1.5	0.4	0.9	-0.3
Frequency of depressed mood in last 2 weeks	0.6	0.8	2.0	-0.7	1.4	0.1	-1.1	-0.5
Hearing difficulty/problems: Yes	0.3	0.4	0.8	0.7	0.9	0.7	-0.1	-0.3
Relative age of first facial hair	1.5	3.1	9.4	0.0	1.2	-3.1	-0.3	-2.2
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.0	0.4	0.1	0.5	-1.0	-0.3
Ever used hormone-replacement therapy (HRT)	1.1	1.4	4.0	0.3	-0.1	-2.0	1.0	-1.4
Ever had hysterectomy (womb removed)	1.0	1.1	2.7	-0.8	-0.1	-1.6	-0.5	-1.5
Systolic blood pressure, automated reading	1.0	2.9	10.8	0.5	-0.1	1.5	3.3	1.0
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.5	0.5	0.7	0.6	-0.0	-0.2
Angina	0.5	0.6	1.5	0.2	0.8	-1.2	-0.9	-0.4
Medication for hormone replacement therapy	1.5	1.7	4.4	-0.6	-0.5	-2.1	0.4	-1.8
Vitamin and mineral supplements	0.1	0.2	0.3	-0.4	-0.5	-0.5	-0.0	0.5
Supplements: Zinc	0.3	0.4	0.9	1.0	0.7	-0.0	-0.1	-0.6
Medication: Co-codamol	0.0	0.0	0.1	-0.1	0.2	-0.1	0.3	0.0
Medication: Metformin	1.6	2.2	4.5	0.2	-1.5	-0.8	1.9	-2.1
Diabetes (father)	0.9	1.1	1.9	0.9	-0.8	-0.4	1.4	-1.3
Diabetes (mother)	0.7	0.9	2.2	-1.2	-1.5	-0.9	0.2	-0.1
Severe depression (siblings)	0.9	1.0	2.0	1.4	-1.1	0.6	0.9	-0.7
Pack years adult smoking proportion	0.6	1.0	3.5	-0.7	0.9	-0.0	-1.9	-0.3
Impedance of leg (right)	1.0	4.9	20.2	-1.1	-4.5	-1.0	0.4	1.4
Leg fat-free mass (left)	1.5	7.8	29.2	0.7	2.1	0.2	5.4	-2.3
Trunk fat percentage	0.4	1.6	5.2	-0.3	0.6	-2.3	-1.0	-1.2
Hand grip strength (right)	1.9	5.1	18.4	0.2	2.6	0.7	4.3	-0.1
Townsend deprivation index at recruitment	1.9	2.7	6.9	1.3	1.4	-1.6	-0.5	-2.6
Current tobacco smoking	0.2	0.4	1.0	-0.7	0.2	1.0	-0.3	0.5
Average weekly fortified wine intake	0.9	1.1	2.0	0.6	-0.3	-1.1	1.4	-1.3
Maternal smoking around birth	0.2	0.4	0.7	-0.4	0.6	0.4	-0.6	-0.9
Fed-up feelings	0.6	1.0	2.5	-0.3	1.6	-0.9	-1.3	-0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.3	-1.4	0.5	0.1	-1.5	0.1
Relative age voice broke	0.4	0.6	1.2	0.7	0.4	-1.1	0.4	-1.1
Taking other prescription medications	0.4	0.7	1.4	0.6	1.2	-0.8	-0.6	-0.8
Age when periods started (menarche)	0.8	1.8	4.3	0.5	1.0	2.1	-0.6	1.7
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	0.6	-0.4	-0.7	-0.7	0.6	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	3.0	-0.5	-1.7	-0.8	-1.4	-0.6
Tinnitus: Yes, but not now, but have in the past	1.0	1.0	1.8	1.3	-1.0	0.8	1.3	-0.4
Qualifications: CSEs or equivalent	1.0	1.3	4.4	-0.1	2.1	-0.9	-1.0	0.1
Serious illness, injury or assault to yourself	1.8	2.2	6.1	2.5	0.3	1.6	1.3	-0.6
High blood pressure	0.9	2.5	4.8	1.2	-1.2	2.0	0.4	2.2
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.5	0.4	1.1	-0.2	1.2	-0.0
Multivitamins +/- minerals	0.1	0.1	0.2	0.5	0.2	0.4	0.3	-0.3
Stomach or abdominal pain in last month	0.8	0.9	2.4	-0.4	0.6	1.5	-1.2	0.7
Supplements: Glucosamine	0.3	0.4	1.2	-0.3	0.8	-0.3	0.1	1.1
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.6	-0.1	-0.4	-0.3	-0.8	0.4
Medication: Atenolol	0.6	0.8	2.1	-0.4	-0.8	-1.4	0.6	-0.7
Medication: Levothyroxine sodium	0.2	0.4	1.5	-0.2	1.2	0.6	0.1	-0.1
Sitting height	4.0	28.2	134.6	0.9	-0.9	2.2	11.6	0.2
Chronic bronchitis/emphysema (father)	0.7	0.8	1.7	-1.2	-0.0	0.9	-0.1	1.3
High blood pressure (mother)	0.4	0.6	1.5	-1.0	-0.5	-0.0	1.2	-0.4
Body mass index (BMI)	1.2	4.9	10.2	0.2	3.2	-1.9	-2.8	-1.7
Impedance of leg (left)	0.9	4.2	17.0	-1.1	-4.1	-0.8	0.1	1.5
Leg predicted mass (left)	1.5	7.8	29.3	0.7	2.0	0.3	5.4	-2.3
Trunk fat mass	0.4	1.8	3.1	0.1	1.2	-1.7	1.2	-1.8
Waist circumference	0.4	1.5	3.1	1.1	1.1	-1.3	-0.1	-1.8
Number of incorrect matches in round	1.1	1.8	6.4	-0.2	-2.5	1.5	0.1	0.6
Past tobacco smoking	0.1	0.2	0.5	0.5	0.4	-0.6	-0.7	-0.1
Alcohol usually taken with meals	1.4	2.2	4.4	-0.5	-2.1	-1.6	1.5	-1.2
Nervous feelings	0.2	0.3	0.9	-0.1	0.4	0.6	-0.4	0.9
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.2	-0.8	-0.2	1.1	-0.2	1.0
Hearing difficulty/problems with background noise	0.1	0.2	0.7	-0.3	-0.0	0.3	-0.8	-0.3
Hair/balding pattern: Pattern 2	1.4	1.8	4.1	-0.3	-0.7	1.6	-2.0	1.4
Had menopause	1.1	1.4	3.8	0.8	1.1	-2.0	-0.2	-1.2
Had other major operations	0.7	0.9	1.9	-0.2	0.2	-1.3	-0.9	-1.4
Forced vital capacity (FVC)	0.8	3.2	9.6	-2.3	-3.1	0.7	0.9	0.4
Heel bone mineral density (BMD) T-score, automated (right)	1.3	2.9	7.1	-2.1	-1.6	-0.7	-2.7	-0.1
Ever unenthusiastic/disinterested for a whole week	0.9	1.0	4.1	0.2	0.3	2.0	0.0	1.0
Qualifications: None of the above	0.4	1.0	1.7	-0.5	-0.8	-1.0	-1.0	-1.3
Financial difficulties in last 2 years	0.6	0.8	2.4	0.2	-1.0	0.5	-1.6	0.6
Mouth/teeth dental problems	0.7	1.1	4.3	0.5	0.2	1.0	2.1	-0.3
Heart attack	0.6	0.7	1.9	0.5	-1.4	-1.0	-0.2	-0.7
Allergy	0.2	0.4	1.1	-0.5	-1.1	0.0	-0.7	-0.1
Pain all over the body in last month	0.2	0.3	0.7	-0.1	-0.7	-0.3	0.8	-0.2
Diabetes (self-reported)	1.1	1.8	5.8	0.3	-2.4	-0.2	1.1	-1.3
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.6	-1.0	-0.2	0.8	-1.3	0.9
Medication: Ramipril	1.8	2.3	5.4	1.3	-2.3	-1.5	-0.0	-1.4
Medication: Simvastatin	1.9	2.8	8.8	0.7	0.8	-3.0	-0.4	-2.0
Fluid intelligence score	0.4	0.8	2.5	0.3	0.1	1.6	1.2	0.5
Illnesses of siblings	0.6	0.8	1.6	-0.0	1.1	1.3	0.8	0.7
Neuroticism score	0.1	0.2	0.6	-0.2	0.7	-0.2	0.4	-0.6
Weight	0.9	4.3	11.9	1.0	2.0	-0.7	3.5	-2.0
Impedance of arm (right)	1.0	4.8	18.3	-1.3	-4.3	0.3	0.5	1.9
Arm fat percentage (right)	0.8	3.2	8.0	-0.3	1.5	-2.1	-2.8	-1.2
Trunk fat-free mass	2.6	14.9	62.3	1.6	1.8	1.4	7.9	-2.1
Hip circumference	0.9	3.9	6.4	1.5	2.5	-1.9	1.6	-2.2
Time employed in main current job	0.5	0.6	1.9	0.1	-1.0	1.4	0.1	0.6
Alcohol intake versus 10 years previously	1.0	1.5	2.9	1.7	0.6	-0.9	0.9	-1.7
Father’s age at death	0.2	0.3	0.7	0.3	-0.8	-0.2	0.0	-0.8
Worrier / anxious feelings	0.5	0.9	2.7	-0.6	1.6	0.6	-0.6	0.9
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	2.5	0.6	-0.6	1.6	-0.1	0.2
Falls in the last year	1.0	1.4	3.9	0.7	0.1	-2.0	-0.5	-1.5
Hair/balding pattern: Pattern 3	0.5	0.7	1.4	1.2	0.2	-0.0	1.2	-0.9
Number of live births	0.8	1.2	2.9	1.7	1.1	0.0	-1.3	0.0
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	6.6	-1.6	-2.6	-0.3	0.6	-0.5
Pulse rate	0.7	1.2	2.2	0.3	0.6	1.2	1.3	1.5
Happiness	1.4	1.6	4.4	2.1	-0.2	0.4	0.9	-1.7
Noisy workplace	1.2	1.5	3.5	0.3	1.9	-1.5	-1.0	-0.8
Qualifications: A levels/AS levels or equivalent	0.9	2.0	6.8	0.6	-1.6	0.4	2.6	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.4	-0.7	-0.9	1.2	0.1	0.5
Mouth/teeth dental problems: Dentures	0.7	1.2	1.9	1.1	-1.2	0.1	-1.4	1.2
Asthma	0.1	0.3	0.7	-0.8	0.3	0.2	0.7	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.6	0.5	0.4	0.5	-0.8	0.4
Medication: Cholesterol lowering	1.1	1.7	3.5	1.1	0.6	-1.9	0.8	-1.7
Depression (self-reported)	1.0	1.1	2.1	-1.0	1.4	-1.5	0.0	-0.8
Medication: Lansoprazole	0.7	0.8	2.3	-1.0	-0.2	-0.4	-1.5	0.7
Prospective memory result	0.2	0.2	0.3	-0.6	-0.6	0.3	-0.5	0.2
Lung cancer (father)	1.5	1.7	3.6	0.9	0.6	-1.9	-0.7	-1.8
Illnesses of mother	0.4	0.5	1.3	-0.5	-0.8	-0.0	-1.1	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	3.9	-1.9	-2.0	-0.3	-0.3	0.0
Pulse wave Arterial Stiffness index	0.5	0.6	1.1	0.9	1.1	0.8	0.6	-0.2
Impedance of arm (left)	1.0	4.5	18.9	-0.9	-4.3	0.2	0.7	1.6
Arm fat mass (right)	0.5	1.9	3.5	0.0	1.9	-1.7	-0.5	-1.7
Trunk predicted mass	2.6	14.9	61.8	1.7	1.8	1.4	7.9	-2.2
Standing height	4.1	40.7	190.4	1.5	-2.1	2.3	13.8	-1.0
Length of working week for main job	0.7	0.8	2.7	1.6	-0.5	0.6	0.8	-0.1
Exposure to tobacco smoke at home	1.0	1.1	5.2	-0.3	0.0	-0.3	-2.3	-0.2
Breastfed as a baby	0.6	0.7	1.5	0.7	0.9	1.2	0.5	0.5
Tense / ‘highly strung’	0.3	0.5	1.4	0.4	-0.0	-0.9	-0.0	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.4	-0.5	0.1	-0.2	-0.7	-0.0
Hair/balding pattern: Pattern 4	0.5	1.2	2.6	-0.3	1.4	0.3	1.2	1.6
Birth weight of first child	0.9	1.6	7.6	-0.2	-2.8	0.2	-0.1	0.5
Peak expiratory flow (PEF)	0.3	0.8	1.4	1.1	-1.0	0.3	1.2	-0.6
Pulse wave reflection index	0.6	0.7	3.4	0.6	-0.0	0.1	-1.8	-0.1
Ever highly irritable/argumentative for 2 days	1.9	2.3	4.3	-0.5	1.1	1.6	-1.8	2.1
Loud music exposure frequency	1.6	1.8	4.8	0.9	2.2	-1.4	-0.9	-0.8
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	3.3	1.4	-1.2	0.8	1.8	-0.7
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.3	-0.6	0.4	-0.3	0.3	0.4
Blood clot in the leg (DVT)	0.6	0.7	2.9	0.2	0.1	-1.7	-0.5	-0.7
Medication: Paracetamol	1.0	1.7	2.9	-0.1	1.3	-1.7	-1.5	-1.4
Headache pain in last month	0.5	0.9	2.7	-1.0	-0.0	0.2	-1.6	0.7
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.8	-1.4	0.7	0.0	-1.0	0.0
Glaucoma (self-reported)	0.9	1.0	2.1	0.2	1.0	0.9	-1.5	1.1
Gout (self-reported)	0.2	0.2	0.8	0.3	0.9	0.1	-0.2	-0.3
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	3.5	-0.8	1.9	-0.2	-0.0	-0.8
Medication: Amlodipine	1.3	1.8	3.3	1.4	-1.2	1.4	0.4	1.8
Medication: Ventolin 100micrograms inhaler	0.9	1.1	1.9	-1.0	-0.6	1.2	0.9	1.4
Birth weight	0.9	1.9	4.4	-1.9	-2.1	-1.2	0.1	0.3
Chronic bronchitis/emphysema (mother)	1.8	2.1	7.3	-1.1	1.0	-0.7	-2.7	0.5
High blood pressure (siblings)	0.4	0.5	1.6	-0.2	-1.3	0.0	0.1	1.0
Forced vital capacity (FVC), Best measure	0.6	2.1	5.5	-2.1	-2.3	0.6	0.2	0.2
Body fat percentage	0.5	2.1	5.0	-0.0	0.8	-2.2	-1.9	-1.2
Leg fat percentage (right)	1.2	4.3	9.7	0.0	1.0	-2.9	-3.1	-1.4
Arm fat-free mass (right)	2.2	11.4	42.5	1.6	2.4	0.5	6.5	-2.5
Exposure to tobacco smoke outside home	0.8	1.0	3.3	-0.3	1.8	-0.7	-1.0	-0.4
Comparative body size at age 10	0.8	2.2	5.4	-0.9	2.3	-0.1	-2.1	0.6
Number of full brothers	0.5	0.6	1.5	1.2	1.1	0.5	-0.5	0.1
Worry too long after embarrassment	0.6	1.0	1.5	-1.1	-1.1	1.2	-0.2	1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.5	1.2	-0.6	0.9	0.8	-0.5
Wheeze or whistling in the chest in last year	0.4	0.7	3.0	-1.7	-0.6	-0.4	0.1	0.0
Number of children fathered	0.8	0.9	4.2	-0.4	0.2	-0.3	-2.1	0.3
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	3.5	0.3	1.4	-0.7	-1.9	-0.2
Age at first live birth	0.3	0.6	1.7	-0.6	-0.4	0.8	1.3	0.0
Pulse wave peak to peak time	0.5	0.6	1.8	-0.8	-1.3	-0.7	0.3	-0.0
Health satisfaction	0.8	1.1	1.8	1.1	0.5	-0.6	1.3	-1.2
Shortness of breath walking on level ground	0.6	0.7	2.1	1.0	-1.4	0.4	0.7	-0.4
Qualifications: College or University degree	1.3	4.0	11.2	0.4	-2.3	1.7	3.4	0.6
Eye problems/disorders: None of the above	0.6	0.6	1.7	-1.3	0.3	-0.6	-0.4	0.9
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.4	-0.5	0.7	-0.0	-0.5	0.2
Emphysema/chronic bronchitis	0.4	0.4	1.0	0.4	0.9	1.0	-0.1	-0.3
Medication for pain relief, constipation, heartburn	0.5	0.9	1.6	-0.9	-1.3	0.0	0.7	1.2
Neck or shoulder pain in last month	2.9	4.2	8.4	-1.0	2.0	-1.9	-2.9	-2.0
Medication: Blood pressure	0.6	1.1	2.8	0.7	-1.7	0.8	1.1	0.6
Angina (self-reported)	0.5	0.6	1.6	0.1	0.6	-1.3	-1.0	-0.2
Migraine (self-reported)	0.5	0.6	1.7	1.2	1.3	0.0	-0.4	-0.1
Medication: Ibuprofen	0.3	0.3	0.5	0.6	0.4	0.5	-0.7	0.7
Medication: Allopurinol	0.4	0.6	1.0	0.2	1.0	-0.5	0.7	-1.0
Medication: Omeprazole	0.3	0.4	1.1	0.0	1.0	0.7	-0.1	0.6
Medication: Seretide 50 evohaler	0.6	0.7	2.4	-0.1	0.0	0.8	-1.5	0.7
Mean time to correctly identify matches	0.4	0.8	1.4	1.2	0.0	0.6	-1.2	0.8
Heart disease (mother)	1.0	1.2	3.8	1.1	0.5	0.2	1.9	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	2.9	-0.9	-0.0	1.7	-0.2	1.7
Whole body fat mass	0.4	1.5	2.8	0.3	1.4	-1.6	0.4	-1.7
Leg fat mass (right)	0.5	1.8	3.5	0.1	1.6	-1.9	-0.4	-1.7
Arm predicted mass (right)	2.2	11.4	42.1	1.6	2.3	0.5	6.5	-2.6
Pulse rate, automated reading	0.2	0.7	2.0	-0.3	0.9	0.7	-0.4	1.4
Alcohol intake frequency.	0.2	0.4	1.3	0.9	0.2	0.1	-1.1	-0.0
Comparative height size at age 10	4.8	26.2	114.5	2.5	-2.0	1.8	10.7	-1.9
Number of full sisters	1.1	1.4	6.2	-0.3	-0.5	-0.5	-2.5	-0.4
Suffer from ‘nerves’	0.9	1.4	2.5	-0.5	-1.4	1.6	-0.0	1.6
Overall health rating	0.7	1.5	3.7	1.5	1.9	-0.4	-0.4	-1.2
Chest pain or discomfort	0.2	0.3	1.2	0.2	1.1	0.5	-0.0	-0.5
Had major operations	1.3	1.5	3.8	1.2	-2.0	0.7	0.7	1.0
Age at last live birth	0.8	1.1	3.8	0.5	-0.7	1.0	2.0	-0.4
Family relationship satisfaction	0.3	0.4	0.6	0.8	0.4	0.6	0.8	-0.6
Leg pain on walking	0.9	1.1	2.6	1.1	-1.6	-0.5	1.2	-0.1
Qualifications: NVQ or HND or HNC or equivalent	2.3	2.7	4.2	1.4	-0.2	1.8	-2.1	2.0
Commuting to job workplace: Car/motor vehicle	1.1	1.2	3.1	-0.1	0.6	0.7	-1.8	1.5
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	3.1	-0.4	1.7	-1.8	0.6	-1.0
Medication: Aspirin	0.6	0.8	1.3	0.8	-1.1	-0.1	1.1	-1.0
Supplements: Vitamin C	0.4	0.4	1.3	0.4	0.8	0.4	-1.2	0.1
Knee pain experienced in last month	1.2	1.8	4.3	0.3	0.9	-1.2	-2.1	1.6
Hypertension (Self-reported)	0.7	1.9	3.3	1.5	-0.9	1.7	0.5	1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	2.0	0.2	1.4	-0.3	0.4	-0.7
Illnesses of father: Heart disease	1.3	1.8	6.1	-2.5	-1.2	-1.0	-0.5	0.2
Illnesses of siblings: Diabetes	1.5	1.8	4.5	-0.6	-0.4	-2.0	0.3	-2.1
Smoking status: Previous	0.5	0.8	1.3	-1.1	-1.0	0.7	0.0	1.1
Forced expiratory volume in 1-second (FEV1), predicted	3.5	7.2	30.5	-0.4	-1.1	2.0	5.5	0.4
Whole body fat-free mass	2.2	12.4	50.3	1.4	2.0	0.9	7.1	-2.3
Leg fat-free mass (right)	1.5	8.2	30.4	0.8	2.2	0.6	5.5	-2.2
Arm fat percentage (left)	0.7	3.0	7.2	-0.1	1.5	-1.9	-2.7	-1.3
Average weekly red wine intake	0.1	0.1	0.4	-0.7	-0.2	-0.3	-0.1	0.3
Handedness (chirality/laterality): Left-handed	0.8	0.9	2.7	0.2	0.4	-1.1	0.7	-1.7
Mood swings	1.6	2.9	9.3	0.8	3.1	-1.5	-0.0	-1.6
Loneliness, isolation	0.1	0.2	0.3	0.1	0.4	-0.5	-0.3	-0.6
Long-standing illness, disability or infirmity	0.3	0.4	1.1	1.0	-0.8	-0.4	0.1	0.1
Ever had bowel cancer screening	0.3	0.4	0.8	0.5	0.5	0.3	0.7	0.9
Diabetes diagnosed by doctor	0.7	1.1	4.3	0.7	-2.1	0.1	0.4	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	-0.4	0.3	0.0	-0.2	-0.2
Friendships satisfaction	1.0	1.3	3.9	1.3	-0.7	2.0	0.3	0.6
Qualifications: nursing, teaching	0.3	0.4	0.6	0.8	-0.4	0.7	-0.6	0.8
Commuting to job workplace: Walk	0.8	0.8	2.0	0.4	1.0	0.4	1.4	-1.0
Eye problems/disorders: Cataract	0.9	1.0	3.0	0.2	-1.1	1.7	0.6	0.6
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	1.7	-1.3	0.6	-1.3	-0.7	-0.7
Medication for cholesterol	0.7	1.0	2.6	-0.3	0.4	1.6	1.4	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.9	0.4	1.0	0.1	-0.6	-0.8
Back pain experienced in last month	0.4	0.6	1.5	0.7	1.2	-0.0	-0.3	-1.1
Mineral and other dietary supplements	0.0	0.1	0.1	-0.2	-0.3	0.0	-0.1	0.3
Breast cancer (self-reported)	0.6	0.7	2.2	0.7	1.5	-0.5	0.1	-0.7
Asthma (self-reported)	0.1	0.2	0.6	-0.7	0.3	-0.2	0.3	-0.1
Osteoporosis (self-reported)	0.4	0.5	1.0	-0.2	0.9	-1.0	-0.6	-0.4
Osteoarthritis (self-reported)	0.7	0.9	3.0	-0.5	0.6	-0.8	-1.7	0.6
Medication: Aspirin	0.3	0.4	1.0	0.5	-1.0	-0.2	0.6	-0.7
Medication: Gliclazide	1.3	1.4	5.5	-0.4	-2.4	-0.8	0.8	-0.5
Illnesses of father: None of the above (group 1)	1.6	1.9	7.1	2.7	1.4	0.1	0.2	-0.7
Smoking status: Current	0.2	0.4	1.0	-0.8	0.0	1.0	-0.3	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.8	7.9	31.6	-1.9	-1.5	-1.5	-5.6	0.1
Whole body water mass	2.2	12.7	50.4	1.4	2.1	0.9	7.1	-2.4
Leg predicted mass (right)	1.6	8.8	32.2	0.9	2.3	0.6	5.7	-2.3
Arm fat mass (left)	0.4	1.7	3.6	0.5	1.9	-1.4	-0.2	-1.7
Number of self-reported non-cancer illnesses	0.4	0.8	1.6	1.3	-0.4	1.1	-0.6	0.7
Average weekly champagne plus white wine intake	2.3	3.1	7.6	0.3	-0.1	-2.6	1.0	-2.8
Miserableness	0.3	0.6	1.4	-1.2	-0.0	-0.7	-0.0	-1.0
Guilty feelings	0.7	1.1	2.1	-0.0	0.8	-1.2	-1.0	-1.5
Wears glasses or contact lenses	1.5	1.7	4.2	-0.5	-2.0	-0.5	0.1	-2.0
Ever taken oral contraceptive pill	0.4	0.5	1.3	0.8	-1.1	-0.2	0.6	-0.3
Hearing aid user	0.5	0.5	0.9	-0.2	-0.8	-1.0	-0.6	-0.8
Mother’s age at death	0.7	0.9	1.9	1.4	0.8	0.3	-0.2	-1.3
Financial situation satisfaction	0.8	1.0	2.4	0.5	1.4	-0.0	-1.6	0.6
Tinnitus: Yes, now most or all of the time	0.6	0.7	2.2	1.5	0.2	-0.6	0.0	-1.0
Commuting to job workplace: Public transport	0.8	0.9	2.9	0.9	-1.7	-0.4	0.8	-0.1
Eye problems/disorders: Glaucoma	1.0	1.2	3.6	0.9	1.0	0.3	-1.9	0.7
Medication: Blood pressure	0.7	1.2	2.4	0.9	-1.2	-0.0	-1.6	1.2
Pain type(s) experienced in last month: Hip pain	0.9	1.2	2.1	-0.1	1.2	-1.2	-1.5	-0.9
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.7	0.8	0.5	-0.6	-0.5	-0.7
High cholesterol (Self-reported)	1.3	2.3	7.6	2.8	0.6	-1.4	0.2	-1.3
Medication: Bendroflumethiazide	0.7	1.1	2.3	-0.0	-1.4	1.5	0.1	1.1
Medication: Paracetamol	0.9	1.5	3.4	-1.2	0.4	-1.8	-1.4	-0.6
Medication: Lisinopril	1.1	1.4	2.3	1.1	-1.5	1.4	-0.5	1.1
Medication: Atorvastatin	0.6	0.7	1.7	1.3	-1.3	0.2	0.3	0.1
Illnesses of father: High blood pressure	1.3	1.7	4.3	-1.3	-1.2	0.9	-0.1	2.1
Alcohol drinker status: Never	0.3	0.3	0.9	0.2	0.6	-0.3	-1.0	0.4
Ever smoked	0.3	0.5	1.2	0.1	0.8	-0.3	1.1	-0.9
Basal metabolic rate	1.8	10.1	39.2	1.2	2.0	0.5	6.3	-2.3
Leg fat percentage (left)	1.2	4.4	10.3	-0.1	1.4	-2.7	-3.2	-1.5
Arm fat-free mass (left)	1.9	9.8	37.1	1.4	2.3	0.5	6.1	-2.2
Number of operations (self-reported)	0.8	1.2	2.2	1.1	-1.4	-0.1	-1.5	0.6
Average weekly beer plus cider intake	1.0	1.5	5.9	-1.2	0.1	-0.4	-2.4	0.1
Irritability	1.6	2.7	7.6	1.6	2.8	-0.3	1.0	-1.6
Risk taking	0.1	0.2	0.6	-0.8	-0.2	-0.0	0.3	-0.3
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.6	-0.6	0.5	0.3	-0.3	0.8
Fractured/broken bones in last 5 years	0.2	0.3	0.5	0.6	-0.0	-0.2	0.7	-0.7
Age started oral contraceptive pill	0.9	1.1	2.7	0.4	-0.2	-1.0	1.3	-1.6
Diastolic blood pressure, automated reading	0.4	1.1	4.6	-0.4	-0.4	0.5	0.6	2.2
Ever depressed for a whole week	0.5	0.6	2.1	0.5	0.9	1.5	0.1	0.4
Unable to work because of sickness or disability	0.8	1.1	1.8	0.5	-1.3	1.3	-1.3	-0.0
Commuting to job workplace: Cycle	0.8	1.0	2.5	0.4	-1.0	0.9	1.6	0.6
Myopia	0.3	0.4	1.0	-1.0	0.3	0.5	0.8	-0.1
Vascular/heart problems diagnosed by doctor	0.6	1.6	3.2	-1.2	1.2	-1.4	-0.0	-1.8
Cholesterol lowering medication	0.9	1.4	2.5	0.8	-0.4	-1.6	-1.6	-1.1
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.6	-0.8	1.3	0.8	-1.0	0.6
Pain experienced in last month	1.3	2.2	5.1	-0.4	-2.3	1.2	2.0	-0.5
Supplements: Calcium	1.3	1.4	2.2	1.5	-1.1	0.1	1.3	-1.3
Basal cell carcinoma (self-reported)	2.0	2.3	5.3	1.4	-1.4	2.3	1.0	1.1
Heart attack/myocardial infarction (self-reported)	1.0	1.2	3.2	0.5	-1.8	-1.2	-0.0	-1.1
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	2.2	0.2	-0.2	-1.5	-0.8	-0.5
Heart disease (siblings)	1.4	1.8	4.7	0.7	-1.4	-1.3	-2.2	-0.1
Alcohol drinker status: Previous	1.1	1.3	4.4	1.0	0.3	2.1	0.5	0.9
Pack years of smoking	0.5	0.8	2.1	-0.2	1.0	-0.5	-1.5	-0.7
Impedance of whole body	1.0	5.0	20.2	-1.1	-4.5	-0.1	0.8	1.8
Leg fat mass (left)	0.5	1.8	3.1	0.0	1.8	-1.7	-0.4	-1.6
Arm predicted mass (left)	2.0	10.3	37.8	1.5	2.5	0.2	6.2	-2.3