Hub : Genes

IREB2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.155	0.0360	9.1e-12	0.174	0.131	0.178	0.173	0.174	1.1e-20	1.0e-15	4.1e-21	1.6e-20	1.1e-20
2	GTEx	Cells Transformed fibroblasts	0.191	0.0600	1.4e-04	0.082	NA	0.055	NA	0.069	9.3e-07	NA	5.6e-05	NA	7.0e-06
3	YFS	Blood	0.180	0.0259	0.0e+00	0.195	0.218	0.242	0.241	0.242	1.4e-61	1.1e-69	4.0e-78	6.8e-78	4.3e-78
4	TCGA	Liver Hepatocellular Carcinoma	0.090	0.0510	3.1e-03	0.029	0.043	0.009	NA	0.032	1.6e-02	4.3e-03	1.2e-01	NA	1.2e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.6	0.9	1.6	-1.3	-0.8	-0.9	-0.9
Bipolar Disorder or Schizophrenia	1.9	4.6	12.2	-1.2	-0.6	-3.5	-2.1
Depressed Affect (Nagel 2018)	1.4	3.0	4.8	2.2	1.6	-1.3	1.7
Depression (Nagel 2018)	0.5	0.8	1.6	1.3	0.8	-1.0	0.3
Intelligence (Savage-Jansen 2018)	0.7	2.2	4.9	-1.9	0.0	0.3	-2.2
Neuroticism (Nagel 2018)	0.3	0.7	1.6	1.3	0.7	-0.2	0.8
Schizophrenia (2018)	2.2	4.6	14.0	-0.5	-0.1	-3.7	-2.0
Schizophrenia vs Biploar Disorder	0.8	1.0	2.8	-0.9	-1.7	0.2	-0.6
Worry (Nagel 2018)	0.3	0.6	1.2	0.8	0.8	-1.1	0.1
Alzheimer’s Disease (in mother)	1.4	1.6	2.8	1.1	0.9	-1.7	1.3
Alzheimer’s Disease (in father)	0.4	0.4	1.3	-0.4	-1.1	0.1	-0.3
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	-0.3	-0.2	-0.2	-0.5
Crohns Disease (2017)	0.1	0.1	0.2	-0.3	0.5	-0.4	-0.2
Irritable Bowel Disease (IBD)	0.1	0.2	0.7	0.3	0.8	-0.3	-0.1
Ulcerative Colitis (UC)	0.1	0.2	0.5	-0.2	0.1	0.7	-0.6
Major Depression (MDD)	0.2	0.3	0.5	-0.6	-0.5	0.7	-0.3
Reaction Time	4.6	8.7	13.9	3.4	2.3	-2.0	3.7
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.5	-0.7	0.3	0.1	-0.7
Breast Cancer	0.5	1.2	2.1	-1.5	-0.5	1.2	-1.1
Ovarian Cancer	0.5	0.6	1.7	-0.4	0.6	0.4	-1.3
Prostate Cancer	1.4	2.0	2.2	-1.5	-1.4	1.5	-1.4
Age at First Birth	0.1	0.1	0.3	-0.2	0.5	0.3	0.1
Bipolar Disorder (2011)	0.4	0.4	1.0	0.3	-0.5	-0.5	1.0
Body Mass Index (BMI) (2010)	0.3	0.4	1.2	0.1	-0.4	1.1	-0.1
Coronary Artery Disease (CAD)	0.4	0.5	0.9	0.7	0.7	-1.0	-0.1
Crohns Disease (2012)	0.1	0.2	0.6	-0.3	0.2	-0.8	-0.2
Mean Putamen Volume	0.8	0.9	1.6	0.9	1.3	-1.0	0.3
Fasting Glucose	0.3	0.4	0.9	-0.3	-0.4	-0.7	-0.9
HbA1C	1.0	1.2	2.3	0.4	1.5	-1.4	-0.4
HDL Cholesterol	0.9	1.5	3.2	-1.3	-0.7	1.8	-0.9
LDL Cholesterol	1.8	2.8	5.5	0.6	2.3	-2.3	-0.2
Lupus	0.4	0.6	1.5	-0.9	-0.3	1.2	-0.1
Neuroticism (2016)	0.1	0.2	0.5	0.3	-0.2	-0.7	-0.4
Primary Biliary Cirrhosis	0.5	0.7	1.2	1.0	1.1	-0.8	0.1
Rheumatoid Arthritis	0.6	0.8	1.8	-0.4	1.1	-0.2	-1.3
Schizophrenia (2014)	1.7	3.7	8.6	-0.7	-0.8	-2.9	-2.2
Triglycerides	2.4	4.0	7.4	1.7	2.0	-2.7	1.2
Type 2 Diabetes (T2D) (2012)	2.0	2.3	3.0	-1.7	-1.4	1.4	-1.5
Ulcerative Colitis	0.1	0.2	0.3	-0.1	-0.5	-0.5	-0.5
Blood Eosinophil Count	0.1	0.5	1.5	0.8	1.2	-0.0	0.2
Blood Platelet Count	0.7	7.7	13.7	3.2	3.7	-1.8	1.9
Blood Red Count	1.3	12.4	17.5	-3.8	-3.4	4.2	-2.5
Blood White Count	0.2	1.6	4.5	0.2	1.2	-2.1	-0.6
Heel T-Score	0.1	0.5	1.1	0.3	0.8	-1.0	0.4
BMI	0.4	2.3	3.7	-1.9	-1.6	1.1	-1.4
Height	0.1	2.3	4.8	-1.1	-1.8	2.2	-0.5
Waist Hip Ratio (WHR)	1.6	7.3	14.7	2.2	3.8	-3.2	-0.1
Systolic Blood Pressure	0.2	1.1	2.9	-0.7	-1.7	1.0	-0.0
Smoking Status	2.6	6.3	15.2	-2.6	-1.1	1.4	-3.9
Allergy or Eczema	0.9	2.3	8.8	-0.5	-0.1	3.0	0.3
Cardiovascular Disease	0.2	0.7	2.2	0.2	0.7	-1.5	0.0
Hypothyroidism (self reported)	0.8	1.8	3.6	1.9	1.0	-1.0	1.3
Respiratory disease	2.5	5.5	8.4	2.7	2.9	-1.6	2.0
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.2	-0.1	1.1	-1.1	-0.9
Lung FEV1/FVC ratio	1.6	8.1	23.1	-1.7	-2.4	4.8	-0.5
Lung FVC	2.9	14.9	27.1	-4.3	-1.5	5.2	-3.4
Neuroticism	1.9	4.6	7.3	2.7	2.1	-1.5	2.2
Chronotype (morning person)	0.3	0.7	1.8	-0.8	-0.2	1.4	-0.7
Hair Pigment	0.0	1.4	4.5	0.8	0.4	0.2	2.1
Tanning	0.0	0.1	0.2	0.4	-0.3	-0.5	-0.3
Hand grip strength (left)	0.1	0.3	0.4	0.4	-0.6	-0.6	0.5
Number of treatments/medications taken	0.5	0.9	2.0	-0.6	0.4	-1.4	-1.1
Average weekly spirits intake	0.4	0.6	0.8	-0.2	0.7	0.9	-0.9
Sensitivity / hurt feelings	0.2	0.4	0.8	0.3	-0.9	0.7	0.2
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.4	0.5	-0.1	-0.6	-0.5
Hearing difficulty/problems: Yes	0.4	0.6	0.9	0.9	-0.5	0.8	0.9
Relative age of first facial hair	0.3	0.6	1.3	-0.8	-0.5	1.2	-0.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.6	0.3	0.1	-1.3	0.3
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.1	0.2	-0.2	0.1	0.3
Ever had hysterectomy (womb removed)	0.6	0.7	1.3	-0.5	-1.0	1.1	0.3
Systolic blood pressure, automated reading	0.0	0.1	0.1	0.3	-0.3	0.2	-0.1
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.3	0.2	0.6	-0.5	-0.6
Angina	1.7	2.3	5.1	-1.1	1.3	1.0	-2.3
Medication for hormone replacement therapy	0.0	0.0	0.1	0.1	0.3	-0.1	0.0
Vitamin and mineral supplements	2.2	3.0	6.6	1.6	0.7	-2.6	1.6
Supplements: Zinc	5.3	5.8	10.8	-2.8	-1.9	1.0	-3.3
Medication: Co-codamol	1.1	1.3	2.4	-0.1	0.6	-1.5	-1.5
Medication: Metformin	0.2	0.2	0.6	-0.4	0.2	-0.4	-0.8
Diabetes (father)	0.7	0.8	2.1	1.4	0.8	-0.2	0.8
Diabetes (mother)	1.4	1.7	3.3	-1.3	0.4	1.3	-1.8
Severe depression (siblings)	2.0	2.3	5.3	-1.4	-2.3	1.3	-0.6
Pack years adult smoking proportion	57.1	87.1	231.0	8.2	5.4	-15.2	4.6
Impedance of leg (right)	0.5	2.4	5.2	1.8	2.3	-0.5	0.9
Leg fat-free mass (left)	1.0	5.4	10.4	-2.6	-3.2	1.3	-1.6
Trunk fat percentage	0.2	0.7	1.2	-1.1	0.3	0.9	-0.8
Hand grip strength (right)	0.5	1.3	3.6	-0.9	-1.9	0.5	-0.7
Townsend deprivation index at recruitment	1.4	1.9	4.0	-0.1	0.7	-2.0	-1.8
Current tobacco smoking	1.7	2.8	5.9	-0.7	-0.1	-2.1	-2.4
Average weekly fortified wine intake	1.6	1.9	2.7	1.4	1.6	-1.1	1.4
Maternal smoking around birth	4.2	6.1	11.9	-1.2	-0.6	-3.4	-3.3
Fed-up feelings	0.9	1.6	3.1	1.6	0.7	-1.8	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	2.1	2.8	6.3	1.1	1.4	-2.5	-1.3
Relative age voice broke	0.4	0.6	1.1	0.7	-0.7	0.6	1.1
Taking other prescription medications	1.1	1.8	2.9	-1.7	-1.0	-0.6	-1.7
Age when periods started (menarche)	0.8	1.9	5.5	-1.2	-0.2	2.3	-1.0
Bilateral oophorectomy (both ovaries removed)	6.3	7.3	10.5	-3.0	-2.5	3.2	-1.9
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	2.5	0.7	0.5	-1.6	0.2
Tinnitus: Yes, but not now, but have in the past	1.8	2.0	2.9	-1.6	-1.7	0.6	-1.4
Qualifications: CSEs or equivalent	1.0	1.3	4.5	0.8	0.2	-2.1	0.3
Serious illness, injury or assault to yourself	2.5	3.0	5.1	-2.3	-1.0	1.3	-2.0
High blood pressure	0.3	0.7	2.0	-0.8	-1.4	0.2	-0.4
Hayfever, allergic rhinitis or eczema	1.1	2.3	8.2	-0.9	-0.6	2.9	0.1
Multivitamins +/- minerals	4.1	5.2	14.2	-2.0	-1.4	3.8	-0.9
Stomach or abdominal pain in last month	0.9	1.2	2.3	-1.4	-0.6	0.2	-1.5
Supplements: Glucosamine	1.2	1.5	3.2	-1.6	-0.4	1.8	-0.5
Diverticular disease/diverticulitis (self-reported)	0.7	0.9	2.1	0.9	-0.7	-0.2	1.5
Medication: Atenolol	1.3	1.6	2.4	-1.5	-0.7	1.4	-1.4
Medication: Levothyroxine sodium	0.2	0.4	0.5	0.7	0.7	-0.6	0.4
Sitting height	1.2	8.7	15.6	-2.6	-4.0	3.4	-1.0
Chronic bronchitis/emphysema (father)	16.6	19.5	45.3	4.0	3.7	-6.7	1.7
High blood pressure (mother)	0.1	0.1	0.4	-0.0	0.2	0.6	-0.2
Body mass index (BMI)	0.2	0.9	1.7	-1.3	-0.7	0.2	-1.1
Impedance of leg (left)	1.1	5.2	10.8	2.6	3.3	-1.2	1.3
Leg predicted mass (left)	0.9	4.9	10.0	-2.5	-3.2	1.2	-1.5
Trunk fat mass	0.3	1.3	2.4	-1.5	-0.5	1.1	-1.2
Waist circumference	0.3	1.1	2.5	-1.4	-0.3	0.0	-1.6
Number of incorrect matches in round	2.6	4.3	6.7	2.6	1.9	-2.2	1.5
Past tobacco smoking	2.2	4.0	8.9	2.2	0.6	-1.3	3.0
Alcohol usually taken with meals	1.8	2.9	7.1	-0.5	-1.4	2.7	1.5
Nervous feelings	0.5	0.9	2.1	0.9	0.4	-1.4	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.3	2.7	1.6	0.2	-1.6	0.2
Hearing difficulty/problems with background noise	0.3	0.5	1.5	0.6	-0.3	1.2	0.1
Hair/balding pattern: Pattern 2	1.7	2.1	5.1	-1.1	-2.3	1.5	0.3
Had menopause	0.2	0.2	0.5	0.2	0.4	-0.7	-0.4
Had other major operations	2.3	2.8	3.6	-1.9	-1.5	1.4	-1.9
Forced vital capacity (FVC)	2.9	11.0	23.3	-3.3	-2.7	4.8	-1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.6	1.8	-0.0	0.2	-1.3	-0.6
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.4	-0.8	-1.2	0.6	0.5
Qualifications: None of the above	0.3	0.7	2.2	-0.1	0.0	1.5	-0.8
Financial difficulties in last 2 years	1.4	1.8	2.0	-1.3	-1.3	1.4	-1.4
Mouth/teeth dental problems	0.5	0.8	1.7	0.7	0.6	1.3	0.8
Heart attack	0.4	0.6	1.0	-0.8	0.8	-0.2	-1.0
Allergy	0.2	0.5	0.9	-0.6	-1.0	-0.8	-0.3
Pain all over the body in last month	0.9	1.0	3.1	0.8	0.1	-1.8	-0.5
Diabetes (self-reported)	0.1	0.1	0.3	-0.3	0.2	-0.3	-0.5
Hayfever/allergic rhinitis (self-reported)	1.5	1.9	4.0	-1.3	0.7	1.2	-2.0
Medication: Ramipril	0.2	0.2	0.4	-0.6	-0.6	0.2	-0.1
Medication: Simvastatin	0.6	0.9	1.8	-0.5	0.8	-1.4	-0.9
Fluid intelligence score	0.2	0.4	0.6	-0.1	0.6	-0.8	-0.7
Illnesses of siblings	0.2	0.3	0.8	-0.3	-0.5	0.9	0.1
Neuroticism score	0.6	1.3	2.1	1.5	0.5	-1.4	0.9
Weight	0.5	2.4	3.4	-1.9	-1.8	1.0	-1.3
Impedance of arm (right)	0.4	1.7	5.0	1.1	2.2	-0.6	0.5
Arm fat percentage (right)	0.1	0.5	1.0	-1.0	0.2	0.2	-0.9
Trunk fat-free mass	0.7	4.1	8.5	-2.1	-2.9	1.3	-1.4
Hip circumference	0.7	3.2	5.1	-2.1	-2.3	1.2	-1.3
Time employed in main current job	0.1	0.1	0.4	0.4	-0.1	0.0	0.6
Alcohol intake versus 10 years previously	0.3	0.5	1.8	-0.4	0.0	0.0	-1.3
Father’s age at death	11.4	15.3	38.2	-3.3	-3.2	6.2	-1.5
Worrier / anxious feelings	0.2	0.4	1.3	0.1	-0.2	-1.2	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	1.1	0.2	-0.2	-0.7	-1.0
Falls in the last year	6.2	8.4	11.7	-3.4	-3.2	2.4	-2.5
Hair/balding pattern: Pattern 3	1.5	2.3	3.3	1.8	1.6	-1.0	1.5
Number of live births	1.1	1.6	4.4	-0.1	-1.3	2.1	0.5
Forced expiratory volume in 1-second (FEV1)	4.3	14.6	36.6	-3.4	-3.1	6.0	-0.8
Pulse rate	0.5	0.9	1.2	1.1	0.2	-1.0	1.0
Happiness	0.1	0.2	0.4	0.6	-0.1	-0.0	0.5
Noisy workplace	0.2	0.3	0.7	0.3	-0.8	-0.5	0.4
Qualifications: A levels/AS levels or equivalent	1.1	2.4	4.7	1.4	1.7	0.1	2.2
Serious illness, injury or assault of a close relative in last 2 years	2.1	2.4	3.8	-1.8	-2.0	1.0	-1.2
Mouth/teeth dental problems: Dentures	1.6	2.7	10.1	0.8	-0.2	-3.2	0.4
Asthma	1.3	2.6	4.0	2.0	1.5	-0.3	2.0
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.4	0.1	-0.0	0.6	0.2
Medication: Cholesterol lowering	0.7	1.1	1.9	-0.8	1.0	-0.9	-1.4
Depression (self-reported)	0.8	0.9	2.5	0.7	0.9	-1.6	0.1
Medication: Lansoprazole	1.7	1.9	4.5	1.3	1.3	-2.1	0.1
Prospective memory result	1.1	1.4	3.2	1.8	0.8	-0.1	1.3
Lung cancer (father)	12.4	14.5	42.1	3.4	1.6	-6.5	1.4
Illnesses of mother	0.1	0.1	0.2	0.5	-0.1	0.3	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	5.1	16.2	36.9	-3.9	-3.0	6.1	-1.9
Pulse wave Arterial Stiffness index	1.5	1.7	3.3	-1.5	-1.8	0.4	-1.0
Impedance of arm (left)	0.4	1.7	4.8	1.2	2.2	-0.0	0.7
Arm fat mass (right)	0.2	0.8	1.6	-1.3	-0.6	0.6	-0.9
Trunk predicted mass	0.7	3.8	8.0	-2.0	-2.8	1.2	-1.3
Standing height	0.3	3.2	6.0	-1.3	-2.4	2.2	-0.3
Length of working week for main job	2.1	2.4	4.4	-1.3	-1.8	2.1	-0.2
Exposure to tobacco smoke at home	1.1	1.3	4.1	-0.9	-0.2	2.0	-0.5
Breastfed as a baby	0.9	1.1	2.3	-1.2	-0.6	0.4	-1.5
Tense / ‘highly strung’	0.1	0.1	0.2	0.4	-0.3	0.4	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.5	0.1	-0.5	-0.7	0.0
Hair/balding pattern: Pattern 4	0.6	1.5	3.2	1.1	1.8	-1.1	0.6
Birth weight of first child	2.0	3.6	5.8	-1.9	-2.4	2.1	-0.9
Peak expiratory flow (PEF)	1.6	3.7	10.5	-1.2	-1.6	3.2	0.5
Pulse wave reflection index	1.1	1.4	4.3	-1.0	-2.1	0.4	0.2
Ever highly irritable/argumentative for 2 days	0.9	1.1	1.8	1.3	1.0	-0.4	1.3
Loud music exposure frequency	1.9	2.1	6.1	-1.2	0.1	0.9	-2.5
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	1.3	0.4	0.6	-1.1	0.4
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.4	0.1	0.2	0.6	-0.6
Blood clot in the leg (DVT)	1.2	1.6	5.3	-0.8	-0.6	0.2	-2.3
Medication: Paracetamol	0.2	0.4	0.9	0.3	0.9	-0.7	-0.1
Headache pain in last month	1.3	2.3	4.9	-2.2	-1.2	0.8	-1.5
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.0	1.0	-0.2	0.5	1.4
Glaucoma (self-reported)	0.3	0.4	1.2	0.2	0.4	-1.1	0.5
Gout (self-reported)	0.0	0.1	0.1	0.4	0.2	-0.2	0.2
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.5	0.7	0.6	-0.4	0.1
Medication: Amlodipine	0.2	0.2	0.3	-0.5	-0.4	0.5	0.3
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.7	1.1	0.9	-1.6	0.6
Birth weight	1.9	4.0	10.0	-0.5	-2.1	3.2	1.1
Chronic bronchitis/emphysema (mother)	9.3	10.9	29.4	2.7	2.3	-5.4	1.1
High blood pressure (siblings)	0.1	0.1	0.3	0.2	0.6	-0.1	-0.3
Forced vital capacity (FVC), Best measure	3.8	13.7	25.2	-3.9	-2.9	5.0	-2.4
Body fat percentage	0.2	0.7	1.3	-1.1	0.2	0.7	-1.0
Leg fat percentage (right)	0.2	0.7	1.6	-1.1	-0.2	0.2	-1.3
Arm fat-free mass (right)	0.6	3.2	7.2	-1.8	-2.7	1.1	-1.1
Exposure to tobacco smoke outside home	1.1	1.5	2.7	-1.6	-1.1	1.3	-0.7
Comparative body size at age 10	0.8	2.3	7.7	0.9	0.8	-2.8	-0.1
Number of full brothers	0.9	1.1	3.5	0.6	0.8	-1.9	0.1
Worry too long after embarrassment	0.2	0.3	0.6	-0.3	-0.5	0.3	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	2.1	-0.5	-1.4	0.1	-0.3
Wheeze or whistling in the chest in last year	4.6	8.3	14.7	3.1	2.5	-3.8	1.5
Number of children fathered	0.6	0.7	1.7	1.0	-0.0	0.3	1.3
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	3.4	1.2	1.8	-1.0	0.2
Age at first live birth	0.2	0.3	0.5	0.1	0.5	-0.7	0.7
Pulse wave peak to peak time	1.5	1.7	2.9	1.6	1.7	-0.3	1.1
Health satisfaction	1.0	1.3	3.5	0.6	-0.9	-1.9	0.7
Shortness of breath walking on level ground	0.5	0.6	2.2	0.3	-0.1	-1.5	-0.3
Qualifications: College or University degree	0.5	1.7	3.5	-0.5	-0.8	1.5	1.9
Eye problems/disorders: None of the above	0.6	0.7	1.7	1.3	0.4	0.4	0.8
Mouth/teeth dental problems: Loose teeth	1.5	1.7	4.4	-0.2	0.8	-2.1	-1.3
Emphysema/chronic bronchitis	2.0	2.3	8.5	0.7	0.2	-2.9	0.2
Medication for pain relief, constipation, heartburn	0.1	0.2	0.5	-0.3	-0.7	0.3	0.2
Neck or shoulder pain in last month	2.1	2.9	4.8	-2.0	-0.8	1.4	-2.2
Medication: Blood pressure	1.1	1.9	3.3	-1.8	-1.5	0.7	-1.3
Angina (self-reported)	2.0	2.6	5.9	-1.5	1.0	1.2	-2.4
Migraine (self-reported)	0.6	0.8	2.5	-0.7	-1.6	0.3	0.4
Medication: Ibuprofen	0.2	0.2	0.4	0.3	0.3	0.7	0.5
Medication: Allopurinol	0.9	1.3	2.0	-1.4	-1.4	0.9	-0.6
Medication: Omeprazole	0.6	0.7	1.8	0.2	0.9	-1.3	-0.4
Medication: Seretide 50 evohaler	0.9	1.0	2.6	0.6	1.6	-0.9	-0.5
Mean time to correctly identify matches	2.2	4.2	8.8	2.1	1.8	-0.9	3.0
Heart disease (mother)	2.2	2.7	9.1	-1.0	-0.6	3.0	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	3.0	1.4	0.4	-0.3	1.7
Whole body fat mass	0.4	1.6	2.8	-1.7	-0.9	1.0	-1.3
Leg fat mass (right)	0.3	1.1	2.0	-1.4	-0.6	0.4	-1.4
Arm predicted mass (right)	0.6	3.3	8.3	-1.7	-2.9	1.2	-0.8
Pulse rate, automated reading	0.6	1.9	2.4	1.6	1.5	-1.5	0.7
Alcohol intake frequency.	1.3	2.9	5.2	-1.7	-1.6	-1.1	-2.3
Comparative height size at age 10	0.1	0.4	0.5	-0.6	-0.7	0.4	-0.7
Number of full sisters	0.1	0.2	0.5	0.7	-0.4	0.3	-0.0
Suffer from ‘nerves’	0.5	0.8	2.5	0.7	0.5	-1.6	0.3
Overall health rating	1.5	3.3	10.5	1.0	0.6	-3.2	-1.1
Chest pain or discomfort	0.1	0.2	0.3	0.6	0.5	-0.2	-0.0
Had major operations	0.1	0.1	0.4	-0.0	-0.1	-0.3	-0.6
Age at last live birth	0.4	0.5	1.0	-1.0	0.8	-0.1	-0.6
Family relationship satisfaction	0.3	0.3	0.6	-0.8	-0.4	-0.5	-0.6
Leg pain on walking	1.1	1.4	3.2	-0.4	-1.8	1.1	1.0
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	2.5	1.4	1.1	-1.6	0.2
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.5	-0.6	-0.6	0.7	0.4
Illness, injury, bereavement, stress in last 2 years	3.0	3.7	5.2	2.3	2.0	-1.8	1.5
Medication: Aspirin	0.9	1.1	2.6	-1.2	0.7	-0.0	-1.6
Supplements: Vitamin C	0.9	1.1	2.3	-1.1	-0.7	1.5	-0.7
Knee pain experienced in last month	3.8	5.9	12.3	-2.2	-2.4	3.5	-1.0
Hypertension (Self-reported)	0.1	0.3	0.8	-0.2	-0.9	-0.2	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.5	0.9	-0.9	-0.6	-0.4	-0.9
Illnesses of father: Heart disease	0.7	1.0	2.7	-0.4	0.5	0.9	-1.6
Illnesses of siblings: Diabetes	1.1	1.3	2.3	1.5	0.9	-0.9	1.1
Smoking status: Previous	3.3	4.9	7.4	-2.3	-0.6	2.7	-2.5
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.6	3.7	-1.8	-1.7	1.9	-0.8
Whole body fat-free mass	0.8	4.5	9.5	-2.3	-3.1	1.2	-1.4
Leg fat-free mass (right)	0.8	4.2	8.6	-2.3	-2.9	1.1	-1.4
Arm fat percentage (left)	0.1	0.4	0.8	-0.9	0.3	0.2	-0.8
Average weekly red wine intake	0.6	0.9	2.1	0.9	1.4	0.7	0.2
Handedness (chirality/laterality): Left-handed	0.8	0.9	3.3	-0.3	0.5	-0.0	-1.8
Mood swings	0.6	1.2	2.4	1.6	0.9	-1.1	0.5
Loneliness, isolation	0.2	0.3	0.5	-0.6	-0.4	-0.1	-0.7
Long-standing illness, disability or infirmity	0.9	1.4	4.8	-0.2	0.0	-2.2	-0.9
Ever had bowel cancer screening	0.1	0.1	0.3	-0.1	-0.2	0.4	0.5
Diabetes diagnosed by doctor	0.1	0.2	0.5	-0.4	0.0	-0.7	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	1.2	-0.7	-0.9	1.1	-0.8
Friendships satisfaction	0.1	0.2	0.4	0.4	-0.1	-0.6	0.3
Qualifications: nursing, teaching	1.4	2.2	3.5	-0.7	-1.4	1.9	1.7
Commuting to job workplace: Walk	2.4	2.6	6.6	0.9	1.5	-2.6	-0.9
Eye problems/disorders: Cataract	0.0	0.1	0.1	-0.4	0.0	0.2	-0.2
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	3.2	0.8	1.8	-1.6	1.4
Medication for cholesterol	0.6	0.9	1.5	-1.0	-0.3	1.2	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.3	-0.3	-0.7	1.1	-0.2
Back pain experienced in last month	4.4	6.4	9.8	-2.5	-2.8	1.3	-3.1
Mineral and other dietary supplements	0.8	1.1	3.3	0.5	0.9	-1.8	-0.0
Breast cancer (self-reported)	0.9	1.1	2.6	-0.7	-1.0	1.6	-0.5
Asthma (self-reported)	1.2	2.4	3.5	1.9	1.6	-0.3	1.8
Osteoporosis (self-reported)	4.3	5.4	8.9	-3.0	-2.1	1.8	-2.2
Osteoarthritis (self-reported)	0.2	0.3	0.6	-0.6	0.2	-0.4	-0.8
Medication: Aspirin	0.8	1.0	2.3	-1.2	0.5	0.1	-1.5
Medication: Gliclazide	0.1	0.1	0.2	-0.1	-0.1	-0.4	-0.3
Illnesses of father: None of the above (group 1)	1.2	1.4	3.2	-1.2	-1.8	1.1	-0.1
Smoking status: Current	1.4	2.3	6.4	-1.4	-0.8	-0.3	-2.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	10.7	22.6	55.5	-4.5	-2.6	7.4	-2.8
Whole body water mass	0.8	4.6	9.9	-2.3	-3.1	1.2	-1.3
Leg predicted mass (right)	0.8	4.2	8.3	-2.3	-2.9	1.1	-1.5
Arm fat mass (left)	0.2	1.0	1.9	-1.4	-0.8	0.7	-1.0
Number of self-reported non-cancer illnesses	0.7	1.2	2.0	-1.4	-0.8	-0.2	-1.4
Average weekly champagne plus white wine intake	1.2	1.6	5.4	-1.0	0.2	2.3	-0.0
Miserableness	1.9	3.3	5.2	2.1	0.9	-2.3	1.6
Guilty feelings	0.3	0.5	0.6	-0.7	-0.8	0.6	-0.6
Wears glasses or contact lenses	0.9	1.0	2.2	-1.2	-0.1	-0.5	-1.5
Ever taken oral contraceptive pill	3.3	3.7	5.6	-2.1	-2.0	2.4	-0.8
Hearing aid user	0.6	0.7	1.8	0.7	0.6	-0.2	1.3
Mother’s age at death	2.3	2.9	9.1	-1.3	-0.7	3.0	-0.2
Financial situation satisfaction	0.4	0.5	0.9	0.9	-0.4	0.6	0.9
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.4	0.3	-0.5	0.1	1.2
Commuting to job workplace: Public transport	2.9	3.5	5.0	1.9	1.8	-2.2	1.4
Eye problems/disorders: Glaucoma	0.2	0.2	0.4	-0.6	-0.1	-0.6	-0.4
Medication: Blood pressure	1.3	2.4	3.4	1.5	0.8	-1.9	1.8
Pain type(s) experienced in last month: Hip pain	1.7	2.1	4.5	-1.7	-0.2	0.9	-2.1
Supplements: Fish oil (including cod liver oil)	0.6	0.7	1.7	0.5	-0.2	1.3	1.0
High cholesterol (Self-reported)	0.9	1.6	4.4	0.7	2.1	-1.2	-0.4
Medication: Bendroflumethiazide	1.2	1.9	2.9	1.6	1.1	-1.7	1.1
Medication: Paracetamol	0.5	0.8	1.9	0.8	1.4	-0.8	0.3
Medication: Lisinopril	0.2	0.2	0.6	-0.4	0.2	0.4	-0.8
Medication: Atorvastatin	0.1	0.2	0.4	-0.2	-0.0	0.5	-0.6
Illnesses of father: High blood pressure	0.6	0.7	1.3	0.6	-0.7	0.9	1.2
Alcohol drinker status: Never	1.7	2.0	3.4	-1.7	-1.1	0.7	-1.8
Ever smoked	3.4	5.9	11.8	-2.4	-0.9	3.4	-2.3
Basal metabolic rate	0.8	4.2	8.3	-2.3	-2.9	1.2	-1.4
Leg fat percentage (left)	0.1	0.4	1.0	-0.7	0.3	-0.1	-1.0
Arm fat-free mass (left)	0.8	3.9	8.9	-2.0	-3.0	1.3	-1.0
Number of operations (self-reported)	0.1	0.2	0.4	-0.0	-0.7	0.5	0.2
Average weekly beer plus cider intake	0.6	0.8	1.5	0.6	-1.2	0.8	1.0
Irritability	0.7	1.3	2.7	1.6	1.2	0.4	0.9
Risk taking	1.3	1.9	7.2	-0.3	0.2	2.7	0.6
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.1	-0.8	-1.0	0.3	-0.3
Fractured/broken bones in last 5 years	2.0	2.5	3.5	-1.9	-1.8	1.9	-0.2
Age started oral contraceptive pill	0.3	0.3	0.9	-0.4	0.1	-0.5	-1.0
Diastolic blood pressure, automated reading	0.3	1.0	3.5	-0.0	-1.9	-0.5	-0.3
Ever depressed for a whole week	0.8	1.0	1.3	1.1	0.9	-1.0	0.9
Unable to work because of sickness or disability	1.4	1.9	2.8	-0.9	-1.1	-1.7	-1.6
Commuting to job workplace: Cycle	0.3	0.4	1.1	0.5	-0.3	-1.0	0.3
Myopia	1.8	2.6	3.8	-1.9	-0.0	1.7	-1.9
Vascular/heart problems diagnosed by doctor	0.4	1.2	2.1	1.5	1.1	-0.2	1.2
Cholesterol lowering medication	0.1	0.2	0.4	-0.4	-0.6	-0.4	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.9	0.8	0.6	-1.7	0.1
Pain experienced in last month	6.0	10.1	15.2	3.9	2.4	-2.3	3.8
Supplements: Calcium	0.4	0.4	0.9	-0.8	-0.4	0.9	-0.2
Basal cell carcinoma (self-reported)	0.0	0.1	0.1	0.2	0.1	0.3	0.1
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.1	-0.6	1.0	-0.2	-0.8
Deep venous thrombosis (DVT) (self-reported)	1.2	1.6	4.8	-0.8	-0.9	0.2	-2.2
Heart disease (siblings)	0.7	0.9	2.3	-0.7	0.9	-0.0	-1.5
Alcohol drinker status: Previous	0.2	0.3	0.6	-0.4	-0.2	-0.6	-0.8
Pack years of smoking	51.8	76.0	204.5	7.5	4.9	-14.3	4.3
Impedance of whole body	0.6	3.0	7.6	1.8	2.8	-0.5	1.0
Leg fat mass (left)	0.1	0.6	1.2	-1.0	-0.4	0.1	-1.1
Arm predicted mass (left)	0.7	3.5	7.8	-2.0	-2.8	0.9	-1.2