Hub : Genes

BMP6

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Nerve Tibial 0.176 0.0569 0.0015 0.124 NA 0.096 NA 0.112 4.2e-09 NA 2.6e-07 NA 2.7e-08
2 YFS Blood 0.127 0.0204 0.0000 0.099 0.096 0.110 0.113 0.110 1.4e-30 1.3e-29 3.7e-34 6.6e-35 5.6e-34
3 TCGA Cervical Squamous Cell Carcinoma 0.215 0.0760 0.0002 0.032 0.058 0.050 NA 0.042 1.1e-02 7.9e-04 1.7e-03 NA 3.9e-03
4 TCGA Skin Cutaneous Melanoma 0.286 0.1110 0.0079 -0.001 0.029 -0.010 NA -0.003 3.5e-01 5.6e-02 7.8e-01 NA 4.1e-01
5 TCGA Thyroid Carcinoma 0.076 0.0360 0.0056 0.000 0.005 -0.003 NA -0.002 3.5e-01 9.1e-02 8.3e-01 NA 6.4e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.9 3.1 7.3 -0.3 -0.7 2.7 -1.1 2.5
Bipolar Disorder or Schizophrenia 2.2 5.5 16.5 1.5 -0.8 4.1 -0.5 2.8
Depressed Affect (Nagel 2018) 0.3 0.7 1.4 0.7 1.2 -0.7 0.3 -0.9
Depression (Nagel 2018) 0.6 0.9 3.0 -0.4 1.2 0.0 -1.7 -0.4
Intelligence (Savage-Jansen 2018) 1.0 3.0 6.9 1.6 -0.3 2.3 2.6 -0.5
Neuroticism (Nagel 2018) 0.3 0.7 1.9 0.7 1.4 -0.4 0.7 -0.8
Schizophrenia (2018) 1.6 3.3 9.1 2.1 -0.5 3.0 0.2 1.6
Schizophrenia vs Biploar Disorder 0.5 0.7 1.2 0.7 0.1 -1.0 1.0 -1.1
Worry (Nagel 2018) 0.1 0.2 0.7 0.2 0.3 0.4 0.8 -0.2
Alzheimer’s Disease (in mother) 1.0 1.1 1.8 -1.0 -0.3 1.1 -1.2 1.3
Alzheimer’s Disease (in father) 1.1 1.2 3.3 -0.0 0.7 -1.8 -1.0 -1.0
Alzheimer’s Disease (including proxy) 0.4 0.5 1.7 -0.9 -0.1 -0.3 -1.3 0.3
Crohns Disease (2017) 1.2 2.6 6.9 -0.7 -2.6 1.5 0.1 1.8
Irritable Bowel Disease (IBD) 1.4 3.3 6.4 -0.2 -2.5 2.1 -0.6 2.4
Ulcerative Colitis (UC) 1.6 3.0 6.3 0.2 -1.6 2.0 -1.4 2.5
Major Depression (MDD) 0.5 0.6 1.6 -1.1 1.3 0.2 -0.6 0.1
Reaction Time 0.1 0.3 0.8 0.9 -0.2 0.6 -0.1 0.2
Verbal and Numeric Reasoning (VNR) 0.6 1.4 4.7 0.5 -0.8 2.2 1.0 0.6
Breast Cancer 0.1 0.2 0.4 -0.2 -0.6 -0.5 0.4 -0.3
Ovarian Cancer 0.4 0.6 2.1 0.0 -0.0 -0.6 0.5 -1.5
Prostate Cancer 1.3 1.8 3.1 1.2 -1.3 1.8 0.6 1.5
Age at First Birth 0.7 1.0 2.2 1.5 -0.7 -0.2 1.4 0.2
Bipolar Disorder (2011) 1.6 1.6 3.8 0.7 0.2 1.9 -0.1 1.9
Body Mass Index (BMI) (2010) 1.0 1.3 3.4 -0.5 1.4 0.2 -1.8 1.1
Coronary Artery Disease (CAD) 2.2 2.6 8.7 0.6 2.9 -1.5 -1.3 -0.2
Crohns Disease (2012) 0.7 1.1 2.6 -0.2 -1.3 1.0 0.2 1.6
Mean Putamen Volume 0.4 0.5 1.1 0.1 -0.3 0.9 -1.1 0.5
Fasting Glucose 0.6 0.7 2.3 0.3 -0.9 -0.5 0.5 -1.5
HbA1C 2.4 2.6 6.6 -1.0 2.6 -1.6 -1.7 -0.1
HDL Cholesterol 1.0 1.7 6.1 -1.1 2.5 -0.4 -0.9 0.3
LDL Cholesterol 1.1 1.8 4.2 1.8 2.0 -0.7 -0.2 -0.9
Lupus 0.2 0.3 0.5 0.5 0.7 0.7 -0.4 -0.6
Neuroticism (2016) 0.5 0.8 1.8 -0.6 0.9 -0.2 -1.4 0.8
Primary Biliary Cirrhosis 0.1 0.1 0.5 -0.1 0.2 0.1 -0.7 -0.1
Rheumatoid Arthritis 1.9 2.6 5.1 0.6 2.3 -1.8 -1.4 -1.4
Schizophrenia (2014) 2.1 4.5 13.4 1.2 -1.0 3.7 -0.1 2.6
Triglycerides 1.2 1.9 3.9 2.0 -0.6 -0.3 1.8 -1.4
Type 2 Diabetes (T2D) (2012) 1.1 1.2 2.5 -1.2 -1.6 -1.3 -0.7 0.2
Ulcerative Colitis 1.2 1.7 4.5 0.7 0.0 0.9 -2.1 1.7
Blood Eosinophil Count 0.4 2.8 7.6 1.7 2.8 -1.0 0.6 -1.4
Blood Platelet Count 0.5 5.5 11.3 3.4 3.0 1.5 2.2 -0.4
Blood Red Count 0.1 0.9 3.5 -0.4 -0.7 0.3 -1.9 0.6
Blood White Count 0.7 4.8 11.6 3.4 1.7 1.7 2.5 -0.6
Heel T-Score 1.0 7.9 19.4 -0.8 -3.5 -2.5 -4.4 -1.1
BMI 1.2 7.0 19.2 0.2 4.4 -1.1 -3.5 -1.5
Height 4.2 81.6 388.1 0.7 -2.9 1.2 19.7 -3.1
Waist Hip Ratio (WHR) 0.9 3.8 15.8 -0.5 -4.0 1.5 0.4 0.8
Systolic Blood Pressure 2.0 9.9 24.7 1.8 -1.4 3.7 5.0 2.4
Smoking Status 0.3 0.8 1.4 -1.1 -0.5 1.2 0.8 0.7
Allergy or Eczema 0.0 0.1 0.2 -0.1 0.4 0.1 0.4 0.2
Cardiovascular Disease 0.5 1.6 4.5 2.1 -1.0 1.1 0.4 1.0
Hypothyroidism (self reported) 0.9 2.0 5.7 -0.8 2.4 -0.9 -0.1 -1.7
Respiratory disease 0.1 0.3 1.1 -1.1 0.4 -0.1 -0.1 -0.1
Type 2 Diabetes (T2D) (2018) 1.5 2.8 8.9 1.2 -3.0 0.1 1.3 -1.2
Lung FEV1/FVC ratio 0.6 3.3 6.1 1.0 1.6 -2.5 -1.5 -2.1
Lung FVC 3.3 17.0 62.6 -4.1 -1.9 -1.4 -7.9 -0.1
Neuroticism 0.2 0.4 1.0 -0.4 0.6 -0.2 0.8 -1.0
Chronotype (morning person) 0.2 0.5 1.9 0.4 0.4 0.4 -1.4 0.4
Hair Pigment 0.0 0.4 1.0 0.9 -1.0 0.4 -0.4 -0.1
Tanning 0.1 1.2 2.0 -1.4 1.3 -0.9 1.1 -0.7
Hand grip strength (left) 1.6 4.1 17.1 0.5 1.3 0.4 4.1 -1.1
Number of treatments/medications taken 0.8 1.5 3.1 1.8 1.5 -1.1 -0.6 -0.9
Average weekly spirits intake 0.2 0.2 0.4 -0.0 -0.6 0.4 -0.6 0.5
Sensitivity / hurt feelings 0.4 0.7 2.4 0.1 1.5 0.4 0.9 -0.3
Frequency of depressed mood in last 2 weeks 0.6 0.8 2.0 -0.7 1.4 0.1 -1.1 -0.5
Hearing difficulty/problems: Yes 0.3 0.4 0.8 0.7 0.9 0.7 -0.1 -0.3
Relative age of first facial hair 1.5 3.1 9.4 0.0 1.2 -3.1 -0.3 -2.2
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 1.0 0.4 0.1 0.5 -1.0 -0.3
Ever used hormone-replacement therapy (HRT) 1.1 1.4 4.0 0.3 -0.1 -2.0 1.0 -1.4
Ever had hysterectomy (womb removed) 1.0 1.1 2.7 -0.8 -0.1 -1.6 -0.5 -1.5
Systolic blood pressure, automated reading 1.0 2.9 10.8 0.5 -0.1 1.5 3.3 1.0
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.5 0.5 0.7 0.6 -0.0 -0.2
Angina 0.5 0.6 1.5 0.2 0.8 -1.2 -0.9 -0.4
Medication for hormone replacement therapy 1.5 1.7 4.4 -0.6 -0.5 -2.1 0.4 -1.8
Vitamin and mineral supplements 0.1 0.2 0.3 -0.4 -0.5 -0.5 -0.0 0.5
Supplements: Zinc 0.3 0.4 0.9 1.0 0.7 -0.0 -0.1 -0.6
Medication: Co-codamol 0.0 0.0 0.1 -0.1 0.2 -0.1 0.3 0.0
Medication: Metformin 1.6 2.2 4.5 0.2 -1.5 -0.8 1.9 -2.1
Diabetes (father) 0.9 1.1 1.9 0.9 -0.8 -0.4 1.4 -1.3
Diabetes (mother) 0.7 0.9 2.2 -1.2 -1.5 -0.9 0.2 -0.1
Severe depression (siblings) 0.9 1.0 2.0 1.4 -1.1 0.6 0.9 -0.7
Pack years adult smoking proportion 0.6 1.0 3.5 -0.7 0.9 -0.0 -1.9 -0.3
Impedance of leg (right) 1.0 4.9 20.2 -1.1 -4.5 -1.0 0.4 1.4
Leg fat-free mass (left) 1.5 7.8 29.2 0.7 2.1 0.2 5.4 -2.3
Trunk fat percentage 0.4 1.6 5.2 -0.3 0.6 -2.3 -1.0 -1.2
Hand grip strength (right) 1.9 5.1 18.4 0.2 2.6 0.7 4.3 -0.1
Townsend deprivation index at recruitment 1.9 2.7 6.9 1.3 1.4 -1.6 -0.5 -2.6
Current tobacco smoking 0.2 0.4 1.0 -0.7 0.2 1.0 -0.3 0.5
Average weekly fortified wine intake 0.9 1.1 2.0 0.6 -0.3 -1.1 1.4 -1.3
Maternal smoking around birth 0.2 0.4 0.7 -0.4 0.6 0.4 -0.6 -0.9
Fed-up feelings 0.6 1.0 2.5 -0.3 1.6 -0.9 -1.3 -0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 2.3 -1.4 0.5 0.1 -1.5 0.1
Relative age voice broke 0.4 0.6 1.2 0.7 0.4 -1.1 0.4 -1.1
Taking other prescription medications 0.4 0.7 1.4 0.6 1.2 -0.8 -0.6 -0.8
Age when periods started (menarche) 0.8 1.8 4.3 0.5 1.0 2.1 -0.6 1.7
Bilateral oophorectomy (both ovaries removed) 0.4 0.4 0.6 -0.4 -0.7 -0.7 0.6 -0.8
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 3.0 -0.5 -1.7 -0.8 -1.4 -0.6
Tinnitus: Yes, but not now, but have in the past 1.0 1.0 1.8 1.3 -1.0 0.8 1.3 -0.4
Qualifications: CSEs or equivalent 1.0 1.3 4.4 -0.1 2.1 -0.9 -1.0 0.1
Serious illness, injury or assault to yourself 1.8 2.2 6.1 2.5 0.3 1.6 1.3 -0.6
High blood pressure 0.9 2.5 4.8 1.2 -1.2 2.0 0.4 2.2
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.5 0.4 1.1 -0.2 1.2 -0.0
Multivitamins +/- minerals 0.1 0.1 0.2 0.5 0.2 0.4 0.3 -0.3
Stomach or abdominal pain in last month 0.8 0.9 2.4 -0.4 0.6 1.5 -1.2 0.7
Supplements: Glucosamine 0.3 0.4 1.2 -0.3 0.8 -0.3 0.1 1.1
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.6 -0.1 -0.4 -0.3 -0.8 0.4
Medication: Atenolol 0.6 0.8 2.1 -0.4 -0.8 -1.4 0.6 -0.7
Medication: Levothyroxine sodium 0.2 0.4 1.5 -0.2 1.2 0.6 0.1 -0.1
Sitting height 4.0 28.2 134.6 0.9 -0.9 2.2 11.6 0.2
Chronic bronchitis/emphysema (father) 0.7 0.8 1.7 -1.2 -0.0 0.9 -0.1 1.3
High blood pressure (mother) 0.4 0.6 1.5 -1.0 -0.5 -0.0 1.2 -0.4
Body mass index (BMI) 1.2 4.9 10.2 0.2 3.2 -1.9 -2.8 -1.7
Impedance of leg (left) 0.9 4.2 17.0 -1.1 -4.1 -0.8 0.1 1.5
Leg predicted mass (left) 1.5 7.8 29.3 0.7 2.0 0.3 5.4 -2.3
Trunk fat mass 0.4 1.8 3.1 0.1 1.2 -1.7 1.2 -1.8
Waist circumference 0.4 1.5 3.1 1.1 1.1 -1.3 -0.1 -1.8
Number of incorrect matches in round 1.1 1.8 6.4 -0.2 -2.5 1.5 0.1 0.6
Past tobacco smoking 0.1 0.2 0.5 0.5 0.4 -0.6 -0.7 -0.1
Alcohol usually taken with meals 1.4 2.2 4.4 -0.5 -2.1 -1.6 1.5 -1.2
Nervous feelings 0.2 0.3 0.9 -0.1 0.4 0.6 -0.4 0.9
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.6 1.2 -0.8 -0.2 1.1 -0.2 1.0
Hearing difficulty/problems with background noise 0.1 0.2 0.7 -0.3 -0.0 0.3 -0.8 -0.3
Hair/balding pattern: Pattern 2 1.4 1.8 4.1 -0.3 -0.7 1.6 -2.0 1.4
Had menopause 1.1 1.4 3.8 0.8 1.1 -2.0 -0.2 -1.2
Had other major operations 0.7 0.9 1.9 -0.2 0.2 -1.3 -0.9 -1.4
Forced vital capacity (FVC) 0.8 3.2 9.6 -2.3 -3.1 0.7 0.9 0.4
Heel bone mineral density (BMD) T-score, automated (right) 1.3 2.9 7.1 -2.1 -1.6 -0.7 -2.7 -0.1
Ever unenthusiastic/disinterested for a whole week 0.9 1.0 4.1 0.2 0.3 2.0 0.0 1.0
Qualifications: None of the above 0.4 1.0 1.7 -0.5 -0.8 -1.0 -1.0 -1.3
Financial difficulties in last 2 years 0.6 0.8 2.4 0.2 -1.0 0.5 -1.6 0.6
Mouth/teeth dental problems 0.7 1.1 4.3 0.5 0.2 1.0 2.1 -0.3
Heart attack 0.6 0.7 1.9 0.5 -1.4 -1.0 -0.2 -0.7
Allergy 0.2 0.4 1.1 -0.5 -1.1 0.0 -0.7 -0.1
Pain all over the body in last month 0.2 0.3 0.7 -0.1 -0.7 -0.3 0.8 -0.2
Diabetes (self-reported) 1.1 1.8 5.8 0.3 -2.4 -0.2 1.1 -1.3
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 1.6 -1.0 -0.2 0.8 -1.3 0.9
Medication: Ramipril 1.8 2.3 5.4 1.3 -2.3 -1.5 -0.0 -1.4
Medication: Simvastatin 1.9 2.8 8.8 0.7 0.8 -3.0 -0.4 -2.0
Fluid intelligence score 0.4 0.8 2.5 0.3 0.1 1.6 1.2 0.5
Illnesses of siblings 0.6 0.8 1.6 -0.0 1.1 1.3 0.8 0.7
Neuroticism score 0.1 0.2 0.6 -0.2 0.7 -0.2 0.4 -0.6
Weight 0.9 4.3 11.9 1.0 2.0 -0.7 3.5 -2.0
Impedance of arm (right) 1.0 4.8 18.3 -1.3 -4.3 0.3 0.5 1.9
Arm fat percentage (right) 0.8 3.2 8.0 -0.3 1.5 -2.1 -2.8 -1.2
Trunk fat-free mass 2.6 14.9 62.3 1.6 1.8 1.4 7.9 -2.1
Hip circumference 0.9 3.9 6.4 1.5 2.5 -1.9 1.6 -2.2
Time employed in main current job 0.5 0.6 1.9 0.1 -1.0 1.4 0.1 0.6
Alcohol intake versus 10 years previously 1.0 1.5 2.9 1.7 0.6 -0.9 0.9 -1.7
Father’s age at death 0.2 0.3 0.7 0.3 -0.8 -0.2 0.0 -0.8
Worrier / anxious feelings 0.5 0.9 2.7 -0.6 1.6 0.6 -0.6 0.9
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 2.5 0.6 -0.6 1.6 -0.1 0.2
Falls in the last year 1.0 1.4 3.9 0.7 0.1 -2.0 -0.5 -1.5
Hair/balding pattern: Pattern 3 0.5 0.7 1.4 1.2 0.2 -0.0 1.2 -0.9
Number of live births 0.8 1.2 2.9 1.7 1.1 0.0 -1.3 0.0
Forced expiratory volume in 1-second (FEV1) 0.6 2.0 6.6 -1.6 -2.6 -0.3 0.6 -0.5
Pulse rate 0.7 1.2 2.2 0.3 0.6 1.2 1.3 1.5
Happiness 1.4 1.6 4.4 2.1 -0.2 0.4 0.9 -1.7
Noisy workplace 1.2 1.5 3.5 0.3 1.9 -1.5 -1.0 -0.8
Qualifications: A levels/AS levels or equivalent 0.9 2.0 6.8 0.6 -1.6 0.4 2.6 -0.5
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 1.4 -0.7 -0.9 1.2 0.1 0.5
Mouth/teeth dental problems: Dentures 0.7 1.2 1.9 1.1 -1.2 0.1 -1.4 1.2
Asthma 0.1 0.3 0.7 -0.8 0.3 0.2 0.7 0.2
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.6 0.5 0.4 0.5 -0.8 0.4
Medication: Cholesterol lowering 1.1 1.7 3.5 1.1 0.6 -1.9 0.8 -1.7
Depression (self-reported) 1.0 1.1 2.1 -1.0 1.4 -1.5 0.0 -0.8
Medication: Lansoprazole 0.7 0.8 2.3 -1.0 -0.2 -0.4 -1.5 0.7
Prospective memory result 0.2 0.2 0.3 -0.6 -0.6 0.3 -0.5 0.2
Lung cancer (father) 1.5 1.7 3.6 0.9 0.6 -1.9 -0.7 -1.8
Illnesses of mother 0.4 0.5 1.3 -0.5 -0.8 -0.0 -1.1 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.6 3.9 -1.9 -2.0 -0.3 -0.3 0.0
Pulse wave Arterial Stiffness index 0.5 0.6 1.1 0.9 1.1 0.8 0.6 -0.2
Impedance of arm (left) 1.0 4.5 18.9 -0.9 -4.3 0.2 0.7 1.6
Arm fat mass (right) 0.5 1.9 3.5 0.0 1.9 -1.7 -0.5 -1.7
Trunk predicted mass 2.6 14.9 61.8 1.7 1.8 1.4 7.9 -2.2
Standing height 4.1 40.7 190.4 1.5 -2.1 2.3 13.8 -1.0
Length of working week for main job 0.7 0.8 2.7 1.6 -0.5 0.6 0.8 -0.1
Exposure to tobacco smoke at home 1.0 1.1 5.2 -0.3 0.0 -0.3 -2.3 -0.2
Breastfed as a baby 0.6 0.7 1.5 0.7 0.9 1.2 0.5 0.5
Tense / ‘highly strung’ 0.3 0.5 1.4 0.4 -0.0 -0.9 -0.0 -1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.1 0.4 -0.5 0.1 -0.2 -0.7 -0.0
Hair/balding pattern: Pattern 4 0.5 1.2 2.6 -0.3 1.4 0.3 1.2 1.6
Birth weight of first child 0.9 1.6 7.6 -0.2 -2.8 0.2 -0.1 0.5
Peak expiratory flow (PEF) 0.3 0.8 1.4 1.1 -1.0 0.3 1.2 -0.6
Pulse wave reflection index 0.6 0.7 3.4 0.6 -0.0 0.1 -1.8 -0.1
Ever highly irritable/argumentative for 2 days 1.9 2.3 4.3 -0.5 1.1 1.6 -1.8 2.1
Loud music exposure frequency 1.6 1.8 4.8 0.9 2.2 -1.4 -0.9 -0.8
Qualifications: O levels/GCSEs or equivalent 1.0 1.6 3.3 1.4 -1.2 0.8 1.8 -0.7
Mouth/teeth dental problems: Bleeding gums 0.1 0.2 0.3 -0.6 0.4 -0.3 0.3 0.4
Blood clot in the leg (DVT) 0.6 0.7 2.9 0.2 0.1 -1.7 -0.5 -0.7
Medication: Paracetamol 1.0 1.7 2.9 -0.1 1.3 -1.7 -1.5 -1.4
Headache pain in last month 0.5 0.9 2.7 -1.0 -0.0 0.2 -1.6 0.7
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 1.8 -1.4 0.7 0.0 -1.0 0.0
Glaucoma (self-reported) 0.9 1.0 2.1 0.2 1.0 0.9 -1.5 1.1
Gout (self-reported) 0.2 0.2 0.8 0.3 0.9 0.1 -0.2 -0.3
Hypothyroidism/myxoedema (self-reported) 0.5 0.9 3.5 -0.8 1.9 -0.2 -0.0 -0.8
Medication: Amlodipine 1.3 1.8 3.3 1.4 -1.2 1.4 0.4 1.8
Medication: Ventolin 100micrograms inhaler 0.9 1.1 1.9 -1.0 -0.6 1.2 0.9 1.4
Birth weight 0.9 1.9 4.4 -1.9 -2.1 -1.2 0.1 0.3
Chronic bronchitis/emphysema (mother) 1.8 2.1 7.3 -1.1 1.0 -0.7 -2.7 0.5
High blood pressure (siblings) 0.4 0.5 1.6 -0.2 -1.3 0.0 0.1 1.0
Forced vital capacity (FVC), Best measure 0.6 2.1 5.5 -2.1 -2.3 0.6 0.2 0.2
Body fat percentage 0.5 2.1 5.0 -0.0 0.8 -2.2 -1.9 -1.2
Leg fat percentage (right) 1.2 4.3 9.7 0.0 1.0 -2.9 -3.1 -1.4
Arm fat-free mass (right) 2.2 11.4 42.5 1.6 2.4 0.5 6.5 -2.5
Exposure to tobacco smoke outside home 0.8 1.0 3.3 -0.3 1.8 -0.7 -1.0 -0.4
Comparative body size at age 10 0.8 2.2 5.4 -0.9 2.3 -0.1 -2.1 0.6
Number of full brothers 0.5 0.6 1.5 1.2 1.1 0.5 -0.5 0.1
Worry too long after embarrassment 0.6 1.0 1.5 -1.1 -1.1 1.2 -0.2 1.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.7 1.5 1.2 -0.6 0.9 0.8 -0.5
Wheeze or whistling in the chest in last year 0.4 0.7 3.0 -1.7 -0.6 -0.4 0.1 0.0
Number of children fathered 0.8 0.9 4.2 -0.4 0.2 -0.3 -2.1 0.3
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.2 3.5 0.3 1.4 -0.7 -1.9 -0.2
Age at first live birth 0.3 0.6 1.7 -0.6 -0.4 0.8 1.3 0.0
Pulse wave peak to peak time 0.5 0.6 1.8 -0.8 -1.3 -0.7 0.3 -0.0
Health satisfaction 0.8 1.1 1.8 1.1 0.5 -0.6 1.3 -1.2
Shortness of breath walking on level ground 0.6 0.7 2.1 1.0 -1.4 0.4 0.7 -0.4
Qualifications: College or University degree 1.3 4.0 11.2 0.4 -2.3 1.7 3.4 0.6
Eye problems/disorders: None of the above 0.6 0.6 1.7 -1.3 0.3 -0.6 -0.4 0.9
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.4 -0.5 0.7 -0.0 -0.5 0.2
Emphysema/chronic bronchitis 0.4 0.4 1.0 0.4 0.9 1.0 -0.1 -0.3
Medication for pain relief, constipation, heartburn 0.5 0.9 1.6 -0.9 -1.3 0.0 0.7 1.2
Neck or shoulder pain in last month 2.9 4.2 8.4 -1.0 2.0 -1.9 -2.9 -2.0
Medication: Blood pressure 0.6 1.1 2.8 0.7 -1.7 0.8 1.1 0.6
Angina (self-reported) 0.5 0.6 1.6 0.1 0.6 -1.3 -1.0 -0.2
Migraine (self-reported) 0.5 0.6 1.7 1.2 1.3 0.0 -0.4 -0.1
Medication: Ibuprofen 0.3 0.3 0.5 0.6 0.4 0.5 -0.7 0.7
Medication: Allopurinol 0.4 0.6 1.0 0.2 1.0 -0.5 0.7 -1.0
Medication: Omeprazole 0.3 0.4 1.1 0.0 1.0 0.7 -0.1 0.6
Medication: Seretide 50 evohaler 0.6 0.7 2.4 -0.1 0.0 0.8 -1.5 0.7
Mean time to correctly identify matches 0.4 0.8 1.4 1.2 0.0 0.6 -1.2 0.8
Heart disease (mother) 1.0 1.2 3.8 1.1 0.5 0.2 1.9 -0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 2.9 -0.9 -0.0 1.7 -0.2 1.7
Whole body fat mass 0.4 1.5 2.8 0.3 1.4 -1.6 0.4 -1.7
Leg fat mass (right) 0.5 1.8 3.5 0.1 1.6 -1.9 -0.4 -1.7
Arm predicted mass (right) 2.2 11.4 42.1 1.6 2.3 0.5 6.5 -2.6
Pulse rate, automated reading 0.2 0.7 2.0 -0.3 0.9 0.7 -0.4 1.4
Alcohol intake frequency. 0.2 0.4 1.3 0.9 0.2 0.1 -1.1 -0.0
Comparative height size at age 10 4.8 26.2 114.5 2.5 -2.0 1.8 10.7 -1.9
Number of full sisters 1.1 1.4 6.2 -0.3 -0.5 -0.5 -2.5 -0.4
Suffer from ‘nerves’ 0.9 1.4 2.5 -0.5 -1.4 1.6 -0.0 1.6
Overall health rating 0.7 1.5 3.7 1.5 1.9 -0.4 -0.4 -1.2
Chest pain or discomfort 0.2 0.3 1.2 0.2 1.1 0.5 -0.0 -0.5
Had major operations 1.3 1.5 3.8 1.2 -2.0 0.7 0.7 1.0
Age at last live birth 0.8 1.1 3.8 0.5 -0.7 1.0 2.0 -0.4
Family relationship satisfaction 0.3 0.4 0.6 0.8 0.4 0.6 0.8 -0.6
Leg pain on walking 0.9 1.1 2.6 1.1 -1.6 -0.5 1.2 -0.1
Qualifications: NVQ or HND or HNC or equivalent 2.3 2.7 4.2 1.4 -0.2 1.8 -2.1 2.0
Commuting to job workplace: Car/motor vehicle 1.1 1.2 3.1 -0.1 0.6 0.7 -1.8 1.5
Illness, injury, bereavement, stress in last 2 years 1.2 1.5 3.1 -0.4 1.7 -1.8 0.6 -1.0
Medication: Aspirin 0.6 0.8 1.3 0.8 -1.1 -0.1 1.1 -1.0
Supplements: Vitamin C 0.4 0.4 1.3 0.4 0.8 0.4 -1.2 0.1
Knee pain experienced in last month 1.2 1.8 4.3 0.3 0.9 -1.2 -2.1 1.6
Hypertension (Self-reported) 0.7 1.9 3.3 1.5 -0.9 1.7 0.5 1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 2.0 0.2 1.4 -0.3 0.4 -0.7
Illnesses of father: Heart disease 1.3 1.8 6.1 -2.5 -1.2 -1.0 -0.5 0.2
Illnesses of siblings: Diabetes 1.5 1.8 4.5 -0.6 -0.4 -2.0 0.3 -2.1
Smoking status: Previous 0.5 0.8 1.3 -1.1 -1.0 0.7 0.0 1.1
Forced expiratory volume in 1-second (FEV1), predicted 3.5 7.2 30.5 -0.4 -1.1 2.0 5.5 0.4
Whole body fat-free mass 2.2 12.4 50.3 1.4 2.0 0.9 7.1 -2.3
Leg fat-free mass (right) 1.5 8.2 30.4 0.8 2.2 0.6 5.5 -2.2
Arm fat percentage (left) 0.7 3.0 7.2 -0.1 1.5 -1.9 -2.7 -1.3
Average weekly red wine intake 0.1 0.1 0.4 -0.7 -0.2 -0.3 -0.1 0.3
Handedness (chirality/laterality): Left-handed 0.8 0.9 2.7 0.2 0.4 -1.1 0.7 -1.7
Mood swings 1.6 2.9 9.3 0.8 3.1 -1.5 -0.0 -1.6
Loneliness, isolation 0.1 0.2 0.3 0.1 0.4 -0.5 -0.3 -0.6
Long-standing illness, disability or infirmity 0.3 0.4 1.1 1.0 -0.8 -0.4 0.1 0.1
Ever had bowel cancer screening 0.3 0.4 0.8 0.5 0.5 0.3 0.7 0.9
Diabetes diagnosed by doctor 0.7 1.1 4.3 0.7 -2.1 0.1 0.4 -0.8
Ever had stillbirth, spontaneous miscarriage or termination 0.1 0.1 0.2 -0.4 0.3 0.0 -0.2 -0.2
Friendships satisfaction 1.0 1.3 3.9 1.3 -0.7 2.0 0.3 0.6
Qualifications: nursing, teaching 0.3 0.4 0.6 0.8 -0.4 0.7 -0.6 0.8
Commuting to job workplace: Walk 0.8 0.8 2.0 0.4 1.0 0.4 1.4 -1.0
Eye problems/disorders: Cataract 0.9 1.0 3.0 0.2 -1.1 1.7 0.6 0.6
Mouth/teeth dental problems: Mouth ulcers 0.6 0.9 1.7 -1.3 0.6 -1.3 -0.7 -0.7
Medication for cholesterol 0.7 1.0 2.6 -0.3 0.4 1.6 1.4 0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 0.9 0.4 1.0 0.1 -0.6 -0.8
Back pain experienced in last month 0.4 0.6 1.5 0.7 1.2 -0.0 -0.3 -1.1
Mineral and other dietary supplements 0.0 0.1 0.1 -0.2 -0.3 0.0 -0.1 0.3
Breast cancer (self-reported) 0.6 0.7 2.2 0.7 1.5 -0.5 0.1 -0.7
Asthma (self-reported) 0.1 0.2 0.6 -0.7 0.3 -0.2 0.3 -0.1
Osteoporosis (self-reported) 0.4 0.5 1.0 -0.2 0.9 -1.0 -0.6 -0.4
Osteoarthritis (self-reported) 0.7 0.9 3.0 -0.5 0.6 -0.8 -1.7 0.6
Medication: Aspirin 0.3 0.4 1.0 0.5 -1.0 -0.2 0.6 -0.7
Medication: Gliclazide 1.3 1.4 5.5 -0.4 -2.4 -0.8 0.8 -0.5
Illnesses of father: None of the above (group 1) 1.6 1.9 7.1 2.7 1.4 0.1 0.2 -0.7
Smoking status: Current 0.2 0.4 1.0 -0.8 0.0 1.0 -0.3 0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.8 7.9 31.6 -1.9 -1.5 -1.5 -5.6 0.1
Whole body water mass 2.2 12.7 50.4 1.4 2.1 0.9 7.1 -2.4
Leg predicted mass (right) 1.6 8.8 32.2 0.9 2.3 0.6 5.7 -2.3
Arm fat mass (left) 0.4 1.7 3.6 0.5 1.9 -1.4 -0.2 -1.7
Number of self-reported non-cancer illnesses 0.4 0.8 1.6 1.3 -0.4 1.1 -0.6 0.7
Average weekly champagne plus white wine intake 2.3 3.1 7.6 0.3 -0.1 -2.6 1.0 -2.8
Miserableness 0.3 0.6 1.4 -1.2 -0.0 -0.7 -0.0 -1.0
Guilty feelings 0.7 1.1 2.1 -0.0 0.8 -1.2 -1.0 -1.5
Wears glasses or contact lenses 1.5 1.7 4.2 -0.5 -2.0 -0.5 0.1 -2.0
Ever taken oral contraceptive pill 0.4 0.5 1.3 0.8 -1.1 -0.2 0.6 -0.3
Hearing aid user 0.5 0.5 0.9 -0.2 -0.8 -1.0 -0.6 -0.8
Mother’s age at death 0.7 0.9 1.9 1.4 0.8 0.3 -0.2 -1.3
Financial situation satisfaction 0.8 1.0 2.4 0.5 1.4 -0.0 -1.6 0.6
Tinnitus: Yes, now most or all of the time 0.6 0.7 2.2 1.5 0.2 -0.6 0.0 -1.0
Commuting to job workplace: Public transport 0.8 0.9 2.9 0.9 -1.7 -0.4 0.8 -0.1
Eye problems/disorders: Glaucoma 1.0 1.2 3.6 0.9 1.0 0.3 -1.9 0.7
Medication: Blood pressure 0.7 1.2 2.4 0.9 -1.2 -0.0 -1.6 1.2
Pain type(s) experienced in last month: Hip pain 0.9 1.2 2.1 -0.1 1.2 -1.2 -1.5 -0.9
Supplements: Fish oil (including cod liver oil) 0.3 0.4 0.7 0.8 0.5 -0.6 -0.5 -0.7
High cholesterol (Self-reported) 1.3 2.3 7.6 2.8 0.6 -1.4 0.2 -1.3
Medication: Bendroflumethiazide 0.7 1.1 2.3 -0.0 -1.4 1.5 0.1 1.1
Medication: Paracetamol 0.9 1.5 3.4 -1.2 0.4 -1.8 -1.4 -0.6
Medication: Lisinopril 1.1 1.4 2.3 1.1 -1.5 1.4 -0.5 1.1
Medication: Atorvastatin 0.6 0.7 1.7 1.3 -1.3 0.2 0.3 0.1
Illnesses of father: High blood pressure 1.3 1.7 4.3 -1.3 -1.2 0.9 -0.1 2.1
Alcohol drinker status: Never 0.3 0.3 0.9 0.2 0.6 -0.3 -1.0 0.4
Ever smoked 0.3 0.5 1.2 0.1 0.8 -0.3 1.1 -0.9
Basal metabolic rate 1.8 10.1 39.2 1.2 2.0 0.5 6.3 -2.3
Leg fat percentage (left) 1.2 4.4 10.3 -0.1 1.4 -2.7 -3.2 -1.5
Arm fat-free mass (left) 1.9 9.8 37.1 1.4 2.3 0.5 6.1 -2.2
Number of operations (self-reported) 0.8 1.2 2.2 1.1 -1.4 -0.1 -1.5 0.6
Average weekly beer plus cider intake 1.0 1.5 5.9 -1.2 0.1 -0.4 -2.4 0.1
Irritability 1.6 2.7 7.6 1.6 2.8 -0.3 1.0 -1.6
Risk taking 0.1 0.2 0.6 -0.8 -0.2 -0.0 0.3 -0.3
Ever had prostate specific antigen (PSA) test 0.2 0.3 0.6 -0.6 0.5 0.3 -0.3 0.8
Fractured/broken bones in last 5 years 0.2 0.3 0.5 0.6 -0.0 -0.2 0.7 -0.7
Age started oral contraceptive pill 0.9 1.1 2.7 0.4 -0.2 -1.0 1.3 -1.6
Diastolic blood pressure, automated reading 0.4 1.1 4.6 -0.4 -0.4 0.5 0.6 2.2
Ever depressed for a whole week 0.5 0.6 2.1 0.5 0.9 1.5 0.1 0.4
Unable to work because of sickness or disability 0.8 1.1 1.8 0.5 -1.3 1.3 -1.3 -0.0
Commuting to job workplace: Cycle 0.8 1.0 2.5 0.4 -1.0 0.9 1.6 0.6
Myopia 0.3 0.4 1.0 -1.0 0.3 0.5 0.8 -0.1
Vascular/heart problems diagnosed by doctor 0.6 1.6 3.2 -1.2 1.2 -1.4 -0.0 -1.8
Cholesterol lowering medication 0.9 1.4 2.5 0.8 -0.4 -1.6 -1.6 -1.1
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 1.6 -0.8 1.3 0.8 -1.0 0.6
Pain experienced in last month 1.3 2.2 5.1 -0.4 -2.3 1.2 2.0 -0.5
Supplements: Calcium 1.3 1.4 2.2 1.5 -1.1 0.1 1.3 -1.3
Basal cell carcinoma (self-reported) 2.0 2.3 5.3 1.4 -1.4 2.3 1.0 1.1
Heart attack/myocardial infarction (self-reported) 1.0 1.2 3.2 0.5 -1.8 -1.2 -0.0 -1.1
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 2.2 0.2 -0.2 -1.5 -0.8 -0.5
Heart disease (siblings) 1.4 1.8 4.7 0.7 -1.4 -1.3 -2.2 -0.1
Alcohol drinker status: Previous 1.1 1.3 4.4 1.0 0.3 2.1 0.5 0.9
Pack years of smoking 0.5 0.8 2.1 -0.2 1.0 -0.5 -1.5 -0.7
Impedance of whole body 1.0 5.0 20.2 -1.1 -4.5 -0.1 0.8 1.8
Leg fat mass (left) 0.5 1.8 3.1 0.0 1.8 -1.7 -0.4 -1.6
Arm predicted mass (left) 2.0 10.3 37.8 1.5 2.5 0.2 6.2 -2.3