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chr15:90,712,555-92,135,418

Best TWAS P=5.95e-10 · Best GWAS P=3.2e-08 conditioned to 0.851

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	FURIN	0.12	0.14	lasso	2	0.13	1.2e-15	5.2	-5.1	2.8e-07	0.83	0.02	0.98	FALSE
2	GTEx	Cells Transformed fibroblasts	FES	0.28	0.17	enet	21	0.20	2.8e-15	-5.1	6.2	6.0e-10	-0.91	0.01	0.99	TRUE
3	YFS	Blood	FES	0.31	0.11	enet	77	0.22	1.2e-68	-5.1	5.6	2.0e-08	-0.69	0.02	0.98	FALSE
4	YFS	Blood	FURIN	0.11	0.03	enet	37	0.06	8.3e-19	5.2	5.7	1.0e-08	-0.67	0.01	0.99	FALSE
5	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FES	0.06	0.05	blup	46	0.06	1.9e-05	-5.5	5.5	3.9e-08	-0.83	0.00	0.99	FALSE
6	The Cancer Genome Atlas	Breast Invasive Carcinoma	FES	0.06	0.05	blup	46	0.07	7.4e-14	-5.1	6.1	9.2e-10	-0.90	0.01	0.99	FALSE
7	The Cancer Genome Atlas	Glioblastoma Multiforme	FES	0.12	0.06	enet	6	0.06	5.7e-03	-5.4	5.2	1.6e-07	-0.95	0.00	0.92	FALSE
8	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FES	0.06	0.03	blup	46	0.05	5.6e-06	-5.4	5.8	7.7e-09	-0.82	0.01	0.99	FALSE
9	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FES	0.10	0.07	enet	5	0.05	2.8e-06	-5.5	5.6	2.5e-08	-0.99	0.00	1.00	FALSE
10	The Cancer Genome Atlas	Lung Adenocarcinoma	FES	0.05	0.04	lasso	2	0.04	2.2e-05	-5.1	5.6	1.6e-08	-0.90	0.01	0.99	FALSE
11	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FES	0.08	0.07	enet	7	0.08	4.2e-09	-5.1	5.3	1.4e-07	-0.82	0.03	0.97	FALSE
12	The Cancer Genome Atlas	Prostate Adenocarcinoma	FES	0.12	0.09	lasso	5	0.08	4.1e-09	-5.1	5.4	5.7e-08	-0.81	0.02	0.97	FALSE
13	The Cancer Genome Atlas	Stomach Adenocarcinoma	FES	0.04	0.01	blup	46	0.02	1.7e-02	-5.5	5.7	1.3e-08	-0.78	0.01	0.69	FALSE
14	The Cancer Genome Atlas	Thyroid Carcinoma	FES	0.30	0.30	lasso	7	0.32	1.3e-31	-4.7	5.4	6.0e-08	-0.85	0.05	0.95	FALSE