TWAS hub - SESN1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0348	0.0121	1.1e-05	0.035	0.018	0.028	0.030	0.033	1.7e-11	9.4e-07	1.9e-09	3.6e-10	5.4e-11
2	YFS	Blood	0.0966	0.0193	0.0e+00	0.120	0.105	0.116	0.117	0.118	3.8e-37	2.3e-32	5.5e-36	2.7e-36	1.4e-36
3	TCGA	Pancreatic Adenocarcinoma	0.1680	0.1050	4.9e-03	0.006	0.018	-0.002	NA	0.010	1.7e-01	5.5e-02	4.1e-01	NA	1.2e-01
4	TCGA	Prostate Adenocarcinoma	0.0247	0.0132	5.9e-04	0.036	0.033	0.033	NA	0.036	9.9e-05	2.1e-04	2.2e-04	NA	1.1e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Birth weight	27.5	59.6	63.4	7.9	7.9	-7.0	8.0
Birth weight of first child	10.7	19.4	23.3	4.2	4.4	-4.8	4.2
Hypothyroidism/myxoedema (self-reported)	10.3	20.2	23.6	4.8	4.7	-3.5	4.9
Father’s age at death	10.1	13.5	14.9	3.9	3.9	-3.1	3.9
Hypothyroidism (self reported)	8.5	19.5	21.8	4.7	4.5	-3.7	4.7
Medication: Levothyroxine sodium	7.4	12.5	14.7	3.8	3.6	-2.8	3.8
Allergy or Eczema	7.3	19.2	22.7	-4.7	-4.7	3.3	-4.8
Bilateral oophorectomy (both ovaries removed)	7.3	8.4	10.4	-3.0	-3.2	2.2	-3.0
Blood Eosinophil Count	6.5	49.8	54.3	-7.3	-7.3	6.2	-7.4
Lung FEV1/FVC ratio	6.5	33.2	40.1	6.3	6.3	-3.7	6.3
Asthma	6.0	11.7	14.9	-3.8	-3.7	1.9	-3.9
Hayfever, allergic rhinitis or eczema	5.7	12.3	15.3	-3.8	-3.9	2.2	-3.8
LDL Cholesterol	5.6	8.9	10.2	-3.1	-3.2	2.4	-3.1
Blood Red Count	5.5	52.8	59.8	7.4	7.7	-6.4	7.4
Allergy	5.5	12.7	16.3	4.0	4.0	-1.4	4.0
Irritable Bowel Disease (IBD)	5.1	12.1	15.2	-3.7	-3.9	2.3	-3.7
Ulcerative Colitis (UC)	5.0	9.4	12.7	-3.4	-3.6	1.5	-3.4
Asthma (self-reported)	5.0	10.0	12.9	-3.5	-3.5	1.5	-3.6
Type 2 Diabetes (T2D) (2012)	4.9	5.7	6.7	2.5	2.6	-2.1	2.3
Ever had hysterectomy (womb removed)	4.9	5.5	6.6	-2.2	-2.3	2.6	-2.3
Medication: Cholesterol lowering	4.9	7.5	9.5	-2.7	-3.1	2.4	-2.8
Wheeze or whistling in the chest in last year	4.9	8.7	10.4	-3.2	-3.2	2.0	-3.2
Respiratory disease	4.4	9.8	12.6	-3.5	-3.3	1.7	-3.6
Medication: Seretide 50 evohaler	4.4	5.1	6.2	-2.5	-2.4	1.3	-2.5
High cholesterol (Self-reported)	4.4	7.8	10.3	-2.9	-3.2	2.2	-2.8
Medication: Atorvastatin	4.1	5.0	6.3	-2.4	-2.5	1.5	-2.4
Shortness of breath walking on level ground	3.8	4.6	5.9	-2.4	-2.4	1.0	-2.4
Pack years adult smoking proportion	3.6	5.4	7.9	2.2	2.0	-2.8	2.2
Neck or shoulder pain in last month	3.6	5.1	6.7	2.0	2.3	-2.6	2.1
Guilty feelings	3.6	5.4	7.3	-2.2	-2.1	2.7	-2.2
Medication: Lisinopril	3.6	4.7	6.2	-2.2	-2.5	1.7	-2.2
Hayfever/allergic rhinitis (self-reported)	3.4	4.5	5.7	-2.2	-2.4	1.5	-2.2
Seen doctor (GP) for nerves, anxiety, tension or depression	3.4	5.2	5.6	2.3	2.2	-2.4	2.3
Current tobacco smoking	3.3	5.3	6.8	2.1	2.3	-2.6	2.2
Tense / ‘highly strung’	3.3	5.5	7.4	2.5	2.7	-1.4	2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.3	3.9	4.1	-2.0	-2.0	1.9	-2.0
Smoking status: Current	3.3	5.2	6.2	2.1	2.3	-2.5	2.2
Illnesses of siblings: Diabetes	3.2	3.9	5.1	-2.3	-2.0	1.3	-2.3
Major Depression (MDD)	3.0	3.6	6.2	1.7	1.6	-2.5	1.7
Medication: Ramipril	3.0	3.9	5.7	-2.1	-2.4	0.9	-2.1
Fractured/broken bones in last 5 years	3.0	3.8	4.7	-2.2	-1.9	1.6	-2.1
Pack years of smoking	3.0	4.5	6.7	2.0	1.8	-2.6	2.0
Length of working week for main job	2.8	3.1	4.0	-1.9	-2.0	1.0	-1.9
Loneliness, isolation	2.8	3.9	4.2	-2.0	-2.0	2.0	-1.9
Mean Putamen Volume	2.7	3.1	3.3	1.8	1.8	-1.7	1.7
Ulcerative Colitis	2.6	3.7	5.2	-2.1	-2.3	0.9	-2.1
Medication: Simvastatin	2.6	3.8	5.1	-1.9	-2.3	1.6	-2.0
Angina (self-reported)	2.6	3.5	3.6	-1.8	-1.8	1.9	-1.9
Mouth/teeth dental problems: Loose teeth	2.5	3.0	4.2	2.0	1.7	-0.9	2.0
Crohns Disease (2017)	2.4	5.3	5.4	-2.2	-2.3	2.3	-2.3
Angina	2.4	3.2	3.3	-1.8	-1.8	1.8	-1.8
Blood clot in the leg (DVT)	2.4	3.1	3.5	-1.9	-1.8	1.6	-1.8
Had major operations	2.4	2.8	3.6	1.9	1.6	-1.3	1.9
Ever had bowel cancer screening	2.4	2.8	3.5	-1.8	-1.9	1.1	-1.8
Cholesterol lowering medication	2.4	3.6	4.5	-1.9	-2.1	1.6	-1.9
Deep venous thrombosis (DVT) (self-reported)	2.4	3.1	3.4	-1.8	-1.7	1.7	-1.8
Medication: Ventolin 100micrograms inhaler	2.3	2.9	4.1	-1.9	-2.0	0.7	-1.9
Number of self-reported non-cancer illnesses	2.3	4.0	5.4	-2.1	-2.3	1.2	-2.1
Reaction Time	2.2	4.1	4.4	2.0	2.1	-2.0	2.0
Chronic bronchitis/emphysema (mother)	2.2	2.6	3.3	-1.8	-1.7	1.0	-1.8
Triglycerides	2.1	3.5	6.0	-1.8	-1.3	2.5	-1.6
Medication for cholesterol	2.1	3.2	4.1	1.8	2.0	-1.5	1.8
Ovarian Cancer	2.0	2.6	3.2	1.6	1.6	-1.8	1.6
HDL Cholesterol	1.8	3.0	4.4	-1.9	-2.0	-0.0	-2.1
Rheumatoid Arthritis	1.8	2.5	3.4	-1.8	-1.8	0.6	-1.7
Hearing difficulty/problems: Yes	1.8	2.7	3.0	1.7	1.7	-1.4	1.7
Heart attack	1.8	2.3	3.3	-1.4	-1.4	1.8	-1.4
Pulse wave reflection index	1.8	2.3	3.8	-1.3	-1.3	2.0	-1.3
Heart attack/myocardial infarction (self-reported)	1.8	2.3	3.0	-1.4	-1.4	1.7	-1.4
Neuroticism (2016)	1.7	2.4	3.3	1.8	1.5	-0.8	1.8
Diabetes (mother)	1.6	2.0	2.8	1.2	1.4	-1.7	1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	2.9	-1.4	-1.7	0.9	-1.4
Illnesses of father: High blood pressure	1.6	2.0	3.1	1.4	1.1	-1.8	1.4
Medication for hormone replacement therapy	1.5	1.6	2.2	-1.4	-1.5	0.7	-1.4
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.9	2.7	1.4	1.6	-0.7	1.4
Qualifications: O levels/GCSEs or equivalent	1.4	2.3	3.7	1.5	1.0	-1.9	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	5.0	0.9	0.8	-2.2	0.9
Alcohol drinker status: Previous	1.4	1.6	1.9	-1.4	-1.4	0.9	-1.4
Height	1.3	24.3	29.1	5.4	5.1	-3.7	5.4
Age when periods started (menarche)	1.3	3.0	3.9	2.0	2.0	-0.8	1.9
Diverticular disease/diverticulitis (self-reported)	1.3	1.6	1.8	-1.3	-1.3	1.1	-1.3
Alzheimer’s Disease (in father)	1.2	1.3	1.8	-1.2	-1.4	-0.6	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	3.2	1.5	1.4	-1.8	1.6
Average weekly fortified wine intake	1.1	1.3	1.7	1.3	1.1	-0.6	1.3
Mouth/teeth dental problems: Dentures	1.1	1.8	2.6	1.6	1.4	-0.4	1.6
Chest pain or discomfort	1.1	1.6	2.5	-1.4	-1.6	0.4	-1.4
Average weekly beer plus cider intake	1.1	1.6	2.0	1.4	1.3	-0.9	1.4
Unable to work because of sickness or disability	1.1	1.5	3.5	0.8	1.0	-1.9	0.9
Hand grip strength (left)	1.0	2.6	4.1	1.5	1.3	-2.0	1.6
Ever highly irritable/argumentative for 2 days	1.0	1.2	1.7	1.0	1.0	-1.3	1.0
Glaucoma (self-reported)	1.0	1.2	1.3	-1.1	-1.0	1.1	-1.1
Hearing aid user	1.0	1.1	1.4	1.2	1.2	-0.8	1.1
Alzheimer’s Disease (in mother)	0.9	1.0	2.3	0.8	0.9	-1.5	0.8
Blood Platelet Count	0.9	11.0	19.7	-2.9	-2.7	4.4	-2.9
Hand grip strength (right)	0.9	2.4	4.1	1.4	1.2	-2.0	1.5
Serious illness, injury or assault to yourself	0.9	1.1	1.6	-1.2	-1.2	-0.3	-1.2
Pulse rate	0.9	1.6	2.1	1.1	1.3	-1.5	1.1
Medication: Lansoprazole	0.9	1.0	2.3	-0.7	-0.7	1.5	-0.8
Hair/balding pattern: Pattern 4	0.9	2.2	5.6	1.1	1.0	-2.4	1.1
Headache pain in last month	0.9	1.6	1.8	-1.2	-1.3	1.3	-1.2
Medication: Allopurinol	0.9	1.2	1.5	-1.2	-1.2	0.8	-1.2
Supplements: Vitamin C	0.9	1.1	1.6	1.2	1.2	-0.3	1.1
Financial situation satisfaction	0.9	1.1	1.4	1.2	1.1	-0.7	1.2
Intelligence (Savage-Jansen 2018)	0.8	2.4	3.2	1.6	1.2	-1.8	1.5
Relative age voice broke	0.8	1.3	1.8	1.2	1.3	-0.8	1.1
Hair/balding pattern: Pattern 2	0.8	1.0	1.3	1.0	1.0	-1.1	1.0
Medication: Paracetamol	0.8	1.3	1.8	1.3	1.3	0.3	1.3
Emphysema/chronic bronchitis	0.8	0.9	2.0	0.8	0.6	-1.4	0.8
Diabetes diagnosed by doctor	0.8	1.3	1.6	-1.0	-1.3	1.2	-1.1
Osteoarthritis (self-reported)	0.8	1.0	1.5	-1.0	-0.8	1.2	-0.9
Medication: Gliclazide	0.8	0.9	2.7	0.6	0.3	-1.6	0.5
Supplements: Calcium	0.8	0.9	1.9	0.8	0.6	-1.4	0.8
Worry (Nagel 2018)	0.7	1.4	2.2	1.3	1.5	-0.5	1.2
HbA1C	0.7	0.7	1.5	-0.8	-1.2	0.3	-0.8
Lung FVC	0.7	3.7	4.9	-2.2	-2.2	0.8	-2.2
Stomach or abdominal pain in last month	0.7	0.9	1.1	-1.0	-1.1	0.9	-0.9
High blood pressure (mother)	0.7	1.0	1.5	-1.2	-1.2	-0.2	-1.2
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	2.4	1.6	1.4	-1.5	1.6
Number of full sisters	0.7	0.9	1.2	1.1	1.0	0.2	1.1
Medication: Blood pressure	0.7	1.4	2.2	-1.2	-1.5	0.7	-1.3
Medication: Bendroflumethiazide	0.7	1.0	1.2	-0.9	-1.1	1.0	-1.0
Alcohol drinker status: Never	0.7	0.8	1.0	0.8	1.0	-0.9	0.9
Smoking Status	0.6	1.4	2.0	1.1	1.1	-1.4	1.1
Noisy workplace	0.6	0.8	1.1	0.9	1.1	-0.2	1.0
Standing height	0.6	5.6	6.9	2.6	2.5	-1.6	2.6
Breast cancer (self-reported)	0.6	0.7	1.6	0.6	0.8	-1.3	0.6
Wears glasses or contact lenses	0.6	0.7	1.9	0.6	0.4	-1.4	0.5
Bipolar Disorder or Schizophrenia	0.5	1.1	2.4	-0.9	-0.8	-1.5	-0.9
Blood White Count	0.5	3.5	6.4	-1.6	-1.5	2.5	-1.6
Type 2 Diabetes (T2D) (2018)	0.5	1.0	1.3	-0.8	-1.0	1.1	-0.9
Medication: Metformin	0.5	0.7	1.2	-0.7	-1.1	0.5	-0.9
Impedance of leg (right)	0.5	2.6	3.4	1.6	1.8	-1.5	1.5
Taking other prescription medications	0.5	0.8	1.2	-1.0	-1.1	0.4	-1.0
Falls in the last year	0.5	0.7	1.0	-1.0	-1.0	0.3	-1.0
Hair/balding pattern: Pattern 3	0.5	0.8	1.1	1.1	0.9	-0.2	1.0
Gout (self-reported)	0.5	0.7	1.1	-0.9	-1.0	0.0	-0.9
Suffer from ‘nerves’	0.5	0.7	1.7	-0.7	-0.5	1.3	-0.7
Family relationship satisfaction	0.5	0.6	1.0	-0.8	-1.0	0.3	-0.8
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.8	0.3	0.5	1.4	0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	0.8	-0.8	-0.9	0.3	-0.8
Medication: Aspirin	0.5	0.7	1.2	-0.8	-1.1	0.6	-0.8
Average weekly champagne plus white wine intake	0.5	0.7	1.9	0.6	0.4	-1.4	0.6
Myopia	0.5	0.8	1.3	-0.9	-1.1	0.5	-0.8
Schizophrenia (2018)	0.4	0.7	1.9	-0.7	-0.4	-1.4	-0.7
Alzheimer’s Disease (including proxy)	0.4	0.6	2.2	0.0	0.3	-1.5	0.2
Coronary Artery Disease (CAD)	0.4	0.5	1.2	0.3	0.6	-1.1	0.5
Schizophrenia (2014)	0.4	0.8	0.9	-1.0	-0.8	-0.9	-1.0
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.5	0.5	0.0	-1.2	0.4
Nervous feelings	0.4	0.7	1.0	0.8	1.0	-0.6	0.8
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.3	0.5	0.5	-1.1	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	2.0	-0.2	-0.1	1.4	-0.3
Depression (self-reported)	0.4	0.5	0.8	0.7	0.9	-0.2	0.7
Impedance of arm (left)	0.4	1.9	5.0	0.8	1.1	-2.2	0.8
Breastfed as a baby	0.4	0.5	0.5	0.7	0.7	-0.7	0.7
Comparative body size at age 10	0.4	1.0	1.2	1.0	0.9	-1.0	1.1
Health satisfaction	0.4	0.5	0.7	-0.7	-0.8	-0.7	-0.7
Mean time to correctly identify matches	0.4	0.7	0.9	0.9	0.9	-0.5	0.9
Pulse rate, automated reading	0.4	1.4	1.6	1.1	1.2	-1.3	1.1
Osteoporosis (self-reported)	0.4	0.5	0.9	0.6	0.5	-0.9	0.6
Illnesses of father: None of the above (group 1)	0.4	0.5	1.4	0.5	0.6	1.2	0.4
Supplements: Fish oil (including cod liver oil)	0.4	0.5	0.8	0.9	0.7	-0.1	0.8
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	1.1	-0.6	-0.6	1.0	-0.5
Bipolar Disorder (2018)	0.3	0.5	0.7	-0.5	-0.8	-0.7	-0.6
Fasting Glucose	0.3	0.4	0.5	0.7	0.3	-0.6	0.7
Lupus	0.3	0.5	1.8	0.1	0.1	-1.3	0.1
Severe depression (siblings)	0.3	0.3	0.5	0.7	0.5	-0.1	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	0.8	0.9	0.8	-0.3	0.9
Medication: Atenolol	0.3	0.4	1.1	-0.4	-0.5	1.1	-0.5
Impedance of leg (left)	0.3	1.7	2.3	1.2	1.5	-1.2	1.2
Number of incorrect matches in round	0.3	0.4	1.5	0.2	0.3	1.2	0.1
Qualifications: None of the above	0.3	0.7	1.1	0.9	1.1	0.1	0.9
Financial difficulties in last 2 years	0.3	0.3	0.6	-0.6	-0.8	0.3	-0.6
Mouth/teeth dental problems	0.3	0.5	0.8	-0.9	-0.5	-0.5	-0.9
Impedance of arm (right)	0.3	1.2	3.2	0.5	1.0	-1.8	0.5
Arm fat percentage (right)	0.3	1.2	1.5	-1.2	-1.2	0.5	-1.2
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	0.8	-0.7	-0.9	0.1	-0.6
Age at first live birth	0.3	0.5	0.7	0.8	0.5	-0.6	0.8
Qualifications: College or University degree	0.3	1.0	1.6	-1.1	-1.3	-0.0	-1.1
Medication: Ibuprofen	0.3	0.4	1.4	0.0	0.1	1.2	0.0
Medication: Aspirin	0.3	0.4	0.8	-0.6	-0.9	0.4	-0.6
Illnesses of father: Heart disease	0.3	0.4	0.5	-0.6	-0.7	0.7	-0.6
Arm fat percentage (left)	0.3	1.2	1.7	-1.3	-1.3	0.4	-1.2
Qualifications: nursing, teaching	0.3	0.4	0.5	-0.7	-0.6	-0.6	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	0.9	0.7	0.7	-0.9	0.7
Number of operations (self-reported)	0.3	0.5	0.6	0.7	0.5	-0.8	0.7
Risk taking	0.3	0.5	0.8	-0.9	-0.6	0.5	-0.8
Age started oral contraceptive pill	0.3	0.4	0.7	0.5	0.5	0.9	0.5
Pain experienced in last month	0.3	0.5	0.7	-0.8	-0.8	0.3	-0.8
Basal cell carcinoma (self-reported)	0.3	0.4	0.7	-0.5	-0.6	0.8	-0.5
Heart disease (siblings)	0.3	0.4	1.3	0.4	0.4	-1.1	0.3
Impedance of whole body	0.3	1.7	3.7	0.9	1.3	-1.9	0.9
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.6	0.6	0.2	-1.2	0.5
Bipolar Disorder (2011)	0.2	0.2	0.2	-0.4	-0.4	-0.4	-0.4
Body Mass Index (BMI) (2010)	0.2	0.2	0.5	0.5	0.7	-0.1	0.5
Waist Hip Ratio (WHR)	0.2	0.9	2.9	0.5	0.5	1.7	0.5
Number of treatments/medications taken	0.2	0.4	0.6	-0.7	-0.8	0.5	-0.7
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.4	-0.5	-0.5	0.6	-0.6
Chronic bronchitis/emphysema (father)	0.2	0.3	0.4	-0.6	-0.5	0.0	-0.6
Body mass index (BMI)	0.2	1.0	1.3	-0.9	-1.2	0.9	-0.9
Forced vital capacity (FVC)	0.2	0.8	2.0	0.7	0.6	-1.4	0.7
Fluid intelligence score	0.2	0.5	0.8	0.7	0.4	-0.9	0.6
Illnesses of siblings	0.2	0.3	0.6	0.5	0.8	-0.1	0.5
Number of live births	0.2	0.3	0.4	0.6	0.7	0.2	0.5
Qualifications: A levels/AS levels or equivalent	0.2	0.5	0.8	-0.4	-0.9	-0.9	-0.5
Prospective memory result	0.2	0.2	0.7	0.4	0.2	0.9	0.3
Illnesses of mother	0.2	0.3	0.4	0.5	0.5	0.7	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	0.7	0.8	0.6	-0.6	0.8
Pulse wave Arterial Stiffness index	0.2	0.2	0.6	0.4	0.4	0.8	0.3
Arm fat mass (right)	0.2	0.9	1.3	-1.0	-1.1	0.8	-0.9
Exposure to tobacco smoke at home	0.2	0.2	0.3	0.5	0.5	-0.3	0.5
High blood pressure (siblings)	0.2	0.3	0.4	0.6	0.3	-0.3	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.7	0.2	0.3	0.8	0.3
Pulse wave peak to peak time	0.2	0.2	0.9	-0.1	-0.1	-1.0	-0.1
Medication for pain relief, constipation, heartburn	0.2	0.4	1.6	0.1	0.2	-1.3	0.1
Overall health rating	0.2	0.4	0.7	-0.6	-0.8	0.3	-0.6
Knee pain experienced in last month	0.2	0.3	0.4	0.6	0.6	0.1	0.6
Commuting to job workplace: Walk	0.2	0.2	0.3	0.6	0.5	-0.3	0.4
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.2	-0.2	-0.2	1.1	-0.2
Mineral and other dietary supplements	0.2	0.3	0.5	-0.7	-0.5	0.3	-0.6
Arm fat mass (left)	0.2	0.6	0.9	-0.8	-1.0	0.5	-0.8
Mother’s age at death	0.2	0.3	0.4	0.6	0.5	-0.4	0.6
Medication: Paracetamol	0.2	0.4	1.2	0.3	0.4	1.1	0.3
Depressed Affect (Nagel 2018)	0.1	0.1	0.3	-0.2	-0.3	0.5	-0.2
Schizophrenia vs Biploar Disorder	0.1	0.1	0.4	-0.2	-0.0	0.6	-0.2
Breast Cancer	0.1	0.1	0.2	0.4	0.4	-0.2	0.4
Age at First Birth	0.1	0.1	0.3	-0.1	-0.5	-0.5	-0.1
Heel T-Score	0.1	0.9	1.4	0.9	1.2	-0.7	0.9
Systolic Blood Pressure	0.1	0.6	1.5	0.6	0.5	-1.2	0.6
Neuroticism	0.1	0.2	0.2	0.4	0.5	0.2	0.5
Average weekly spirits intake	0.1	0.1	0.2	0.4	0.5	0.0	0.5
Sensitivity / hurt feelings	0.1	0.1	0.2	0.4	0.5	0.2	0.4
Relative age of first facial hair	0.1	0.2	0.4	0.2	0.4	-0.6	0.2
Supplements: Zinc	0.1	0.1	0.2	0.4	0.4	-0.4	0.4
Diabetes (father)	0.1	0.2	0.5	0.3	0.1	-0.7	0.3
Townsend deprivation index at recruitment	0.1	0.1	0.1	0.2	0.4	0.3	0.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.5	-0.0	-0.2	0.7	-0.1
High blood pressure	0.1	0.3	0.4	0.6	0.5	-0.4	0.6
Multivitamins +/- minerals	0.1	0.1	0.4	-0.1	-0.2	0.6	-0.1
Waist circumference	0.1	0.3	1.0	-0.0	-0.3	1.0	-0.0
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.2	-0.2	0.1	-0.5	-0.2
Hearing difficulty/problems with background noise	0.1	0.1	0.4	0.1	-0.2	-0.6	0.0
Had menopause	0.1	0.1	0.2	0.4	0.3	-0.2	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.4	0.6	0.5	-0.4	0.6
Pain all over the body in last month	0.1	0.1	0.1	0.4	0.3	-0.3	0.4
Neuroticism score	0.1	0.1	0.2	0.4	0.5	0.3	0.4
Time employed in main current job	0.1	0.1	0.1	0.3	0.1	0.4	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.2	-0.3	-0.4	-0.5	-0.2
Peak expiratory flow (PEF)	0.1	0.2	0.8	0.3	0.1	-0.9	0.3
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.3	0.3	0.6	-0.4	0.3
Body fat percentage	0.1	0.2	0.3	-0.5	-0.5	0.0	-0.5
Arm fat-free mass (right)	0.1	0.4	1.2	-0.1	-0.5	1.1	-0.1
Exposure to tobacco smoke outside home	0.1	0.2	0.2	0.5	0.5	-0.3	0.5
Worry too long after embarrassment	0.1	0.2	0.2	-0.4	-0.4	0.3	-0.5
Number of children fathered	0.1	0.1	0.1	0.3	0.2	-0.4	0.3
Eye problems/disorders: None of the above	0.1	0.1	0.2	0.3	0.4	0.1	0.4
Migraine (self-reported)	0.1	0.1	0.1	0.4	0.3	-0.2	0.4
Medication: Omeprazole	0.1	0.1	0.3	0.1	0.1	0.6	0.1
Arm predicted mass (right)	0.1	0.4	1.2	-0.2	-0.6	1.1	-0.1
Alcohol intake frequency.	0.1	0.1	0.2	-0.5	-0.3	-0.3	-0.4
Age at last live birth	0.1	0.1	0.1	-0.2	-0.3	0.3	-0.3
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.4	0.2	0.2	0.7	0.2
Smoking status: Previous	0.1	0.1	0.2	-0.2	-0.4	0.3	-0.3
Average weekly red wine intake	0.1	0.2	0.7	0.2	0.2	0.8	0.1
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.3	0.0	0.3	0.5	0.1
Friendships satisfaction	0.1	0.1	0.2	-0.1	-0.3	-0.4	-0.2
Eye problems/disorders: Cataract	0.1	0.1	0.2	-0.5	-0.2	0.2	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.2	0.5	0.4	0.2	0.4
Miserableness	0.1	0.2	0.3	-0.3	-0.4	0.6	-0.3
Ever smoked	0.1	0.1	0.2	-0.4	-0.4	0.1	-0.4
Arm fat-free mass (left)	0.1	0.4	1.3	0.0	-0.3	1.1	0.0
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.5	-0.1	-0.2	-0.7	-0.2
Diastolic blood pressure, automated reading	0.1	0.2	0.3	-0.5	-0.5	-0.3	-0.5
Arm predicted mass (left)	0.1	0.7	2.2	-0.4	-0.7	1.5	-0.3
Depression (Nagel 2018)	0.0	0.0	0.1	0.0	-0.1	0.2	-0.0
Neuroticism (Nagel 2018)	0.0	0.1	0.4	0.1	0.1	0.6	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.1	0.1	-0.2	-0.2	0.3	-0.2
Primary Biliary Cirrhosis	0.0	0.0	0.1	0.1	-0.1	-0.3	0.1
BMI	0.0	0.3	0.6	-0.4	-0.8	0.4	-0.4
Cardiovascular Disease	0.0	0.1	0.1	-0.2	-0.4	-0.3	-0.2
Chronotype (morning person)	0.0	0.1	0.2	-0.4	-0.3	-0.1	-0.4
Hair Pigment	0.0	0.3	0.7	0.5	0.8	0.0	0.6
Tanning	0.0	0.4	0.5	0.6	0.5	-0.7	0.6
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.0	-0.0	-0.1	-0.1	0.0
Systolic blood pressure, automated reading	0.0	0.0	0.0	0.1	0.1	-0.1	0.1
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.1	-0.1	-0.3	-0.3	-0.1
Vitamin and mineral supplements	0.0	0.0	0.1	-0.0	-0.1	-0.3	0.0
Medication: Co-codamol	0.0	0.0	0.0	0.1	-0.0	0.0	0.1
Leg fat-free mass (left)	0.0	0.0	0.0	0.1	-0.2	0.1	0.2
Trunk fat percentage	0.0	0.1	0.2	-0.4	-0.4	-0.2	-0.4
Maternal smoking around birth	0.0	0.0	0.1	0.1	0.1	-0.1	0.3
Fed-up feelings	0.0	0.1	0.3	0.1	-0.0	0.5	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.1	0.3	0.2	-0.1	0.2
Qualifications: CSEs or equivalent	0.0	0.1	0.2	0.1	0.4	0.1	0.2
Supplements: Glucosamine	0.0	0.0	0.0	0.1	0.1	0.1	0.2
Sitting height	0.0	0.2	0.2	0.5	0.4	0.2	0.5
Leg predicted mass (left)	0.0	0.0	0.0	0.2	-0.2	0.0	0.2
Trunk fat mass	0.0	0.0	0.0	-0.0	-0.1	-0.2	0.0
Past tobacco smoking	0.0	0.0	0.0	-0.2	-0.1	0.2	-0.1
Alcohol usually taken with meals	0.0	0.0	0.0	-0.2	-0.1	0.1	-0.1
Had other major operations	0.0	0.1	0.1	-0.3	-0.3	0.1	-0.2
Diabetes (self-reported)	0.0	0.1	0.1	-0.0	-0.4	0.4	-0.1
Weight	0.0	0.0	0.1	0.2	-0.1	0.1	0.3
Trunk fat-free mass	0.0	0.2	0.7	0.3	-0.1	0.9	0.4
Hip circumference	0.0	0.0	0.1	-0.0	-0.3	-0.1	0.0
Alcohol intake versus 10 years previously	0.0	0.0	0.0	0.1	0.1	0.2	0.2
Worrier / anxious feelings	0.0	0.1	0.3	-0.1	-0.1	0.6	-0.2
Happiness	0.0	0.0	0.1	-0.1	-0.3	0.1	-0.1
Lung cancer (father)	0.0	0.0	0.1	-0.0	0.0	-0.3	-0.0
Trunk predicted mass	0.0	0.2	0.7	0.3	-0.1	0.8	0.4
Loud music exposure frequency	0.0	0.1	0.1	0.2	-0.0	0.4	0.2
Mouth/teeth dental problems: Bleeding gums	0.0	0.0	0.1	0.1	-0.3	0.2	0.1
Medication: Amlodipine	0.0	0.1	0.1	0.2	0.3	-0.3	0.2
Forced vital capacity (FVC), Best measure	0.0	0.0	0.0	-0.1	-0.2	-0.2	-0.1
Leg fat percentage (right)	0.0	0.0	0.0	-0.0	-0.1	-0.1	-0.0
Number of full brothers	0.0	0.0	0.1	0.1	0.2	-0.3	0.1
Medication: Blood pressure	0.0	0.1	0.1	0.4	0.3	0.1	0.4
Heart disease (mother)	0.0	0.0	0.0	0.1	0.2	-0.1	0.2
Whole body fat mass	0.0	0.0	0.0	-0.0	-0.1	-0.1	0.0
Leg fat mass (right)	0.0	0.0	0.0	0.0	-0.2	0.1	0.0
Comparative height size at age 10	0.0	0.1	0.5	0.0	-0.0	0.7	0.1
Leg pain on walking	0.0	0.1	0.2	-0.2	-0.1	-0.4	-0.1
Hypertension (Self-reported)	0.0	0.1	0.2	0.5	0.3	-0.1	0.4
Whole body fat-free mass	0.0	0.2	0.6	0.1	-0.4	0.7	0.1
Leg fat-free mass (right)	0.0	0.1	0.2	-0.1	-0.5	0.3	-0.1
Mood swings	0.0	0.1	0.2	0.1	0.2	-0.4	0.2
Long-standing illness, disability or infirmity	0.0	0.1	0.2	0.1	-0.2	-0.5	0.0
Back pain experienced in last month	0.0	0.1	0.1	0.3	0.0	0.2	0.4
Whole body water mass	0.0	0.2	0.7	-0.1	-0.5	0.8	-0.0
Leg predicted mass (right)	0.0	0.1	0.2	-0.1	-0.5	0.3	-0.1
Ever taken oral contraceptive pill	0.0	0.0	0.1	0.1	0.2	0.3	0.2
Tinnitus: Yes, now most or all of the time	0.0	0.0	0.0	0.1	0.2	0.2	0.1
Commuting to job workplace: Public transport	0.0	0.0	0.0	0.1	-0.1	0.2	0.0
Eye problems/disorders: Glaucoma	0.0	0.0	0.1	0.2	0.2	-0.1	0.1
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.0	0.2	0.0	-0.2	0.2
Basal metabolic rate	0.0	0.1	0.4	0.1	-0.3	0.6	0.1
Leg fat percentage (left)	0.0	0.1	0.2	-0.3	-0.4	0.1	-0.3
Irritability	0.0	0.0	0.1	0.2	0.3	0.1	0.2
Ever depressed for a whole week	0.0	0.0	0.0	-0.0	-0.1	0.1	-0.0
Commuting to job workplace: Cycle	0.0	0.0	0.1	0.3	0.2	-0.0	0.2
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.1	-0.3	-0.1	0.1	-0.3
Leg fat mass (left)	0.0	0.1	0.1	-0.2	-0.4	0.3	-0.2

Hub : Genes

SESN1

Models

Trait associations