Best TWAS P=7.37e-13 · Best GWAS P=3.4e-14 conditioned to 1.08e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SLC22A3 | 0.10 | 0.02 | blup | 582 | 0.05 | 4.4e-07 | 4.7 | 7.2 | 7.4e-13 | 0.09 | 0.01 | 0.99 | TRUE |
| 2 | GTEx | Brain Frontal Cortex BA9 | SLC22A3 | 0.26 | 0.08 | lasso | 6 | 0.05 | 1.5e-02 | 5.6 | 5.5 | 4.6e-08 | 0.00 | 0.34 | 0.06 | FALSE |
| 3 | GTEx | Skin Sun Exposed Lower leg | SLC22A3 | 0.29 | 0.14 | lasso | 10 | 0.20 | 3.7e-16 | -5.9 | 5.4 | 7.1e-08 | 0.00 | 0.73 | 0.27 | FALSE |
| 4 | METSIM | Adipose | SLC22A3 | 0.04 | 0.01 | lasso | 2 | 0.01 | 2.3e-03 | -5.9 | 5.9 | 3.3e-09 | 0.02 | 0.17 | 0.22 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | SLC22A3 | 0.14 | 0.20 | lasso | 10 | 0.19 | 2.4e-24 | 4.7 | 5.3 | 1.0e-07 | 0.04 | 0.88 | 0.12 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SLC22A1 | 0.04 | 0.01 | enet | 17 | 0.01 | 5.2e-04 | 5.5 | -5.8 | 8.4e-09 | -0.59 | 0.01 | 0.94 | TRUE |
| 7 | The Cancer Genome Atlas | Colon Adenocarcinoma | SLC22A1 | 0.12 | 0.02 | blup | 82 | 0.02 | 3.4e-02 | 5.1 | -5.2 | 1.7e-07 | -0.23 | 0.06 | 0.06 | FALSE |
| 8 | The Cancer Genome Atlas | Colon Adenocarcinoma | SLC22A3 | 0.17 | 0.06 | lasso | 5 | 0.04 | 2.8e-03 | 5.5 | -5.5 | 3.3e-08 | -0.04 | 0.03 | 0.69 | FALSE |