Best TWAS P=1.44e-16 · Best GWAS P=3.97e-15 conditioned to 0.12
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Liver | PSMA4 | 0.18 | 0.14 | lasso | 1 | 0.11 | 6.5e-04 | 7.9 | 7.9 | 4.0e-15 | 1.00 | 0.01 | 0.97 | FALSE |
| 2 | GTEx | Testis | CHRNA5 | 0.16 | 0.07 | enet | 11 | 0.11 | 1.4e-05 | 7.9 | 6.7 | 2.3e-11 | 0.86 | 0.01 | 0.99 | FALSE |
| 3 | YFS | Blood | IREB2 | 0.18 | 0.20 | enet | 28 | 0.24 | 4.0e-78 | 7.2 | -6.5 | 8.6e-11 | -0.74 | 0.22 | 0.78 | FALSE |
| 4 | YFS | Blood | PSMA4 | 0.08 | 0.08 | lasso | 10 | 0.11 | 8.3e-35 | 7.7 | 8.3 | 1.4e-16 | 0.85 | 0.01 | 0.99 | TRUE |
| 5 | The Cancer Genome Atlas | Esophageal Carcinoma | CHRNA3 | 0.24 | 0.15 | enet | 5 | 0.16 | 6.5e-06 | 7.9 | -6.8 | 8.9e-12 | -0.94 | 0.00 | 1.00 | FALSE |
| 6 | The Cancer Genome Atlas | Esophageal Carcinoma | CHRNA5 | 0.17 | 0.15 | lasso | 4 | 0.14 | 3.1e-05 | 7.9 | -7.9 | 3.3e-15 | -0.98 | 0.00 | 0.98 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ADAMTS7 | 0.08 | 0.07 | lasso | 3 | 0.06 | 4.2e-04 | 5.5 | 5.5 | 4.9e-08 | 0.62 | 0.02 | 0.79 | FALSE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ADAMTS7 | 0.08 | 0.07 | lasso | 3 | 0.07 | 4.9e-08 | 5.4 | 5.5 | 3.7e-08 | 0.62 | 0.03 | 0.97 | FALSE |
| 9 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | PSMA4 | 0.08 | 0.02 | blup | 40 | 0.03 | 1.1e-02 | -4.6 | -6.2 | 6.1e-10 | -0.54 | 0.05 | 0.21 | FALSE |
| 10 | The Cancer Genome Atlas | Lung Adenocarcinoma | CHRNA5 | 0.02 | 0.01 | blup | 50 | 0.02 | 2.6e-03 | -2.7 | -5.5 | 4.9e-08 | -0.86 | 0.02 | 0.75 | FALSE |
| 11 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PSMA4 | 0.03 | 0.02 | blup | 40 | 0.02 | 3.1e-03 | -2.7 | 5.5 | 4.8e-08 | 0.81 | 0.02 | 0.50 | FALSE |
| 12 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CHRNA5 | 0.15 | 0.07 | blup | 50 | 0.09 | 2.5e-04 | -5.9 | -7.4 | 1.5e-13 | -0.66 | 0.20 | 0.48 | FALSE |
| 13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CHRNA3 | 0.04 | 0.04 | blup | 44 | 0.06 | 1.4e-06 | 7.2 | -5.9 | 3.5e-09 | -0.85 | 0.02 | 0.98 | FALSE |
| 14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CHRNA5 | 0.04 | 0.01 | enet | 10 | 0.03 | 6.0e-04 | 7.9 | -6.3 | 2.7e-10 | -0.78 | 0.01 | 0.85 | FALSE |
| 15 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CHRNA3 | 0.05 | 0.02 | blup | 44 | 0.02 | 7.6e-03 | 7.9 | -6.0 | 2.1e-09 | -0.90 | 0.00 | 0.98 | FALSE |