Hub : Genes

ST3GAL3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1970	0.0680	2.4e-04	0.015	NA	0.056	NA	0.024	2.0e-02	NA	2.3e-05	NA	4.0e-03
2	GTEx	Breast Mammary Tissue (Female)	0.0286	0.0447	2.9e-01	-0.010	NA	-0.008	NA	0.010	8.7e-01	NA	6.8e-01	NA	1.6e-01
3	GTEx	Muscle Skeletal	0.0999	0.0363	4.2e-04	0.014	NA	0.013	NA	0.012	1.4e-02	NA	1.6e-02	NA	2.1e-02
4	GTEx	Nerve Tibial	0.1798	0.0540	2.2e-04	0.033	NA	0.044	NA	0.051	2.0e-03	NA	4.3e-04	NA	1.7e-04
5	GTEx	Thyroid	0.1510	0.0600	2.0e-03	0.109	NA	0.083	NA	0.109	1.1e-08	NA	6.7e-07	NA	1.1e-08
6	METSIM	Adipose	0.0792	0.0276	1.5e-04	-0.001	0.028	0.005	0.03	0.001	4.3e-01	3.7e-05	5.9e-02	2.4e-05	2.6e-01
7	YFS	Blood	0.0223	0.0087	2.4e-05	0.017	0.019	0.023	0.02	0.025	2.5e-06	5.0e-07	3.4e-08	2.7e-07	9.4e-09
8	TCGA	Head and Neck Squamous Cell Carcinoma	0.1782	0.0648	3.8e-07	0.085	0.056	0.063	NA	0.080	8.6e-10	7.1e-07	1.4e-07	NA	2.8e-09
9	TCGA	Kidney Renal Papillary Cell Carcinoma	0.1070	0.0570	9.9e-03	0.026	-0.004	-0.004	NA	0.002	1.3e-02	6.5e-01	6.2e-01	NA	2.3e-01
10	TCGA	Thyroid Carcinoma	0.3020	0.0850	3.1e-11	0.176	0.137	0.188	NA	0.188	6.7e-17	2.9e-13	5.3e-18	NA	5.7e-18

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.4	0.7	4.4	0.1	-0.5	2.1	-0.9	0.3	-0.6	-0.2	0.4	-0.9	-0.2
Bipolar Disorder or Schizophrenia	2.2	5.4	26.6	-0.3	1.7	5.2	-3.9	-0.1	1.0	-2.3	0.7	0.0	-1.5
Depressed Affect (Nagel 2018)	0.3	0.7	2.2	-1.3	-0.2	-0.3	-1.4	-0.5	-0.1	-1.5	-0.6	-0.1	-0.6
Depression (Nagel 2018)	0.8	1.2	5.7	-0.3	-0.6	2.4	-1.3	-0.8	-0.2	-1.0	-0.6	-0.8	-1.2
Intelligence (Savage-Jansen 2018)	4.0	12.2	39.4	0.6	-6.3	-5.0	3.2	1.9	-3.5	3.3	0.7	3.1	3.2
Neuroticism (Nagel 2018)	0.3	0.7	4.0	0.0	0.6	-2.0	0.6	0.2	1.3	-0.0	-0.2	0.0	0.7
Schizophrenia (2018)	3.2	6.6	24.6	-0.5	2.6	5.0	-4.3	-0.4	1.7	-2.8	0.7	0.8	-1.7
Schizophrenia vs Biploar Disorder	1.3	1.7	8.5	0.9	0.8	-0.1	-0.8	0.3	2.4	-0.9	0.4	2.9	0.3
Worry (Nagel 2018)	0.6	1.2	3.4	1.5	0.2	-1.8	1.7	-0.5	1.2	0.4	-1.2	-0.5	0.3
Alzheimer’s Disease (in mother)	0.6	0.7	1.7	-0.2	0.6	0.7	0.8	-1.2	-0.0	1.1	-0.9	-1.3	-0.9
Alzheimer’s Disease (in father)	0.3	0.3	1.2	0.8	0.5	-0.1	-0.4	-0.1	-0.6	1.1	0.3	0.1	0.1
Alzheimer’s Disease (including proxy)	0.5	0.8	1.8	0.2	0.9	0.8	0.1	-1.4	-0.3	1.0	-0.8	-1.3	-1.1
Crohns Disease (2017)	0.8	1.8	3.6	0.9	0.8	-0.6	1.2	1.6	1.9	1.6	1.8	0.4	1.7
Irritable Bowel Disease (IBD)	0.3	0.7	3.5	0.4	0.9	0.5	0.6	-0.5	1.9	0.2	-0.5	-1.1	-0.7
Ulcerative Colitis (UC)	1.2	2.3	5.4	-0.1	0.5	1.3	-0.1	-2.0	1.1	-0.9	-2.1	-2.3	-2.3
Major Depression (MDD)	0.5	0.6	2.5	0.6	1.3	1.6	-0.0	0.4	0.9	-0.2	0.6	-0.1	-0.2
Reaction Time	1.6	3.0	8.9	3.0	1.9	0.5	1.1	-1.4	2.2	2.4	-0.6	-1.6	-1.0
Verbal and Numeric Reasoning (VNR)	3.5	8.4	27.8	-0.4	-5.3	-4.3	2.5	1.7	-2.8	3.1	1.1	1.6	2.9
Breast Cancer	1.2	2.8	14.3	2.4	2.0	-0.0	0.5	-0.1	3.8	1.8	0.5	0.5	-0.1
Ovarian Cancer	2.9	3.8	10.5	2.3	-1.3	-0.6	3.2	-1.9	-0.2	2.8	-2.2	-1.9	-0.6
Prostate Cancer	0.5	0.7	2.9	0.2	0.4	0.1	1.6	0.4	1.7	0.2	-0.6	0.8	0.7
Age at First Birth	1.1	1.6	5.2	0.8	-1.0	-1.2	-0.3	-2.0	-0.1	-0.2	-2.3	-0.7	-1.6
Bipolar Disorder (2011)	0.3	0.3	0.8	-0.3	-0.3	0.3	0.3	-0.8	-0.3	-0.3	-0.9	-0.4	-0.8
Body Mass Index (BMI) (2010)	0.8	1.1	2.8	0.5	1.4	0.0	0.8	1.2	0.4	1.1	1.7	0.3	1.5
Coronary Artery Disease (CAD)	0.6	0.7	1.7	-0.2	0.7	0.3	-0.5	1.2	-1.0	-0.2	1.3	0.7	1.1
Crohns Disease (2012)	1.5	2.4	6.0	0.9	0.9	-0.2	0.6	2.0	2.1	1.7	2.4	1.1	1.9
Mean Putamen Volume	0.7	0.8	2.1	-0.2	1.1	0.4	-0.4	1.0	1.2	-0.6	1.1	1.5	0.5
Fasting Glucose	0.8	1.0	5.4	0.1	-2.3	-1.5	0.1	0.2	-1.2	0.3	0.1	-0.1	0.7
HbA1C	0.8	0.9	2.5	1.2	0.3	0.7	1.2	-1.0	1.6	1.3	-0.5	-0.1	-0.4
HDL Cholesterol	1.1	1.9	4.7	1.3	-0.3	0.0	1.6	-2.2	0.9	0.8	-2.0	-1.5	-1.3
LDL Cholesterol	0.4	0.6	1.3	-1.1	0.5	0.3	-1.1	0.8	0.4	-1.2	0.8	0.7	0.5
Lupus	0.4	0.6	1.8	1.4	0.4	0.5	0.3	-0.9	0.9	0.5	-0.9	-0.0	-0.8
Neuroticism (2016)	1.0	1.4	4.2	0.7	-1.0	0.4	1.9	-1.1	-0.6	2.1	-0.8	-1.6	-0.3
Primary Biliary Cirrhosis	0.9	1.2	4.0	2.0	0.9	-0.9	1.2	0.2	1.5	1.5	-0.0	0.6	0.6
Rheumatoid Arthritis	0.6	0.9	2.5	-0.2	0.3	1.2	0.1	1.2	1.0	0.3	1.6	1.2	0.9
Schizophrenia (2014)	2.0	4.4	16.7	0.3	1.6	4.1	-3.3	1.0	1.4	-2.3	1.7	1.6	-0.1
Triglycerides	0.7	1.2	4.6	-1.8	-0.1	-0.3	-2.1	0.2	-1.1	-1.4	0.4	-0.9	-0.4
Type 2 Diabetes (T2D) (2012)	1.1	1.2	4.6	-2.1	0.5	0.2	-0.9	1.2	0.6	-1.0	1.0	1.5	0.7
Ulcerative Colitis	0.3	0.4	1.0	0.3	-0.1	0.9	-0.3	-0.4	0.9	-1.0	-0.4	-0.6	-0.9
Blood Eosinophil Count	0.5	4.1	9.7	3.1	2.0	-1.3	-0.2	1.4	2.4	2.5	1.8	2.5	1.4
Blood Platelet Count	0.5	6.0	20.8	4.6	-2.4	4.2	-1.2	-1.9	-0.8	-0.8	-1.5	1.4	-2.2
Blood Red Count	1.6	15.2	51.0	6.2	2.5	-4.2	3.9	1.2	3.2	7.1	1.3	1.3	3.1
Blood White Count	0.2	1.6	7.2	0.5	0.9	0.1	-1.4	-0.8	-2.7	-1.4	-1.2	0.2	-1.1
Heel T-Score	0.5	4.2	23.0	-2.5	-0.0	1.0	-4.8	0.7	-0.3	-3.2	0.7	0.6	-0.4
BMI	0.3	1.9	12.2	-1.4	3.5	-0.6	-1.2	0.4	0.6	-1.0	0.6	1.0	-0.1
Height	0.5	9.3	21.5	0.9	-0.8	-4.6	3.4	2.6	-0.0	4.5	3.0	2.4	4.1
Waist Hip Ratio (WHR)	0.6	2.9	8.0	-2.2	0.5	2.1	-2.8	-1.1	-0.6	-2.0	-0.7	-0.9	-2.1
Systolic Blood Pressure	0.6	3.2	12.5	-0.2	0.5	-3.5	-0.5	1.2	-3.1	0.3	0.8	2.1	1.6
Smoking Status	3.6	8.5	37.7	-1.5	1.2	6.1	-3.5	-2.4	0.8	-2.5	-1.3	-1.5	-3.9
Allergy or Eczema	1.9	4.9	12.1	-1.5	0.6	0.7	-1.1	-2.9	-1.6	-2.8	-3.1	-2.1	-3.5
Cardiovascular Disease	0.3	0.9	3.2	0.2	1.7	-1.8	0.8	-0.2	-0.4	1.1	0.3	0.1	0.5
Hypothyroidism (self reported)	0.4	0.8	1.7	0.8	1.2	-1.3	1.1	0.1	0.2	1.1	-0.0	1.3	0.3
Respiratory disease	0.9	1.9	6.7	-1.2	-1.0	2.6	-2.0	-0.8	-1.0	-1.2	-0.5	-0.9	-1.2
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.4	-0.4	0.6	0.4	0.6	-0.3	-0.4	-1.2	-1.0	-0.3	-0.4
Lung FEV1/FVC ratio	0.9	4.5	11.4	1.6	-0.2	1.5	0.5	-3.3	-0.4	-0.1	-3.4	-2.5	-3.4
Lung FVC	0.2	1.1	4.1	-1.1	-2.0	-0.6	-1.2	-0.6	-0.8	0.1	-0.7	-1.5	-0.4
Neuroticism	0.3	0.8	5.1	-0.0	0.2	-2.2	0.3	0.5	0.7	0.2	-0.1	0.9	0.9
Chronotype (morning person)	2.8	6.4	14.8	0.8	-1.1	-3.8	2.5	2.7	1.1	2.7	2.4	2.1	3.8
Hair Pigment	0.1	2.3	5.6	-0.4	-0.1	1.9	-2.4	-1.4	-1.4	-2.0	-1.3	-0.0	-1.8
Tanning	0.2	2.9	12.3	1.4	2.2	0.7	1.0	-0.9	3.5	2.8	-0.1	-0.5	-0.6
Hand grip strength (left)	0.8	2.1	9.5	-3.1	-0.9	0.5	-2.1	0.5	-1.2	-1.5	0.7	1.2	-0.1
Number of treatments/medications taken	0.7	1.2	9.4	0.5	3.1	0.0	1.4	-0.3	-0.0	0.4	-0.2	-0.3	-0.3
Average weekly spirits intake	1.7	2.2	9.0	1.4	2.0	0.6	0.2	0.5	3.0	2.1	1.1	0.3	0.3
Sensitivity / hurt feelings	0.7	1.2	3.3	-0.3	1.8	0.0	-1.4	1.5	0.7	0.4	1.8	0.2	1.2
Frequency of depressed mood in last 2 weeks	0.4	0.5	3.8	-0.2	-0.3	1.9	-0.7	-0.1	-0.2	-0.6	-0.1	-0.0	-0.4
Hearing difficulty/problems: Yes	0.7	1.1	5.0	1.3	0.5	1.3	0.5	-0.9	2.2	0.2	-0.7	-0.3	-0.8
Relative age of first facial hair	0.8	1.7	4.5	-0.8	0.9	1.8	-2.0	1.2	1.0	0.8	2.1	-0.7	0.7
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	6.2	-1.3	-0.0	-0.8	-0.8	1.5	1.4	0.2	1.6	2.5	1.3
Ever used hormone-replacement therapy (HRT)	2.3	3.0	6.7	0.7	2.1	2.0	-1.0	-2.5	0.1	-0.3	-1.8	-1.9	-2.6
Ever had hysterectomy (womb removed)	1.4	1.6	9.5	0.9	3.1	1.1	-0.9	-0.7	1.1	-0.8	-0.4	0.1	-0.9
Systolic blood pressure, automated reading	0.5	1.5	5.2	1.2	1.6	-2.3	-0.1	0.6	-0.1	0.8	0.6	1.9	1.0
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	2.1	-0.1	1.1	1.2	0.3	0.6	0.8	-1.4	0.5	1.2	0.4
Angina	0.4	0.5	2.0	-0.1	0.9	-1.0	-1.4	-0.4	-0.4	-0.2	-0.3	-0.1	-0.8
Medication for hormone replacement therapy	4.1	4.6	11.5	0.0	1.6	3.4	-1.2	-3.0	1.7	-1.0	-2.1	-1.8	-3.1
Vitamin and mineral supplements	0.7	1.0	4.4	-0.9	-2.1	-1.8	-0.1	0.5	0.3	0.5	0.2	0.2	0.7
Supplements: Zinc	0.7	0.8	4.7	1.3	0.4	0.3	2.2	-0.2	-0.6	1.1	-0.1	-0.1	0.3
Medication: Co-codamol	0.6	0.7	2.8	-0.4	1.7	0.3	-0.9	-0.4	0.9	-1.0	-0.5	0.4	-1.0
Medication: Metformin	0.6	0.8	2.8	-0.2	0.3	1.7	0.2	-0.2	-1.2	-1.2	-0.1	-1.4	-0.6
Diabetes (father)	0.6	0.7	1.6	0.6	1.3	-0.4	-0.4	-1.0	1.0	-0.6	-1.0	-0.2	-1.1
Diabetes (mother)	0.7	0.9	6.2	-0.6	2.5	0.9	-0.1	0.5	1.1	0.2	0.7	-0.3	-0.1
Severe depression (siblings)	0.4	0.4	1.0	-0.1	-0.7	-0.9	0.7	0.4	-0.8	1.0	0.5	-0.4	0.7
Pack years adult smoking proportion	2.3	3.5	9.3	-1.8	2.4	3.0	-2.5	-0.6	1.0	-2.4	-0.1	0.1	-1.7
Impedance of leg (right)	0.3	1.6	3.4	1.8	0.8	1.8	0.2	0.9	0.9	1.8	1.7	0.3	0.9
Leg fat-free mass (left)	0.1	0.7	4.6	-1.2	-0.0	-2.1	-0.2	0.3	-0.6	-0.2	0.3	0.6	0.3
Trunk fat percentage	0.4	1.5	5.5	1.4	2.3	1.4	-0.6	-1.0	1.4	0.5	-0.2	-0.8	-1.3
Hand grip strength (right)	0.5	1.3	5.0	-2.2	-0.8	-0.9	-0.9	0.6	-0.8	-0.0	1.1	1.7	0.5
Townsend deprivation index at recruitment	1.6	2.3	11.3	-0.8	1.9	3.4	-1.1	1.0	1.7	-0.8	1.4	-0.4	-0.0
Current tobacco smoking	3.1	5.0	24.6	0.7	2.4	5.0	-1.5	-2.0	0.9	-1.3	-1.2	-0.7	-2.9
Average weekly fortified wine intake	0.7	0.8	5.1	-0.6	-2.3	0.6	-0.1	-0.1	-0.7	-0.2	-0.3	-1.3	0.0
Maternal smoking around birth	5.5	8.0	22.8	-2.2	3.1	3.8	-4.8	-1.2	1.2	-4.1	-0.4	0.5	-2.9
Fed-up feelings	0.2	0.4	1.1	-0.8	0.3	0.6	-1.1	-0.2	-0.0	-0.9	-0.3	-0.4	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.6	11.5	-1.4	0.0	3.4	-2.0	-0.9	0.8	-1.5	-0.4	-1.1	-1.7
Relative age voice broke	1.3	2.0	9.0	-1.1	-0.1	3.0	-2.5	0.1	-0.1	-0.2	0.7	-1.6	-0.7
Taking other prescription medications	0.1	0.2	0.6	-0.2	0.7	0.6	0.5	-0.3	-0.5	-0.5	-0.4	-0.2	-0.5
Age when periods started (menarche)	3.3	7.9	39.5	-2.1	2.0	6.3	-3.8	0.1	1.4	-3.0	1.1	-1.1	-2.0
Bilateral oophorectomy (both ovaries removed)	1.4	1.6	3.7	1.4	0.5	1.1	-0.7	-1.9	-0.8	-0.3	-1.5	-1.7	-1.7
Heel bone mineral density (BMD) T-score, automated (left)	0.9	1.9	7.3	-2.7	-1.5	-0.3	-1.9	0.7	-1.7	-1.4	0.3	0.8	0.3
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	3.3	-0.9	-1.7	-0.9	1.1	0.1	-0.8	-1.1	-0.7	1.8	0.5
Qualifications: CSEs or equivalent	2.4	3.2	16.2	0.2	4.0	0.9	-1.3	0.2	3.4	-0.8	0.4	0.2	-0.5
Serious illness, injury or assault to yourself	0.7	0.9	2.8	0.3	-0.5	-1.1	-0.3	0.8	0.4	1.0	1.0	1.7	1.1
High blood pressure	0.7	1.9	4.9	1.4	1.5	-1.5	2.0	-1.1	-0.4	2.2	-0.8	-0.8	-0.2
Hayfever, allergic rhinitis or eczema	2.1	4.6	12.3	-1.6	1.3	0.5	-1.5	-2.6	-1.5	-2.8	-2.9	-1.3	-3.5
Multivitamins +/- minerals	0.8	1.0	4.5	0.1	1.2	2.1	-0.6	-1.0	-0.4	-0.4	-0.8	-0.0	-1.2
Stomach or abdominal pain in last month	0.7	0.9	2.2	-0.4	-1.5	1.3	-0.5	-0.8	-1.1	-0.6	-0.8	-0.9	-0.8
Supplements: Glucosamine	0.2	0.3	1.2	-0.2	1.0	1.1	0.4	0.3	-0.5	0.6	0.3	-0.1	0.1
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	2.2	-1.1	-0.6	0.7	-0.5	1.5	-0.4	-0.8	1.2	1.3	0.9
Medication: Atenolol	2.1	2.6	8.5	1.2	2.1	-0.2	1.0	-1.8	-0.7	0.7	-1.7	-2.9	-1.8
Medication: Levothyroxine sodium	0.4	0.7	2.0	-0.2	0.8	-1.4	0.2	0.8	0.7	0.9	0.7	1.2	0.8
Sitting height	0.8	5.8	15.5	-1.0	-2.1	-3.9	1.2	2.6	-2.4	0.9	2.0	2.2	3.6
Chronic bronchitis/emphysema (father)	0.3	0.3	2.5	0.4	-0.1	0.3	-0.3	-0.2	-0.2	-0.0	0.2	1.6	-0.1
High blood pressure (mother)	0.6	0.8	3.7	-0.1	-0.2	-1.1	0.4	0.4	-1.9	0.6	-0.1	1.4	0.5
Body mass index (BMI)	0.4	1.5	6.5	-0.8	2.5	0.6	-1.3	-0.9	0.3	-1.4	-0.6	-0.3	-1.6
Impedance of leg (left)	0.3	1.7	4.9	2.2	1.3	1.9	0.5	0.0	1.0	2.1	0.8	-0.4	0.2
Leg predicted mass (left)	0.1	0.7	4.7	-1.2	-0.0	-2.2	-0.0	0.4	-0.5	-0.1	0.4	0.6	0.4
Trunk fat mass	0.2	0.8	5.0	0.7	2.2	0.7	-0.7	-0.4	1.0	0.2	0.3	-0.1	-0.7
Waist circumference	0.4	1.3	3.9	-1.3	1.9	0.6	-2.0	-0.2	-0.2	-1.5	0.2	0.0	-1.0
Number of incorrect matches in round	1.2	2.1	10.0	0.1	2.7	0.4	-1.0	0.5	3.2	-1.1	0.7	-0.1	-0.2
Past tobacco smoking	2.0	3.7	12.9	2.1	-1.5	-3.6	3.3	0.1	-0.5	1.9	-0.7	0.3	1.4
Alcohol usually taken with meals	3.1	5.0	16.9	0.4	-3.4	-2.9	2.5	-0.4	-4.1	2.1	-0.9	0.6	1.1
Nervous feelings	1.3	2.4	7.2	2.3	1.2	-2.7	2.2	-0.3	1.3	1.3	-0.9	0.1	0.6
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	7.2	-1.0	0.1	2.7	-1.9	-0.9	-0.7	-1.8	-1.0	-1.0	-1.5
Hearing difficulty/problems with background noise	1.3	2.1	5.4	1.3	1.1	0.7	0.1	-2.3	1.3	0.8	-1.9	-1.5	-1.9
Hair/balding pattern: Pattern 2	0.4	0.6	3.8	0.1	-1.9	-0.0	-0.3	-0.3	-0.5	-0.4	-0.7	0.7	-0.3
Had menopause	1.4	1.7	4.7	-0.3	1.2	0.4	-0.3	-2.2	0.2	-0.2	-1.8	-1.7	-2.0
Had other major operations	1.6	2.0	8.6	-0.7	-1.4	-2.4	1.2	-0.2	-2.9	0.5	-0.8	-0.7	0.4
Forced vital capacity (FVC)	0.7	2.7	6.9	-2.1	-2.6	-2.1	-1.3	1.4	-1.4	0.6	1.2	0.8	1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	3.8	-2.0	-0.5	-0.6	-1.9	1.2	-1.2	-1.5	0.9	1.7	0.8
Ever unenthusiastic/disinterested for a whole week	1.2	1.4	5.2	0.4	2.3	1.5	-0.8	-0.2	2.2	-0.7	0.2	0.2	-0.6
Qualifications: None of the above	6.4	13.8	39.8	-0.4	6.3	6.1	-4.0	-1.4	4.9	-2.5	0.0	-1.2	-3.4
Financial difficulties in last 2 years	1.1	1.5	6.6	-0.5	0.9	2.6	-1.4	-0.2	0.3	-1.4	-0.0	-1.2	-1.1
Mouth/teeth dental problems	2.5	3.8	9.7	-0.9	-1.2	-3.1	0.4	2.4	-2.0	0.9	2.3	1.7	2.8
Heart attack	1.2	1.5	4.4	1.0	0.4	-1.9	1.3	1.1	0.3	2.1	1.0	0.6	1.2
Allergy	2.2	5.0	12.0	1.9	-0.9	-1.5	1.6	2.6	1.8	3.1	2.8	1.3	3.5
Pain all over the body in last month	0.6	0.6	1.6	-0.9	-0.9	1.1	-0.9	0.0	-0.4	-1.3	-0.3	0.6	-0.5
Diabetes (self-reported)	0.5	0.8	3.3	-1.0	0.4	1.0	0.4	-0.5	-0.5	-1.8	-1.1	-0.3	-0.9
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	7.7	-1.2	1.6	0.2	-0.9	-1.2	0.7	-1.2	-1.2	-2.8	-1.9
Medication: Ramipril	0.4	0.5	2.5	0.7	1.6	-0.2	0.8	0.1	-0.2	0.6	0.1	-1.0	0.0
Medication: Simvastatin	0.8	1.2	5.9	1.1	2.4	0.1	1.2	0.7	1.5	0.3	0.5	-0.1	0.6
Fluid intelligence score	6.2	12.9	37.8	0.0	-6.1	-5.6	3.9	2.1	-3.5	3.3	0.8	2.2	3.5
Illnesses of siblings	1.8	2.5	17.0	-0.4	-4.1	-0.4	0.3	-0.3	-2.6	0.2	-0.5	-0.3	0.3
Neuroticism score	0.4	0.8	4.1	0.2	1.5	-0.9	-0.2	0.4	2.0	0.1	0.2	0.5	0.5
Weight	0.1	0.5	3.5	-0.6	1.9	-0.7	-0.6	0.1	0.1	-0.2	0.5	0.6	-0.1
Impedance of arm (right)	0.3	1.5	5.3	2.3	-0.9	0.4	0.6	0.5	1.2	2.1	0.9	0.6	0.9
Arm fat percentage (right)	0.3	1.1	6.6	0.5	2.6	0.8	-0.9	-0.3	1.4	-0.3	0.3	0.1	-0.8
Trunk fat-free mass	0.5	2.6	6.7	-2.0	0.1	-2.6	-0.0	1.9	-1.2	-0.2	1.7	2.0	1.9
Hip circumference	0.1	0.4	1.7	-0.5	1.3	-0.6	-1.1	-0.0	-0.5	-0.6	0.3	0.2	-0.2
Time employed in main current job	0.6	0.7	2.8	1.7	0.1	-0.6	0.9	-0.7	-0.2	1.4	-0.8	0.1	-0.2
Alcohol intake versus 10 years previously	2.4	3.5	14.4	-0.6	3.8	1.3	-2.8	0.9	2.3	-0.7	1.4	1.4	-0.3
Father’s age at death	0.5	0.7	2.1	1.0	-1.2	-0.4	1.5	-0.2	-0.4	0.6	-0.5	-1.1	0.0
Worrier / anxious feelings	1.7	3.2	10.4	1.9	1.3	-3.2	2.6	0.8	2.0	1.3	0.3	0.4	1.8
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.7	-0.9	0.3	0.1	-0.7	-0.3	0.7	-1.3	-0.4	0.9	-0.5
Falls in the last year	1.0	1.3	3.8	0.0	1.0	1.9	-0.4	-1.1	1.3	-0.2	-0.8	-1.8	-1.3
Hair/balding pattern: Pattern 3	1.1	1.7	7.8	-0.1	-0.5	-2.8	1.9	0.9	-0.3	1.4	0.3	0.1	1.5
Number of live births	1.0	1.4	5.0	-0.1	1.2	-0.1	-1.1	1.5	0.2	-0.3	1.7	2.2	1.0
Forced expiratory volume in 1-second (FEV1)	0.5	1.8	5.2	-1.6	-2.3	-2.3	-1.5	0.3	-1.6	0.3	0.0	0.2	0.4
Pulse rate	0.6	1.0	2.4	0.6	-1.1	-0.2	-0.7	1.1	-0.1	1.6	1.3	0.6	1.4
Happiness	0.3	0.4	1.0	-0.3	-0.0	-0.7	0.2	0.9	-0.4	-0.7	0.7	0.6	1.0
Noisy workplace	1.9	2.4	8.8	1.9	3.0	1.6	0.0	-0.1	2.8	0.9	0.5	0.0	-0.2
Qualifications: A levels/AS levels or equivalent	6.4	14.3	48.6	1.4	-7.0	-5.9	4.3	1.1	-3.7	2.7	-0.5	2.8	2.9
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.1	10.0	1.6	-3.2	-1.6	1.6	0.1	-0.7	1.3	-0.4	0.6	0.9
Mouth/teeth dental problems: Dentures	2.7	4.6	8.0	2.0	2.6	2.4	0.7	-2.1	2.8	2.0	-1.6	-2.4	-2.1
Asthma	0.6	1.2	3.4	-1.2	-0.3	1.5	-1.8	-0.2	-0.8	-1.9	-0.1	-0.0	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	1.0	-0.3	0.4	0.6	-0.2	1.0	-0.4	-0.4	0.8	0.8	0.8
Medication: Cholesterol lowering	0.6	1.0	5.4	1.5	2.3	-0.2	0.6	0.3	1.1	0.2	0.4	-0.3	0.3
Depression (self-reported)	1.6	1.9	8.6	-0.8	1.6	2.9	-1.3	0.4	0.9	-1.9	0.6	0.2	-0.7
Medication: Lansoprazole	0.2	0.2	0.6	-0.7	-0.3	0.3	0.1	-0.6	0.4	-0.5	-0.3	0.2	-0.7
Prospective memory result	1.2	1.4	5.5	-0.3	2.4	1.5	-1.2	-0.9	0.3	-1.1	-0.7	-0.7	-1.4
Lung cancer (father)	2.1	2.4	9.5	-0.5	-0.9	3.1	-2.0	-0.5	-1.2	-2.5	-0.4	-0.3	-1.2
Illnesses of mother	0.9	1.1	5.3	-0.6	-2.3	0.2	0.0	-1.1	0.1	-0.2	-1.5	-1.2	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.5	11.8	-1.8	-3.4	-2.1	-0.6	0.3	-2.1	0.6	-0.2	-0.1	0.5
Pulse wave Arterial Stiffness index	0.6	0.7	2.3	0.7	0.3	0.4	-0.6	0.4	1.5	1.2	1.2	0.4	0.5
Impedance of arm (left)	0.3	1.5	6.0	2.4	-1.7	0.6	0.5	-0.1	0.5	2.1	0.3	-0.5	0.3
Arm fat mass (right)	0.2	1.0	6.7	-0.2	2.6	0.1	-1.0	-0.1	1.0	-0.4	0.6	0.4	-0.5
Trunk predicted mass	0.5	2.6	6.7	-1.9	0.2	-2.6	0.0	1.9	-1.1	-0.2	1.8	2.0	1.9
Standing height	0.4	4.4	9.9	-0.1	-1.2	-3.0	1.4	2.3	-0.5	2.4	2.5	2.1	3.1
Length of working week for main job	0.7	0.8	1.8	-0.5	-1.1	-1.1	0.2	1.3	-0.5	-0.1	0.8	0.6	1.4
Exposure to tobacco smoke at home	0.6	0.6	1.6	1.0	1.3	-0.2	0.4	-0.8	-0.2	0.2	-0.8	-1.0	-1.0
Breastfed as a baby	1.2	1.4	3.7	1.6	-1.3	-0.7	0.8	-1.8	-0.4	0.7	-1.9	-0.1	-1.1
Tense / ‘highly strung’	1.1	1.9	4.4	1.1	1.4	1.6	0.1	-1.4	2.1	-1.2	-1.7	-0.7	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.6	9.7	-1.0	1.0	1.9	-1.9	-1.1	1.3	-3.1	-1.1	-0.3	-1.8
Hair/balding pattern: Pattern 4	0.2	0.5	1.3	-0.2	-0.4	-1.0	-0.0	-1.1	-0.9	-0.1	-1.1	0.5	-0.7
Birth weight of first child	1.1	1.9	5.8	0.1	-0.7	-2.4	1.8	1.2	1.0	0.9	1.1	1.7	1.5
Peak expiratory flow (PEF)	1.4	3.3	12.7	-1.8	-2.1	-2.9	-1.7	0.2	-3.6	-0.8	-0.2	0.8	0.2
Pulse wave reflection index	0.1	0.1	0.4	-0.1	-0.4	0.2	-0.5	0.2	-0.0	0.6	0.4	-0.1	0.1
Ever highly irritable/argumentative for 2 days	1.4	1.7	4.0	-0.7	0.7	2.0	-1.8	-0.9	1.6	-1.5	-0.6	-0.6	-1.6
Loud music exposure frequency	2.1	2.2	4.8	-1.7	2.1	0.8	-1.6	-1.5	1.1	-1.3	-1.3	0.2	-2.2
Qualifications: O levels/GCSEs or equivalent	5.8	9.3	28.8	-0.5	-5.4	-3.2	2.6	3.1	-2.8	1.4	1.7	3.0	3.9
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	3.5	-0.7	0.6	0.5	-1.5	-0.6	1.9	-1.6	-0.6	0.9	-0.7
Blood clot in the leg (DVT)	1.1	1.4	4.7	0.6	0.8	0.8	-0.0	-1.6	-0.5	-0.5	-1.5	-2.2	-1.6
Medication: Paracetamol	1.3	2.1	12.4	-0.3	3.5	-0.4	-0.4	-0.3	2.5	-0.8	-0.4	0.6	-0.7
Headache pain in last month	0.6	1.1	2.4	-0.8	1.5	-1.1	0.0	-1.2	1.1	-0.8	-1.3	0.2	-1.1
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	5.2	-1.0	-2.3	1.3	-0.3	-1.4	-0.2	-0.2	-1.4	-0.9	-1.4
Glaucoma (self-reported)	0.9	1.0	2.6	0.1	1.3	-1.0	1.1	-1.3	1.1	0.4	-1.6	0.3	-0.8
Gout (self-reported)	0.5	0.7	2.9	-0.0	-0.3	0.7	-0.2	-1.0	-1.1	0.3	-0.6	-1.7	-1.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.8	0.5	1.3	-0.7	1.0	-0.1	0.8	0.8	-0.2	0.9	0.0
Medication: Amlodipine	0.3	0.4	2.1	-0.3	1.5	-0.6	0.4	0.4	0.8	-0.4	0.5	0.2	0.5
Medication: Ventolin 100micrograms inhaler	0.5	0.7	3.2	-1.8	-0.3	0.2	0.1	0.1	-0.7	-1.5	0.1	0.7	0.0
Birth weight	0.3	0.6	1.4	-0.5	-0.9	0.6	1.2	-0.5	-0.7	-1.0	-1.0	-0.2	-0.5
Chronic bronchitis/emphysema (mother)	2.5	2.9	11.6	1.4	2.9	1.0	-1.0	-1.0	3.4	-1.6	-0.7	0.5	-1.1
High blood pressure (siblings)	0.6	0.9	7.0	0.1	2.7	0.5	-0.0	0.7	0.8	-0.1	0.6	0.2	0.2
Forced vital capacity (FVC), Best measure	0.9	3.4	14.5	-2.3	-3.8	-2.3	-0.3	1.1	-2.1	1.0	0.6	0.5	1.5
Body fat percentage	0.5	1.9	7.6	1.2	2.8	1.7	-0.8	-1.1	1.5	0.1	-0.2	-0.6	-1.5
Leg fat percentage (right)	0.6	2.2	11.3	0.6	3.4	2.2	-1.0	-0.8	1.0	-0.8	-0.1	-0.2	-1.5
Arm fat-free mass (right)	0.1	0.7	2.5	-1.1	0.9	-1.6	-0.1	0.7	-0.9	-0.2	0.7	0.5	0.6
Exposure to tobacco smoke outside home	2.2	3.0	8.5	0.1	1.7	2.9	-1.9	-1.0	0.0	-2.6	-0.9	-1.5	-2.0
Comparative body size at age 10	0.2	0.6	3.1	-0.2	0.5	1.8	-0.2	-0.4	1.1	-0.7	-0.3	-0.8	-0.7
Number of full brothers	1.5	1.9	4.7	1.9	2.2	0.6	0.8	0.9	2.1	1.2	1.1	1.1	0.9
Worry too long after embarrassment	2.4	4.0	9.0	1.1	0.7	-2.9	2.1	1.0	3.0	3.0	0.9	1.0	2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.7	2.2	4.8	-1.9	0.5	1.4	-1.6	-1.6	-0.1	-2.2	-1.3	-0.3	-1.9
Wheeze or whistling in the chest in last year	2.1	3.7	10.2	-3.2	1.1	2.0	-2.1	-1.4	0.0	-3.0	-1.1	-0.4	-2.1
Number of children fathered	1.8	2.0	6.7	0.5	0.1	-0.1	0.3	-2.5	-0.8	-0.3	-2.6	-1.3	-2.2
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.7	6.1	2.5	0.7	1.0	-0.4	-1.6	1.2	0.9	-1.2	-1.2	-1.3
Age at first live birth	1.4	2.5	11.6	-0.5	-3.4	-2.4	1.4	-0.7	-1.4	0.1	-1.5	-0.4	0.2
Pulse wave peak to peak time	0.5	0.5	2.0	-0.6	-0.4	-0.3	0.7	-0.2	-1.4	-1.1	-1.0	-0.3	-0.2
Health satisfaction	0.6	0.8	4.1	0.3	0.8	0.1	-0.6	0.7	-0.7	-1.0	0.6	2.0	0.6
Shortness of breath walking on level ground	0.7	0.8	2.7	-0.6	1.1	0.2	-1.6	0.5	1.1	-0.8	0.8	1.1	-0.0
Qualifications: College or University degree	4.6	14.5	52.6	-0.4	-6.6	-7.2	4.3	0.2	-3.8	2.6	-1.2	1.2	2.3
Eye problems/disorders: None of the above	0.4	0.5	1.5	-0.2	0.1	0.3	-0.9	1.0	-0.9	0.2	1.2	-0.2	0.7
Mouth/teeth dental problems: Loose teeth	0.9	1.0	4.1	0.1	0.5	2.0	-1.1	-0.9	-0.2	-0.8	-0.8	-0.7	-1.3
Emphysema/chronic bronchitis	0.3	0.4	1.1	-1.1	0.4	0.6	0.2	0.7	0.2	-0.2	0.4	1.1	0.4
Medication for pain relief, constipation, heartburn	0.4	0.7	4.6	-0.2	-2.1	0.4	-1.0	0.5	0.1	-0.2	0.8	0.0	0.4
Neck or shoulder pain in last month	0.4	0.5	3.1	0.3	1.8	1.1	-0.4	0.4	0.2	-0.7	0.5	0.2	-0.2
Medication: Blood pressure	0.3	0.5	2.1	0.2	1.4	-1.2	-0.2	0.7	-0.2	-0.2	0.7	0.7	0.6
Angina (self-reported)	0.3	0.4	1.4	-0.2	0.5	-1.0	-1.2	-0.3	-0.5	-0.1	-0.3	-0.2	-0.7
Migraine (self-reported)	1.4	1.8	7.1	1.0	0.0	-1.8	2.7	-1.2	1.1	0.8	-1.5	-0.6	-0.4
Medication: Ibuprofen	0.3	0.3	1.1	0.2	1.0	-0.4	0.1	0.6	-0.2	0.0	0.5	1.0	0.6
Medication: Allopurinol	0.6	0.7	2.9	-0.9	0.0	1.7	-1.1	-0.0	-1.1	-0.8	0.3	-0.7	-0.6
Medication: Omeprazole	0.2	0.3	1.4	0.3	0.8	1.2	-0.5	-0.0	-0.1	-0.3	0.0	0.4	-0.2
Medication: Seretide 50 evohaler	0.6	0.7	1.7	-0.7	-1.2	1.2	-1.2	0.2	-1.3	-0.3	0.2	-0.5	-0.2
Mean time to correctly identify matches	2.9	5.6	17.2	4.2	2.9	0.5	2.4	-0.9	3.2	3.3	0.0	-1.3	-0.4
Heart disease (mother)	1.2	1.4	4.3	0.4	0.4	-1.9	0.5	1.3	-0.1	0.2	1.4	2.1	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.7	1.8	-0.4	1.0	1.2	-1.2	-0.1	0.5	-1.4	0.1	0.5	-0.4
Whole body fat mass	0.2	1.0	6.6	0.3	2.6	0.7	-0.9	-0.4	1.0	-0.1	0.3	0.1	-0.8
Leg fat mass (right)	0.3	1.3	8.6	0.1	2.9	1.2	-1.0	-0.4	0.9	-0.5	0.3	0.1	-1.0
Arm predicted mass (right)	0.1	0.7	3.0	-1.4	0.7	-1.7	-0.2	0.5	-0.9	-0.4	0.5	0.4	0.5
Pulse rate, automated reading	0.7	2.2	5.9	-0.7	-1.6	-1.5	-0.7	1.5	-2.4	0.1	1.1	2.1	1.6
Alcohol intake frequency.	0.6	1.3	6.2	-0.4	2.2	0.0	-0.5	0.7	2.5	-0.3	1.0	0.4	0.1
Comparative height size at age 10	1.2	6.5	25.3	2.2	-0.4	-5.0	3.5	0.9	-0.3	3.5	0.5	1.6	2.6
Number of full sisters	0.2	0.3	0.8	-0.4	0.8	-0.5	-0.9	0.4	-0.1	-0.3	0.7	0.1	0.0
Suffer from ‘nerves’	1.8	2.8	10.2	3.2	0.6	-0.0	2.2	-1.4	1.8	1.9	-1.6	-1.1	-0.7
Overall health rating	1.1	2.3	9.0	-0.7	3.0	1.3	-1.3	-0.9	0.7	-2.0	-0.5	1.6	-1.5
Chest pain or discomfort	0.9	1.2	3.7	-1.6	-1.4	-0.3	-0.4	0.4	-1.6	-1.9	0.1	0.9	0.3
Had major operations	0.3	0.4	1.6	-0.2	0.4	0.3	-0.9	0.5	-0.5	-1.2	0.3	0.6	0.2
Age at last live birth	0.9	1.3	3.6	-0.0	-1.9	-1.7	1.5	-1.2	-0.1	0.7	-1.6	-0.4	-0.5
Family relationship satisfaction	0.5	0.6	1.5	-1.0	-0.5	-0.6	-1.2	-0.9	-1.0	-0.3	-0.4	0.9	-0.5
Leg pain on walking	1.7	2.1	5.5	-0.8	1.5	0.9	-1.5	-1.7	-0.4	-0.8	-1.1	-2.4	-2.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.0	0.9	0.7	-0.5	0.5	0.2	-0.7	0.8	0.6	1.0	0.7
Commuting to job workplace: Car/motor vehicle	0.5	0.6	2.5	-0.3	1.6	-0.4	-0.1	0.9	0.3	-0.2	1.0	0.8	0.6
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	3.2	0.6	1.7	-0.2	1.8	-0.6	-0.6	0.3	-0.7	-0.6	-0.4
Medication: Aspirin	0.9	1.1	4.5	0.8	0.3	-0.8	1.9	-0.1	-2.1	1.3	-0.2	-0.4	0.3
Supplements: Vitamin C	0.6	0.7	2.9	1.7	1.5	0.6	0.8	-0.7	0.0	0.4	-0.4	-0.4	-0.3
Knee pain experienced in last month	0.5	0.8	1.7	-0.4	1.0	1.3	-0.6	-1.0	-0.5	-0.7	-0.9	-0.9	-1.2
Hypertension (Self-reported)	0.5	1.4	2.9	1.2	1.2	-1.3	1.6	-1.2	-0.4	1.7	-1.0	-0.9	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	2.7	-0.9	-0.9	0.9	-0.2	-0.2	-1.6	-0.3	-0.4	0.4	-0.2
Illnesses of father: Heart disease	3.0	4.1	10.2	-0.1	1.7	-3.2	0.2	2.7	0.2	1.4	2.8	1.5	2.8
Illnesses of siblings: Diabetes	1.3	1.6	7.1	0.7	2.7	0.1	0.7	-0.8	1.9	1.2	-0.3	-1.0	-0.8
Smoking status: Previous	1.4	2.1	6.9	-2.0	0.8	2.4	-2.6	-0.1	0.4	-1.3	0.6	-0.4	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	6.3	-2.5	-1.1	-0.8	-1.6	1.0	-1.0	-0.2	1.1	1.4	0.8
Whole body fat-free mass	0.3	1.5	5.9	-1.7	0.1	-2.4	0.0	1.1	-0.9	-0.2	1.0	1.3	1.1
Leg fat-free mass (right)	0.1	0.7	4.6	-1.3	-0.2	-2.1	0.0	-0.1	-0.7	-0.2	-0.2	0.2	0.0
Arm fat percentage (left)	0.2	1.0	4.3	0.7	2.1	1.1	-0.9	-0.7	0.9	-0.3	-0.1	-0.6	-1.2
Average weekly red wine intake	1.2	1.8	8.7	-0.9	-2.9	-1.8	1.2	-0.1	-1.2	0.9	-0.6	0.9	0.9
Handedness (chirality/laterality): Left-handed	1.3	1.6	6.6	-1.3	-1.1	2.6	-1.1	-0.2	-0.6	-2.0	-0.4	-0.0	-0.7
Mood swings	1.6	2.9	7.2	-1.8	0.8	1.2	-2.6	-1.6	-0.0	-2.7	-1.6	0.5	-2.2
Loneliness, isolation	0.7	1.0	3.2	0.5	0.4	1.8	-1.2	-1.3	0.3	-0.3	-0.9	-0.8	-1.3
Long-standing illness, disability or infirmity	0.6	0.9	1.7	0.6	0.6	-0.2	0.8	1.2	-0.1	1.0	1.2	1.3	1.2
Ever had bowel cancer screening	0.4	0.5	1.1	-1.0	-0.3	-1.1	1.0	0.6	-0.2	-0.4	-0.0	0.7	0.7
Diabetes diagnosed by doctor	0.3	0.5	1.7	-0.6	0.7	1.1	0.4	-0.0	-0.6	-1.3	-0.4	-0.4	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	4.0	-0.2	-0.8	-1.2	0.3	1.4	0.9	0.8	1.5	2.0	1.4
Friendships satisfaction	0.3	0.4	1.1	0.9	-0.9	0.3	0.0	-0.3	0.7	0.5	-0.5	1.0	0.1
Qualifications: nursing, teaching	3.4	5.4	18.8	-0.8	-4.3	-3.2	1.5	1.7	-3.1	0.3	0.6	1.6	2.5
Commuting to job workplace: Walk	0.6	0.7	2.8	1.0	-0.1	1.7	0.9	0.3	-0.0	0.7	0.5	-1.2	0.3
Eye problems/disorders: Cataract	1.0	1.2	2.0	1.3	-0.8	0.6	1.4	-1.4	0.2	1.0	-1.4	-1.3	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	3.4	-0.0	-0.5	1.9	-0.1	0.1	1.4	-1.2	-0.4	0.9	-0.4
Medication for cholesterol	2.1	3.2	10.2	-1.3	-3.2	-1.3	-0.9	1.8	-1.9	-0.8	1.2	2.4	1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.6	3.9	1.8	0.1	0.4	-0.2	-2.0	0.9	1.6	-1.6	-0.4	-1.5
Back pain experienced in last month	0.9	1.4	3.8	-1.2	1.3	1.9	-1.7	-0.6	0.1	-1.3	-0.2	-0.5	-1.3
Mineral and other dietary supplements	1.3	1.7	6.4	-2.1	-0.4	0.3	-2.5	-0.7	0.2	-1.9	-0.3	-0.8	-1.2
Breast cancer (self-reported)	0.3	0.4	1.9	-0.1	0.2	-1.4	-0.2	-0.6	-0.7	-0.0	-0.8	-0.7	-0.4
Asthma (self-reported)	0.5	1.0	2.9	-1.0	-0.6	1.6	-1.7	0.2	-1.0	-1.6	0.3	0.4	-0.2
Osteoporosis (self-reported)	0.7	0.8	2.5	0.3	0.5	-0.9	0.5	1.3	-0.6	0.3	0.8	1.6	1.2
Osteoarthritis (self-reported)	0.8	1.0	2.0	0.8	1.2	0.5	0.6	-1.4	-0.8	0.4	-1.3	-1.1	-1.2
Medication: Aspirin	0.8	1.1	3.5	0.8	0.5	-0.9	1.7	-0.4	-1.9	1.2	-0.6	-0.7	-0.0
Medication: Gliclazide	0.4	0.5	1.4	-0.5	-0.6	1.2	1.1	-0.1	-0.3	0.7	-0.3	-0.8	0.0
Illnesses of father: None of the above (group 1)	1.3	1.7	4.7	0.8	-2.2	1.8	0.7	-1.2	-0.2	0.6	-1.2	-1.8	-0.9
Smoking status: Current	3.4	5.4	27.6	0.5	2.2	5.3	-1.8	-1.9	0.7	-1.5	-1.2	-0.8	-3.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	6.2	-0.9	-2.5	-2.0	-0.4	-0.4	-1.2	-0.3	-1.2	-0.4	-0.3
Whole body water mass	0.3	1.5	6.1	-1.8	0.2	-2.5	-0.1	1.1	-0.9	-0.3	1.0	1.3	1.1
Leg predicted mass (right)	0.1	0.7	5.2	-1.1	-0.2	-2.3	0.1	-0.1	-0.6	-0.0	-0.2	0.2	0.1
Arm fat mass (left)	0.2	0.8	5.0	-0.3	2.2	0.3	-1.1	-0.4	0.6	-0.7	0.2	0.2	-0.9
Number of self-reported non-cancer illnesses	0.8	1.4	6.9	0.8	2.6	0.6	0.7	-1.3	0.5	-0.5	-1.1	-0.6	-1.2
Average weekly champagne plus white wine intake	1.5	2.0	10.4	0.0	-2.4	-1.4	1.0	-0.5	-3.2	0.2	-0.7	-0.2	0.1
Miserableness	0.5	0.8	3.5	-0.6	-1.9	0.1	-0.0	0.9	-0.9	-1.0	0.5	-0.3	1.0
Guilty feelings	1.8	2.7	7.7	0.2	2.3	-2.2	-0.4	1.3	2.8	1.4	1.8	0.8	1.3
Wears glasses or contact lenses	0.2	0.2	1.1	-0.5	0.3	0.3	0.4	-0.3	-0.7	0.1	-0.3	-1.0	-0.1
Ever taken oral contraceptive pill	0.3	0.3	1.6	0.6	-0.5	0.6	0.2	-0.1	-0.5	0.6	-0.0	-1.2	-0.0
Hearing aid user	0.2	0.2	0.7	-0.5	-0.1	0.4	0.2	0.6	-0.0	0.2	0.6	0.9	0.5
Mother’s age at death	1.5	1.9	3.5	0.8	-0.4	-1.7	1.8	1.4	0.2	1.9	1.5	1.1	1.8
Financial situation satisfaction	1.1	1.4	2.7	-0.6	0.7	0.4	-1.4	-1.4	-0.1	-1.6	-1.5	-1.1	-1.6
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.4	0.4	-0.5	0.4	-0.3	0.6	1.2	1.2	0.8	0.7	0.5
Commuting to job workplace: Public transport	1.8	2.1	5.8	0.5	-2.3	-1.3	2.4	0.9	-2.0	1.3	-0.1	-0.4	1.3
Eye problems/disorders: Glaucoma	1.1	1.3	4.8	-0.9	0.1	-0.3	0.3	-2.1	0.3	-0.1	-2.2	-0.6	-1.7
Medication: Blood pressure	0.6	1.2	2.8	1.7	1.3	-0.8	1.2	-0.7	0.2	1.4	-0.5	-1.6	-0.2
Pain type(s) experienced in last month: Hip pain	1.5	1.9	6.4	-1.3	0.2	2.5	-1.2	-0.7	-1.0	-2.1	-0.9	-0.8	-1.3
Supplements: Fish oil (including cod liver oil)	1.2	1.5	6.9	1.7	0.4	-0.3	2.6	1.1	0.1	1.2	0.6	0.7	1.4
High cholesterol (Self-reported)	0.3	0.5	2.4	0.8	1.6	0.6	-0.1	0.2	-0.2	0.1	0.4	-1.2	0.1
Medication: Bendroflumethiazide	3.5	5.3	14.6	3.8	1.7	-2.1	3.1	-1.3	1.2	3.1	-1.2	-2.6	-0.2
Medication: Paracetamol	1.6	2.4	13.8	-0.6	3.7	-0.6	-1.4	-0.3	2.2	-1.1	-0.1	0.9	-0.8
Medication: Lisinopril	1.3	1.7	3.7	0.8	-0.1	-0.0	1.9	1.6	-1.3	0.6	1.4	1.4	1.9
Medication: Atorvastatin	0.9	1.1	2.2	-0.2	-0.1	0.6	-1.2	-1.3	-1.5	0.2	-0.9	-1.3	-1.5
Illnesses of father: High blood pressure	0.7	0.8	2.9	0.4	1.7	-1.4	-0.2	0.4	0.6	-1.1	0.1	1.1	0.4
Alcohol drinker status: Never	3.1	3.7	7.2	1.8	0.9	-2.4	1.0	1.5	2.3	2.7	2.1	1.9	2.0
Ever smoked	0.9	1.6	6.9	-1.5	0.5	2.6	-2.1	0.1	0.6	-0.9	0.6	0.1	-0.7
Basal metabolic rate	0.2	1.0	4.2	-1.4	0.6	-2.0	-0.1	0.8	-0.6	-0.2	0.8	1.1	0.7
Leg fat percentage (left)	0.7	2.7	11.5	0.8	3.4	2.2	-0.9	-1.4	0.9	-0.7	-0.8	-0.8	-2.1
Arm fat-free mass (left)	0.3	1.3	4.6	-1.6	1.4	-2.1	-0.0	0.8	-0.5	-0.2	0.9	1.3	0.8
Number of operations (self-reported)	0.4	0.7	4.7	-0.7	-0.1	-0.6	-0.6	-0.3	-2.2	-0.6	-0.5	-0.1	-0.2
Average weekly beer plus cider intake	2.0	2.9	7.7	-0.0	0.9	1.9	-1.7	-2.2	1.1	-1.0	-1.9	-1.6	-2.8
Irritability	3.8	6.4	12.6	-2.5	0.1	2.3	-2.6	-2.8	-0.0	-3.4	-2.9	-2.2	-3.6
Risk taking	2.1	3.0	7.8	0.7	1.8	2.8	-1.0	-2.1	0.9	-0.9	-1.9	-1.2	-2.6
Ever had prostate specific antigen (PSA) test	0.9	1.1	2.7	0.4	0.7	-1.6	0.8	1.3	-0.9	0.0	0.9	1.1	1.5
Fractured/broken bones in last 5 years	0.3	0.3	1.5	0.3	-0.2	-1.2	-0.1	0.5	-0.5	0.5	0.4	0.1	0.8
Age started oral contraceptive pill	0.3	0.4	0.7	-0.8	0.2	-0.0	0.8	-0.5	0.6	-0.6	-0.8	-0.7	-0.3
Diastolic blood pressure, automated reading	1.0	3.0	14.1	0.7	-0.1	-3.8	-0.3	1.1	-0.0	1.9	0.9	2.5	1.9
Ever depressed for a whole week	1.5	1.8	6.0	-0.1	1.6	0.7	-1.5	-1.4	2.5	-1.2	-1.0	-0.4	-1.6
Unable to work because of sickness or disability	2.3	3.0	8.9	-2.4	0.8	2.4	-2.5	-0.4	0.4	-3.0	-0.1	-0.1	-1.5
Commuting to job workplace: Cycle	0.6	0.7	4.0	2.0	-0.3	-0.9	0.6	-0.8	0.1	0.6	-0.8	-0.6	-0.2
Myopia	1.3	1.9	5.8	0.1	-2.4	-2.0	0.8	1.2	-0.9	0.7	1.0	0.5	2.1
Vascular/heart problems diagnosed by doctor	1.0	2.6	6.7	-2.0	-2.5	1.4	-2.2	1.0	0.2	-2.6	0.6	1.0	0.2
Cholesterol lowering medication	0.5	0.7	4.8	-0.5	2.2	0.8	0.1	0.0	0.9	0.6	0.4	-0.6	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	1.3	0.4	1.1	0.8	0.3	-0.4	0.1	0.1	-0.3	0.2	-0.5
Pain experienced in last month	1.3	2.1	6.5	2.5	-1.5	-1.3	1.2	0.7	-0.4	2.5	0.8	0.3	1.3
Supplements: Calcium	0.5	0.5	1.8	1.4	0.4	-0.1	0.1	-0.9	-0.4	0.5	-0.8	1.0	-0.5
Basal cell carcinoma (self-reported)	0.9	1.1	4.1	-1.4	-1.8	-0.8	-0.8	0.0	-2.0	-0.3	-0.3	-0.7	0.0
Heart attack/myocardial infarction (self-reported)	1.0	1.3	3.4	0.9	0.3	-1.9	0.9	1.1	0.3	1.8	1.0	0.8	1.2
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	4.5	0.4	0.7	0.8	-0.0	-1.4	-0.5	-0.6	-1.3	-2.1	-1.4
Heart disease (siblings)	2.4	3.0	7.1	0.9	1.9	-1.3	0.3	1.7	2.3	1.1	1.9	2.7	1.8
Alcohol drinker status: Previous	2.4	2.7	6.9	-2.4	0.7	1.2	-2.6	-1.3	0.5	-2.5	-1.1	-0.2	-1.9
Pack years of smoking	2.5	3.7	7.8	-2.2	2.2	2.8	-2.8	-0.8	0.7	-2.7	-0.3	0.0	-1.9
Impedance of whole body	0.4	1.9	8.1	2.9	-0.5	1.3	0.8	-0.2	1.0	2.6	0.5	-0.6	0.3
Leg fat mass (left)	0.4	1.6	8.9	0.1	3.0	1.3	-1.0	-0.9	0.7	-0.5	-0.2	-0.4	-1.5
Arm predicted mass (left)	0.3	1.3	4.2	-1.5	1.4	-2.0	0.1	0.9	-0.3	-0.2	1.1	1.3	1.0