Best TWAS P=1.66e-10 · Best GWAS P=3.92e-10 conditioned to 0.122
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Liver | PSMA4 | 0.18 | 0.14 | lasso | 1 | 0.11 | 6.5e-04 | 6.3 | 6.3 | 3.9e-10 | 1.00 | 0.01 | 0.95 | FALSE |
| 2 | GTEx | Testis | CHRNA5 | 0.16 | 0.07 | enet | 11 | 0.11 | 1.4e-05 | 6.3 | 6.0 | 2.4e-09 | 0.86 | 0.01 | 0.98 | FALSE |
| 3 | YFS | Blood | IREB2 | 0.18 | 0.20 | enet | 28 | 0.24 | 4.0e-78 | 5.7 | -5.4 | 5.8e-08 | -0.74 | 0.08 | 0.92 | FALSE |
| 4 | YFS | Blood | PSMA4 | 0.08 | 0.08 | lasso | 10 | 0.11 | 8.3e-35 | 6.0 | 6.4 | 1.7e-10 | 0.85 | 0.02 | 0.98 | TRUE |
| 5 | The Cancer Genome Atlas | Esophageal Carcinoma | CHRNA3 | 0.24 | 0.15 | enet | 5 | 0.16 | 6.5e-06 | 6.3 | -6.0 | 1.8e-09 | -0.94 | 0.00 | 0.99 | FALSE |
| 6 | The Cancer Genome Atlas | Esophageal Carcinoma | CHRNA5 | 0.17 | 0.15 | lasso | 4 | 0.14 | 3.1e-05 | 6.3 | -6.3 | 3.2e-10 | -0.98 | 0.00 | 0.98 | FALSE |
| 7 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | PSMA4 | 0.08 | 0.02 | blup | 40 | 0.03 | 1.1e-02 | -4.6 | -5.2 | 2.5e-07 | -0.54 | 0.05 | 0.20 | FALSE |
| 8 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CHRNA5 | 0.15 | 0.07 | blup | 50 | 0.09 | 2.5e-04 | -4.3 | -5.6 | 2.2e-08 | -0.66 | 0.17 | 0.56 | FALSE |
| 9 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CHRNA3 | 0.05 | 0.02 | blup | 44 | 0.02 | 7.6e-03 | 6.3 | -5.3 | 1.4e-07 | -0.90 | 0.00 | 0.97 | FALSE |