Hub : Traits :

Lung cancer (father)

16 significantly associated models · 6 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	5	619022	2041665	1	1	2.0e-09	3e-10	0.036	89	CLPTM1L
2	15	78032707	79573404	5	1	1.4e-16	4e-15	0.120	96	PSMA4

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Pack years adult smoking proportion	107.38	1	1	2.2	1	PSMA4
Pack years of smoking	99.66	1	1	2.2	1	PSMA4
Chronic bronchitis/emphysema (father)	21.36	1	1	2.2	1	PSMA4
Chronic bronchitis/emphysema (mother)	17.69	1	1	2.2	1	PSMA4
Father's age at death	16.63	1	1	2.2	1	PSMA4
Forced expiratory volume in 1-second (FEV1), predicted percentage	15.98	1	1	2.2	1	PSMA4
Basal cell carcinoma (self-reported)	13.20	1	1	2.2	1	CLPTM1L
Ever had prostate specific antigen (PSA) test	10.50	1	0	0.0	1	CLPTM1L
Schizophrenia (2018)	10.30	1	1	2.2	1	PSMA4
Emphysema/chronic bronchitis	9.44	1	0	0.0	1	PSMA4
Forced expiratory volume in 1-second (FEV1), Best measure	9.04	2	1	2.2	1	CLPTM1L PSMA4
Maternal smoking around birth	8.88	1	0	0.0	1	PSMA4
Bipolar Disorder or Schizophrenia	8.52	1	1	2.2	1	PSMA4
Forced expiratory volume in 1-second (FEV1)	7.80	1	1	2.2	1	PSMA4
Depression (self-reported)	6.98	1	0	0.0	1	CLPTM1L
Mouth/teeth dental problems: Dentures	6.89	1	0	0.0	1	PSMA4
Schizophrenia (2014)	6.50	1	1	2.2	1	PSMA4
Number of live births	6.47	1	0	0.0	1	PSMA4
Risk taking	6.06	1	0	0.0	1	PSMA4
Mother's age at death	5.79	1	0	0.0	1	PSMA4
Overall health rating	5.51	1	0	0.0	1	PSMA4
Forced vital capacity (FVC), Best measure	5.36	2	0	0.0	1	CLPTM1L PSMA4
Heart disease (mother)	5.24	1	0	0.0	1	PSMA4
Ever smoked	4.90	1	0	0.0	1	PSMA4
Lung FVC	4.76	2	1	2.2	1	CLPTM1L PSMA4
Wheeze or whistling in the chest in last year	4.60	1	0	0.0	1	PSMA4
Prostate Cancer	4.59	1	0	0.0	1	CLPTM1L
Forced vital capacity (FVC)	4.54	2	0	0.0	1	CLPTM1L PSMA4
Allergy or Eczema	4.42	1	0	0.0	1	PSMA4
Peak expiratory flow (PEF)	4.22	1	0	0.0	1	PSMA4
Current tobacco smoking	4.04	1	0	0.0	1	PSMA4
Multivitamins +/- minerals	3.91	1	0	0.0	1	PSMA4
Alcohol drinker status: Never	3.91	1	0	0.0	1	CLPTM1L
Unable to work because of sickness or disability	3.90	1	0	0.0	1	PSMA4
Smoking status: Previous	3.72	1	0	0.0	1	PSMA4
Qualifications: CSEs or equivalent	3.58	1	0	0.0	1	PSMA4
Hayfever, allergic rhinitis or eczema	3.50	1	0	0.0	1	PSMA4
Lung FEV1/FVC ratio	3.40	1	1	2.2	1	PSMA4
Knee pain experienced in last month	2.91	1	0	0.0	1	PSMA4
Age when periods started (menarche)	2.55	1	0	0.0	1	PSMA4
Birth weight	2.51	1	0	0.0	1	PSMA4
Hypertension (Self-reported)	2.51	1	0	0.0	1	CLPTM1L
High blood pressure	2.35	1	0	0.0	1	CLPTM1L
Alcohol intake frequency.	2.31	1	0	0.0	1	PSMA4
Impedance of leg (left)	1.44	1	0	0.0	1	CLPTM1L
Body mass index (BMI)	1.22	1	0	0.0	1	CLPTM1L
Systolic Blood Pressure	1.17	1	0	0.0	1	CLPTM1L
Impedance of whole body	1.09	1	0	0.0	1	CLPTM1L
Impedance of leg (right)	0.98	1	0	0.0	1	CLPTM1L
Blood Eosinophil Count	0.86	1	0	0.0	1	CLPTM1L
Blood White Count	0.74	1	0	0.0	1	PSMA4
Hair Pigment	0.31	1	0	0.0	1	CLPTM1L

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Brain Putamen basal ganglia	0	0.000	1.3
GTEx	Vagina	0	0.000	1.3
The Cancer Genome Atlas	Esophageal Carcinoma	2	0.292	1.3
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.3
GTEx	Adipose Subcutaneous	0	0.000	1.2
GTEx	Adipose Visceral Omentum	0	0.000	1.2
GTEx	Adrenal Gland	0	0.000	1.2
GTEx	Artery Coronary	0	0.000	1.2
GTEx	Artery Tibial	0	0.000	1.2
GTEx	Brain Caudate basal ganglia	0	0.000	1.2
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.2
GTEx	Brain Cerebellum	0	0.000	1.2
GTEx	Brain Cortex	0	0.000	1.2
GTEx	Brain Frontal Cortex BA9	0	0.000	1.2
GTEx	Brain Hippocampus	0	0.000	1.2
GTEx	Brain Hypothalamus	0	0.000	1.2
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.2
GTEx	Breast Mammary Tissue	0	0.000	1.2
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.2
GTEx	Cells Transformed fibroblasts	0	0.000	1.2
GTEx	Colon Sigmoid	0	0.000	1.2
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.2
GTEx	Esophagus Mucosa	0	0.000	1.2
GTEx	Esophagus Muscularis	0	0.000	1.2
GTEx	Heart Left Ventricle	0	0.000	1.2
GTEx	Liver	1	0.139	1.2
GTEx	Lung	0	0.000	1.2
GTEx	Muscle Skeletal	0	0.000	1.2
GTEx	Nerve Tibial	0	0.000	1.2
GTEx	Ovary	0	0.000	1.2
GTEx	Pancreas	0	0.000	1.2
GTEx	Prostate	0	0.000	1.2
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.2
GTEx	Skin Sun Exposed Lower leg	1	0.027	1.2
GTEx	Small Intestine Terminal Ileum	0	0.000	1.2
GTEx	Spleen	0	0.000	1.2
GTEx	Testis	1	0.032	1.2
GTEx	Uterus	0	0.000	1.2
GTEx	Whole Blood	0	0.000	1.2
NTR	Blood	0	0.000	1.2
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.2
YFS	Blood	2	0.043	1.2
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.2
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.2
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	1	0.049	1.2
The Cancer Genome Atlas	Brain Lower Grade Glioma	1	0.023	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	1	0.090	1.2
The Cancer Genome Atlas	Lung Adenocarcinoma	1	0.034	1.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	1	0.040	1.2
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	1	0.075	1.2
The Cancer Genome Atlas	Prostate Adenocarcinoma	2	0.043	1.2
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.2
The Cancer Genome Atlas	Stomach Adenocarcinoma	1	0.059	1.2
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.2
GTEx	Artery Aorta	0	0.000	1.1
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.1
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.1
GTEx	Colon Transverse	0	0.000	1.1
GTEx	Heart Atrial Appendage	0	0.000	1.1
GTEx	Pituitary	0	0.000	1.1
GTEx	Stomach	0	0.000	1.1
GTEx	Thyroid	0	0.000	1.1
METSIM	Adipose	0	0.000	1.1
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.1