Best TWAS P=1.04e-09 · Best GWAS P=2.94e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | PLEKHA1 | 0.14 | 0.06 | lasso | 2 | 0.03 | 2.4e-03 | 5.9 | -5.8 | 8.3e-09 | -0.99 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Nerve Tibial | PLEKHA1 | 0.22 | 0.23 | enet | 17 | 0.19 | 1.1e-13 | 5.9 | -6.1 | 1.0e-09 | -0.97 | 0.01 | 0.99 | TRUE |
| 3 | METSIM | Adipose | PLEKHA1 | 0.05 | 0.03 | lasso | 4 | 0.04 | 3.6e-07 | 5.9 | -5.2 | 1.6e-07 | -0.86 | 0.01 | 0.99 | FALSE |
| 4 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PLEKHA1 | 0.04 | 0.05 | lasso | 2 | 0.04 | 4.3e-05 | 5.9 | -5.9 | 3.8e-09 | -0.99 | 0.01 | 0.99 | FALSE |
| 5 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | PLEKHA1 | 0.08 | 0.06 | blup | 103 | 0.02 | 4.0e-02 | 5.9 | -5.6 | 2.5e-08 | -0.93 | 0.01 | 0.89 | FALSE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | PLEKHA1 | 0.08 | 0.10 | lasso | 1 | 0.09 | 3.5e-09 | 5.9 | -5.9 | 4.8e-09 | -0.99 | 0.01 | 0.99 | FALSE |