[Hub]/) : Traits : Chronic bronchitis/emphysema (father) :

chr15:78,032,707-79,573,404

Best TWAS P=3.09e-13 · Best GWAS P=3.62e-13 conditioned to 0.234

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Colon Sigmoid CHRNA5 0.20 -0.01 enet 14 0.03 2.9e-02 7.0 -5.7 1.2e-08 -0.65 0.02 0.77 FALSE
2 GTEx Liver PSMA4 0.18 0.14 lasso 1 0.11 6.5e-04 6.9 6.9 4.3e-12 0.87 0.02 0.92 FALSE
3 GTEx Testis CHRNA5 0.16 0.07 enet 11 0.11 1.4e-05 6.9 6.0 2.3e-09 0.83 0.01 0.98 FALSE
4 YFS Blood IREB2 0.18 0.20 enet 28 0.24 4.0e-78 6.6 -6.7 1.7e-11 -0.72 0.14 0.86 FALSE
5 YFS Blood PSMA4 0.08 0.08 lasso 10 0.11 8.3e-35 6.9 7.1 1.7e-12 0.77 0.02 0.98 FALSE
6 The Cancer Genome Atlas Esophageal Carcinoma CHRNA3 0.24 0.15 enet 5 0.16 6.5e-06 6.9 -6.5 8.2e-11 -0.87 0.01 0.98 FALSE
7 The Cancer Genome Atlas Esophageal Carcinoma CHRNA5 0.17 0.15 lasso 4 0.14 3.1e-05 6.9 -7.3 3.1e-13 -0.94 0.01 0.97 TRUE
8 The Cancer Genome Atlas Liver Hepatocellular Carcinoma PSMA4 0.08 0.02 blup 40 0.03 1.1e-02 -5.2 -5.8 5.6e-09 -0.57 0.04 0.22 FALSE
9 The Cancer Genome Atlas Lung Adenocarcinoma CHRNA5 0.02 0.01 blup 50 0.02 2.6e-03 -2.9 -5.5 3.6e-08 -0.77 0.04 0.41 FALSE
10 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma CHRNA5 0.15 0.07 blup 50 0.09 2.5e-04 -4.9 -6.2 7.3e-10 -0.65 0.15 0.62 FALSE
11 The Cancer Genome Atlas Prostate Adenocarcinoma CHRNA3 0.04 0.04 blup 44 0.06 1.4e-06 7.3 -5.9 3.7e-09 -0.88 0.00 1.00 FALSE
12 The Cancer Genome Atlas Prostate Adenocarcinoma CHRNA5 0.04 0.01 enet 10 0.03 6.0e-04 6.9 -6.4 1.2e-10 -0.78 0.02 0.72 FALSE
13 The Cancer Genome Atlas Stomach Adenocarcinoma CHRNA3 0.05 0.02 blup 44 0.02 7.6e-03 6.9 -5.8 5.1e-09 -0.87 0.02 0.88 FALSE