Hub : Traits :

Chronic bronchitis/emphysema (mother)

10 significantly associated models · 4 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 15 78032707 79573404 4 1 1.7e-10 3.9e-10 0.12 94 PSMA4

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder or Schizophrenia 16.71 1 1 2.2 0 1 PSMA4
Schizophrenia (2018) 20.41 1 1 2.2 0 1 PSMA4
Schizophrenia (2014) 12.54 1 1 2.2 0 1 PSMA4
Blood Red Count 0.85 1 0 0.0 0 1 PSMA4
Blood White Count 1.22 1 0 0.0 0 1 PSMA4
Allergy or Eczema 6.15 1 0 0.0 0 1 PSMA4
Lung FEV1/FVC ratio 6.79 1 1 2.2 0 1 PSMA4
Lung FVC 7.05 1 1 2.2 0 1 PSMA4
Pack years adult smoking proportion 214.70 1 1 2.2 0 1 PSMA4
Current tobacco smoking 7.67 1 0 0.0 0 1 PSMA4
Maternal smoking around birth 17.46 1 0 0.0 0 1 PSMA4
Age when periods started (menarche) 5.05 1 0 0.0 0 1 PSMA4
Qualifications: CSEs or equivalent 7.05 1 0 0.0 0 1 PSMA4
Hayfever, allergic rhinitis or eczema 5.02 1 0 0.0 0 1 PSMA4
Multivitamins +/- minerals 7.77 1 0 0.0 0 1 PSMA4
Chronic bronchitis/emphysema (father) 42.45 1 1 2.2 0 1 PSMA4
Forced vital capacity (FVC) 6.67 1 0 0.0 0 1 PSMA4
Father's age at death 31.77 1 1 2.2 0 1 PSMA4
Number of live births 7.15 1 0 0.0 0 1 PSMA4
Forced expiratory volume in 1-second (FEV1) 13.40 1 1 2.2 0 1 PSMA4
Mouth/teeth dental problems: Dentures 13.76 1 0 0.0 0 1 PSMA4
Lung cancer (father) 58.33 1 1 2.2 0 1 PSMA4
Forced expiratory volume in 1-second (FEV1), Best measure 14.48 1 1 2.2 0 1 PSMA4
Peak expiratory flow (PEF) 6.68 1 0 0.0 0 1 PSMA4
Birth weight 4.63 1 0 0.0 0 1 PSMA4
Forced vital capacity (FVC), Best measure 6.90 1 0 0.0 0 1 PSMA4
Comparative body size at age 10 3.10 1 0 0.0 0 1 PSMA4
Wheeze or whistling in the chest in last year 7.02 1 0 0.0 0 1 PSMA4
Mouth/teeth dental problems: Loose teeth 7.14 1 0 0.0 0 1 PSMA4
Emphysema/chronic bronchitis 16.44 1 0 0.0 0 1 PSMA4
Heart disease (mother) 9.71 1 0 0.0 0 1 PSMA4
Alcohol intake frequency. 4.63 1 0 0.0 0 1 PSMA4
Overall health rating 8.98 1 0 0.0 0 1 PSMA4
Knee pain experienced in last month 5.75 1 0 0.0 0 1 PSMA4
Smoking status: Previous 7.16 1 0 0.0 0 1 PSMA4
Average weekly red wine intake 5.50 1 0 0.0 0 1 PSMA4
Forced expiratory volume in 1-second (FEV1), predicted percentage 31.08 1 1 2.2 0 1 PSMA4
Average weekly champagne plus white wine intake 5.89 1 0 0.0 0 1 PSMA4
Mother's age at death 11.46 1 0 0.0 0 1 PSMA4
Ever smoked 9.25 1 0 0.0 0 1 PSMA4
Risk taking 12.10 1 0 0.0 0 1 PSMA4
Unable to work because of sickness or disability 7.33 1 0 0.0 0 1 PSMA4
Pack years of smoking 199.10 1 1 2.2 0 1 PSMA4

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.2
GTEx Adipose Visceral Omentum 0 0.000 1.2
GTEx Adrenal Gland 0 0.000 1.1
GTEx Artery Aorta 0 0.000 1.2
GTEx Artery Coronary 0 0.000 1.2
GTEx Artery Tibial 0 0.000 1.1
GTEx Brain Caudate basal ganglia 0 0.000 1.1
GTEx Brain Cerebellar Hemisphere 0 0.000 1.2
GTEx Brain Cerebellum 0 0.000 1.2
GTEx Brain Cortex 0 0.000 1.2
GTEx Brain Frontal Cortex BA9 0 0.000 1.2
GTEx Brain Hippocampus 0 0.000 1.1
GTEx Brain Hypothalamus 0 0.000 1.3
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.2
GTEx Brain Putamen basal ganglia 0 0.000 1.2
GTEx Breast Mammary Tissue 0 0.000 1.2
GTEx Breast Mammary Tissue (Male) 0 0.000 1.2
GTEx Breast Mammary Tissue (Female) 0 0.000 1.1
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.2
GTEx Cells Transformed fibroblasts 0 0.000 1.2
GTEx Colon Sigmoid 0 0.000 1.2
GTEx Colon Transverse 0 0.000 1.2
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.3
GTEx Esophagus Mucosa 0 0.000 1.2
GTEx Esophagus Muscularis 0 0.000 1.2
GTEx Heart Atrial Appendage 0 0.000 1.2
GTEx Heart Left Ventricle 0 0.000 1.2
GTEx Liver 1 0.139 1.2
GTEx Lung 0 0.000 1.2
GTEx Muscle Skeletal 0 0.000 1.2
GTEx Nerve Tibial 0 0.000 1.2
GTEx Ovary 0 0.000 1.2
GTEx Pancreas 0 0.000 1.1
GTEx Pituitary 0 0.000 1.3
GTEx Prostate 0 0.000 1.1
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.3
GTEx Skin Sun Exposed Lower leg 0 0.000 1.2
GTEx Small Intestine Terminal Ileum 0 0.000 1.1
GTEx Spleen 0 0.000 1.2
GTEx Stomach 0 0.000 1.2
GTEx Testis 1 0.032 1.2
GTEx Thyroid 0 0.000 1.2
GTEx Uterus 0 0.000 1.3
GTEx Vagina 0 0.000 1.3
GTEx Whole Blood 0 0.000 1.2
METSIM Adipose 0 0.000 1.1
NTR Blood 0 0.000 1.2
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.1
YFS Blood 2 0.043 1.1
CommonMind Brain Pre-frontal Cortex 0 0.000 1.1
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Esophageal Carcinoma 2 0.292 1.2
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.1
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 1 0.090 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 1 0.075 1.2
The Cancer Genome Atlas Prostate Adenocarcinoma 1 0.022 1.2
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.2
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.1
The Cancer Genome Atlas Stomach Adenocarcinoma 1 0.059 1.1
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.2
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.2