Hub : Genes

SSR1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.203	0.0520	0.00003	0.030	0.030	0.092	0.137	0.076	1.2e-04	1.4e-04	2.5e-11	2.3e-16	1.6e-09
2	GTEx	Cells Transformed fibroblasts	0.145	0.0500	0.00470	0.100	NA	0.113	NA	0.117	6.1e-08	NA	8.0e-09	NA	4.2e-09
3	GTEx	Esophagus Mucosa	0.159	0.0600	0.00870	0.039	NA	0.023	NA	0.042	1.2e-03	NA	1.1e-02	NA	8.2e-04
4	GTEx	Esophagus Muscularis	0.185	0.0520	0.00015	0.103	NA	0.113	NA	0.095	8.1e-07	NA	2.3e-07	NA	2.3e-06
5	GTEx	Thyroid	0.092	0.0350	0.00500	0.007	NA	0.022	NA	0.029	8.4e-02	NA	8.2e-03	NA	2.7e-03
6	ROSMAP	Brain Pre-frontal Cortex	0.243	0.0379	0.00000	0.208	0.179	0.237	0.213	0.221	3.5e-26	2.0e-22	4.8e-30	8.1e-27	6.4e-28
7	YFS	Blood	0.287	0.0282	0.00000	0.166	0.204	0.229	0.249	0.237	6.0e-52	1.0e-64	2.4e-73	7.2e-81	3.2e-76
8	TCGA	Glioblastoma Multiforme	0.173	0.0750	0.00027	0.016	0.129	0.113	NA	0.123	1.0e-01	9.7e-05	2.7e-04	NA	1.5e-04
9	TCGA	Ovarian Serous Cystadenocarcinoma	0.064	0.0320	0.00100	0.052	0.053	0.044	NA	0.047	2.1e-04	1.8e-04	6.1e-04	NA	4.2e-04
10	TCGA	Thyroid Carcinoma	0.061	0.0330	0.00250	0.010	0.021	0.009	NA	0.001	3.0e-02	3.3e-03	3.6e-02	NA	2.4e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	3.5	5.5	13.3	0.5	-2.3	0.8	-2.8	-0.5	-2.9	-1.2	-3.5	-2.5	-3.6
Bipolar Disorder or Schizophrenia	2.8	6.8	14.3	1.3	-2.0	1.9	-3.8	-1.0	-3.2	-2.0	-3.1	-3.2	-2.9
Depressed Affect (Nagel 2018)	0.8	1.7	3.7	-1.7	1.0	-0.2	1.9	0.1	1.7	0.3	1.8	1.3	1.3
Depression (Nagel 2018)	0.5	0.8	2.0	-0.5	1.4	1.1	0.7	0.8	1.0	-0.7	0.9	0.1	0.6
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.7	0.3	-1.3	0.2	-0.9	0.0	-0.8	0.7	-1.3	-0.6	0.3
Neuroticism (Nagel 2018)	1.6	3.8	9.7	-0.9	2.6	0.1	2.6	0.2	2.3	-0.8	3.1	2.0	2.1
Schizophrenia (2018)	1.2	2.5	6.9	1.3	-0.7	1.8	-2.6	-0.8	-1.8	-1.7	-1.2	-2.1	-0.8
Schizophrenia vs Biploar Disorder	0.5	0.7	2.3	-0.6	0.6	-0.3	0.4	0.9	0.3	-0.6	1.5	0.6	1.4
Worry (Nagel 2018)	1.4	3.0	7.0	-0.4	2.6	0.9	2.5	-0.1	1.9	-1.0	2.6	1.4	1.6
Alzheimer’s Disease (in mother)	0.4	0.5	2.1	-1.5	0.7	0.8	0.3	-1.1	-0.1	0.2	0.5	0.3	0.3
Alzheimer’s Disease (in father)	0.4	0.4	2.2	-0.6	-1.5	0.2	0.1	0.2	-0.7	-0.6	-0.2	-0.1	-0.5
Alzheimer’s Disease (including proxy)	0.9	1.3	5.5	-2.4	0.4	0.1	1.7	-0.5	0.7	0.9	0.9	1.1	0.6
Crohns Disease (2017)	0.2	0.4	1.3	1.1	-0.0	-0.1	-0.8	0.1	-0.6	-1.2	0.4	0.2	0.1
Irritable Bowel Disease (IBD)	0.2	0.5	2.8	-0.1	0.5	-0.2	0.3	1.7	0.5	0.1	0.6	0.5	1.0
Ulcerative Colitis (UC)	0.7	1.4	3.3	-1.4	1.0	-0.3	1.0	1.8	1.5	0.8	0.8	0.8	1.5
Major Depression (MDD)	0.5	0.6	1.7	1.0	0.6	-0.5	0.2	0.8	0.8	-0.2	1.0	0.5	1.3
Reaction Time	0.3	0.5	1.8	0.6	1.3	0.9	-0.1	-0.2	0.1	-1.1	0.4	0.0	0.7
Verbal and Numeric Reasoning (VNR)	0.4	0.8	3.4	0.5	-0.7	0.1	-1.2	1.8	-0.5	0.3	-1.3	-1.0	0.0
Breast Cancer	0.7	1.6	5.8	-2.4	-2.1	-0.6	1.6	-0.6	-0.3	0.7	0.4	1.2	0.3
Ovarian Cancer	1.2	1.6	3.5	0.9	-1.1	0.7	-1.5	1.0	-1.3	-0.6	-1.7	-1.9	-1.5
Prostate Cancer	1.1	1.6	4.0	-0.5	0.9	-2.0	1.2	1.1	1.5	0.7	1.0	1.3	1.5
Age at First Birth	0.2	0.3	1.2	0.1	0.1	-1.1	0.3	0.9	0.3	0.1	0.4	0.7	-0.1
Bipolar Disorder (2011)	2.4	2.3	7.8	0.6	-1.3	1.3	-1.0	-0.6	-1.3	0.9	-2.8	-1.8	-2.0
Body Mass Index (BMI) (2010)	0.8	1.1	3.5	0.8	1.0	-1.0	0.7	1.9	0.9	1.6	-0.1	-0.3	0.8
Coronary Artery Disease (CAD)	0.8	1.0	2.0	1.4	0.6	1.0	-0.3	1.1	-0.9	-1.4	-0.4	-1.2	-0.9
Crohns Disease (2012)	0.7	1.1	3.1	1.6	-0.1	0.5	-1.8	0.6	-1.4	-1.0	-0.5	-1.1	-0.2
Mean Putamen Volume	1.6	1.9	4.5	1.0	-2.0	0.6	-2.1	-0.4	-1.8	-1.0	-1.4	-1.1	-1.1
Fasting Glucose	4.3	5.1	15.0	-2.3	1.6	-0.5	1.6	-1.5	1.1	0.7	3.8	2.6	3.9
HbA1C	3.5	3.9	7.8	-2.7	2.7	0.6	2.3	-1.6	1.6	-1.3	2.8	1.8	0.9
HDL Cholesterol	0.1	0.2	0.6	0.4	-0.5	0.5	0.4	-0.4	-0.5	-0.8	0.2	0.4	-0.7
LDL Cholesterol	0.7	1.2	3.2	1.5	-0.2	-0.5	-1.8	0.1	-0.8	0.5	-1.5	-0.7	-1.5
Lupus	0.9	1.4	3.7	-1.6	1.9	0.3	1.5	0.2	1.4	0.1	1.3	0.5	1.1
Neuroticism (2016)	0.5	0.7	2.1	-0.2	0.7	1.2	0.3	-0.1	0.6	-1.3	1.5	0.6	0.2
Primary Biliary Cirrhosis	0.5	0.7	2.4	0.8	1.4	0.2	0.3	-1.2	-0.4	-1.5	0.5	-0.6	-0.2
Rheumatoid Arthritis	0.2	0.3	1.1	-0.1	1.0	-0.1	-0.6	-0.7	0.5	0.7	-0.1	-0.1	0.5
Schizophrenia (2014)	1.4	3.1	8.2	1.7	-1.2	0.7	-2.9	-0.4	-2.4	-1.3	-1.8	-2.2	-1.6
Triglycerides	0.2	0.3	0.8	0.4	0.7	-0.9	0.2	0.1	0.7	0.5	0.4	0.5	0.9
Type 2 Diabetes (T2D) (2012)	7.3	8.4	24.0	-4.9	2.0	-1.6	3.1	-1.3	2.8	0.7	3.7	3.4	3.0
Ulcerative Colitis	0.3	0.4	1.2	0.4	1.1	0.6	0.3	0.9	0.1	0.0	-0.2	-0.7	1.0
Blood Eosinophil Count	0.1	0.8	2.6	-1.3	-0.7	-0.1	-0.6	-1.6	0.1	-0.2	0.6	1.2	0.8
Blood Platelet Count	0.2	2.9	9.8	1.1	1.0	0.3	-0.3	0.2	-1.0	1.1	-3.0	-2.3	-3.1
Blood Red Count	1.2	11.1	55.8	-1.7	-7.5	-1.4	-3.2	1.7	-3.4	1.7	-4.3	-1.0	-1.9
Blood White Count	0.4	2.9	9.1	1.1	-1.5	-0.8	-1.0	-0.7	-2.0	0.8	-2.9	-1.2	-3.0
Heel T-Score	2.3	18.7	51.8	-3.9	-6.2	7.2	-3.1	-3.0	-5.1	-2.1	-2.5	-2.2	-4.7
BMI	0.0	0.2	0.5	-0.5	0.4	0.1	0.0	0.6	0.6	0.3	-0.3	-0.7	-0.5
Height	1.0	20.1	99.0	-9.9	-7.8	-2.2	-0.9	-1.8	-2.0	3.3	1.3	4.0	0.3
Waist Hip Ratio (WHR)	0.6	2.5	6.2	-0.9	1.9	1.7	0.3	2.1	0.1	-0.5	-2.4	-2.5	-1.1
Systolic Blood Pressure	0.1	0.6	3.0	-0.1	1.7	-0.1	-0.5	-0.3	0.3	-1.0	1.2	0.6	0.5
Smoking Status	0.3	0.7	1.4	0.7	-1.0	-0.0	-0.6	-1.2	-1.0	0.3	-1.0	-0.5	-1.2
Allergy or Eczema	0.9	2.4	5.6	-2.4	-0.5	-1.5	1.5	-0.1	1.2	1.2	1.6	2.4	1.7
Cardiovascular Disease	0.7	2.5	6.4	-0.9	1.7	-0.3	1.4	-0.7	1.5	-0.0	2.5	2.0	2.3
Hypothyroidism (self reported)	0.8	1.8	3.2	-1.8	0.5	-0.9	1.3	-1.6	1.6	1.1	1.5	1.6	1.1
Respiratory disease	1.1	2.5	8.6	-2.9	-2.0	2.6	-0.5	-1.5	-1.2	-1.0	0.3	0.2	0.1
Type 2 Diabetes (T2D) (2018)	6.7	12.5	51.4	-7.2	-0.9	-0.3	3.6	-4.0	1.6	0.2	4.1	4.2	2.7
Lung FEV1/FVC ratio	1.5	7.9	25.5	1.1	5.0	-1.3	3.0	5.0	3.4	1.9	-0.8	-0.7	0.1
Lung FVC	2.0	10.2	21.9	-3.7	-0.7	-0.8	4.0	-4.7	2.6	1.7	3.9	3.9	3.0
Neuroticism	0.9	2.2	5.5	0.0	2.4	1.5	1.5	-0.5	1.2	-1.7	2.2	0.6	1.5
Chronotype (morning person)	0.3	0.6	3.6	-0.5	-0.2	-1.2	0.6	1.9	-0.0	-0.0	-0.3	-0.1	-0.5
Hair Pigment	0.1	1.8	13.2	3.6	0.9	-0.8	-1.3	-0.4	-0.5	-0.0	-0.1	-0.8	0.5
Tanning	0.1	1.3	4.5	-0.6	-2.1	0.3	-1.6	-1.8	-0.9	-0.3	-0.7	0.2	-1.0
Hand grip strength (left)	1.0	2.7	7.4	-2.6	-2.7	-0.0	-1.1	-0.6	-1.3	1.5	-1.9	-0.9	-1.7
Number of treatments/medications taken	2.0	3.6	9.1	-2.9	1.2	0.9	1.1	-2.5	0.5	-1.0	3.0	2.0	1.7
Average weekly spirits intake	1.4	1.8	7.5	-2.7	-0.4	0.0	0.9	-1.4	0.7	-0.3	1.4	2.1	0.7
Sensitivity / hurt feelings	0.5	0.8	3.7	-0.1	0.2	1.6	0.6	-0.3	-0.6	-1.9	0.7	-0.2	-0.6
Frequency of depressed mood in last 2 weeks	0.6	0.8	3.1	-0.6	1.2	0.7	1.8	-0.4	1.0	-0.1	1.0	0.4	0.7
Hearing difficulty/problems: Yes	1.0	1.5	3.5	-1.9	-1.7	1.5	-0.5	1.1	-1.0	-0.6	-1.1	-1.2	-1.2
Relative age of first facial hair	1.5	3.1	7.9	0.7	2.6	0.0	2.3	-0.0	2.1	-0.2	2.8	1.5	1.8
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	5.7	-1.2	2.0	0.5	0.9	-0.8	1.7	-0.1	1.7	0.9	2.4
Ever used hormone-replacement therapy (HRT)	2.0	2.5	9.3	-3.1	1.2	0.5	1.8	-0.9	1.4	-0.3	2.0	1.4	1.3
Ever had hysterectomy (womb removed)	0.2	0.2	0.9	-0.9	-0.3	0.1	0.3	-0.6	0.1	0.2	-0.1	0.4	-0.0
Systolic blood pressure, automated reading	0.1	0.3	1.3	0.6	0.5	-0.6	-1.1	0.4	0.1	-0.0	-0.4	-0.3	-0.8
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	3.1	-1.8	-0.8	-0.0	1.6	-0.5	0.4	-0.0	0.8	1.1	0.5
Angina	0.5	0.6	2.9	-1.2	0.6	0.1	0.1	-1.7	0.5	-0.4	0.8	0.8	0.2
Medication for hormone replacement therapy	1.3	1.4	7.2	-0.4	0.1	1.6	-0.5	-2.7	-0.8	-1.4	0.9	0.1	0.7
Vitamin and mineral supplements	0.3	0.4	1.3	-0.6	-1.1	-0.8	-0.7	-0.6	-0.1	0.4	-0.6	-0.3	-0.6
Supplements: Zinc	0.6	0.7	1.3	-1.1	-0.5	0.1	-0.4	-1.1	-0.4	1.0	-0.9	-0.7	-1.1
Medication: Co-codamol	2.8	3.3	9.1	-1.2	1.4	-1.0	2.0	0.3	1.9	0.1	2.8	2.1	3.0
Medication: Metformin	2.1	3.0	13.9	-3.7	-1.3	1.4	0.9	-2.2	-0.9	-1.5	1.4	1.2	0.7
Diabetes (father)	2.4	3.0	23.5	-4.8	-0.8	0.8	-0.1	-1.3	0.1	-0.5	1.2	1.1	0.8
Diabetes (mother)	2.2	2.8	7.0	-2.1	0.9	0.0	1.9	-1.9	0.7	-1.0	2.6	1.8	2.0
Severe depression (siblings)	1.0	1.2	5.2	2.3	0.5	0.7	-0.7	-1.4	-1.0	-1.4	0.1	-0.5	0.2
Pack years adult smoking proportion	0.3	0.4	2.3	0.4	0.6	1.5	-0.3	0.5	-0.1	-0.7	0.3	-0.1	0.8
Impedance of leg (right)	0.8	4.1	10.5	0.9	-3.2	0.6	-0.4	0.9	-2.7	1.2	-3.2	-1.8	-2.4
Leg fat-free mass (left)	0.5	2.4	11.3	-3.4	-0.4	-0.8	0.2	-1.0	0.9	0.1	2.1	2.0	1.3
Trunk fat percentage	0.8	3.2	9.5	-0.2	-2.5	0.5	-0.9	0.6	-1.9	0.3	-2.7	-1.8	-3.1
Hand grip strength (right)	0.7	1.8	4.1	-1.8	-2.0	-1.1	-1.0	-0.2	-0.7	2.0	-1.6	-0.6	-1.1
Townsend deprivation index at recruitment	0.6	0.8	2.6	0.0	1.6	1.2	1.0	-0.4	0.7	-0.0	1.2	0.5	0.6
Current tobacco smoking	0.5	0.7	2.4	-0.7	1.2	1.5	-0.0	-0.3	-0.3	-1.4	0.8	0.1	0.7
Average weekly fortified wine intake	0.4	0.4	1.9	-1.4	-0.7	0.2	-0.4	0.7	-0.2	-0.8	0.3	0.2	-0.7
Maternal smoking around birth	1.0	1.4	5.6	-1.1	-1.0	2.4	-0.2	0.3	-0.6	-0.2	-0.9	-0.9	-1.9
Fed-up feelings	1.5	2.7	11.2	-3.4	0.5	0.1	2.8	-0.5	1.7	1.1	1.1	1.3	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	3.0	-0.7	1.5	0.9	1.4	-0.8	0.7	-1.2	1.7	0.6	0.6
Relative age voice broke	0.4	0.6	4.3	2.1	0.5	-0.1	0.6	0.6	0.5	0.6	0.2	-0.1	0.6
Taking other prescription medications	1.3	2.0	5.8	-1.7	0.5	2.0	-0.4	-2.4	-0.8	-2.0	1.5	0.3	0.4
Age when periods started (menarche)	0.3	0.7	1.8	0.7	1.0	0.6	0.8	0.1	0.7	-0.4	1.3	0.7	1.1
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	4.7	-2.2	1.0	0.5	0.6	-1.1	0.8	-0.5	0.7	0.9	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	5.8	-2.4	-1.9	1.8	0.1	-0.9	-1.4	-0.4	-0.8	-0.4	-1.6
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	3.1	-0.5	1.7	0.9	0.8	0.3	0.6	-0.4	0.5	-0.4	0.2
Qualifications: CSEs or equivalent	1.1	1.5	4.1	1.0	2.0	0.7	0.4	-0.6	0.1	-1.8	2.0	0.5	1.0
Serious illness, injury or assault to yourself	1.6	1.9	4.2	-0.3	0.9	-1.7	1.0	-0.3	1.5	1.2	2.1	1.7	1.9
High blood pressure	0.9	2.5	7.8	-1.5	0.8	0.1	0.8	-0.6	1.4	-0.9	2.8	2.4	2.3
Hayfever, allergic rhinitis or eczema	1.1	2.4	8.2	-2.9	-0.7	-1.7	1.2	-0.3	1.0	1.8	1.2	1.9	1.3
Multivitamins +/- minerals	0.2	0.2	0.8	-0.4	0.1	0.3	0.6	0.0	0.2	0.3	0.6	0.6	0.9
Stomach or abdominal pain in last month	1.0	1.2	3.7	-1.9	1.4	0.3	1.2	-0.8	1.2	0.3	1.5	0.6	0.5
Supplements: Glucosamine	0.5	0.7	2.0	0.3	-1.1	0.2	-1.4	-0.7	-1.1	-0.9	-0.7	-0.8	-0.3
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	4.5	-1.5	0.7	0.2	1.6	-2.1	0.8	0.4	1.3	1.1	1.2
Medication: Atenolol	1.1	1.4	4.2	-0.6	1.9	0.8	0.8	0.2	1.0	-0.1	2.0	1.0	1.6
Medication: Levothyroxine sodium	0.4	0.7	3.4	-1.9	-0.5	-0.7	0.7	0.6	0.6	0.8	0.3	0.4	0.5
Sitting height	1.2	8.4	40.4	-5.2	-6.4	-1.2	-1.6	-0.4	-2.5	1.6	-1.2	1.2	-0.6
Chronic bronchitis/emphysema (father)	0.6	0.7	1.6	0.5	-1.3	1.1	-0.8	0.5	-1.0	-0.3	-0.9	-0.8	-0.8
High blood pressure (mother)	0.5	0.7	1.7	-1.3	1.2	-0.2	-0.3	0.7	0.7	0.2	1.2	0.5	1.0
Body mass index (BMI)	0.1	0.3	1.3	-1.1	0.0	-0.1	0.7	0.0	0.6	-0.0	0.0	-0.2	-0.6
Impedance of leg (left)	1.0	4.9	12.4	1.0	-3.5	0.9	-0.9	0.7	-3.0	1.4	-3.5	-2.0	-2.6
Leg predicted mass (left)	0.4	2.2	11.0	-3.3	-0.4	-0.6	0.1	-0.8	0.8	-0.0	2.0	1.9	1.2
Trunk fat mass	0.5	2.2	7.7	-1.6	-2.8	0.2	-0.7	0.0	-1.4	0.5	-1.8	-0.8	-2.2
Waist circumference	0.3	0.9	3.1	-1.8	-1.2	0.1	-0.2	0.4	-0.6	-0.2	-1.2	-0.8	-1.5
Number of incorrect matches in round	1.3	2.1	6.3	0.8	0.1	2.5	-1.2	-2.2	-1.5	-1.8	-0.5	-1.1	-1.0
Past tobacco smoking	1.8	3.3	7.4	-0.9	2.6	-0.1	2.2	0.7	1.7	-0.4	2.6	1.7	2.7
Alcohol usually taken with meals	1.1	1.9	5.2	0.3	-1.0	-1.6	-1.2	2.0	-0.2	1.2	-2.3	-1.2	-1.2
Nervous feelings	0.8	1.5	3.5	-1.5	0.7	1.4	1.9	-0.6	0.3	-1.4	1.7	1.0	0.6
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	3.4	-1.1	1.3	1.5	1.4	-1.8	0.6	-1.4	1.7	0.8	1.1
Hearing difficulty/problems with background noise	0.3	0.5	2.6	-1.6	-0.4	0.4	1.3	0.1	0.1	0.1	0.2	0.0	0.1
Hair/balding pattern: Pattern 2	2.4	3.1	6.9	-2.2	1.2	0.3	1.8	-1.4	1.6	0.7	2.6	2.2	2.0
Had menopause	0.6	0.7	5.6	-2.4	-0.5	-0.5	0.4	0.2	0.4	0.5	0.2	0.6	-0.3
Had other major operations	0.7	0.8	4.2	-0.2	-2.0	-0.9	-0.7	0.4	-0.9	0.0	-0.4	-0.1	-1.1
Forced vital capacity (FVC)	1.0	4.0	16.7	-4.1	-2.2	-0.5	1.4	-2.2	0.3	2.1	1.2	1.9	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	3.1	-1.6	-1.2	1.5	-0.1	-0.9	-1.1	-0.5	-0.6	-0.4	-1.8
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	2.7	0.8	-1.1	0.7	-0.5	-0.6	-1.4	0.1	-1.6	-1.5	-1.5
Qualifications: None of the above	0.5	1.0	3.4	1.1	1.8	1.6	-0.3	1.0	0.3	-0.1	-0.2	-1.1	-0.9
Financial difficulties in last 2 years	1.6	2.1	11.1	0.1	1.1	0.6	0.9	-3.3	0.7	-1.4	1.8	1.2	1.0
Mouth/teeth dental problems	1.8	2.8	5.5	-0.7	-2.3	-0.1	-2.2	2.2	-1.7	0.3	-2.3	-1.7	-1.2
Heart attack	2.1	2.7	8.6	1.0	1.6	2.2	-0.8	2.9	-0.0	-2.6	0.7	-0.9	0.9
Allergy	1.1	2.5	11.4	3.4	1.1	0.5	-1.1	1.2	-0.7	-1.5	-1.3	-1.9	-1.0
Pain all over the body in last month	7.8	8.4	14.7	-2.8	2.2	-1.7	3.2	-1.2	3.8	1.7	3.8	3.8	3.1
Diabetes (self-reported)	6.8	10.5	44.2	-6.7	-1.2	-0.5	3.2	-3.5	1.2	-0.3	3.7	4.0	2.5
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.6	-0.1	-0.4	0.4	0.5	-0.3	-0.2	-0.2	0.6	0.8	0.5
Medication: Ramipril	1.3	1.7	4.5	-0.6	1.2	-0.6	1.1	-0.8	1.3	0.0	1.7	1.9	2.1
Medication: Simvastatin	0.1	0.2	0.6	-0.4	0.8	0.3	-0.3	-0.5	0.3	-0.6	0.4	0.4	-0.1
Fluid intelligence score	0.7	1.5	4.0	0.9	-1.1	-0.1	-2.0	1.2	-0.7	1.1	-1.7	-1.5	0.2
Illnesses of siblings	0.5	0.7	2.3	0.5	-1.5	-0.9	0.1	1.1	-0.2	0.6	-1.0	-0.4	-0.9
Neuroticism score	1.0	2.2	6.6	-1.2	1.6	1.2	2.6	-0.8	1.2	-1.1	2.1	0.9	0.9
Weight	0.4	1.8	11.5	-3.4	-2.1	-0.4	0.0	-0.4	-0.3	0.7	0.0	0.6	-0.6
Impedance of arm (right)	1.7	7.8	19.0	3.1	-2.1	0.6	-2.0	2.6	-3.3	-0.2	-4.4	-3.1	-3.5
Arm fat percentage (right)	0.4	1.5	5.4	0.5	-1.1	0.5	-0.2	0.9	-1.0	-0.2	-1.9	-1.7	-2.3
Trunk fat-free mass	0.8	4.4	22.0	-4.7	-1.4	-0.4	0.1	-1.6	0.8	0.4	2.6	2.5	1.9
Hip circumference	0.3	1.4	7.0	-1.6	-2.6	-1.5	-0.3	-0.3	-0.5	1.0	-0.2	0.8	-0.5
Time employed in main current job	0.4	0.5	1.7	0.0	1.1	0.5	-0.6	1.0	0.1	-0.1	-0.7	-1.3	0.2
Alcohol intake versus 10 years previously	0.2	0.2	0.7	0.2	0.8	-0.5	0.6	-0.3	0.4	-0.2	0.7	0.5	-0.1
Father’s age at death	1.5	2.0	5.8	1.0	-2.4	1.4	-1.6	0.4	-1.7	-0.5	-1.7	-1.2	-1.1
Worrier / anxious feelings	1.2	2.3	5.5	-0.2	2.0	0.9	2.3	-0.5	1.9	-0.3	2.3	1.2	1.5
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	6.0	-1.3	1.3	0.4	2.5	-1.6	0.9	-0.9	2.2	1.3	1.2
Falls in the last year	0.6	0.9	2.1	-1.4	0.3	0.5	1.4	0.5	0.8	1.1	0.9	0.6	0.9
Hair/balding pattern: Pattern 3	1.8	2.6	7.3	2.7	0.2	-2.5	-0.2	0.1	0.3	2.1	-2.1	-1.2	-1.4
Number of live births	0.5	0.7	1.9	0.7	0.3	-0.4	1.1	-1.1	0.7	-0.1	1.4	1.0	0.8
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	10.0	-3.2	-0.8	-0.8	1.8	-0.1	0.8	2.6	0.1	0.8	0.3
Pulse rate	0.3	0.4	1.4	1.2	0.9	0.3	-0.3	-0.5	-0.3	-1.1	0.6	-0.4	-0.2
Happiness	0.4	0.5	2.0	1.4	0.2	-0.8	-0.3	1.0	0.1	0.9	-0.3	-0.4	-0.3
Noisy workplace	0.9	1.1	2.8	-1.2	1.7	-0.0	1.6	0.0	1.3	0.7	1.2	0.6	0.1
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.0	-0.5	-1.4	-1.4	0.2	-0.8	-0.6	1.3	-0.4	0.5	0.1
Serious illness, injury or assault of a close relative in last 2 years	2.3	2.7	6.9	0.5	1.8	-1.1	1.9	0.0	2.6	1.1	2.0	2.1	1.4
Mouth/teeth dental problems: Dentures	0.4	0.7	2.1	0.9	-0.4	-0.6	-0.1	0.5	-0.1	1.4	-1.2	-0.7	-1.2
Asthma	1.0	2.0	7.6	-2.4	-1.1	2.8	-0.1	-1.7	-0.5	-1.1	0.9	0.3	0.7
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.2	6.1	-1.3	1.7	-0.5	2.5	-0.8	1.5	0.7	2.0	1.5	1.3
Medication: Cholesterol lowering	0.5	0.8	4.6	0.1	1.1	1.2	-0.2	0.2	-0.6	-2.1	0.8	-0.1	0.1
Depression (self-reported)	0.8	1.0	3.7	-1.9	0.7	0.3	0.3	-1.5	0.5	-1.1	0.6	0.6	0.9
Medication: Lansoprazole	2.4	2.7	6.2	-1.4	1.2	-0.5	1.6	-2.2	1.4	-0.4	2.5	2.4	1.6
Prospective memory result	0.3	0.4	1.4	0.4	1.2	-0.1	0.5	-0.1	0.9	0.5	0.9	0.5	0.3
Lung cancer (father)	1.2	1.4	3.0	1.5	1.2	-1.4	0.5	-1.7	1.1	1.4	1.0	0.7	0.6
Illnesses of mother	0.8	1.0	3.0	1.3	-0.8	-0.5	-0.3	1.2	-0.7	-0.2	-1.7	-1.2	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	10.3	-3.2	-1.2	-0.7	2.1	-1.0	0.7	2.4	0.4	1.2	0.5
Pulse wave Arterial Stiffness index	0.3	0.4	2.1	0.6	-0.2	-0.7	-1.4	-0.3	-0.3	-0.4	0.2	-0.2	0.5
Impedance of arm (left)	1.0	4.7	12.1	2.7	-1.6	-0.1	-1.2	1.8	-2.5	0.3	-3.5	-2.1	-3.1
Arm fat mass (right)	0.2	0.8	2.4	-1.4	-1.4	0.2	0.2	0.3	-0.6	0.1	-0.9	-0.6	-1.6
Trunk predicted mass	0.8	4.4	21.9	-4.7	-1.4	-0.4	0.1	-1.7	0.7	0.4	2.6	2.5	1.9
Standing height	0.7	6.6	28.6	-5.3	-5.0	-0.6	-1.7	-0.7	-2.0	1.5	-0.1	1.5	-0.2
Length of working week for main job	1.0	1.1	3.1	-0.2	-1.8	0.0	-1.4	0.7	-1.2	0.4	-1.6	-0.7	-0.9
Exposure to tobacco smoke at home	0.2	0.2	0.7	-0.8	0.8	0.2	0.7	0.6	-0.0	-0.3	0.5	0.0	-0.1
Breastfed as a baby	1.5	1.8	4.2	-0.4	0.6	-1.1	0.2	-1.6	1.7	0.5	2.0	2.0	1.7
Tense / ‘highly strung’	1.4	2.4	5.6	-0.8	1.8	0.6	1.7	-1.5	1.3	-1.1	2.4	1.4	1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.3	3.6	-1.7	1.3	0.7	1.9	0.1	1.8	0.9	0.3	0.4	0.5
Hair/balding pattern: Pattern 4	2.5	6.1	17.4	-0.2	4.1	2.2	1.3	0.3	1.7	-2.6	4.2	1.4	3.0
Birth weight of first child	4.1	7.4	19.6	-4.4	-1.0	-0.6	3.1	-2.6	1.9	0.6	3.2	3.6	3.1
Peak expiratory flow (PEF)	0.9	2.0	6.1	-2.3	-0.3	-0.7	1.1	1.9	0.6	2.5	-1.5	-0.4	-0.9
Pulse wave reflection index	2.7	3.3	7.8	-0.6	0.6	-2.8	1.4	-1.6	2.0	2.4	1.4	2.1	2.0
Ever highly irritable/argumentative for 2 days	0.3	0.4	1.8	0.1	-0.5	0.8	0.1	-0.4	-0.7	-1.3	0.0	-0.4	-0.4
Loud music exposure frequency	0.4	0.5	2.8	1.7	0.4	0.1	-0.4	-1.1	-0.3	-0.2	0.4	0.1	0.1
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	3.5	-1.1	-1.9	-0.3	0.2	-0.9	-1.3	0.6	-0.8	-0.3	-1.0
Mouth/teeth dental problems: Bleeding gums	1.4	1.9	5.5	-0.1	1.4	0.2	1.3	-2.3	0.5	-1.1	2.1	1.5	1.2
Blood clot in the leg (DVT)	0.5	0.6	3.6	1.9	0.6	-0.9	-0.2	0.2	0.4	0.9	-0.4	-0.5	-0.3
Medication: Paracetamol	1.0	1.7	4.2	-1.8	0.4	0.9	1.5	-1.5	0.3	-0.7	2.1	1.5	1.0
Headache pain in last month	0.8	1.3	7.1	0.0	0.0	2.0	-0.3	0.0	-1.2	-2.7	0.4	-0.7	-0.3
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	2.7	1.1	-0.9	-1.3	0.0	0.7	0.2	1.7	-1.5	-1.1	-1.2
Glaucoma (self-reported)	0.3	0.4	1.1	0.7	0.8	0.0	-0.5	1.0	-0.3	-0.6	-0.4	-0.6	-0.8
Gout (self-reported)	0.7	0.9	2.8	1.0	1.5	0.3	0.7	-0.8	0.7	0.0	1.7	0.6	0.8
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	5.4	-2.3	-0.3	-0.7	1.1	-0.6	1.0	1.1	1.1	1.2	0.7
Medication: Amlodipine	2.0	2.8	7.1	-2.7	0.7	-0.1	1.1	-1.7	1.2	-0.6	2.5	2.5	1.6
Medication: Ventolin 100micrograms inhaler	0.5	0.6	2.6	-1.6	-0.5	1.3	-0.1	-1.0	0.0	-0.1	0.6	0.5	0.4
Birth weight	1.7	3.7	13.2	-3.6	-1.4	-1.1	2.5	-0.3	1.6	0.2	1.8	2.6	1.3
Chronic bronchitis/emphysema (mother)	1.2	1.4	2.8	-0.7	-1.2	1.4	0.2	-0.1	-1.2	0.7	-1.7	-1.6	-1.6
High blood pressure (siblings)	0.3	0.5	1.8	0.1	0.5	0.8	-1.0	-1.4	-0.5	-0.2	-0.0	-0.3	-0.7
Forced vital capacity (FVC), Best measure	1.1	4.0	15.8	-4.0	-2.6	-0.4	1.4	-2.4	-0.0	2.0	1.1	1.8	0.9
Body fat percentage	0.7	2.7	8.1	-0.3	-2.4	0.4	-0.6	0.4	-1.6	0.5	-2.5	-1.6	-2.9
Leg fat percentage (right)	0.5	1.7	4.8	-0.7	-2.2	0.3	0.2	0.6	-0.9	0.9	-2.1	-1.2	-2.1
Arm fat-free mass (right)	0.9	4.9	26.2	-5.1	-1.6	-0.5	0.3	-1.9	0.9	0.8	2.4	2.5	1.7
Exposure to tobacco smoke outside home	0.9	1.2	3.2	-0.8	1.5	-0.8	1.4	0.9	1.4	1.8	0.4	0.5	0.6
Comparative body size at age 10	0.7	1.9	5.4	-2.1	-0.1	-0.5	2.0	-1.6	1.2	2.3	-0.2	0.6	-0.9
Number of full brothers	0.1	0.1	0.2	0.3	-0.1	0.1	-0.1	0.5	-0.2	-0.5	0.3	-0.2	0.2
Worry too long after embarrassment	1.1	1.9	4.7	-0.2	1.9	1.3	0.9	-1.3	0.5	-2.2	2.0	0.4	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	3.2	-0.6	0.2	0.7	-0.1	-1.8	-0.6	-0.4	-0.4	-0.4	-1.2
Wheeze or whistling in the chest in last year	1.5	2.7	7.2	-2.2	-0.6	1.3	0.6	-2.7	-0.6	-1.9	2.1	1.4	1.6
Number of children fathered	1.0	1.2	2.7	0.0	-1.6	-0.5	-0.6	1.6	-0.8	0.3	-1.5	-1.1	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.7	1.3	-0.1	0.8	-1.1	-0.2	-0.7	-0.8	0.5	-0.1	-0.3
Age at first live birth	0.9	1.7	7.7	-0.2	-1.7	-2.8	-0.7	1.3	-0.0	1.6	-0.7	0.8	0.5
Pulse wave peak to peak time	0.4	0.4	1.9	-1.1	-0.1	0.4	1.4	0.2	0.4	0.7	-0.1	0.4	-0.4
Health satisfaction	1.4	1.8	5.9	-1.2	0.6	0.3	1.1	-1.6	0.6	-1.1	2.4	1.6	1.3
Shortness of breath walking on level ground	0.6	0.7	1.7	-0.6	0.2	0.8	0.5	-1.1	-0.3	-1.2	1.3	1.0	-0.0
Qualifications: College or University degree	0.7	2.3	11.5	-3.4	-1.8	-1.5	-0.2	-1.2	0.1	0.8	0.5	1.5	1.0
Eye problems/disorders: None of the above	0.9	1.1	4.3	1.4	1.6	0.1	0.1	-2.1	0.2	-0.5	1.0	0.7	0.4
Mouth/teeth dental problems: Loose teeth	1.3	1.5	7.1	-0.7	1.5	2.7	0.2	0.9	0.0	-1.8	0.4	-0.8	0.2
Emphysema/chronic bronchitis	0.3	0.3	1.2	-0.4	-1.1	-0.3	-0.0	0.6	-0.5	0.8	-0.1	-0.1	-0.3
Medication for pain relief, constipation, heartburn	1.5	2.6	5.9	2.4	-0.7	-1.5	-1.8	2.0	-0.4	1.1	-2.3	-1.5	-1.1
Neck or shoulder pain in last month	0.5	0.8	2.5	0.6	0.5	1.6	0.2	-0.3	-0.1	-1.5	0.8	-0.1	1.2
Medication: Blood pressure	1.1	2.0	5.1	-1.7	1.0	0.2	0.8	-0.7	0.6	-1.1	2.3	2.0	1.9
Angina (self-reported)	0.4	0.6	2.7	-1.0	0.6	0.2	0.1	-1.6	0.5	-0.5	0.8	0.7	0.2
Migraine (self-reported)	1.1	1.3	2.6	1.3	1.3	1.1	-0.5	1.6	-0.3	-0.9	-1.2	-1.4	-1.2
Medication: Ibuprofen	2.7	3.2	7.6	-0.9	1.8	-1.3	2.8	-0.9	2.0	1.5	2.4	1.9	1.5
Medication: Allopurinol	0.6	0.8	3.2	-0.7	0.2	-0.0	0.5	-1.4	0.2	-0.1	1.8	1.1	1.1
Medication: Omeprazole	2.2	2.6	6.4	2.5	-1.1	2.4	-1.4	-1.3	-1.8	-2.0	-0.5	-1.4	-0.2
Medication: Seretide 50 evohaler	0.6	0.7	2.2	1.0	0.5	1.5	-0.1	-1.0	-0.4	-1.1	0.9	0.1	0.5
Mean time to correctly identify matches	0.2	0.3	0.9	0.3	0.9	0.2	0.1	-0.4	0.3	-0.7	0.7	0.6	0.9
Heart disease (mother)	0.2	0.3	0.6	-0.6	0.7	0.1	0.2	0.5	0.6	0.8	0.4	0.6	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.9	2.2	9.4	-3.1	-0.4	-0.8	1.7	0.1	0.9	0.3	1.8	2.2	0.7
Whole body fat mass	0.4	1.6	5.6	-1.5	-2.4	0.1	-0.6	0.1	-1.1	0.6	-1.5	-0.7	-2.0
Leg fat mass (right)	0.3	1.0	3.5	-1.6	-1.9	0.3	0.0	-0.1	-0.7	0.5	-1.0	-0.5	-1.4
Arm predicted mass (right)	0.8	4.1	21.3	-4.6	-1.2	-0.3	0.2	-1.7	0.9	0.6	2.3	2.3	1.7
Pulse rate, automated reading	0.2	0.7	3.0	1.1	1.7	0.6	0.2	0.9	1.1	0.3	0.2	-0.3	0.5
Alcohol intake frequency.	1.3	3.0	8.2	0.8	2.9	-1.2	2.2	-0.3	2.2	1.4	2.0	1.6	1.0
Comparative height size at age 10	0.5	2.8	10.6	-2.1	-3.3	-0.4	-1.8	0.4	-2.2	1.2	-1.4	-0.4	-1.0
Number of full sisters	0.5	0.7	2.3	-0.6	-0.5	0.7	-0.3	-1.5	-0.6	-0.7	-0.7	-0.2	-1.4
Suffer from ‘nerves’	2.1	3.2	9.6	-0.7	2.3	-0.5	3.1	-0.9	2.3	0.5	2.2	2.1	0.8
Overall health rating	2.5	5.4	14.4	-1.9	2.8	0.4	2.5	-1.7	1.9	-1.0	3.8	2.6	2.8
Chest pain or discomfort	0.8	1.1	2.5	0.6	1.2	-1.1	0.5	-1.6	0.9	-0.1	1.4	0.9	1.2
Had major operations	0.9	1.1	2.4	-1.5	-0.8	1.6	-0.2	-0.8	-1.2	-1.5	-0.6	-0.6	-0.5
Age at last live birth	1.2	1.8	7.0	1.7	-0.8	-1.6	-1.1	2.6	-0.5	1.0	-1.1	-0.6	-0.6
Family relationship satisfaction	1.0	1.2	4.0	0.6	1.8	-0.1	1.3	-0.4	1.5	2.0	0.2	0.1	0.8
Leg pain on walking	1.3	1.7	4.4	0.3	1.2	-0.8	1.9	-0.9	0.9	0.1	2.1	1.8	1.2
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	1.5	0.2	0.5	-1.2	1.2	0.4	0.3	-0.2	0.3	0.7	0.4
Commuting to job workplace: Car/motor vehicle	0.2	0.3	1.3	0.0	0.3	-0.1	0.6	0.1	1.1	0.7	0.1	0.5	0.3
Illness, injury, bereavement, stress in last 2 years	1.5	1.9	3.4	0.5	-1.8	0.5	-1.2	1.4	-1.9	-0.6	-1.7	-1.5	-1.6
Medication: Aspirin	1.6	2.1	4.4	-2.0	0.8	1.2	0.9	-1.7	0.6	-1.0	2.1	1.7	1.6
Supplements: Vitamin C	0.3	0.3	1.3	-0.3	0.2	-0.6	1.1	0.2	0.4	0.7	0.5	0.8	0.1
Knee pain experienced in last month	1.5	2.3	6.8	0.7	2.6	-0.1	1.4	0.1	1.2	-0.7	2.5	1.2	2.0
Hypertension (Self-reported)	0.7	2.0	6.2	-1.4	0.7	0.2	0.9	-0.5	1.1	-0.9	2.5	2.1	2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	2.0	5.2	0.4	-2.0	1.9	-0.7	-0.9	-1.8	-2.3	-0.7	-0.9	-1.2
Illnesses of father: Heart disease	0.6	0.8	4.1	-0.9	2.0	-0.6	1.2	-0.7	0.7	0.0	0.5	0.4	0.5
Illnesses of siblings: Diabetes	1.8	2.2	5.8	-2.4	-0.0	0.3	2.2	-2.2	0.6	0.5	1.7	1.2	1.2
Smoking status: Previous	2.0	3.1	6.7	1.8	-2.5	-0.8	-1.9	-0.3	-1.1	0.9	-2.6	-1.4	-2.4
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	2.1	-1.4	-0.6	-0.4	0.4	-0.9	0.3	1.0	1.2	1.4	1.4
Whole body fat-free mass	0.7	3.7	19.1	-4.4	-1.0	-0.5	0.1	-1.5	0.8	0.3	2.4	2.3	1.6
Leg fat-free mass (right)	0.5	2.4	11.0	-3.3	-0.2	-0.7	0.0	-1.2	0.9	0.0	2.1	2.0	1.3
Arm fat percentage (left)	0.2	1.0	4.3	0.1	-0.9	0.0	0.1	0.6	-0.6	-0.0	-1.6	-1.1	-2.1
Average weekly red wine intake	0.9	1.3	3.2	-1.4	0.4	-1.6	0.2	0.1	1.8	1.7	0.5	0.7	1.3
Handedness (chirality/laterality): Left-handed	1.3	1.6	2.8	-0.1	-1.3	1.0	-1.5	1.1	-1.5	0.3	-1.7	-1.6	-1.4
Mood swings	0.9	1.7	7.5	-2.7	1.4	0.6	1.3	-0.4	1.1	-0.6	1.5	0.6	1.0
Loneliness, isolation	0.2	0.3	0.9	1.0	0.0	0.4	0.8	-0.5	-0.5	0.2	-0.1	-0.4	-0.8
Long-standing illness, disability or infirmity	1.7	2.6	7.9	-1.5	0.7	1.8	1.2	-2.0	0.4	-1.5	2.8	1.4	1.4
Ever had bowel cancer screening	0.9	1.0	2.4	0.2	-0.3	1.2	-0.9	0.1	-1.5	-1.4	-0.7	-1.0	-1.3
Diabetes diagnosed by doctor	7.1	11.7	41.2	-6.4	-0.6	-0.2	3.3	-4.4	1.5	-0.2	4.1	4.2	2.8
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	3.1	-0.4	-0.4	-0.7	-0.1	-1.8	0.4	1.2	0.9	1.1	1.5
Friendships satisfaction	2.4	2.9	8.7	1.1	1.6	-1.6	1.9	-0.2	2.1	3.0	1.2	1.1	1.9
Qualifications: nursing, teaching	0.2	0.2	0.8	0.6	-0.7	-0.2	0.6	-0.1	-0.1	0.9	-0.4	0.0	0.1
Commuting to job workplace: Walk	3.9	4.2	9.2	2.6	-0.5	1.0	-3.0	1.6	-1.9	-1.3	-2.2	-3.0	-1.6
Eye problems/disorders: Cataract	0.3	0.4	1.8	-0.3	-1.3	0.3	-0.8	0.2	-0.6	-0.3	-0.6	-0.4	-0.0
Mouth/teeth dental problems: Mouth ulcers	6.3	10.0	22.8	-1.1	3.7	-0.5	3.6	-3.9	3.0	-0.8	4.8	3.6	3.4
Medication for cholesterol	2.4	3.6	12.7	1.8	-0.5	-0.1	-1.4	3.6	-0.8	1.0	-3.0	-2.2	-1.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.7	-1.3	-0.1	0.5	0.8	-0.9	0.3	-1.2	1.6	1.1	1.0
Back pain experienced in last month	0.2	0.3	0.7	-0.3	-0.4	0.8	0.2	-0.9	-0.4	-0.4	0.5	0.1	0.6
Mineral and other dietary supplements	0.2	0.2	0.8	0.1	0.7	-0.3	0.5	0.9	0.5	0.3	-0.1	0.1	-0.5
Breast cancer (self-reported)	0.8	0.9	3.9	1.8	-0.9	-0.1	-1.0	-2.0	-0.5	0.3	-0.5	-0.0	-0.0
Asthma (self-reported)	1.1	2.2	7.4	-2.7	-0.9	2.6	0.2	-1.6	-0.3	-1.0	1.1	0.6	1.1
Osteoporosis (self-reported)	0.2	0.2	0.9	0.4	0.9	-0.1	0.0	0.8	0.4	0.2	-0.1	-0.4	0.0
Osteoarthritis (self-reported)	0.3	0.4	1.4	-1.2	0.5	1.1	0.3	0.0	0.4	-0.5	0.8	0.2	0.4
Medication: Aspirin	1.2	1.6	3.3	-1.8	0.3	1.5	0.5	-1.4	0.1	-1.3	1.7	1.3	1.3
Medication: Gliclazide	4.1	4.7	9.5	-2.7	1.1	-1.1	2.8	-1.0	1.7	-0.5	3.1	2.8	2.8
Illnesses of father: None of the above (group 1)	0.7	0.9	4.4	2.1	-0.3	-1.2	-0.1	1.0	0.5	1.2	-0.4	-0.1	-0.4
Smoking status: Current	0.5	0.7	2.2	-1.1	0.8	1.5	0.1	-0.6	-0.4	-1.4	0.8	0.2	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.2	7.3	-2.0	0.5	-1.1	2.7	-0.1	1.8	1.8	1.0	1.2	0.6
Whole body water mass	0.7	4.0	20.2	-4.5	-1.0	-0.6	0.2	-1.5	0.9	0.3	2.5	2.4	1.8
Leg predicted mass (right)	0.4	2.3	10.8	-3.3	-0.2	-0.6	-0.1	-1.2	0.9	-0.0	2.1	1.9	1.3
Arm fat mass (left)	0.2	0.6	2.2	-1.5	-1.1	0.1	0.1	0.3	-0.3	0.1	-0.8	-0.5	-1.4
Number of self-reported non-cancer illnesses	1.5	2.6	6.7	-2.5	-0.8	2.6	-0.9	-1.1	-1.2	-2.3	1.6	0.6	0.7
Average weekly champagne plus white wine intake	0.6	0.8	3.7	1.9	1.1	-1.4	-0.8	0.4	0.1	-0.2	0.1	0.1	-0.3
Miserableness	0.6	1.1	3.8	-1.0	1.0	0.0	1.9	-0.7	1.1	0.2	1.3	0.8	0.9
Guilty feelings	0.4	0.7	4.4	0.4	0.2	-0.1	1.1	-2.1	-0.1	-0.2	0.7	0.4	-0.4
Wears glasses or contact lenses	0.2	0.2	0.7	-0.7	0.4	-0.4	-0.1	0.8	0.3	-0.7	-0.2	-0.2	-0.2
Ever taken oral contraceptive pill	1.1	1.2	8.2	0.9	0.1	1.8	0.0	-2.9	-0.2	0.1	0.2	-0.1	-0.3
Hearing aid user	0.3	0.4	1.6	-0.4	0.1	1.1	1.2	-0.4	-0.2	-0.7	0.3	-0.3	-0.3
Mother’s age at death	0.5	0.7	2.2	0.1	-0.9	-1.5	-0.7	0.7	-0.4	0.8	-0.9	-0.3	-0.9
Financial situation satisfaction	1.4	1.7	4.6	0.0	0.7	-2.1	1.6	-0.9	1.6	1.5	1.3	1.6	0.3
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.8	-0.8	-1.3	1.0	0.4	0.6	-0.7	-0.5	-1.3	-0.6	-1.3
Commuting to job workplace: Public transport	0.9	1.1	3.3	1.3	0.0	1.4	-1.1	-0.4	-1.2	-1.8	-0.2	-0.9	-0.2
Eye problems/disorders: Glaucoma	0.3	0.3	1.3	0.9	-0.2	-0.2	-0.5	1.1	-0.5	-0.3	-0.4	-0.5	-0.5
Medication: Blood pressure	1.3	2.4	7.7	-1.3	0.9	0.5	1.1	-2.8	1.1	-0.8	2.3	1.7	1.5
Pain type(s) experienced in last month: Hip pain	0.2	0.2	1.0	1.0	0.4	0.3	0.2	0.0	0.2	0.3	0.3	-0.5	0.6
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.9	0.9	-0.8	0.2	-0.5	-0.9	-0.6	-0.2	0.1	0.2	0.8
High cholesterol (Self-reported)	0.4	0.7	3.6	-0.3	0.6	0.5	-0.2	-0.0	-0.6	-1.9	1.3	0.2	0.3
Medication: Bendroflumethiazide	1.4	2.1	5.9	-2.0	0.4	0.2	1.3	-1.2	1.2	-1.0	2.4	1.9	1.1
Medication: Paracetamol	1.3	2.1	5.8	-1.1	1.3	1.0	1.8	-1.9	0.6	-0.5	2.4	1.5	1.1
Medication: Lisinopril	2.0	2.6	7.1	0.5	1.5	-0.5	1.3	-1.4	1.5	-0.7	2.7	2.1	2.2
Medication: Atorvastatin	1.5	1.8	5.6	-0.5	0.5	0.2	1.3	-0.3	0.1	-2.3	2.4	1.1	1.9
Illnesses of father: High blood pressure	1.5	1.9	2.7	-1.2	-1.6	0.9	-1.4	1.1	-1.6	-1.2	-1.6	-1.4	-1.5
Alcohol drinker status: Never	0.8	1.0	4.7	2.2	0.1	-1.0	0.6	1.4	0.4	1.1	-0.5	-0.1	-0.6
Ever smoked	1.1	1.9	4.2	0.5	-2.0	0.2	-1.7	-0.8	-1.6	-0.1	-1.8	-1.1	-2.0
Basal metabolic rate	0.6	3.2	18.6	-4.3	-1.3	-0.6	0.2	-1.2	0.7	0.6	1.9	2.0	1.1
Leg fat percentage (left)	0.5	1.7	4.9	-0.5	-2.2	0.3	-0.2	0.4	-0.9	1.0	-2.0	-1.2	-2.1
Arm fat-free mass (left)	0.7	3.5	22.9	-4.8	-1.6	0.0	0.1	-1.1	0.6	0.4	1.8	1.8	1.2
Number of operations (self-reported)	1.1	1.7	8.6	-1.2	-2.9	0.5	-0.7	0.0	-1.5	-0.3	-1.5	-0.7	-1.1
Average weekly beer plus cider intake	0.2	0.3	1.1	0.7	0.3	0.7	0.2	-0.7	0.3	0.2	0.5	0.2	1.1
Irritability	0.7	1.2	2.8	-1.1	0.2	0.0	1.1	-0.9	1.0	-0.3	1.7	1.6	1.5
Risk taking	0.4	0.6	2.1	0.0	-0.7	-0.4	0.3	1.0	0.2	1.1	-1.0	-0.2	-1.4
Ever had prostate specific antigen (PSA) test	0.5	0.6	2.0	1.4	0.7	0.8	-0.6	-0.9	-0.5	-0.8	0.6	-0.0	-0.4
Fractured/broken bones in last 5 years	0.4	0.6	1.7	-0.3	-1.2	0.0	0.2	-0.4	-1.3	-0.2	-0.9	-0.7	-0.8
Age started oral contraceptive pill	0.9	1.1	2.9	-1.5	-1.7	0.1	-0.4	-0.1	-0.7	0.1	-1.7	-1.1	-1.3
Diastolic blood pressure, automated reading	0.2	0.6	2.3	-1.5	-1.3	0.4	0.1	0.2	-0.3	0.8	-0.7	-0.3	-0.5
Ever depressed for a whole week	0.4	0.5	2.0	1.4	-0.6	0.9	0.1	0.0	-0.7	-0.8	-0.3	-0.9	0.1
Unable to work because of sickness or disability	0.8	1.0	3.5	-1.1	0.6	1.3	-0.1	-1.9	0.2	-0.9	0.9	0.4	1.3
Commuting to job workplace: Cycle	1.7	2.0	6.4	0.5	0.3	-1.6	0.3	-1.0	0.9	-0.9	2.5	2.3	1.8
Myopia	0.4	0.6	2.1	1.4	0.4	-0.4	0.1	-0.9	0.3	-1.0	1.2	0.5	0.6
Vascular/heart problems diagnosed by doctor	1.0	2.6	7.3	1.6	-1.2	-0.5	-0.7	0.6	-1.6	0.6	-2.7	-2.2	-2.4
Cholesterol lowering medication	2.2	3.2	8.4	-1.4	0.9	-1.1	1.6	-1.0	2.0	0.1	2.9	2.3	2.7
Medication: Omeprazole (e.g. Zanprol)	1.6	2.0	4.7	2.0	-0.9	2.2	-0.9	-1.5	-1.3	-2.0	-0.0	-0.9	0.0
Pain experienced in last month	1.0	1.6	5.6	0.1	-1.6	-0.3	-1.0	1.2	-1.0	0.7	-2.4	-1.3	-1.4
Supplements: Calcium	0.6	0.7	2.4	0.0	-1.0	0.1	-1.6	-0.3	-1.1	-0.1	-0.9	-0.9	-0.6
Basal cell carcinoma (self-reported)	0.5	0.6	2.2	0.1	-0.0	-0.2	1.5	0.6	0.2	-0.8	1.2	0.8	0.4
Heart attack/myocardial infarction (self-reported)	1.6	2.0	6.8	0.9	1.1	2.0	-0.7	2.6	-0.2	-2.4	0.4	-0.8	0.7
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	3.2	1.8	0.4	-0.6	-0.3	0.5	0.2	0.7	-0.6	-0.8	-0.4
Heart disease (siblings)	0.5	0.6	3.1	1.8	0.8	-0.3	0.1	1.2	-0.0	-0.6	0.2	-0.2	0.2
Alcohol drinker status: Previous	0.3	0.4	2.6	0.3	0.5	0.0	-0.4	-1.6	0.1	0.2	0.5	0.3	-0.2
Pack years of smoking	0.4	0.7	3.5	0.5	0.1	1.9	-0.9	0.7	-0.5	-0.8	-0.2	-0.5	0.6
Impedance of whole body	1.0	5.3	14.7	2.0	-2.6	0.2	-1.2	1.6	-2.9	0.9	-3.8	-2.3	-3.0
Leg fat mass (left)	0.3	1.0	3.4	-1.8	-1.8	0.2	-0.2	-0.4	-0.6	0.5	-0.9	-0.3	-1.3
Arm predicted mass (left)	0.7	3.5	22.5	-4.7	-1.9	-0.2	0.1	-1.2	0.5	0.7	1.7	1.8	1.0