Best TWAS P=4.41e-11 · Best GWAS P=1.96e-11 conditioned to 0.109
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Coronary | PFDN1 | 0.15 | 0.06 | enet | 11 | 0.04 | 1.9e-02 | -4.7 | 5.3 | 1.5e-07 | -0.74 | 0.06 | 0.66 | FALSE |
| 2 | GTEx | Brain Nucleus accumbens basal ganglia | PFDN1 | 0.16 | 0.01 | lasso | 5 | 0.03 | 5.6e-02 | 5.4 | 5.7 | 1.3e-08 | -0.81 | 0.04 | 0.62 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | PFDN1 | 0.17 | 0.20 | lasso | 5 | 0.19 | 4.1e-10 | -4.6 | 5.4 | 5.4e-08 | -0.72 | 0.54 | 0.46 | FALSE |
| 4 | GTEx | Cells EBV-transformed lymphocytes | PFDN1 | 0.20 | 0.02 | lasso | 3 | 0.03 | 4.4e-02 | -4.6 | 5.7 | 1.5e-08 | -0.63 | 0.12 | 0.24 | FALSE |
| 5 | GTEx | Spleen | PFDN1 | 0.26 | 0.02 | lasso | 5 | 0.12 | 6.0e-04 | 5.4 | 5.5 | 4.2e-08 | -0.71 | 0.03 | 0.56 | FALSE |
| 6 | YFS | Blood | HBEGF | 0.02 | 0.02 | lasso | 3 | 0.02 | 9.8e-07 | 5.4 | 5.9 | 3.4e-09 | -0.82 | 0.20 | 0.80 | FALSE |
| 7 | YFS | Blood | PFDN1 | 0.03 | 0.03 | lasso | 13 | 0.03 | 1.4e-10 | 5.0 | 5.9 | 3.4e-09 | -0.66 | 0.61 | 0.39 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | PFDN1 | 0.03 | 0.02 | blup | 47 | 0.02 | 5.5e-03 | -6.6 | 6.6 | 4.4e-11 | -0.93 | 0.01 | 0.90 | TRUE |
| 9 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PFDN1 | 0.04 | 0.02 | lasso | 3 | 0.03 | 2.0e-04 | -4.7 | 5.2 | 2.0e-07 | -0.64 | 0.41 | 0.12 | FALSE |