Hub : Traits :

Fluid intelligence score

528 significantly associated models · 104 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	31402148	32762733	1	1	1.2e-09	3.2e-09	1.0e+00	100	PEF1
2	1	41130424	42542658	1	1	3.4e-09	5.0e-10	2.8e-05	55	FOXO6
3	1	43221187	45153116	5	2	7.9e-10	1.7e-10	6.0e-02	91	ST3GAL3
4	1	71163715	73435171	1	1	1.4e-10	5.2e-09	1.2e-01	93	NEGR1
5	1	109316076	110716511	1	1	3.0e-07	3.6e-08	1.9e-02	82	SYPL2
6	1	201616627	202161644	1	1	5.2e-08	6.4e-06	9.2e-01	100	LMOD1
7	2	70804467	72356449	1	1	2.8e-08	2.1e-08	1.0e+00	100	ZNF638
8	2	72787254	74187703	2	2	3.9e-09	2.5e-07	1.9e-02	79	ALMS1P FBXO41
9	2	99468341	101731705	2	2	1.4e-08	1.1e-07	1.2e-01	92	AFF3 CHST10
10	2	117979194	119470084	1	1	6.8e-08	7.3e-06	1.7e-01	91	CCDC93
11	2	161297929	162790882	1	1	5.4e-10	1.5e-09	1.0e+00	100	TANK
12	3	23234618	26329265	5	2	7.0e-08	9.7e-12	3.8e-05	64	NKIRAS1 RARB
13	3	48702606	50932324	17	1	7.5e-17	1.5e-16	1.0e+00	100	UBA7
14	3	52148483	53623102	2	1	2.0e-07	6.5e-08	6.6e-02	88	TMEM110
15	3	70757099	71880670	1	1	8.9e-11	1.9e-10	1.0e+00	100	FOXP1
16	3	135806811	136715468	1	1	1.2e-07	1.8e-07	4.0e-01	97	STAG1
17	4	17104059	18507692	1	1	8.6e-09	3.4e-07	1.4e-01	92	DCAF16
18	4	105598022	107092169	1	1	9.6e-13	3.0e-14	2.1e-03	84	PPA2
19	5	138933151	140378983	1	1	1.2e-07	3.6e-06	8.8e-01	100	PFDN1
20	6	108183628	109704062	1	1	3.3e-08	4.6e-10	2.0e-03	76	FOXO3
21	11	16343081	17771487	2	1	1.5e-07	4.6e-07	5.6e-02	86	NUCB2
22	11	46911704	48559571	6	1	5.7e-09	6.5e-08	7.7e-01	100	NUP160
23	11	104797451	106543882	1	1	1.7e-07	4.4e-08	7.8e-02	90	GRIA4
24	12	122713991	124156897	1	1	2.2e-07	3.4e-07	4.0e-01	97	ABCB9
25	14	103466633	104859419	1	1	2.7e-07	1.2e-07	1.6e-02	79	RP11-73M18.8
26	16	27412414	29595483	23	1	1.6e-12	8.8e-11	9.2e-02	93	SULT1A1
27	16	52772129	54235440	2	1	4.0e-10	5.7e-09	8.0e-01	100	RBL2
28	17	34157655	35644076	4	1	9.7e-08	2.5e-07	5.0e-01	98	GGNBP2
29	17	43315547	43913030	1	1	3.0e-07	2.7e-05	3.4e-01	95	MAPT
30	17	55903829	57989860	5	1	8.3e-09	2.1e-08	8.6e-02	91	TRIM37
31	18	4548348	5945376	3	1	1.4e-09	2.4e-09	9.5e-02	92	LOC339290
32	21	18271223	19680363	1	1	1.9e-07	2.4e-08	1.0e+00	100	BTG3
33	22	39101079	40571499	2	2	3.5e-08	1.1e-08	1.0e+00	100	MGAT3

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Intelligence (Savage-Jansen 2018)	15.14	34	32	71.1	0.99	7.3e-30	ABCB9 AFF3 ALMS1P BTG3 CCDC93 CHST10 DCAF16 FBXO41 FOXO3 FOXO6 FOXP1 GGNBP2 GRIA4 LMOD1 LOC339290 MAPT MGAT3 NEGR1 NKIRAS1 NUP160 PEF1 PFDN1 PPA2 RBL2 RP11-73M18.8 ST3GAL3 STAG1 SULT1A1 SYPL2 TANK TMEM110 TRIM37 UBA7 ZNF638
Verbal and Numeric Reasoning (VNR)	14.51	35	27	60.0	0.99	3.5e-31	ABCB9 AFF3 ALMS1P BTG3 CCDC93 CHST10 DCAF16 FBXO41 FOXO3 FOXO6 FOXP1 GGNBP2 GRIA4 LMOD1 LOC339290 MAPT MGAT3 NEGR1 NKIRAS1 NUP160 PEF1 PFDN1 PPA2 RARB RBL2 RP11-73M18.8 ST3GAL3 STAG1 SULT1A1 SYPL2 TANK TMEM110 TRIM37 UBA7 ZNF638
Qualifications: College or University degree	9.94	26	17	37.8	0.98	1.5e-18	ABCB9 AFF3 ALMS1P CCDC93 CHST10 DCAF16 FBXO41 FOXO3 FOXO6 FOXP1 GGNBP2 GRIA4 LMOD1 MAPT MGAT3 NEGR1 NKIRAS1 PFDN1 PPA2 RBL2 RP11-73M18.8 ST3GAL3 SULT1A1 SYPL2 TANK UBA7
Qualifications: A levels/AS levels or equivalent	8.36	19	6	13.3	0.97	1.9e-12	ABCB9 ALMS1P CHST10 DCAF16 FBXO41 FOXO6 FOXP1 GRIA4 MAPT MGAT3 NEGR1 PEF1 PPA2 RBL2 RP11-73M18.8 ST3GAL3 SULT1A1 TANK UBA7
Qualifications: None of the above	7.33	15	7	15.6	-0.99	1.7e-12	ABCB9 ALMS1P CHST10 DCAF16 FOXO3 FOXP1 GGNBP2 NEGR1 PPA2 RBL2 ST3GAL3 SULT1A1 SYPL2 TANK UBA7
Qualifications: nursing, teaching	5.08	6	2	4.4	0.98	7.6e-04	ABCB9 ALMS1P LMOD1 NEGR1 ST3GAL3 UBA7
Qualifications: O levels/GCSEs or equivalent	4.92	4	2	4.4	0.99	6.6e-03	ABCB9 ALMS1P MAPT ST3GAL3
BMI	4.88	14	9	20.0	-0.47	8.9e-02	AFF3 CHST10 FOXO3 FOXP1 GGNBP2 LMOD1 NEGR1 NUCB2 NUP160 PEF1 PFDN1 SULT1A1 SYPL2 UBA7
Sitting height	4.78	11	9	20.0	0.75	7.3e-03	ABCB9 DCAF16 FOXO3 MAPT MGAT3 NUP160 PEF1 PPA2 RBL2 ST3GAL3 ZNF638
Standing height	4.77	15	12	26.7	0.54	3.0e-02	ABCB9 DCAF16 FOXO3 MAPT MGAT3 NKIRAS1 NUCB2 NUP160 PEF1 PPA2 RBL2 RP11-73M18.8 STAG1 SULT1A1 ZNF638
Body mass index (BMI)	4.73	12	8	17.8	-0.63	2.9e-02	AFF3 CHST10 DCAF16 FOXO3 FOXP1 GGNBP2 LMOD1 NEGR1 NUP160 STAG1 SULT1A1 UBA7
Leg fat percentage (left)	4.68	11	9	20.0	-0.67	2.4e-02	AFF3 CHST10 DCAF16 FOXO3 FOXP1 GGNBP2 LMOD1 NEGR1 NUP160 SULT1A1 UBA7
Trunk predicted mass	4.65	14	11	24.4	0.39	1.5e-01	ABCB9 DCAF16 FOXO3 LMOD1 MGAT3 NEGR1 NUP160 PEF1 PPA2 RBL2 SULT1A1 SYPL2 UBA7 ZNF638
Trunk fat-free mass	4.62	14	11	24.4	0.39	1.5e-01	ABCB9 DCAF16 FOXO3 LMOD1 MGAT3 NEGR1 NUP160 PEF1 PPA2 RBL2 SULT1A1 SYPL2 UBA7 ZNF638
Leg fat mass (left)	4.61	11	8	17.8	-0.52	9.9e-02	AFF3 CHST10 FOXO3 FOXP1 GGNBP2 LMOD1 NEGR1 NUP160 PEF1 SULT1A1 UBA7
Whole body water mass	4.56	14	12	26.7	0.28	3.0e-01	ABCB9 DCAF16 FOXO3 GGNBP2 LMOD1 MGAT3 NEGR1 PEF1 PPA2 RBL2 SULT1A1 SYPL2 UBA7 ZNF638
Whole body fat-free mass	4.54	14	12	26.7	0.28	3.1e-01	ABCB9 DCAF16 FOXO3 GGNBP2 LMOD1 MGAT3 NEGR1 PEF1 PPA2 RBL2 SULT1A1 SYPL2 UBA7 ZNF638
Arm fat percentage (right)	4.53	12	8	17.8	-0.70	1.2e-02	AFF3 CHST10 DCAF16 FOXO3 FOXP1 GGNBP2 LMOD1 NEGR1 NUP160 RARB SULT1A1 UBA7
Arm fat mass (right)	4.51	10	7	15.6	-0.59	7.1e-02	AFF3 CHST10 FOXO3 FOXP1 GGNBP2 LMOD1 NEGR1 NUP160 SULT1A1 UBA7
Leg fat mass (right)	4.51	11	8	17.8	-0.52	9.9e-02	AFF3 CHST10 FOXO3 FOXP1 GGNBP2 LMOD1 NEGR1 NUP160 PEF1 SULT1A1 UBA7
Basal metabolic rate	4.51	14	12	26.7	0.24	3.9e-01	ABCB9 DCAF16 FOXO3 GGNBP2 LMOD1 MGAT3 NEGR1 PEF1 PPA2 RBL2 SULT1A1 SYPL2 UBA7 ZNF638
Height	4.49	15	13	28.9	0.61	1.2e-02	ABCB9 DCAF16 FOXO3 MAPT MGAT3 NKIRAS1 NUCB2 NUP160 PEF1 PPA2 RBL2 RP11-73M18.8 ST3GAL3 STAG1 ZNF638
Leg fat percentage (right)	4.49	11	8	17.8	-0.67	2.4e-02	AFF3 CHST10 DCAF16 FOXO3 FOXP1 GGNBP2 LMOD1 NEGR1 NUP160 SULT1A1 UBA7
Arm fat percentage (left)	4.47	12	8	17.8	-0.69	1.2e-02	AFF3 CHST10 DCAF16 FOXO3 FOXP1 GGNBP2 LMOD1 NEGR1 NUP160 RARB SULT1A1 UBA7
Arm predicted mass (left)	4.46	14	11	24.4	0.22	4.3e-01	ABCB9 DCAF16 FOXO3 GGNBP2 LMOD1 MGAT3 NEGR1 PEF1 PPA2 RBL2 SULT1A1 SYPL2 UBA7 ZNF638
Arm predicted mass (right)	4.44	14	10	22.2	0.23	4.1e-01	ABCB9 DCAF16 FOXO3 GGNBP2 LMOD1 MGAT3 NEGR1 PEF1 PPA2 RBL2 SULT1A1 SYPL2 UBA7 ZNF638
Arm fat mass (left)	4.43	10	7	15.6	-0.60	6.8e-02	AFF3 CHST10 FOXO3 FOXP1 GGNBP2 LMOD1 NEGR1 NUP160 SULT1A1 UBA7
Arm fat-free mass (left)	4.42	13	11	24.4	0.22	4.5e-01	ABCB9 DCAF16 FOXO3 GGNBP2 LMOD1 MGAT3 NEGR1 PEF1 PPA2 RBL2 SULT1A1 UBA7 ZNF638
Arm fat-free mass (right)	4.39	14	10	22.2	0.24	3.8e-01	ABCB9 DCAF16 FOXO3 GGNBP2 LMOD1 MGAT3 NEGR1 PEF1 PPA2 RBL2 SULT1A1 SYPL2 UBA7 ZNF638
Forced vital capacity (FVC), Best measure	4.35	9	6	13.3	0.74	2.2e-02	DCAF16 FOXO6 FOXP1 MAPT NUP160 PPA2 RBL2 UBA7 ZNF638
Weight	4.34	13	10	22.2	0.04	8.9e-01	AFF3 DCAF16 FOXO3 GGNBP2 LMOD1 MGAT3 NEGR1 PEF1 PPA2 RBL2 SULT1A1 UBA7 ZNF638
Leg predicted mass (left)	4.33	14	12	26.7	0.26	3.5e-01	ABCB9 DCAF16 FOXO3 GGNBP2 LMOD1 MGAT3 NEGR1 PEF1 PPA2 RBL2 SULT1A1 SYPL2 UBA7 ZNF638
Leg fat-free mass (left)	4.32	14	12	26.7	0.26	3.5e-01	ABCB9 DCAF16 FOXO3 GGNBP2 LMOD1 MGAT3 NEGR1 PEF1 PPA2 RBL2 SULT1A1 SYPL2 UBA7 ZNF638
Leg fat-free mass (right)	4.28	14	11	24.4	0.27	3.3e-01	ABCB9 DCAF16 FOXO3 GGNBP2 LMOD1 MGAT3 NEGR1 PEF1 PPA2 RBL2 SULT1A1 SYPL2 UBA7 ZNF638
Leg predicted mass (right)	4.27	14	11	24.4	0.27	3.4e-01	ABCB9 DCAF16 FOXO3 GGNBP2 LMOD1 MGAT3 NEGR1 PEF1 PPA2 RBL2 SULT1A1 SYPL2 UBA7 ZNF638
Forced expiratory volume in 1-second (FEV1), Best measure	4.25	6	3	6.7	0.90	1.4e-02	DCAF16 FOXP1 MAPT NUP160 PPA2 UBA7
Whole body fat mass	4.23	11	7	15.6	-0.61	4.7e-02	AFF3 CHST10 FOXO3 FOXP1 GGNBP2 LMOD1 NEGR1 NUP160 RARB SULT1A1 UBA7
Forced vital capacity (FVC)	4.18	10	5	11.1	0.77	9.4e-03	BTG3 DCAF16 FOXO6 FOXP1 MAPT NUP160 PPA2 RBL2 UBA7 ZNF638
Body fat percentage	4.18	11	7	15.6	-0.69	1.9e-02	CHST10 DCAF16 FOXO3 FOXP1 GGNBP2 LMOD1 NEGR1 NUP160 RARB SULT1A1 UBA7
Comparative height size at age 10	4.16	13	11	24.4	0.44	1.3e-01	ABCB9 DCAF16 FOXO3 MAPT NUCB2 NUP160 PPA2 RBL2 RP11-73M18.8 ST3GAL3 STAG1 SULT1A1 ZNF638
Forced expiratory volume in 1-second (FEV1)	4.15	7	4	8.9	0.89	7.5e-03	DCAF16 FOXP1 MAPT NUP160 PEF1 PPA2 UBA7
Waist circumference	4.06	9	6	13.3	-0.54	1.3e-01	AFF3 CHST10 FOXO3 GGNBP2 LMOD1 NEGR1 NUP160 SULT1A1 UBA7
Trunk fat mass	3.90	10	7	15.6	-0.61	6.0e-02	CHST10 FOXO3 FOXP1 GGNBP2 LMOD1 NEGR1 NUP160 RARB SULT1A1 UBA7
Hip circumference	3.89	10	7	15.6	-0.09	8.0e-01	ABCB9 FOXO3 GGNBP2 LMOD1 NEGR1 NUP160 PEF1 RBL2 SULT1A1 UBA7
Noisy workplace	3.81	1	0	0.0	0.00	1.0e+00	SYPL2
Trunk fat percentage	3.80	11	8	17.8	-0.63	3.7e-02	CHST10 FOXO3 FOXP1 GGNBP2 LMOD1 MAPT NEGR1 NUP160 RARB SULT1A1 UBA7
Prospective memory result	3.80	2	0	0.0	0.00	1.0e+00	PEF1 ZNF638
Overall health rating	3.78	7	4	8.9	-1.00	3.1e-06	DCAF16 FOXP1 LMOD1 RARB RBL2 TANK UBA7
Alcohol intake frequency.	3.77	8	4	8.9	-0.78	2.3e-02	ABCB9 FOXP1 MAPT NEGR1 NUP160 PPA2 SULT1A1 UBA7
Body Mass Index (BMI) (2010)	3.72	4	2	4.4	-0.41	5.9e-01	LMOD1 NEGR1 NUP160 SULT1A1
Schizophrenia (2018)	3.60	7	2	4.4	-0.50	2.6e-01	ABCB9 FOXP1 MGAT3 RP11-73M18.8 ST3GAL3 STAG1 TMEM110
Depressed Affect (Nagel 2018)	3.56	6	4	8.9	0.14	7.9e-01	MAPT NUP160 RP11-73M18.8 STAG1 TANK UBA7
Schizophrenia (2014)	3.54	7	3	6.7	-0.45	3.1e-01	ABCB9 ALMS1P MGAT3 RP11-73M18.8 ST3GAL3 STAG1 TMEM110
Qualifications: CSEs or equivalent	3.54	3	0	0.0	0.00	1.0e+00	FOXO6 ST3GAL3 UBA7
Comparative body size at age 10	3.53	5	4	8.9	-0.41	5.0e-01	GGNBP2 NEGR1 NUP160 SULT1A1 SYPL2
Alcohol usually taken with meals	3.43	4	1	2.2	1.00	3.2e-03	CHST10 FOXP1 NEGR1 SULT1A1
Neuroticism (Nagel 2018)	3.30	5	3	6.7	-0.64	2.4e-01	BTG3 MAPT NUP160 STAG1 TMEM110
Age when periods started (menarche)	3.26	4	4	8.9	-0.57	4.3e-01	FOXO3 NEGR1 NUP160 ST3GAL3
Age at first live birth	3.21	2	1	2.2	0.00	1.0e+00	DCAF16 UBA7
Smoking Status	3.20	6	2	4.4	-0.75	8.9e-02	FOXP1 NUCB2 NUP160 RARB ST3GAL3 TANK
Bipolar Disorder or Schizophrenia	3.15	6	4	8.9	-0.42	4.1e-01	ABCB9 ALMS1P MGAT3 RP11-73M18.8 ST3GAL3 TMEM110
Forced expiratory volume in 1-second (FEV1), predicted	3.15	4	1	2.2	0.83	1.7e-01	DCAF16 NUP160 PPA2 ZNF638
Average weekly red wine intake	3.14	2	1	2.2	0.00	1.0e+00	ABCB9 FOXP1
Miserableness	3.11	4	3	6.7	-0.02	9.8e-01	NUP160 STAG1 TANK UBA7
Suffer from 'nerves'	3.05	3	2	4.4	0.00	1.0e+00	NUP160 SULT1A1 TMEM110
Number of treatments/medications taken	3.03	6	1	2.2	-0.73	9.9e-02	DCAF16 FBXO41 FOXP1 NEGR1 TANK UBA7
Age at First Birth	3.00	2	1	2.2	0.00	1.0e+00	CHST10 UBA7
Fed-up feelings	3.00	3	2	4.4	0.00	1.0e+00	MAPT STAG1 UBA7
Neuroticism	2.98	6	3	6.7	-0.56	2.4e-01	BTG3 MAPT NUP160 STAG1 TMEM110 UBA7
Commuting to job workplace: Public transport	2.95	2	0	0.0	0.00	1.0e+00	CHST10 NEGR1
Stomach or abdominal pain in last month	2.93	1	0	0.0	0.00	1.0e+00	STAG1
Neuroticism score	2.92	5	3	6.7	0.30	6.3e-01	MAPT NUP160 STAG1 TMEM110 UBA7
Peak expiratory flow (PEF)	2.88	6	2	4.4	0.97	1.0e-03	DCAF16 FOXO3 MAPT PEF1 PPA2 RARB
Impedance of arm (left)	2.85	11	6	13.3	0.12	7.3e-01	AFF3 FOXO3 GGNBP2 LMOD1 MAPT NEGR1 NUCB2 PEF1 STAG1 SYPL2 UBA7
Medication: Paracetamol	2.85	1	1	2.2	0.00	1.0e+00	MAPT
Seen doctor (GP) for nerves, anxiety, tension or depression	2.83	2	1	2.2	0.00	1.0e+00	NEGR1 RP11-73M18.8
Impedance of arm (right)	2.82	11	8	17.8	0.13	7.1e-01	AFF3 FOXO3 GGNBP2 LMOD1 MAPT NEGR1 NUCB2 PEF1 STAG1 SYPL2 UBA7
Loneliness, isolation	2.82	2	1	2.2	0.00	1.0e+00	NUP160 STAG1
Mood swings	2.80	4	2	4.4	-0.37	6.3e-01	MAPT NUP160 STAG1 UBA7
Average weekly beer plus cider intake	2.80	1	1	2.2	0.00	1.0e+00	UBA7
Worry (Nagel 2018)	2.78	6	4	8.9	-0.57	2.4e-01	BTG3 FOXO3 MAPT NUP160 STAG1 TMEM110
Impedance of whole body	2.78	13	8	17.8	-0.16	6.1e-01	FOXO3 GGNBP2 LMOD1 MAPT NEGR1 NUCB2 PEF1 PFDN1 PPA2 RBL2 STAG1 SYPL2 UBA7
Wheeze or whistling in the chest in last year	2.76	2	1	2.2	0.00	1.0e+00	AFF3 UBA7
Worry too long after embarrassment	2.75	3	1	2.2	0.00	1.0e+00	PFDN1 PPA2 STAG1
Major Depression (MDD)	2.72	1	1	2.2	0.00	1.0e+00	NEGR1
Lung FEV1/FVC ratio	2.70	8	5	11.1	0.55	1.6e-01	BTG3 FOXO3 LMOD1 MAPT NEGR1 PEF1 PPA2 RARB
Medication: Paracetamol	2.68	2	1	2.2	0.00	1.0e+00	MAPT SULT1A1
Taking other prescription medications	2.67	1	1	2.2	0.00	1.0e+00	UBA7
Hand grip strength (left)	2.66	6	2	4.4	0.81	5.0e-02	DCAF16 FOXP1 MAPT NUP160 PEF1 ZNF638
Medication for pain relief, constipation, heartburn	2.66	2	0	0.0	0.00	1.0e+00	LMOD1 MAPT
Reaction Time	2.65	3	3	6.7	0.00	1.0e+00	FOXO3 PFDN1 ZNF638
Sensitivity / hurt feelings	2.65	2	1	2.2	0.00	1.0e+00	MAPT STAG1
Mean time to correctly identify matches	2.64	3	2	4.4	0.00	1.0e+00	FOXO3 PFDN1 ZNF638
Impedance of leg (left)	2.63	12	6	13.3	-0.24	4.5e-01	GGNBP2 LMOD1 MAPT MGAT3 NEGR1 NUCB2 PPA2 RBL2 STAG1 SULT1A1 SYPL2 UBA7
Hair/balding pattern: Pattern 4	2.63	1	1	2.2	0.00	1.0e+00	MAPT
Birth weight of first child	2.63	3	1	2.2	0.00	1.0e+00	DCAF16 PPA2 RBL2
Hand grip strength (right)	2.62	7	2	4.4	0.77	4.4e-02	DCAF16 MAPT NUP160 PEF1 RBL2 SULT1A1 ZNF638
Maternal smoking around birth	2.62	1	1	2.2	0.00	1.0e+00	GGNBP2
Lung FVC	2.61	10	6	13.3	0.49	1.5e-01	ABCB9 BTG3 DCAF16 FOXO3 FOXO6 FOXP1 MAPT PPA2 SULT1A1 UBA7
Smoking status: Current	2.60	2	1	2.2	0.00	1.0e+00	NUP160 ST3GAL3
Current tobacco smoking	2.55	2	0	0.0	0.00	1.0e+00	NUP160 ST3GAL3
Depression (Nagel 2018)	2.53	2	1	2.2	0.00	1.0e+00	NUP160 STAG1
Nervous feelings	2.53	4	2	4.4	-0.71	2.9e-01	MAPT NUP160 STAG1 TMEM110
Number of self-reported non-cancer illnesses	2.52	2	1	2.2	0.00	1.0e+00	FBXO41 NEGR1
Health satisfaction	2.51	2	1	2.2	0.00	1.0e+00	LMOD1 UBA7
Impedance of leg (right)	2.48	13	5	11.1	-0.01	9.7e-01	FOXO3 GGNBP2 LMOD1 MAPT NEGR1 NUCB2 NUP160 PPA2 RBL2 STAG1 SULT1A1 SYPL2 UBA7
Number of operations (self-reported)	2.48	2	1	2.2	0.00	1.0e+00	PPA2 TANK
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.47	3	2	4.4	0.00	1.0e+00	MAPT PPA2 RARB
Frequency of tiredness / lethargy in last 2 weeks	2.46	1	0	0.0	0.00	1.0e+00	STAG1
Alcohol intake versus 10 years previously	2.45	2	1	2.2	0.00	1.0e+00	NEGR1 UBA7
Long-standing illness, disability or infirmity	2.45	3	0	0.0	0.00	1.0e+00	NEGR1 RARB RP11-73M18.8
Leg pain on walking	2.44	1	0	0.0	0.00	1.0e+00	UBA7
Age at last live birth	2.40	1	1	2.2	0.00	1.0e+00	UBA7
Diabetes (self-reported)	2.39	2	0	0.0	0.00	1.0e+00	RBL2 UBA7
Past tobacco smoking	2.36	2	0	0.0	0.00	1.0e+00	RARB TANK
Chronic bronchitis/emphysema (mother)	2.36	2	0	0.0	0.00	1.0e+00	RARB UBA7
Ever depressed for a whole week	2.36	1	0	0.0	0.00	1.0e+00	RP11-73M18.8
Type 2 Diabetes (T2D) (2018)	2.35	2	0	0.0	0.00	1.0e+00	RBL2 UBA7
Diabetes diagnosed by doctor	2.33	3	0	0.0	0.00	1.0e+00	ALMS1P RBL2 UBA7
Pain experienced in last month	2.33	2	0	0.0	0.00	1.0e+00	LMOD1 UBA7
Birth weight	2.32	2	1	2.2	0.00	1.0e+00	DCAF16 PPA2
Diastolic blood pressure, automated reading	2.32	6	3	6.7	-0.99	2.4e-04	ABCB9 ALMS1P DCAF16 FBXO41 LMOD1 UBA7
Medication for cholesterol	2.31	2	0	0.0	0.00	1.0e+00	MAPT RBL2
Frequency of unenthusiasm / disinterest in last 2 weeks	2.30	1	0	0.0	0.00	1.0e+00	STAG1
Ulcerative Colitis	2.29	2	0	0.0	0.00	1.0e+00	TMEM110 UBA7
Frequency of depressed mood in last 2 weeks	2.29	2	1	2.2	0.00	1.0e+00	NUP160 STAG1
Neuroticism (2016)	2.27	3	0	0.0	0.00	1.0e+00	MAPT NUP160 TANK
Pack years adult smoking proportion	2.27	1	0	0.0	0.00	1.0e+00	SYPL2
Average weekly champagne plus white wine intake	2.27	1	0	0.0	0.00	1.0e+00	MAPT
Ulcerative Colitis (UC)	2.24	2	2	4.4	0.00	1.0e+00	SULT1A1 UBA7
Frequency of tenseness / restlessness in last 2 weeks	2.24	3	1	2.2	0.00	1.0e+00	MAPT STAG1 TMEM110
Headache pain in last month	2.23	1	1	2.2	0.00	1.0e+00	MAPT
Illnesses of siblings	2.21	2	1	2.2	0.00	1.0e+00	RBL2 ST3GAL3
Irritable Bowel Disease (IBD)	2.18	2	2	4.4	0.00	1.0e+00	SULT1A1 UBA7
Hair/balding pattern: Pattern 3	2.17	1	1	2.2	0.00	1.0e+00	MAPT
Worrier / anxious feelings	2.16	3	1	2.2	0.00	1.0e+00	MAPT STAG1 TMEM110
Financial situation satisfaction	2.13	1	0	0.0	0.00	1.0e+00	UBA7
Relative age of first facial hair	2.08	2	1	2.2	0.00	1.0e+00	FOXO3 MAPT
Father's age at death	2.08	1	0	0.0	0.00	1.0e+00	UBA7
LDL Cholesterol	2.06	1	1	2.2	0.00	1.0e+00	SYPL2
Had other major operations	2.04	1	0	0.0	0.00	1.0e+00	PPA2
Medication: Co-codamol	2.03	1	0	0.0	0.00	1.0e+00	UBA7
Systolic Blood Pressure	2.02	8	4	8.9	-0.25	5.5e-01	DCAF16 FBXO41 FOXO3 MAPT NUCB2 NUP160 UBA7 ZNF638
Commuting to job workplace: Car/motor vehicle	1.98	1	0	0.0	0.00	1.0e+00	NEGR1
Crohns Disease (2012)	1.97	2	2	4.4	0.00	1.0e+00	SULT1A1 UBA7
Shortness of breath walking on level ground	1.94	1	0	0.0	0.00	1.0e+00	LMOD1
Mouth/teeth dental problems: Dentures	1.92	2	0	0.0	0.00	1.0e+00	STAG1 UBA7
Cardiovascular Disease	1.91	4	3	6.7	-0.52	4.8e-01	DCAF16 FBXO41 NEGR1 RBL2
Systolic blood pressure, automated reading	1.91	5	1	2.2	-0.44	4.6e-01	DCAF16 FBXO41 MAPT NUCB2 PPA2
Relative age voice broke	1.91	2	1	2.2	0.00	1.0e+00	FOXO3 MAPT
High blood pressure	1.91	4	1	2.2	-0.52	4.8e-01	DCAF16 FBXO41 NEGR1 RBL2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.90	1	0	0.0	0.00	1.0e+00	RP11-73M18.8
Chronotype (morning person)	1.88	1	1	2.2	0.00	1.0e+00	TRIM37
Waist Hip Ratio (WHR)	1.87	7	3	6.7	-0.60	1.1e-01	ABCB9 GGNBP2 MAPT MGAT3 NUCB2 RBL2 STAG1
Irritability	1.87	1	0	0.0	0.00	1.0e+00	MAPT
Vascular/heart problems diagnosed by doctor	1.87	4	1	2.2	0.58	4.2e-01	DCAF16 FBXO41 NEGR1 RBL2
Handedness (chirality/laterality): Left-handed	1.83	2	1	2.2	0.00	1.0e+00	MAPT SULT1A1
Blood White Count	1.82	9	6	13.3	-0.44	2.1e-01	DCAF16 FOXO6 MGAT3 NUP160 PPA2 RP11-73M18.8 SULT1A1 UBA7 ZNF638
Mouth/teeth dental problems: Mouth ulcers	1.81	1	1	2.2	0.00	1.0e+00	MAPT
Crohns Disease (2017)	1.80	2	2	4.4	0.00	1.0e+00	SULT1A1 UBA7
Heel T-Score	1.79	7	6	13.3	-0.07	8.9e-01	ABCB9 ALMS1P DCAF16 MAPT NEGR1 UBA7 ZNF638
Blood Red Count	1.78	9	5	11.1	-0.22	5.6e-01	ABCB9 AFF3 CHST10 MAPT RP11-73M18.8 ST3GAL3 SULT1A1 TMEM110 UBA7
Unable to work because of sickness or disability	1.78	1	0	0.0	0.00	1.0e+00	FBXO41
Hearing difficulty/problems with background noise	1.77	1	0	0.0	0.00	1.0e+00	MAPT
Ever highly irritable/argumentative for 2 days	1.77	1	0	0.0	0.00	1.0e+00	UBA7
Hypertension (Self-reported)	1.77	4	2	4.4	-0.58	4.2e-01	DCAF16 FBXO41 NEGR1 RBL2
HDL Cholesterol	1.75	1	1	2.2	0.00	1.0e+00	NUP160
Exposure to tobacco smoke at home	1.74	1	0	0.0	0.00	1.0e+00	UBA7
Exposure to tobacco smoke outside home	1.73	1	0	0.0	0.00	1.0e+00	UBA7
Pulse rate, automated reading	1.73	4	3	6.7	-0.64	3.6e-01	LMOD1 NEGR1 RBL2 UBA7
Medication: Blood pressure	1.72	2	0	0.0	0.00	1.0e+00	DCAF16 FBXO41
Medication: Seretide 50 evohaler	1.71	1	0	0.0	0.00	1.0e+00	UBA7
Medication for cholesterol, blood pressure or diabetes	1.68	1	0	0.0	0.00	1.0e+00	UBA7
Allergy or Eczema	1.67	4	1	2.2	0.54	4.6e-01	ABCB9 GGNBP2 NEGR1 SULT1A1
Hypothyroidism (self reported)	1.67	1	1	2.2	0.00	1.0e+00	TANK
Hayfever, allergic rhinitis or eczema	1.67	3	0	0.0	0.00	1.0e+00	ABCB9 GGNBP2 NEGR1
Medication: Ventolin 100micrograms inhaler	1.62	2	0	0.0	0.00	1.0e+00	AFF3 UBA7
Alcohol drinker status: Previous	1.62	1	0	0.0	0.00	1.0e+00	RP11-73M18.8
Cholesterol lowering medication	1.61	1	0	0.0	0.00	1.0e+00	DCAF16
Hypothyroidism/myxoedema (self-reported)	1.60	1	0	0.0	0.00	1.0e+00	TANK
Allergy	1.58	2	1	2.2	0.00	1.0e+00	ABCB9 NEGR1
Medication: Blood pressure	1.55	1	0	0.0	0.00	1.0e+00	MAPT
Illnesses of mother	1.51	1	0	0.0	0.00	1.0e+00	GGNBP2
Medication: Simvastatin	1.49	1	0	0.0	0.00	1.0e+00	DCAF16
Medication: Amlodipine	1.47	1	0	0.0	0.00	1.0e+00	TRIM37
Prostate Cancer	1.46	1	0	0.0	0.00	1.0e+00	UBA7
Medication: Allopurinol	1.46	1	0	0.0	0.00	1.0e+00	TMEM110
Gout (self-reported)	1.44	1	1	2.2	0.00	1.0e+00	TMEM110
Heel bone mineral density (BMD) T-score, automated (left)	1.40	1	0	0.0	0.00	1.0e+00	UBA7
Ovarian Cancer	1.33	1	1	2.2	0.00	1.0e+00	MAPT
Asthma	1.30	1	0	0.0	0.00	1.0e+00	AFF3
Ever had bowel cancer screening	1.29	1	0	0.0	0.00	1.0e+00	UBA7
Asthma (self-reported)	1.29	1	0	0.0	0.00	1.0e+00	AFF3
Hair/balding pattern: Pattern 2	1.27	1	0	0.0	0.00	1.0e+00	MAPT
Alzheimer’s Disease (including proxy)	1.25	1	0	0.0	0.00	1.0e+00	NUP160
Pulse rate	1.25	1	0	0.0	0.00	1.0e+00	RBL2
High cholesterol (Self-reported)	1.25	1	0	0.0	0.00	1.0e+00	DCAF16
Heel bone mineral density (BMD) T-score, automated (right)	1.18	1	0	0.0	0.00	1.0e+00	DCAF16
Breast Cancer	1.16	2	0	0.0	0.00	1.0e+00	MAPT UBA7
Blood Platelet Count	0.93	6	3	6.7	-0.80	5.4e-02	ABCB9 DCAF16 NUP160 RARB ST3GAL3 SULT1A1
Blood Eosinophil Count	0.91	3	3	6.7	0.00	1.0e+00	ABCB9 MAPT UBA7
Tanning	0.26	1	0	0.0	0.00	1.0e+00	PFDN1
Hair Pigment	0.16	3	2	4.4	0.00	1.0e+00	ABCB9 FOXO3 TRIM37

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Ovary	5	0.55	2.5
GTEx	Vagina	6	0.94	2.5
GTEx	Brain Cortex	9	0.87	2.4
GTEx	Esophagus Gastroesophageal Junction	8	0.55	2.4
GTEx	Brain Putamen basal ganglia	2	0.32	2.3
GTEx	Breast Mammary Tissue	11	0.56	2.3
GTEx	Colon Sigmoid	7	0.48	2.3
GTEx	Colon Transverse	8	0.39	2.3
GTEx	Heart Atrial Appendage	8	0.51	2.3
GTEx	Heart Left Ventricle	6	0.39	2.3
GTEx	Small Intestine Terminal Ileum	2	0.43	2.3
GTEx	Spleen	6	0.43	2.3
GTEx	Stomach	7	0.48	2.3
GTEx	Adipose Visceral Omentum	7	0.34	2.2
GTEx	Artery Aorta	16	0.54	2.2
GTEx	Brain Cerebellar Hemisphere	7	0.47	2.2
GTEx	Brain Frontal Cortex BA9	3	0.32	2.2
GTEx	Brain Hippocampus	1	0.19	2.2
GTEx	Brain Nucleus accumbens basal ganglia	5	0.58	2.2
GTEx	Breast Mammary Tissue (Female)	8	0.49	2.2
GTEx	Cells EBV-transformed lymphocytes	4	0.28	2.2
GTEx	Esophagus Mucosa	12	0.36	2.2
GTEx	Esophagus Muscularis	14	0.43	2.2
GTEx	Liver	2	0.28	2.2
GTEx	Lung	15	0.52	2.2
GTEx	Muscle Skeletal	14	0.48	2.2
GTEx	Pancreas	6	0.37	2.2
GTEx	Skin Not Sun Exposed Suprapubic	10	0.41	2.2
GTEx	Skin Sun Exposed Lower leg	14	0.38	2.2
GTEx	Uterus	1	0.18	2.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	4	0.36	2.2
The Cancer Genome Atlas	Glioblastoma Multiforme	3	0.29	2.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	2	0.37	2.2
GTEx	Adipose Subcutaneous	13	0.37	2.1
GTEx	Artery Coronary	5	0.42	2.1
GTEx	Artery Tibial	18	0.48	2.1
GTEx	Brain Caudate basal ganglia	4	0.43	2.1
GTEx	Brain Cerebellum	7	0.35	2.1
GTEx	Brain Hypothalamus	2	0.34	2.1
GTEx	Breast Mammary Tissue (Male)	3	0.25	2.1
GTEx	Cells Transformed fibroblasts	12	0.29	2.1
GTEx	Nerve Tibial	13	0.30	2.1
GTEx	Pituitary	3	0.27	2.1
GTEx	Prostate	4	0.48	2.1
GTEx	Testis	7	0.22	2.1
GTEx	Thyroid	8	0.20	2.1
GTEx	Whole Blood	8	0.40	2.1
ROSMAP	Brain Pre-frontal Cortex	17	0.39	2.1
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	4	0.24	2.1
The Cancer Genome Atlas	Brain Lower Grade Glioma	15	0.35	2.1
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	5	0.45	2.1
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	6	0.36	2.1
GTEx	Adrenal Gland	4	0.27	2.0
NTR	Blood	7	0.29	2.0
CommonMind	Brain Pre-frontal Cortex	10	0.19	2.0
The Cancer Genome Atlas	Colon Adenocarcinoma	4	0.19	2.0
The Cancer Genome Atlas	Esophageal Carcinoma	1	0.15	2.0
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	9	0.33	2.0
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	5	0.24	2.0
The Cancer Genome Atlas	Lung Adenocarcinoma	8	0.27	2.0
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	7	0.28	2.0
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	7	0.44	2.0
The Cancer Genome Atlas	Soft Tissue Sarcoma	3	0.28	2.0
The Cancer Genome Atlas	Stomach Adenocarcinoma	5	0.30	2.0
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	1	0.20	2.0
METSIM	Adipose	15	0.33	1.9
YFS	Blood	8	0.17	1.9
The Cancer Genome Atlas	Breast Invasive Carcinoma	8	0.18	1.9
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	10	0.24	1.9
The Cancer Genome Atlas	Prostate Adenocarcinoma	15	0.32	1.9
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.00	1.9
The Cancer Genome Atlas	Testicular Germ Cell Tumors	2	0.16	1.9
The Cancer Genome Atlas	Thyroid Carcinoma	9	0.17	1.9
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	3	0.23	1.8