TWAS
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Models
Genes
Traits
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Traits
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Birth weight
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chr11:1,242,690-2,640,824
Best TWAS P=2.58e-10 · Best GWAS P=1.41e-12 conditioned to 0.116
1.2M
1.4M
1.6M
1.8M
2M
2.2M
2.4M
2.6M
0
2
4
6
8
10
12
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
The Cancer Genome Atlas
Brain Lower Grade Glioma
IGF2
0.06
0.00
blup
58
0.01
2.7e-02
6.53
6.3
2.6e-10
0.72
0.01
0.57
TRUE
1
GTEx
Artery Aorta
TNNT3
0.21
-0.01
enet
17
0.00
6.4e-01
-0.38
5.9
2.9e-09
0.16
0.03
0.30
TRUE
2
The Cancer Genome Atlas
Brain Lower Grade Glioma
C11orf21
0.08
0.05
blup
65
0.06
6.0e-07
-2.33
-5.2
2.5e-07
-0.10
0.91
0.04
TRUE
4
The Cancer Genome Atlas
Thyroid Carcinoma
TSPAN32
0.05
0.00
blup
69
0.02
8.5e-03
-3.74
-5.2
2.6e-07
-0.10
0.02
0.11
FALSE