Best TWAS P=4.09e-12 · Best GWAS P=3.15e-12 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PSRC1 | 0.20 | 0.04 | lasso | 8 | 0.13 | 4.8e-16 | 2.3 | -5.9 | 4.5e-09 | 0.63 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Esophagus Mucosa | PSRC1 | 0.18 | 0.14 | lasso | 3 | 0.14 | 2.4e-09 | -6.5 | -6.9 | 4.1e-12 | 0.95 | 0.02 | 0.98 | TRUE |
| 3 | GTEx | Liver | CELSR2 | 0.39 | 0.36 | lasso | 1 | 0.35 | 1.0e-10 | -6.5 | -6.5 | 7.3e-11 | 0.97 | 0.02 | 0.97 | FALSE |
| 4 | GTEx | Muscle Skeletal | CELSR2 | 0.41 | 0.31 | lasso | 4 | 0.30 | 2.4e-30 | -6.5 | -6.5 | 8.0e-11 | 0.96 | 0.03 | 0.97 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | CELSR2 | 0.18 | 0.05 | lasso | 6 | 0.06 | 8.1e-06 | -6.6 | -6.8 | 1.4e-11 | 0.73 | 0.02 | 0.95 | FALSE |
| 6 | GTEx | Whole Blood | PSRC1 | 0.14 | 0.04 | lasso | 3 | 0.03 | 6.9e-04 | -6.6 | -6.6 | 4.8e-11 | 0.96 | 0.02 | 0.97 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | PSRC1 | 0.33 | 0.21 | bslmm | 430 | 0.26 | 1.2e-32 | -6.5 | -6.3 | 2.5e-10 | 0.81 | 0.01 | 0.99 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | CELSR2 | 0.25 | 0.21 | lasso | 6 | 0.23 | 4.9e-29 | -6.5 | -6.9 | 6.3e-12 | 0.94 | 0.01 | 0.99 | FALSE |
| 9 | YFS | Blood | PSRC1 | 0.25 | 0.18 | enet | 32 | 0.24 | 1.6e-76 | -6.5 | -6.5 | 9.9e-11 | 0.86 | 0.02 | 0.98 | FALSE |
| 10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PSRC1 | 0.03 | 0.00 | blup | 49 | 0.02 | 5.7e-05 | -6.6 | -6.0 | 1.7e-09 | 0.79 | 0.02 | 0.91 | FALSE |
| 11 | The Cancer Genome Atlas | Colon Adenocarcinoma | PSRC1 | 0.07 | 0.06 | lasso | 1 | 0.04 | 1.8e-03 | -6.6 | -6.6 | 3.8e-11 | 0.77 | 0.01 | 0.85 | FALSE |
| 12 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PSRC1 | 0.12 | 0.11 | lasso | 4 | 0.09 | 4.5e-06 | -6.5 | -6.3 | 2.9e-10 | 0.95 | 0.00 | 0.99 | FALSE |
| 13 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | PSRC1 | 0.16 | 0.20 | lasso | 3 | 0.19 | 3.7e-09 | -6.4 | -6.5 | 1.0e-10 | 0.93 | 0.02 | 0.98 | FALSE |
| 14 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | SORT1 | 0.23 | 0.16 | lasso | 4 | 0.16 | 4.6e-08 | -6.6 | -6.1 | 1.3e-09 | 0.92 | 0.01 | 0.99 | FALSE |
| 15 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | PSRC1 | 0.07 | 0.03 | enet | 8 | 0.05 | 3.4e-04 | -7.0 | -5.2 | 2.0e-07 | 0.77 | 0.00 | 0.94 | FALSE |