Best TWAS P=1.73e-15 · Best GWAS P=1.19e-15 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Thyroid | RP11-425D10.10 | 0.20 | 0.05 | enet | 26 | 0.11 | 5.9e-09 | -2.9 | -5.3 | 1.1e-07 | 0.07 | 1.00 | 0.00 | TRUE |
| 2 | NTR | Blood | SESN1 | 0.03 | 0.04 | lasso | 3 | 0.03 | 5.4e-11 | 7.9 | 7.9 | 2.0e-15 | 1.00 | 0.01 | 0.99 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | AK9 | 0.08 | 0.06 | bslmm | 456 | 0.06 | 5.3e-08 | -3.9 | 5.2 | 2.2e-07 | 0.04 | 1.00 | 0.00 | FALSE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | CCDC162P | 0.10 | 0.04 | bslmm | 398 | 0.07 | 1.1e-09 | 0.3 | -6.0 | 1.5e-09 | -0.52 | 0.89 | 0.07 | FALSE |
| 5 | YFS | Blood | SESN1 | 0.10 | 0.12 | lasso | 15 | 0.12 | 1.4e-36 | 7.9 | 7.9 | 3.1e-15 | 0.99 | 0.01 | 0.99 | FALSE |
| 6 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ARMC2 | 0.04 | 0.05 | lasso | 1 | 0.04 | 3.4e-04 | 7.2 | -7.2 | 8.3e-13 | -0.91 | 0.02 | 0.89 | FALSE |
| 7 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | SESN1 | 0.17 | 0.01 | blup | 45 | 0.02 | 5.5e-02 | 8.0 | -7.0 | 1.8e-12 | -0.81 | 0.01 | 0.50 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SESN1 | 0.02 | 0.04 | lasso | 4 | 0.04 | 1.1e-04 | 8.0 | 8.0 | 1.7e-15 | 1.00 | 0.02 | 0.97 | TRUE |
| 9 | The Cancer Genome Atlas | Rectum Adenocarcinoma | ARMC2 | 0.38 | 0.00 | blup | 88 | 0.08 | 7.2e-03 | 3.2 | -6.5 | 6.3e-11 | -0.67 | 0.01 | 0.21 | FALSE |