Hub : Traits :

Fluid intelligence score

528 significantly associated models · 104 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 31402148 32762733 1 1 1.2e-09 3.2e-09 1.0e+00 100 PEF1
2 1 41130424 42542658 1 1 3.4e-09 5.0e-10 2.8e-05 55 FOXO6
3 1 43221187 45153116 5 2 7.9e-10 1.7e-10 6.0e-02 91 ST3GAL3
4 1 71163715 73435171 1 1 1.4e-10 5.2e-09 1.2e-01 93 NEGR1
5 1 109316076 110716511 1 1 3.0e-07 3.6e-08 1.9e-02 82 SYPL2
6 1 201616627 202161644 1 1 5.2e-08 6.4e-06 9.2e-01 100 LMOD1
7 2 70804467 72356449 1 1 2.8e-08 2.1e-08 1.0e+00 100 ZNF638
8 2 72787254 74187703 2 2 3.9e-09 2.5e-07 1.9e-02 79 ALMS1P FBXO41
9 2 99468341 101731705 2 2 1.4e-08 1.1e-07 1.2e-01 92 AFF3 CHST10
10 2 117979194 119470084 1 1 6.8e-08 7.3e-06 1.7e-01 91 CCDC93
11 2 161297929 162790882 1 1 5.4e-10 1.5e-09 1.0e+00 100 TANK
12 3 23234618 26329265 5 2 7.0e-08 9.7e-12 3.8e-05 64 NKIRAS1 RARB
13 3 48702606 50932324 17 1 7.5e-17 1.5e-16 1.0e+00 100 UBA7
14 3 52148483 53623102 2 1 2.0e-07 6.5e-08 6.6e-02 88 TMEM110
15 3 70757099 71880670 1 1 8.9e-11 1.9e-10 1.0e+00 100 FOXP1
16 3 135806811 136715468 1 1 1.2e-07 1.8e-07 4.0e-01 97 STAG1
17 4 17104059 18507692 1 1 8.6e-09 3.4e-07 1.4e-01 92 DCAF16
18 4 105598022 107092169 1 1 9.6e-13 3.0e-14 2.1e-03 84 PPA2
19 5 138933151 140378983 1 1 1.2e-07 3.6e-06 8.8e-01 100 PFDN1
20 6 108183628 109704062 1 1 3.3e-08 4.6e-10 2.0e-03 76 FOXO3
21 11 16343081 17771487 2 1 1.5e-07 4.6e-07 5.6e-02 86 NUCB2
22 11 46911704 48559571 6 1 5.7e-09 6.5e-08 7.7e-01 100 NUP160
23 11 104797451 106543882 1 1 1.7e-07 4.4e-08 7.8e-02 90 GRIA4
24 12 122713991 124156897 1 1 2.2e-07 3.4e-07 4.0e-01 97 ABCB9
25 14 103466633 104859419 1 1 2.7e-07 1.2e-07 1.6e-02 79 RP11-73M18.8
26 16 27412414 29595483 23 1 1.6e-12 8.8e-11 9.2e-02 93 SULT1A1
27 16 52772129 54235440 2 1 4.0e-10 5.7e-09 8.0e-01 100 RBL2
28 17 34157655 35644076 4 1 9.7e-08 2.5e-07 5.0e-01 98 GGNBP2
29 17 43315547 43913030 1 1 3.0e-07 2.7e-05 3.4e-01 95 MAPT
30 17 55903829 57989860 5 1 8.3e-09 2.1e-08 8.6e-02 91 TRIM37
31 18 4548348 5945376 3 1 1.4e-09 2.4e-09 9.5e-02 92 LOC339290
32 21 18271223 19680363 1 1 1.9e-07 2.4e-08 1.0e+00 100 BTG3
33 22 39101079 40571499 2 2 3.5e-08 1.1e-08 1.0e+00 100 MGAT3

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder or Schizophrenia 3.15 6 4 8.9 -0.42 4.1e-01 ABCB9 ALMS1P MGAT3 RP11-73M18.8 ST3GAL3 TMEM110
Depressed Affect (Nagel 2018) 3.56 6 4 8.9 0.14 7.9e-01 MAPT NUP160 RP11-73M18.8 STAG1 TANK UBA7
Depression (Nagel 2018) 2.53 2 1 2.2 0.00 1.0e+00 NUP160 STAG1
Intelligence (Savage-Jansen 2018) 15.14 34 32 71.1 0.99 7.3e-30 ABCB9 AFF3 ALMS1P BTG3 CCDC93 CHST10 DCAF16 FBXO41 FOXO3 FOXO6 FOXP1 GGNBP2 GRIA4 LMOD1 LOC339290 MAPT MGAT3 NEGR1 NKIRAS1 NUP160 PEF1 PFDN1 PPA2 RBL2 RP11-73M18.8 ST3GAL3 STAG1 SULT1A1 SYPL2 TANK TMEM110 TRIM37 UBA7 ZNF638
Neuroticism (Nagel 2018) 3.30 5 3 6.7 -0.64 2.4e-01 BTG3 MAPT NUP160 STAG1 TMEM110
Schizophrenia (2018) 3.60 7 2 4.4 -0.50 2.6e-01 ABCB9 FOXP1 MGAT3 RP11-73M18.8 ST3GAL3 STAG1 TMEM110
Worry (Nagel 2018) 2.78 6 4 8.9 -0.57 2.4e-01 BTG3 FOXO3 MAPT NUP160 STAG1 TMEM110
Alzheimer’s Disease (including proxy) 1.25 1 0 0.0 0.00 1.0e+00 NUP160
Crohns Disease (2017) 1.80 2 2 4.4 0.00 1.0e+00 SULT1A1 UBA7
Irritable Bowel Disease (IBD) 2.18 2 2 4.4 0.00 1.0e+00 SULT1A1 UBA7
Ulcerative Colitis (UC) 2.24 2 2 4.4 0.00 1.0e+00 SULT1A1 UBA7
Major Depression (MDD) 2.72 1 1 2.2 0.00 1.0e+00 NEGR1
Reaction Time 2.65 3 3 6.7 0.00 1.0e+00 FOXO3 PFDN1 ZNF638
Verbal and Numeric Reasoning (VNR) 14.51 35 27 60.0 0.99 3.5e-31 ABCB9 AFF3 ALMS1P BTG3 CCDC93 CHST10 DCAF16 FBXO41 FOXO3 FOXO6 FOXP1 GGNBP2 GRIA4 LMOD1 LOC339290 MAPT MGAT3 NEGR1 NKIRAS1 NUP160 PEF1 PFDN1 PPA2 RARB RBL2 RP11-73M18.8 ST3GAL3 STAG1 SULT1A1 SYPL2 TANK TMEM110 TRIM37 UBA7 ZNF638
Breast Cancer 1.16 2 0 0.0 0.00 1.0e+00 MAPT UBA7
Ovarian Cancer 1.33 1 1 2.2 0.00 1.0e+00 MAPT
Prostate Cancer 1.46 1 0 0.0 0.00 1.0e+00 UBA7
Age at First Birth 3.00 2 1 2.2 0.00 1.0e+00 CHST10 UBA7
Body Mass Index (BMI) (2010) 3.72 4 2 4.4 -0.41 5.9e-01 LMOD1 NEGR1 NUP160 SULT1A1
Crohns Disease (2012) 1.97 2 2 4.4 0.00 1.0e+00 SULT1A1 UBA7
HDL Cholesterol 1.75 1 1 2.2 0.00 1.0e+00 NUP160
LDL Cholesterol 2.06 1 1 2.2 0.00 1.0e+00 SYPL2
Neuroticism (2016) 2.27 3 0 0.0 0.00 1.0e+00 MAPT NUP160 TANK
Schizophrenia (2014) 3.54 7 3 6.7 -0.45 3.1e-01 ABCB9 ALMS1P MGAT3 RP11-73M18.8 ST3GAL3 STAG1 TMEM110
Ulcerative Colitis 2.29 2 0 0.0 0.00 1.0e+00 TMEM110 UBA7
Blood Eosinophil Count 0.91 3 3 6.7 0.00 1.0e+00 ABCB9 MAPT UBA7
Blood Platelet Count 0.93 6 3 6.7 -0.80 5.4e-02 ABCB9 DCAF16 NUP160 RARB ST3GAL3 SULT1A1
Blood Red Count 1.78 9 5 11.1 -0.22 5.6e-01 ABCB9 AFF3 CHST10 MAPT RP11-73M18.8 ST3GAL3 SULT1A1 TMEM110 UBA7
Blood White Count 1.82 9 6 13.3 -0.44 2.1e-01 DCAF16 FOXO6 MGAT3 NUP160 PPA2 RP11-73M18.8 SULT1A1 UBA7 ZNF638
Heel T-Score 1.79 7 6 13.3 -0.07 8.9e-01 ABCB9 ALMS1P DCAF16 MAPT NEGR1 UBA7 ZNF638
BMI 4.88 14 9 20.0 -0.47 8.9e-02 AFF3 CHST10 FOXO3 FOXP1 GGNBP2 LMOD1 NEGR1 NUCB2 NUP160 PEF1 PFDN1 SULT1A1 SYPL2 UBA7
Height 4.49 15 13 28.9 0.61 1.2e-02 ABCB9 DCAF16 FOXO3 MAPT MGAT3 NKIRAS1 NUCB2 NUP160 PEF1 PPA2 RBL2 RP11-73M18.8 ST3GAL3 STAG1 ZNF638
Waist Hip Ratio (WHR) 1.87 7 3 6.7 -0.60 1.1e-01 ABCB9 GGNBP2 MAPT MGAT3 NUCB2 RBL2 STAG1
Systolic Blood Pressure 2.02 8 4 8.9 -0.25 5.5e-01 DCAF16 FBXO41 FOXO3 MAPT NUCB2 NUP160 UBA7 ZNF638
Smoking Status 3.20 6 2 4.4 -0.75 8.9e-02 FOXP1 NUCB2 NUP160 RARB ST3GAL3 TANK
Allergy or Eczema 1.67 4 1 2.2 0.54 4.6e-01 ABCB9 GGNBP2 NEGR1 SULT1A1
Cardiovascular Disease 1.91 4 3 6.7 -0.52 4.8e-01 DCAF16 FBXO41 NEGR1 RBL2
Hypothyroidism (self reported) 1.67 1 1 2.2 0.00 1.0e+00 TANK
Type 2 Diabetes (T2D) (2018) 2.35 2 0 0.0 0.00 1.0e+00 RBL2 UBA7
Lung FEV1/FVC ratio 2.70 8 5 11.1 0.55 1.6e-01 BTG3 FOXO3 LMOD1 MAPT NEGR1 PEF1 PPA2 RARB
Lung FVC 2.61 10 6 13.3 0.49 1.5e-01 ABCB9 BTG3 DCAF16 FOXO3 FOXO6 FOXP1 MAPT PPA2 SULT1A1 UBA7
Neuroticism 2.98 6 3 6.7 -0.56 2.4e-01 BTG3 MAPT NUP160 STAG1 TMEM110 UBA7
Chronotype (morning person) 1.88 1 1 2.2 0.00 1.0e+00 TRIM37
Hair Pigment 0.16 3 2 4.4 0.00 1.0e+00 ABCB9 FOXO3 TRIM37
Tanning 0.26 1 0 0.0 0.00 1.0e+00 PFDN1
Hand grip strength (left) 2.66 6 2 4.4 0.81 5.0e-02 DCAF16 FOXP1 MAPT NUP160 PEF1 ZNF638
Number of treatments/medications taken 3.03 6 1 2.2 -0.73 9.9e-02 DCAF16 FBXO41 FOXP1 NEGR1 TANK UBA7
Sensitivity / hurt feelings 2.65 2 1 2.2 0.00 1.0e+00 MAPT STAG1
Frequency of depressed mood in last 2 weeks 2.29 2 1 2.2 0.00 1.0e+00 NUP160 STAG1
Relative age of first facial hair 2.08 2 1 2.2 0.00 1.0e+00 FOXO3 MAPT
Systolic blood pressure, automated reading 1.91 5 1 2.2 -0.44 4.6e-01 DCAF16 FBXO41 MAPT NUCB2 PPA2
Medication: Co-codamol 2.03 1 0 0.0 0.00 1.0e+00 UBA7
Pack years adult smoking proportion 2.27 1 0 0.0 0.00 1.0e+00 SYPL2
Impedance of leg (right) 2.48 13 5 11.1 -0.01 9.7e-01 FOXO3 GGNBP2 LMOD1 MAPT NEGR1 NUCB2 NUP160 PPA2 RBL2 STAG1 SULT1A1 SYPL2 UBA7
Leg fat-free mass (left) 4.32 14 12 26.7 0.26 3.5e-01 ABCB9 DCAF16 FOXO3 GGNBP2 LMOD1 MGAT3 NEGR1 PEF1 PPA2 RBL2 SULT1A1 SYPL2 UBA7 ZNF638
Trunk fat percentage 3.80 11 8 17.8 -0.63 3.7e-02 CHST10 FOXO3 FOXP1 GGNBP2 LMOD1 MAPT NEGR1 NUP160 RARB SULT1A1 UBA7
Hand grip strength (right) 2.62 7 2 4.4 0.77 4.4e-02 DCAF16 MAPT NUP160 PEF1 RBL2 SULT1A1 ZNF638
Current tobacco smoking 2.55 2 0 0.0 0.00 1.0e+00 NUP160 ST3GAL3
Maternal smoking around birth 2.62 1 1 2.2 0.00 1.0e+00 GGNBP2
Fed-up feelings 3.00 3 2 4.4 0.00 1.0e+00 MAPT STAG1 UBA7
Frequency of unenthusiasm / disinterest in last 2 weeks 2.30 1 0 0.0 0.00 1.0e+00 STAG1
Relative age voice broke 1.91 2 1 2.2 0.00 1.0e+00 FOXO3 MAPT
Taking other prescription medications 2.67 1 1 2.2 0.00 1.0e+00 UBA7
Age when periods started (menarche) 3.26 4 4 8.9 -0.57 4.3e-01 FOXO3 NEGR1 NUP160 ST3GAL3
Heel bone mineral density (BMD) T-score, automated (left) 1.40 1 0 0.0 0.00 1.0e+00 UBA7
Qualifications: CSEs or equivalent 3.54 3 0 0.0 0.00 1.0e+00 FOXO6 ST3GAL3 UBA7
High blood pressure 1.91 4 1 2.2 -0.52 4.8e-01 DCAF16 FBXO41 NEGR1 RBL2
Hayfever, allergic rhinitis or eczema 1.67 3 0 0.0 0.00 1.0e+00 ABCB9 GGNBP2 NEGR1
Stomach or abdominal pain in last month 2.93 1 0 0.0 0.00 1.0e+00 STAG1
Sitting height 4.78 11 9 20.0 0.75 7.3e-03 ABCB9 DCAF16 FOXO3 MAPT MGAT3 NUP160 PEF1 PPA2 RBL2 ST3GAL3 ZNF638
Body mass index (BMI) 4.73 12 8 17.8 -0.63 2.9e-02 AFF3 CHST10 DCAF16 FOXO3 FOXP1 GGNBP2 LMOD1 NEGR1 NUP160 STAG1 SULT1A1 UBA7
Impedance of leg (left) 2.63 12 6 13.3 -0.24 4.5e-01 GGNBP2 LMOD1 MAPT MGAT3 NEGR1 NUCB2 PPA2 RBL2 STAG1 SULT1A1 SYPL2 UBA7
Leg predicted mass (left) 4.33 14 12 26.7 0.26 3.5e-01 ABCB9 DCAF16 FOXO3 GGNBP2 LMOD1 MGAT3 NEGR1 PEF1 PPA2 RBL2 SULT1A1 SYPL2 UBA7 ZNF638
Trunk fat mass 3.90 10 7 15.6 -0.61 6.0e-02 CHST10 FOXO3 FOXP1 GGNBP2 LMOD1 NEGR1 NUP160 RARB SULT1A1 UBA7
Waist circumference 4.06 9 6 13.3 -0.54 1.3e-01 AFF3 CHST10 FOXO3 GGNBP2 LMOD1 NEGR1 NUP160 SULT1A1 UBA7
Past tobacco smoking 2.36 2 0 0.0 0.00 1.0e+00 RARB TANK
Alcohol usually taken with meals 3.43 4 1 2.2 1.00 3.2e-03 CHST10 FOXP1 NEGR1 SULT1A1
Nervous feelings 2.53 4 2 4.4 -0.71 2.9e-01 MAPT NUP160 STAG1 TMEM110
Frequency of tenseness / restlessness in last 2 weeks 2.24 3 1 2.2 0.00 1.0e+00 MAPT STAG1 TMEM110
Hearing difficulty/problems with background noise 1.77 1 0 0.0 0.00 1.0e+00 MAPT
Hair/balding pattern: Pattern 2 1.27 1 0 0.0 0.00 1.0e+00 MAPT
Had other major operations 2.04 1 0 0.0 0.00 1.0e+00 PPA2
Forced vital capacity (FVC) 4.18 10 5 11.1 0.77 9.4e-03 BTG3 DCAF16 FOXO6 FOXP1 MAPT NUP160 PPA2 RBL2 UBA7 ZNF638
Heel bone mineral density (BMD) T-score, automated (right) 1.18 1 0 0.0 0.00 1.0e+00 DCAF16
Qualifications: None of the above 7.33 15 7 15.6 -0.99 1.7e-12 ABCB9 ALMS1P CHST10 DCAF16 FOXO3 FOXP1 GGNBP2 NEGR1 PPA2 RBL2 ST3GAL3 SULT1A1 SYPL2 TANK UBA7
Allergy 1.58 2 1 2.2 0.00 1.0e+00 ABCB9 NEGR1
Diabetes (self-reported) 2.39 2 0 0.0 0.00 1.0e+00 RBL2 UBA7
Medication: Simvastatin 1.49 1 0 0.0 0.00 1.0e+00 DCAF16
Illnesses of siblings 2.21 2 1 2.2 0.00 1.0e+00 RBL2 ST3GAL3
Neuroticism score 2.92 5 3 6.7 0.30 6.3e-01 MAPT NUP160 STAG1 TMEM110 UBA7
Weight 4.34 13 10 22.2 0.04 8.9e-01 AFF3 DCAF16 FOXO3 GGNBP2 LMOD1 MGAT3 NEGR1 PEF1 PPA2 RBL2 SULT1A1 UBA7 ZNF638
Impedance of arm (right) 2.82 11 8 17.8 0.13 7.1e-01 AFF3 FOXO3 GGNBP2 LMOD1 MAPT NEGR1 NUCB2 PEF1 STAG1 SYPL2 UBA7
Arm fat percentage (right) 4.53 12 8 17.8 -0.70 1.2e-02 AFF3 CHST10 DCAF16 FOXO3 FOXP1 GGNBP2 LMOD1 NEGR1 NUP160 RARB SULT1A1 UBA7
Trunk fat-free mass 4.62 14 11 24.4 0.39 1.5e-01 ABCB9 DCAF16 FOXO3 LMOD1 MGAT3 NEGR1 NUP160 PEF1 PPA2 RBL2 SULT1A1 SYPL2 UBA7 ZNF638
Hip circumference 3.89 10 7 15.6 -0.09 8.0e-01 ABCB9 FOXO3 GGNBP2 LMOD1 NEGR1 NUP160 PEF1 RBL2 SULT1A1 UBA7
Alcohol intake versus 10 years previously 2.45 2 1 2.2 0.00 1.0e+00 NEGR1 UBA7
Father's age at death 2.08 1 0 0.0 0.00 1.0e+00 UBA7
Worrier / anxious feelings 2.16 3 1 2.2 0.00 1.0e+00 MAPT STAG1 TMEM110
Frequency of tiredness / lethargy in last 2 weeks 2.46 1 0 0.0 0.00 1.0e+00 STAG1
Hair/balding pattern: Pattern 3 2.17 1 1 2.2 0.00 1.0e+00 MAPT
Forced expiratory volume in 1-second (FEV1) 4.15 7 4 8.9 0.89 7.5e-03 DCAF16 FOXP1 MAPT NUP160 PEF1 PPA2 UBA7
Pulse rate 1.25 1 0 0.0 0.00 1.0e+00 RBL2
Noisy workplace 3.81 1 0 0.0 0.00 1.0e+00 SYPL2
Qualifications: A levels/AS levels or equivalent 8.36 19 6 13.3 0.97 1.9e-12 ABCB9 ALMS1P CHST10 DCAF16 FBXO41 FOXO6 FOXP1 GRIA4 MAPT MGAT3 NEGR1 PEF1 PPA2 RBL2 RP11-73M18.8 ST3GAL3 SULT1A1 TANK UBA7
Mouth/teeth dental problems: Dentures 1.92 2 0 0.0 0.00 1.0e+00 STAG1 UBA7
Asthma 1.30 1 0 0.0 0.00 1.0e+00 AFF3
Prospective memory result 3.80 2 0 0.0 0.00 1.0e+00 PEF1 ZNF638
Illnesses of mother 1.51 1 0 0.0 0.00 1.0e+00 GGNBP2
Forced expiratory volume in 1-second (FEV1), Best measure 4.25 6 3 6.7 0.90 1.4e-02 DCAF16 FOXP1 MAPT NUP160 PPA2 UBA7
Impedance of arm (left) 2.85 11 6 13.3 0.12 7.3e-01 AFF3 FOXO3 GGNBP2 LMOD1 MAPT NEGR1 NUCB2 PEF1 STAG1 SYPL2 UBA7
Arm fat mass (right) 4.51 10 7 15.6 -0.59 7.1e-02 AFF3 CHST10 FOXO3 FOXP1 GGNBP2 LMOD1 NEGR1 NUP160 SULT1A1 UBA7
Trunk predicted mass 4.65 14 11 24.4 0.39 1.5e-01 ABCB9 DCAF16 FOXO3 LMOD1 MGAT3 NEGR1 NUP160 PEF1 PPA2 RBL2 SULT1A1 SYPL2 UBA7 ZNF638
Standing height 4.77 15 12 26.7 0.54 3.0e-02 ABCB9 DCAF16 FOXO3 MAPT MGAT3 NKIRAS1 NUCB2 NUP160 PEF1 PPA2 RBL2 RP11-73M18.8 STAG1 SULT1A1 ZNF638
Exposure to tobacco smoke at home 1.74 1 0 0.0 0.00 1.0e+00 UBA7
Seen doctor (GP) for nerves, anxiety, tension or depression 2.83 2 1 2.2 0.00 1.0e+00 NEGR1 RP11-73M18.8
Hair/balding pattern: Pattern 4 2.63 1 1 2.2 0.00 1.0e+00 MAPT
Birth weight of first child 2.63 3 1 2.2 0.00 1.0e+00 DCAF16 PPA2 RBL2
Peak expiratory flow (PEF) 2.88 6 2 4.4 0.97 1.0e-03 DCAF16 FOXO3 MAPT PEF1 PPA2 RARB
Ever highly irritable/argumentative for 2 days 1.77 1 0 0.0 0.00 1.0e+00 UBA7
Qualifications: O levels/GCSEs or equivalent 4.92 4 2 4.4 0.99 6.6e-03 ABCB9 ALMS1P MAPT ST3GAL3
Medication: Paracetamol 2.85 1 1 2.2 0.00 1.0e+00 MAPT
Headache pain in last month 2.23 1 1 2.2 0.00 1.0e+00 MAPT
Medication for cholesterol, blood pressure or diabetes 1.68 1 0 0.0 0.00 1.0e+00 UBA7
Gout (self-reported) 1.44 1 1 2.2 0.00 1.0e+00 TMEM110
Hypothyroidism/myxoedema (self-reported) 1.60 1 0 0.0 0.00 1.0e+00 TANK
Medication: Amlodipine 1.47 1 0 0.0 0.00 1.0e+00 TRIM37
Medication: Ventolin 100micrograms inhaler 1.62 2 0 0.0 0.00 1.0e+00 AFF3 UBA7
Birth weight 2.32 2 1 2.2 0.00 1.0e+00 DCAF16 PPA2
Chronic bronchitis/emphysema (mother) 2.36 2 0 0.0 0.00 1.0e+00 RARB UBA7
Forced vital capacity (FVC), Best measure 4.35 9 6 13.3 0.74 2.2e-02 DCAF16 FOXO6 FOXP1 MAPT NUP160 PPA2 RBL2 UBA7 ZNF638
Body fat percentage 4.18 11 7 15.6 -0.69 1.9e-02 CHST10 DCAF16 FOXO3 FOXP1 GGNBP2 LMOD1 NEGR1 NUP160 RARB SULT1A1 UBA7
Leg fat percentage (right) 4.49 11 8 17.8 -0.67 2.4e-02 AFF3 CHST10 DCAF16 FOXO3 FOXP1 GGNBP2 LMOD1 NEGR1 NUP160 SULT1A1 UBA7
Arm fat-free mass (right) 4.39 14 10 22.2 0.24 3.8e-01 ABCB9 DCAF16 FOXO3 GGNBP2 LMOD1 MGAT3 NEGR1 PEF1 PPA2 RBL2 SULT1A1 SYPL2 UBA7 ZNF638
Exposure to tobacco smoke outside home 1.73 1 0 0.0 0.00 1.0e+00 UBA7
Comparative body size at age 10 3.53 5 4 8.9 -0.41 5.0e-01 GGNBP2 NEGR1 NUP160 SULT1A1 SYPL2
Worry too long after embarrassment 2.75 3 1 2.2 0.00 1.0e+00 PFDN1 PPA2 STAG1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.90 1 0 0.0 0.00 1.0e+00 RP11-73M18.8
Wheeze or whistling in the chest in last year 2.76 2 1 2.2 0.00 1.0e+00 AFF3 UBA7
Age at first live birth 3.21 2 1 2.2 0.00 1.0e+00 DCAF16 UBA7
Health satisfaction 2.51 2 1 2.2 0.00 1.0e+00 LMOD1 UBA7
Shortness of breath walking on level ground 1.94 1 0 0.0 0.00 1.0e+00 LMOD1
Qualifications: College or University degree 9.94 26 17 37.8 0.98 1.5e-18 ABCB9 AFF3 ALMS1P CCDC93 CHST10 DCAF16 FBXO41 FOXO3 FOXO6 FOXP1 GGNBP2 GRIA4 LMOD1 MAPT MGAT3 NEGR1 NKIRAS1 PFDN1 PPA2 RBL2 RP11-73M18.8 ST3GAL3 SULT1A1 SYPL2 TANK UBA7
Medication for pain relief, constipation, heartburn 2.66 2 0 0.0 0.00 1.0e+00 LMOD1 MAPT
Medication: Blood pressure 1.72 2 0 0.0 0.00 1.0e+00 DCAF16 FBXO41
Medication: Allopurinol 1.46 1 0 0.0 0.00 1.0e+00 TMEM110
Medication: Seretide 50 evohaler 1.71 1 0 0.0 0.00 1.0e+00 UBA7
Mean time to correctly identify matches 2.64 3 2 4.4 0.00 1.0e+00 FOXO3 PFDN1 ZNF638
Whole body fat mass 4.23 11 7 15.6 -0.61 4.7e-02 AFF3 CHST10 FOXO3 FOXP1 GGNBP2 LMOD1 NEGR1 NUP160 RARB SULT1A1 UBA7
Leg fat mass (right) 4.51 11 8 17.8 -0.52 9.9e-02 AFF3 CHST10 FOXO3 FOXP1 GGNBP2 LMOD1 NEGR1 NUP160 PEF1 SULT1A1 UBA7
Arm predicted mass (right) 4.44 14 10 22.2 0.23 4.1e-01 ABCB9 DCAF16 FOXO3 GGNBP2 LMOD1 MGAT3 NEGR1 PEF1 PPA2 RBL2 SULT1A1 SYPL2 UBA7 ZNF638
Pulse rate, automated reading 1.73 4 3 6.7 -0.64 3.6e-01 LMOD1 NEGR1 RBL2 UBA7
Alcohol intake frequency. 3.77 8 4 8.9 -0.78 2.3e-02 ABCB9 FOXP1 MAPT NEGR1 NUP160 PPA2 SULT1A1 UBA7
Comparative height size at age 10 4.16 13 11 24.4 0.44 1.3e-01 ABCB9 DCAF16 FOXO3 MAPT NUCB2 NUP160 PPA2 RBL2 RP11-73M18.8 ST3GAL3 STAG1 SULT1A1 ZNF638
Suffer from 'nerves' 3.05 3 2 4.4 0.00 1.0e+00 NUP160 SULT1A1 TMEM110
Overall health rating 3.78 7 4 8.9 -1.00 3.1e-06 DCAF16 FOXP1 LMOD1 RARB RBL2 TANK UBA7
Age at last live birth 2.40 1 1 2.2 0.00 1.0e+00 UBA7
Leg pain on walking 2.44 1 0 0.0 0.00 1.0e+00 UBA7
Commuting to job workplace: Car/motor vehicle 1.98 1 0 0.0 0.00 1.0e+00 NEGR1
Hypertension (Self-reported) 1.77 4 2 4.4 -0.58 4.2e-01 DCAF16 FBXO41 NEGR1 RBL2
Forced expiratory volume in 1-second (FEV1), predicted 3.15 4 1 2.2 0.83 1.7e-01 DCAF16 NUP160 PPA2 ZNF638
Whole body fat-free mass 4.54 14 12 26.7 0.28 3.1e-01 ABCB9 DCAF16 FOXO3 GGNBP2 LMOD1 MGAT3 NEGR1 PEF1 PPA2 RBL2 SULT1A1 SYPL2 UBA7 ZNF638
Leg fat-free mass (right) 4.28 14 11 24.4 0.27 3.3e-01 ABCB9 DCAF16 FOXO3 GGNBP2 LMOD1 MGAT3 NEGR1 PEF1 PPA2 RBL2 SULT1A1 SYPL2 UBA7 ZNF638
Arm fat percentage (left) 4.47 12 8 17.8 -0.69 1.2e-02 AFF3 CHST10 DCAF16 FOXO3 FOXP1 GGNBP2 LMOD1 NEGR1 NUP160 RARB SULT1A1 UBA7
Average weekly red wine intake 3.14 2 1 2.2 0.00 1.0e+00 ABCB9 FOXP1
Handedness (chirality/laterality): Left-handed 1.83 2 1 2.2 0.00 1.0e+00 MAPT SULT1A1
Mood swings 2.80 4 2 4.4 -0.37 6.3e-01 MAPT NUP160 STAG1 UBA7
Loneliness, isolation 2.82 2 1 2.2 0.00 1.0e+00 NUP160 STAG1
Long-standing illness, disability or infirmity 2.45 3 0 0.0 0.00 1.0e+00 NEGR1 RARB RP11-73M18.8
Ever had bowel cancer screening 1.29 1 0 0.0 0.00 1.0e+00 UBA7
Diabetes diagnosed by doctor 2.33 3 0 0.0 0.00 1.0e+00 ALMS1P RBL2 UBA7
Qualifications: nursing, teaching 5.08 6 2 4.4 0.98 7.6e-04 ABCB9 ALMS1P LMOD1 NEGR1 ST3GAL3 UBA7
Mouth/teeth dental problems: Mouth ulcers 1.81 1 1 2.2 0.00 1.0e+00 MAPT
Medication for cholesterol 2.31 2 0 0.0 0.00 1.0e+00 MAPT RBL2
Asthma (self-reported) 1.29 1 0 0.0 0.00 1.0e+00 AFF3
Smoking status: Current 2.60 2 1 2.2 0.00 1.0e+00 NUP160 ST3GAL3
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.47 3 2 4.4 0.00 1.0e+00 MAPT PPA2 RARB
Whole body water mass 4.56 14 12 26.7 0.28 3.0e-01 ABCB9 DCAF16 FOXO3 GGNBP2 LMOD1 MGAT3 NEGR1 PEF1 PPA2 RBL2 SULT1A1 SYPL2 UBA7 ZNF638
Leg predicted mass (right) 4.27 14 11 24.4 0.27 3.4e-01 ABCB9 DCAF16 FOXO3 GGNBP2 LMOD1 MGAT3 NEGR1 PEF1 PPA2 RBL2 SULT1A1 SYPL2 UBA7 ZNF638
Arm fat mass (left) 4.43 10 7 15.6 -0.60 6.8e-02 AFF3 CHST10 FOXO3 FOXP1 GGNBP2 LMOD1 NEGR1 NUP160 SULT1A1 UBA7
Number of self-reported non-cancer illnesses 2.52 2 1 2.2 0.00 1.0e+00 FBXO41 NEGR1
Average weekly champagne plus white wine intake 2.27 1 0 0.0 0.00 1.0e+00 MAPT
Miserableness 3.11 4 3 6.7 -0.02 9.8e-01 NUP160 STAG1 TANK UBA7
Financial situation satisfaction 2.13 1 0 0.0 0.00 1.0e+00 UBA7
Commuting to job workplace: Public transport 2.95 2 0 0.0 0.00 1.0e+00 CHST10 NEGR1
Medication: Blood pressure 1.55 1 0 0.0 0.00 1.0e+00 MAPT
High cholesterol (Self-reported) 1.25 1 0 0.0 0.00 1.0e+00 DCAF16
Medication: Paracetamol 2.68 2 1 2.2 0.00 1.0e+00 MAPT SULT1A1
Basal metabolic rate 4.51 14 12 26.7 0.24 3.9e-01 ABCB9 DCAF16 FOXO3 GGNBP2 LMOD1 MGAT3 NEGR1 PEF1 PPA2 RBL2 SULT1A1 SYPL2 UBA7 ZNF638
Leg fat percentage (left) 4.68 11 9 20.0 -0.67 2.4e-02 AFF3 CHST10 DCAF16 FOXO3 FOXP1 GGNBP2 LMOD1 NEGR1 NUP160 SULT1A1 UBA7
Arm fat-free mass (left) 4.42 13 11 24.4 0.22 4.5e-01 ABCB9 DCAF16 FOXO3 GGNBP2 LMOD1 MGAT3 NEGR1 PEF1 PPA2 RBL2 SULT1A1 UBA7 ZNF638
Number of operations (self-reported) 2.48 2 1 2.2 0.00 1.0e+00 PPA2 TANK
Average weekly beer plus cider intake 2.80 1 1 2.2 0.00 1.0e+00 UBA7
Irritability 1.87 1 0 0.0 0.00 1.0e+00 MAPT
Diastolic blood pressure, automated reading 2.32 6 3 6.7 -0.99 2.4e-04 ABCB9 ALMS1P DCAF16 FBXO41 LMOD1 UBA7
Ever depressed for a whole week 2.36 1 0 0.0 0.00 1.0e+00 RP11-73M18.8
Unable to work because of sickness or disability 1.78 1 0 0.0 0.00 1.0e+00 FBXO41
Vascular/heart problems diagnosed by doctor 1.87 4 1 2.2 0.58 4.2e-01 DCAF16 FBXO41 NEGR1 RBL2
Cholesterol lowering medication 1.61 1 0 0.0 0.00 1.0e+00 DCAF16
Pain experienced in last month 2.33 2 0 0.0 0.00 1.0e+00 LMOD1 UBA7
Alcohol drinker status: Previous 1.62 1 0 0.0 0.00 1.0e+00 RP11-73M18.8
Impedance of whole body 2.78 13 8 17.8 -0.16 6.1e-01 FOXO3 GGNBP2 LMOD1 MAPT NEGR1 NUCB2 PEF1 PFDN1 PPA2 RBL2 STAG1 SYPL2 UBA7
Leg fat mass (left) 4.61 11 8 17.8 -0.52 9.9e-02 AFF3 CHST10 FOXO3 FOXP1 GGNBP2 LMOD1 NEGR1 NUP160 PEF1 SULT1A1 UBA7
Arm predicted mass (left) 4.46 14 11 24.4 0.22 4.3e-01 ABCB9 DCAF16 FOXO3 GGNBP2 LMOD1 MGAT3 NEGR1 PEF1 PPA2 RBL2 SULT1A1 SYPL2 UBA7 ZNF638

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 13 0.37 2.1
GTEx Adipose Visceral Omentum 7 0.34 2.2
GTEx Adrenal Gland 4 0.27 2.0
GTEx Artery Aorta 16 0.54 2.2
GTEx Artery Coronary 5 0.42 2.1
GTEx Artery Tibial 18 0.48 2.1
GTEx Brain Caudate basal ganglia 4 0.43 2.1
GTEx Brain Cerebellar Hemisphere 7 0.47 2.2
GTEx Brain Cerebellum 7 0.35 2.1
GTEx Brain Cortex 9 0.87 2.4
GTEx Brain Frontal Cortex BA9 3 0.32 2.2
GTEx Brain Hippocampus 1 0.19 2.2
GTEx Brain Hypothalamus 2 0.34 2.1
GTEx Brain Nucleus accumbens basal ganglia 5 0.58 2.2
GTEx Brain Putamen basal ganglia 2 0.32 2.3
GTEx Breast Mammary Tissue 11 0.56 2.3
GTEx Breast Mammary Tissue (Male) 3 0.25 2.1
GTEx Breast Mammary Tissue (Female) 8 0.49 2.2
GTEx Cells EBV-transformed lymphocytes 4 0.28 2.2
GTEx Cells Transformed fibroblasts 12 0.29 2.1
GTEx Colon Sigmoid 7 0.48 2.3
GTEx Colon Transverse 8 0.39 2.3
GTEx Esophagus Gastroesophageal Junction 8 0.55 2.4
GTEx Esophagus Mucosa 12 0.36 2.2
GTEx Esophagus Muscularis 14 0.43 2.2
GTEx Heart Atrial Appendage 8 0.51 2.3
GTEx Heart Left Ventricle 6 0.39 2.3
GTEx Liver 2 0.28 2.2
GTEx Lung 15 0.52 2.2
GTEx Muscle Skeletal 14 0.48 2.2
GTEx Nerve Tibial 13 0.30 2.1
GTEx Ovary 5 0.55 2.5
GTEx Pancreas 6 0.37 2.2
GTEx Pituitary 3 0.27 2.1
GTEx Prostate 4 0.48 2.1
GTEx Skin Not Sun Exposed Suprapubic 10 0.41 2.2
GTEx Skin Sun Exposed Lower leg 14 0.38 2.2
GTEx Small Intestine Terminal Ileum 2 0.43 2.3
GTEx Spleen 6 0.43 2.3
GTEx Stomach 7 0.48 2.3
GTEx Testis 7 0.22 2.1
GTEx Thyroid 8 0.20 2.1
GTEx Uterus 1 0.18 2.2
GTEx Vagina 6 0.94 2.5
GTEx Whole Blood 8 0.40 2.1
METSIM Adipose 15 0.33 1.9
NTR Blood 7 0.29 2.0
ROSMAP Brain Pre-frontal Cortex 17 0.39 2.1
YFS Blood 8 0.17 1.9
CommonMind Brain Pre-frontal Cortex 10 0.19 2.0
The Cancer Genome Atlas Bladder Urothelial Carcinoma 4 0.24 2.1
The Cancer Genome Atlas Breast Invasive Carcinoma 8 0.18 1.9
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 4 0.36 2.2
The Cancer Genome Atlas Colon Adenocarcinoma 4 0.19 2.0
The Cancer Genome Atlas Esophageal Carcinoma 1 0.15 2.0
The Cancer Genome Atlas Glioblastoma Multiforme 3 0.29 2.2
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 9 0.33 2.0
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 10 0.24 1.9
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 5 0.24 2.0
The Cancer Genome Atlas Brain Lower Grade Glioma 15 0.35 2.1
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 5 0.45 2.1
The Cancer Genome Atlas Lung Adenocarcinoma 8 0.27 2.0
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 7 0.28 2.0
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 7 0.44 2.0
The Cancer Genome Atlas Pancreatic Adenocarcinoma 6 0.36 2.1
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 3 0.23 1.8
The Cancer Genome Atlas Prostate Adenocarcinoma 15 0.32 1.9
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.00 1.9
The Cancer Genome Atlas Soft Tissue Sarcoma 3 0.28 2.0
The Cancer Genome Atlas Skin Cutaneous Melanoma 2 0.37 2.2
The Cancer Genome Atlas Stomach Adenocarcinoma 5 0.30 2.0
The Cancer Genome Atlas Testicular Germ Cell Tumors 2 0.16 1.9
The Cancer Genome Atlas Thyroid Carcinoma 9 0.17 1.9
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 1 0.20 2.0