Best TWAS P=1.45e-09 · Best GWAS P=4.09e-08 conditioned to 0.639
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | RFT1 | 0.21 | 0.22 | lasso | 3 | 0.22 | 5.7e-26 | 5.4 | 5.6 | 2.8e-08 | 0.99 | 0.01 | 0.99 | FALSE |
2 | GTEx | Adipose Subcutaneous | RFT1 | 0.21 | 0.19 | enet | 24 | 0.17 | 3.7e-14 | 5.5 | 5.2 | 2.0e-07 | 0.98 | 0.01 | 0.99 | FALSE |
3 | GTEx | Adipose Visceral Omentum | RFT1 | 0.16 | 0.15 | enet | 12 | 0.10 | 1.0e-05 | 5.4 | 5.5 | 3.1e-08 | 0.97 | 0.01 | 0.99 | FALSE |
4 | GTEx | Adrenal Gland | RFT1 | 0.15 | 0.02 | enet | 11 | 0.03 | 4.0e-02 | 5.4 | 5.5 | 4.6e-08 | 0.94 | 0.02 | 0.92 | FALSE |
5 | GTEx | Artery Aorta | RFT1 | 0.40 | 0.32 | lasso | 13 | 0.31 | 8.1e-18 | 5.5 | -5.3 | 1.3e-07 | -1.00 | 0.01 | 0.99 | FALSE |
6 | GTEx | Artery Coronary | RFT1 | 0.38 | 0.33 | lasso | 5 | 0.34 | 2.6e-12 | 5.5 | 5.5 | 3.9e-08 | 1.00 | 0.01 | 0.99 | FALSE |
7 | GTEx | Artery Tibial | RFT1 | 0.40 | 0.38 | enet | 22 | 0.40 | 8.2e-33 | 5.5 | 5.1 | 3.0e-07 | 0.99 | 0.01 | 0.99 | FALSE |
8 | GTEx | Breast Mammary Tissue (Male) | RFT1 | 0.23 | 0.12 | enet | 8 | 0.13 | 5.5e-04 | 5.4 | 5.4 | 6.3e-08 | 0.99 | 0.01 | 0.88 | FALSE |
9 | GTEx | Cells Transformed fibroblasts | RFT1 | 0.22 | 0.21 | enet | 16 | 0.22 | 2.8e-16 | 5.5 | 5.5 | 3.0e-08 | 0.97 | 0.01 | 0.99 | FALSE |
10 | GTEx | Colon Sigmoid | RFT1 | 0.55 | 0.45 | enet | 15 | 0.43 | 1.0e-16 | 5.4 | 5.4 | 7.4e-08 | 0.99 | 0.01 | 0.99 | FALSE |
11 | GTEx | Colon Transverse | RFT1 | 0.30 | 0.27 | enet | 16 | 0.24 | 8.0e-12 | 5.5 | 5.7 | 1.6e-08 | 0.97 | 0.01 | 0.99 | FALSE |
12 | GTEx | Esophagus Gastroesophageal Junction | RFT1 | 0.43 | 0.37 | enet | 18 | 0.34 | 7.0e-13 | 5.4 | 5.1 | 2.9e-07 | 0.97 | 0.01 | 0.99 | FALSE |
13 | GTEx | Esophagus Mucosa | RFT1 | 0.24 | 0.24 | enet | 10 | 0.22 | 6.2e-15 | 5.4 | 5.8 | 7.1e-09 | 0.98 | 0.01 | 0.99 | FALSE |
14 | GTEx | Lung | RFT1 | 0.24 | 0.23 | enet | 12 | 0.23 | 2.7e-17 | 5.4 | 5.4 | 6.4e-08 | 0.98 | 0.01 | 0.99 | FALSE |
15 | GTEx | Muscle Skeletal | RFT1 | 0.17 | 0.16 | enet | 17 | 0.15 | 3.0e-14 | 5.4 | 5.5 | 4.9e-08 | 0.96 | 0.01 | 0.99 | FALSE |
16 | GTEx | Nerve Tibial | RFT1 | 0.35 | 0.31 | enet | 17 | 0.27 | 1.9e-19 | 5.5 | 5.6 | 2.4e-08 | 0.99 | 0.01 | 0.99 | FALSE |
17 | GTEx | Nerve Tibial | SFMBT1 | 0.21 | 0.10 | enet | 11 | 0.07 | 1.4e-05 | 5.5 | -5.3 | 1.3e-07 | -1.00 | 0.01 | 0.99 | FALSE |
18 | GTEx | Prostate | RFT1 | 0.39 | 0.18 | enet | 17 | 0.24 | 1.1e-06 | 5.5 | 5.9 | 4.6e-09 | 0.87 | 0.01 | 0.99 | FALSE |
19 | GTEx | Skin Sun Exposed Lower leg | RFT1 | 0.18 | 0.16 | enet | 7 | 0.13 | 1.1e-10 | 5.4 | 5.5 | 4.5e-08 | 1.00 | 0.01 | 0.99 | FALSE |
20 | GTEx | Small Intestine Terminal Ileum | RFT1 | 0.20 | 0.20 | enet | 19 | 0.11 | 2.2e-03 | 5.5 | 5.5 | 3.7e-08 | 0.98 | 0.01 | 0.95 | FALSE |
21 | GTEx | Spleen | RFT1 | 0.23 | 0.22 | enet | 7 | 0.13 | 3.6e-04 | 5.4 | 5.5 | 4.5e-08 | 1.00 | 0.01 | 0.97 | FALSE |
22 | GTEx | Stomach | RFT1 | 0.23 | 0.03 | enet | 19 | 0.06 | 6.3e-04 | 5.5 | 5.3 | 1.4e-07 | 0.76 | 0.01 | 0.98 | FALSE |
23 | GTEx | Testis | RFT1 | 0.20 | 0.12 | enet | 8 | 0.10 | 2.9e-05 | 5.5 | 5.4 | 5.5e-08 | 0.98 | 0.01 | 0.99 | FALSE |
24 | GTEx | Thyroid | RFT1 | 0.36 | 0.33 | enet | 17 | 0.35 | 2.4e-27 | 5.4 | 5.3 | 1.4e-07 | 0.98 | 0.01 | 0.99 | FALSE |
25 | METSIM | Adipose | RFT1 | 0.13 | 0.19 | lasso | 7 | 0.18 | 7.8e-27 | 5.5 | 5.5 | 4.1e-08 | 1.00 | 0.01 | 0.99 | FALSE |
26 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RFT1 | 0.10 | 0.08 | enet | 11 | 0.15 | 2.3e-29 | 3.5 | 5.3 | 1.0e-07 | 0.82 | 0.01 | 0.98 | FALSE |
27 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | RFT1 | 0.14 | 0.08 | enet | 12 | 0.15 | 5.5e-08 | 3.6 | 5.5 | 4.7e-08 | 0.83 | 0.02 | 0.98 | FALSE |
28 | The Cancer Genome Atlas | Colon Adenocarcinoma | RFT1 | 0.10 | 0.05 | enet | 12 | 0.05 | 1.0e-03 | 3.5 | 5.2 | 2.5e-07 | 0.73 | 0.03 | 0.72 | FALSE |
29 | The Cancer Genome Atlas | Glioblastoma Multiforme | RFT1 | 0.20 | 0.14 | enet | 11 | 0.09 | 8.8e-04 | 5.5 | 6.0 | 1.4e-09 | 0.93 | 0.01 | 0.96 | TRUE |
30 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | RFT1 | 0.14 | 0.10 | lasso | 4 | 0.12 | 8.4e-14 | 5.5 | 5.6 | 2.5e-08 | 0.93 | 0.01 | 0.99 | FALSE |
31 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RFT1 | 0.15 | 0.21 | lasso | 8 | 0.22 | 1.4e-24 | 5.4 | 5.7 | 1.5e-08 | 0.98 | 0.01 | 0.99 | FALSE |
32 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | RFT1 | 0.24 | 0.12 | lasso | 5 | 0.20 | 1.3e-11 | 3.5 | 5.4 | 7.9e-08 | 0.80 | 0.02 | 0.98 | FALSE |
33 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RFT1 | 0.22 | 0.28 | enet | 13 | 0.31 | 2.5e-36 | 5.5 | 5.7 | 1.4e-08 | 0.94 | 0.01 | 0.99 | FALSE |
34 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | RFT1 | 0.21 | 0.10 | lasso | 6 | 0.23 | 1.9e-15 | 3.5 | 5.4 | 5.9e-08 | 0.81 | 0.02 | 0.98 | FALSE |
35 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | RFT1 | 0.41 | 0.17 | enet | 12 | 0.16 | 2.4e-07 | 5.5 | 5.7 | 9.7e-09 | 0.93 | 0.01 | 0.99 | FALSE |
36 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | RFT1 | 0.23 | 0.09 | blup | 45 | 0.08 | 3.8e-04 | 4.9 | 5.7 | 1.1e-08 | 0.92 | 0.01 | 0.96 | FALSE |
37 | The Cancer Genome Atlas | Stomach Adenocarcinoma | RFT1 | 0.13 | 0.05 | blup | 45 | 0.10 | 6.9e-08 | 3.6 | 5.3 | 1.3e-07 | 0.74 | 0.02 | 0.98 | FALSE |
38 | The Cancer Genome Atlas | Thyroid Carcinoma | RFT1 | 0.25 | 0.30 | lasso | 4 | 0.29 | 3.8e-28 | 5.5 | 5.2 | 2.0e-07 | 0.99 | 0.01 | 0.99 | FALSE |