Hub : Traits :

Chronic bronchitis/emphysema (father)

13 significantly associated models · 4 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 15 78032707 79573404 4 1 3.1e-13 3.6e-13 0.23 97 CHRNA5

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder or Schizophrenia 9.2 1 0 0.0 0 1 CHRNA5
Schizophrenia (2018) 12.6 1 0 0.0 0 1 CHRNA5
Schizophrenia (2014) 7.8 1 0 0.0 0 1 CHRNA5
Blood Red Count 1.5 1 0 0.0 0 1 CHRNA5
Allergy or Eczema 4.1 1 0 0.0 0 1 CHRNA5
Lung FEV1/FVC ratio 8.5 1 1 2.2 0 1 CHRNA5
Lung FVC 7.7 1 1 2.2 0 1 CHRNA5
Angina 9.0 1 0 0.0 0 1 CHRNA5
Pack years adult smoking proportion 224.3 1 1 2.2 0 1 CHRNA5
Maternal smoking around birth 7.6 1 0 0.0 0 1 CHRNA5
Age when periods started (menarche) 4.4 1 0 0.0 0 1 CHRNA5
Bilateral oophorectomy (both ovaries removed) 8.2 1 0 0.0 0 1 CHRNA5
Qualifications: CSEs or equivalent 7.0 1 0 0.0 0 1 CHRNA5
Multivitamins +/- minerals 8.0 1 0 0.0 0 1 CHRNA5
Forced vital capacity (FVC) 6.0 1 0 0.0 0 1 CHRNA5
Father's age at death 32.5 1 1 2.2 0 1 CHRNA5
Forced expiratory volume in 1-second (FEV1) 11.9 1 1 2.2 0 1 CHRNA5
Mouth/teeth dental problems: Dentures 12.0 1 0 0.0 0 1 CHRNA5
Lung cancer (father) 53.0 1 1 2.2 0 1 CHRNA5
Forced expiratory volume in 1-second (FEV1), Best measure 14.6 1 1 2.2 0 1 CHRNA5
Peak expiratory flow (PEF) 4.3 1 0 0.0 0 1 CHRNA5
Chronic bronchitis/emphysema (mother) 33.9 1 1 2.2 0 1 CHRNA5
Forced vital capacity (FVC), Best measure 7.2 1 1 2.2 0 1 CHRNA5
Wheeze or whistling in the chest in last year 7.5 1 0 0.0 0 1 CHRNA5
Emphysema/chronic bronchitis 14.4 1 0 0.0 0 1 CHRNA5
Angina (self-reported) 9.1 1 0 0.0 0 1 CHRNA5
Heart disease (mother) 8.7 1 0 0.0 0 1 CHRNA5
Overall health rating 4.7 1 0 0.0 0 1 CHRNA5
Knee pain experienced in last month 8.6 1 0 0.0 0 1 CHRNA5
Smoking status: Previous 8.4 1 0 0.0 0 1 CHRNA5
Forced expiratory volume in 1-second (FEV1), predicted percentage 33.5 1 1 2.2 0 1 CHRNA5
Mother's age at death 10.1 1 0 0.0 0 1 CHRNA5
Ever smoked 9.3 1 0 0.0 0 1 CHRNA5
Risk taking 9.7 1 0 0.0 0 1 CHRNA5
Pain experienced in last month 5.4 1 0 0.0 0 1 CHRNA5
Pack years of smoking 199.1 1 1 2.2 0 1 CHRNA5

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.2
GTEx Adipose Visceral Omentum 0 0.000 1.2
GTEx Adrenal Gland 0 0.000 1.2
GTEx Artery Aorta 0 0.000 1.2
GTEx Artery Coronary 0 0.000 1.2
GTEx Artery Tibial 0 0.000 1.2
GTEx Brain Caudate basal ganglia 0 0.000 1.3
GTEx Brain Cerebellar Hemisphere 0 0.000 1.2
GTEx Brain Cerebellum 0 0.000 1.2
GTEx Brain Cortex 0 0.000 1.2
GTEx Brain Frontal Cortex BA9 0 0.000 1.2
GTEx Brain Hippocampus 0 0.000 1.3
GTEx Brain Hypothalamus 0 0.000 1.2
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.2
GTEx Brain Putamen basal ganglia 0 0.000 1.2
GTEx Breast Mammary Tissue 0 0.000 1.2
GTEx Breast Mammary Tissue (Male) 0 0.000 1.2
GTEx Breast Mammary Tissue (Female) 0 0.000 1.2
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.2
GTEx Cells Transformed fibroblasts 0 0.000 1.2
GTEx Colon Sigmoid 1 0.068 1.3
GTEx Colon Transverse 0 0.000 1.2
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.2
GTEx Esophagus Mucosa 0 0.000 1.2
GTEx Esophagus Muscularis 0 0.000 1.2
GTEx Heart Atrial Appendage 0 0.000 1.2
GTEx Heart Left Ventricle 0 0.000 1.2
GTEx Liver 1 0.139 1.3
GTEx Lung 0 0.000 1.2
GTEx Muscle Skeletal 0 0.000 1.2
GTEx Nerve Tibial 0 0.000 1.1
GTEx Ovary 0 0.000 1.3
GTEx Pancreas 0 0.000 1.2
GTEx Pituitary 0 0.000 1.3
GTEx Prostate 0 0.000 1.2
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.2
GTEx Skin Sun Exposed Lower leg 0 0.000 1.2
GTEx Small Intestine Terminal Ileum 0 0.000 1.1
GTEx Spleen 0 0.000 1.2
GTEx Stomach 0 0.000 1.2
GTEx Testis 1 0.032 1.2
GTEx Thyroid 0 0.000 1.2
GTEx Uterus 0 0.000 1.2
GTEx Vagina 0 0.000 1.1
GTEx Whole Blood 0 0.000 1.2
METSIM Adipose 0 0.000 1.1
NTR Blood 0 0.000 1.2
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.2
YFS Blood 2 0.043 1.2
CommonMind Brain Pre-frontal Cortex 0 0.000 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Esophageal Carcinoma 2 0.292 1.3
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.2
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 1 0.090 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 1 0.034 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 1 0.075 1.2
The Cancer Genome Atlas Prostate Adenocarcinoma 2 0.043 1.2
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.2
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 1 0.059 1.2
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.2
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.1