Hub : Traits :

Lung cancer (father)

16 significantly associated models · 6 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 5 619022 2041665 1 1 2.0e-09 3e-10 0.036 89 CLPTM1L
2 15 78032707 79573404 5 1 1.4e-16 4e-15 0.120 96 PSMA4

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder or Schizophrenia 8.52 1 1 2.2 0 1 PSMA4
Schizophrenia (2018) 10.30 1 1 2.2 0 1 PSMA4
Prostate Cancer 4.59 1 0 0.0 0 1 CLPTM1L
Schizophrenia (2014) 6.50 1 1 2.2 0 1 PSMA4
Blood Eosinophil Count 0.86 1 0 0.0 0 1 CLPTM1L
Blood White Count 0.74 1 0 0.0 0 1 PSMA4
Systolic Blood Pressure 1.17 1 0 0.0 0 1 CLPTM1L
Allergy or Eczema 4.42 1 0 0.0 0 1 PSMA4
Lung FEV1/FVC ratio 3.40 1 1 2.2 0 1 PSMA4
Lung FVC 4.76 2 1 2.2 0 1 CLPTM1L PSMA4
Hair Pigment 0.31 1 0 0.0 0 1 CLPTM1L
Pack years adult smoking proportion 107.38 1 1 2.2 0 1 PSMA4
Impedance of leg (right) 0.98 1 0 0.0 0 1 CLPTM1L
Current tobacco smoking 4.04 1 0 0.0 0 1 PSMA4
Maternal smoking around birth 8.88 1 0 0.0 0 1 PSMA4
Age when periods started (menarche) 2.55 1 0 0.0 0 1 PSMA4
Qualifications: CSEs or equivalent 3.58 1 0 0.0 0 1 PSMA4
High blood pressure 2.35 1 0 0.0 0 1 CLPTM1L
Hayfever, allergic rhinitis or eczema 3.50 1 0 0.0 0 1 PSMA4
Multivitamins +/- minerals 3.91 1 0 0.0 0 1 PSMA4
Chronic bronchitis/emphysema (father) 21.36 1 1 2.2 0 1 PSMA4
Body mass index (BMI) 1.22 1 0 0.0 0 1 CLPTM1L
Impedance of leg (left) 1.44 1 0 0.0 0 1 CLPTM1L
Forced vital capacity (FVC) 4.54 2 0 0.0 0 1 CLPTM1L PSMA4
Father's age at death 16.63 1 1 2.2 0 1 PSMA4
Number of live births 6.47 1 0 0.0 0 1 PSMA4
Forced expiratory volume in 1-second (FEV1) 7.80 1 1 2.2 0 1 PSMA4
Mouth/teeth dental problems: Dentures 6.89 1 0 0.0 0 1 PSMA4
Depression (self-reported) 6.98 1 0 0.0 0 1 CLPTM1L
Forced expiratory volume in 1-second (FEV1), Best measure 9.04 2 1 2.2 0 1 CLPTM1L PSMA4
Peak expiratory flow (PEF) 4.22 1 0 0.0 0 1 PSMA4
Birth weight 2.51 1 0 0.0 0 1 PSMA4
Chronic bronchitis/emphysema (mother) 17.69 1 1 2.2 0 1 PSMA4
Forced vital capacity (FVC), Best measure 5.36 2 0 0.0 0 1 CLPTM1L PSMA4
Wheeze or whistling in the chest in last year 4.60 1 0 0.0 0 1 PSMA4
Emphysema/chronic bronchitis 9.44 1 0 0.0 0 1 PSMA4
Heart disease (mother) 5.24 1 0 0.0 0 1 PSMA4
Alcohol intake frequency. 2.31 1 0 0.0 0 1 PSMA4
Overall health rating 5.51 1 0 0.0 0 1 PSMA4
Knee pain experienced in last month 2.91 1 0 0.0 0 1 PSMA4
Hypertension (Self-reported) 2.51 1 0 0.0 0 1 CLPTM1L
Smoking status: Previous 3.72 1 0 0.0 0 1 PSMA4
Forced expiratory volume in 1-second (FEV1), predicted percentage 15.98 1 1 2.2 0 1 PSMA4
Mother's age at death 5.79 1 0 0.0 0 1 PSMA4
Alcohol drinker status: Never 3.91 1 0 0.0 0 1 CLPTM1L
Ever smoked 4.90 1 0 0.0 0 1 PSMA4
Risk taking 6.06 1 0 0.0 0 1 PSMA4
Ever had prostate specific antigen (PSA) test 10.50 1 0 0.0 0 1 CLPTM1L
Unable to work because of sickness or disability 3.90 1 0 0.0 0 1 PSMA4
Basal cell carcinoma (self-reported) 13.20 1 1 2.2 0 1 CLPTM1L
Pack years of smoking 99.66 1 1 2.2 0 1 PSMA4
Impedance of whole body 1.09 1 0 0.0 0 1 CLPTM1L

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.2
GTEx Adipose Visceral Omentum 0 0.000 1.2
GTEx Adrenal Gland 0 0.000 1.2
GTEx Artery Aorta 0 0.000 1.1
GTEx Artery Coronary 0 0.000 1.2
GTEx Artery Tibial 0 0.000 1.2
GTEx Brain Caudate basal ganglia 0 0.000 1.2
GTEx Brain Cerebellar Hemisphere 0 0.000 1.2
GTEx Brain Cerebellum 0 0.000 1.2
GTEx Brain Cortex 0 0.000 1.2
GTEx Brain Frontal Cortex BA9 0 0.000 1.2
GTEx Brain Hippocampus 0 0.000 1.2
GTEx Brain Hypothalamus 0 0.000 1.2
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.2
GTEx Brain Putamen basal ganglia 0 0.000 1.3
GTEx Breast Mammary Tissue 0 0.000 1.2
GTEx Breast Mammary Tissue (Male) 0 0.000 1.1
GTEx Breast Mammary Tissue (Female) 0 0.000 1.1
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.2
GTEx Cells Transformed fibroblasts 0 0.000 1.2
GTEx Colon Sigmoid 0 0.000 1.2
GTEx Colon Transverse 0 0.000 1.1
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.2
GTEx Esophagus Mucosa 0 0.000 1.2
GTEx Esophagus Muscularis 0 0.000 1.2
GTEx Heart Atrial Appendage 0 0.000 1.1
GTEx Heart Left Ventricle 0 0.000 1.2
GTEx Liver 1 0.139 1.2
GTEx Lung 0 0.000 1.2
GTEx Muscle Skeletal 0 0.000 1.2
GTEx Nerve Tibial 0 0.000 1.2
GTEx Ovary 0 0.000 1.2
GTEx Pancreas 0 0.000 1.2
GTEx Pituitary 0 0.000 1.1
GTEx Prostate 0 0.000 1.2
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.2
GTEx Skin Sun Exposed Lower leg 1 0.027 1.2
GTEx Small Intestine Terminal Ileum 0 0.000 1.2
GTEx Spleen 0 0.000 1.2
GTEx Stomach 0 0.000 1.1
GTEx Testis 1 0.032 1.2
GTEx Thyroid 0 0.000 1.1
GTEx Uterus 0 0.000 1.2
GTEx Vagina 0 0.000 1.3
GTEx Whole Blood 0 0.000 1.2
METSIM Adipose 0 0.000 1.1
NTR Blood 0 0.000 1.2
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.2
YFS Blood 2 0.043 1.2
CommonMind Brain Pre-frontal Cortex 0 0.000 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Esophageal Carcinoma 2 0.292 1.3
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.2
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 1 0.049 1.2
The Cancer Genome Atlas Brain Lower Grade Glioma 1 0.023 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 1 0.090 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 1 0.034 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 1 0.040 1.2
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 1 0.075 1.2
The Cancer Genome Atlas Prostate Adenocarcinoma 2 0.043 1.2
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.2
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 1 0.059 1.2
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.3
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.2