Best TWAS P=7.92e-10 · Best GWAS P=1.74e-10 conditioned to 0.06
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | HYI | 0.38 | 0.09 | lasso | 9 | 0.07 | 1.6e-06 | -3.6 | -5.4 | 8.2e-08 | 0.29 | 0.98 | 0.02 | FALSE |
| 2 | GTEx | Brain Cerebellar Hemisphere | ARTN | 0.45 | 0.36 | enet | 29 | 0.40 | 2.5e-11 | -4.5 | -5.3 | 1.2e-07 | 0.80 | 0.63 | 0.33 | FALSE |
| 3 | GTEx | Brain Cerebellum | ARTN | 0.47 | 0.33 | lasso | 5 | 0.43 | 6.0e-14 | -4.2 | -5.5 | 3.9e-08 | 0.83 | 0.14 | 0.86 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Female) | ST3GAL3 | 0.03 | -0.01 | lasso | 2 | 0.01 | 1.6e-01 | -6.1 | -6.1 | 7.9e-10 | 0.68 | 0.04 | 0.32 | TRUE |
| 5 | GTEx | Muscle Skeletal | B4GALT2 | 0.04 | 0.05 | lasso | 2 | 0.03 | 6.4e-04 | -5.9 | 5.6 | 2.7e-08 | -0.70 | 0.04 | 0.84 | FALSE |
| 6 | GTEx | Muscle Skeletal | ST3GAL3 | 0.10 | 0.01 | enet | 27 | 0.01 | 1.6e-02 | 5.8 | -5.6 | 2.8e-08 | 0.16 | 0.10 | 0.82 | TRUE |
| 7 | GTEx | Muscle Skeletal | RP11-7O11.3 | 0.05 | 0.02 | lasso | 3 | 0.02 | 7.2e-03 | -6.0 | 5.2 | 1.8e-07 | -0.56 | 0.08 | 0.53 | FALSE |
| 8 | METSIM | Adipose | ARTN | 0.05 | 0.04 | bslmm | 412 | 0.03 | 1.3e-05 | -3.9 | -5.7 | 9.5e-09 | 0.82 | 0.15 | 0.84 | FALSE |