TWAS hub - Chronic bronchitis/emphysema (father)

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	15	78032707	79573404	4	1	3.1e-13	3.6e-13	0.23	97	CHRNA5

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Pack years adult smoking proportion	224.3	1	1	2.2	1	CHRNA5
Pack years of smoking	199.1	1	1	2.2	1	CHRNA5
Lung cancer (father)	53.0	1	1	2.2	1	CHRNA5
Chronic bronchitis/emphysema (mother)	33.9	1	1	2.2	1	CHRNA5
Forced expiratory volume in 1-second (FEV1), predicted percentage	33.5	1	1	2.2	1	CHRNA5
Father's age at death	32.5	1	1	2.2	1	CHRNA5
Forced expiratory volume in 1-second (FEV1), Best measure	14.6	1	1	2.2	1	CHRNA5
Emphysema/chronic bronchitis	14.4	1	0	0.0	1	CHRNA5
Schizophrenia (2018)	12.6	1	0	0.0	1	CHRNA5
Mouth/teeth dental problems: Dentures	12.0	1	0	0.0	1	CHRNA5
Forced expiratory volume in 1-second (FEV1)	11.9	1	1	2.2	1	CHRNA5
Mother's age at death	10.1	1	0	0.0	1	CHRNA5
Risk taking	9.7	1	0	0.0	1	CHRNA5
Ever smoked	9.3	1	0	0.0	1	CHRNA5
Bipolar Disorder or Schizophrenia	9.2	1	0	0.0	1	CHRNA5
Angina (self-reported)	9.1	1	0	0.0	1	CHRNA5
Angina	9.0	1	0	0.0	1	CHRNA5
Heart disease (mother)	8.7	1	0	0.0	1	CHRNA5
Knee pain experienced in last month	8.6	1	0	0.0	1	CHRNA5
Lung FEV1/FVC ratio	8.5	1	1	2.2	1	CHRNA5
Smoking status: Previous	8.4	1	0	0.0	1	CHRNA5
Bilateral oophorectomy (both ovaries removed)	8.2	1	0	0.0	1	CHRNA5
Multivitamins +/- minerals	8.0	1	0	0.0	1	CHRNA5
Schizophrenia (2014)	7.8	1	0	0.0	1	CHRNA5
Lung FVC	7.7	1	1	2.2	1	CHRNA5
Maternal smoking around birth	7.6	1	0	0.0	1	CHRNA5
Wheeze or whistling in the chest in last year	7.5	1	0	0.0	1	CHRNA5
Forced vital capacity (FVC), Best measure	7.2	1	1	2.2	1	CHRNA5
Qualifications: CSEs or equivalent	7.0	1	0	0.0	1	CHRNA5
Forced vital capacity (FVC)	6.0	1	0	0.0	1	CHRNA5
Pain experienced in last month	5.4	1	0	0.0	1	CHRNA5
Overall health rating	4.7	1	0	0.0	1	CHRNA5
Age when periods started (menarche)	4.4	1	0	0.0	1	CHRNA5
Peak expiratory flow (PEF)	4.3	1	0	0.0	1	CHRNA5
Allergy or Eczema	4.1	1	0	0.0	1	CHRNA5
Blood Red Count	1.5	1	0	0.0	1	CHRNA5

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Brain Caudate basal ganglia	0	0.000	1.3
GTEx	Brain Hippocampus	0	0.000	1.3
GTEx	Colon Sigmoid	1	0.068	1.3
GTEx	Liver	1	0.139	1.3
GTEx	Ovary	0	0.000	1.3
GTEx	Pituitary	0	0.000	1.3
The Cancer Genome Atlas	Esophageal Carcinoma	2	0.292	1.3
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.3
GTEx	Adipose Subcutaneous	0	0.000	1.2
GTEx	Adipose Visceral Omentum	0	0.000	1.2
GTEx	Adrenal Gland	0	0.000	1.2
GTEx	Artery Aorta	0	0.000	1.2
GTEx	Artery Coronary	0	0.000	1.2
GTEx	Artery Tibial	0	0.000	1.2
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.2
GTEx	Brain Cerebellum	0	0.000	1.2
GTEx	Brain Cortex	0	0.000	1.2
GTEx	Brain Frontal Cortex BA9	0	0.000	1.2
GTEx	Brain Hypothalamus	0	0.000	1.2
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.2
GTEx	Brain Putamen basal ganglia	0	0.000	1.2
GTEx	Breast Mammary Tissue	0	0.000	1.2
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.2
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.2
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.2
GTEx	Cells Transformed fibroblasts	0	0.000	1.2
GTEx	Colon Transverse	0	0.000	1.2
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.2
GTEx	Esophagus Mucosa	0	0.000	1.2
GTEx	Esophagus Muscularis	0	0.000	1.2
GTEx	Heart Atrial Appendage	0	0.000	1.2
GTEx	Heart Left Ventricle	0	0.000	1.2
GTEx	Lung	0	0.000	1.2
GTEx	Muscle Skeletal	0	0.000	1.2
GTEx	Pancreas	0	0.000	1.2
GTEx	Prostate	0	0.000	1.2
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.2
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.2
GTEx	Spleen	0	0.000	1.2
GTEx	Stomach	0	0.000	1.2
GTEx	Testis	1	0.032	1.2
GTEx	Thyroid	0	0.000	1.2
GTEx	Uterus	0	0.000	1.2
GTEx	Whole Blood	0	0.000	1.2
NTR	Blood	0	0.000	1.2
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.2
YFS	Blood	2	0.043	1.2
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.2
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.2
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	1	0.090	1.2
The Cancer Genome Atlas	Lung Adenocarcinoma	1	0.034	1.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	1	0.075	1.2
The Cancer Genome Atlas	Prostate Adenocarcinoma	2	0.043	1.2
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.2
The Cancer Genome Atlas	Stomach Adenocarcinoma	1	0.059	1.2
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.2
GTEx	Nerve Tibial	0	0.000	1.1
GTEx	Small Intestine Terminal Ileum	0	0.000	1.1
GTEx	Vagina	0	0.000	1.1
METSIM	Adipose	0	0.000	1.1
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.1

Hub : Traits :

Chronic bronchitis/emphysema (father)

Significant Loci

Pleiotropic Associations

Associations by panel