Hub : Traits :

Chronic bronchitis/emphysema (mother)

10 significantly associated models · 4 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	15	78032707	79573404	4	1	1.7e-10	3.9e-10	0.12	94	PSMA4

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Pack years adult smoking proportion	214.70	1	1	2.2	1	PSMA4
Pack years of smoking	199.10	1	1	2.2	1	PSMA4
Lung cancer (father)	58.33	1	1	2.2	1	PSMA4
Chronic bronchitis/emphysema (father)	42.45	1	1	2.2	1	PSMA4
Father's age at death	31.77	1	1	2.2	1	PSMA4
Forced expiratory volume in 1-second (FEV1), predicted percentage	31.08	1	1	2.2	1	PSMA4
Schizophrenia (2018)	20.41	1	1	2.2	1	PSMA4
Maternal smoking around birth	17.46	1	0	0.0	1	PSMA4
Bipolar Disorder or Schizophrenia	16.71	1	1	2.2	1	PSMA4
Emphysema/chronic bronchitis	16.44	1	0	0.0	1	PSMA4
Forced expiratory volume in 1-second (FEV1), Best measure	14.48	1	1	2.2	1	PSMA4
Mouth/teeth dental problems: Dentures	13.76	1	0	0.0	1	PSMA4
Forced expiratory volume in 1-second (FEV1)	13.40	1	1	2.2	1	PSMA4
Schizophrenia (2014)	12.54	1	1	2.2	1	PSMA4
Risk taking	12.10	1	0	0.0	1	PSMA4
Mother's age at death	11.46	1	0	0.0	1	PSMA4
Heart disease (mother)	9.71	1	0	0.0	1	PSMA4
Ever smoked	9.25	1	0	0.0	1	PSMA4
Overall health rating	8.98	1	0	0.0	1	PSMA4
Multivitamins +/- minerals	7.77	1	0	0.0	1	PSMA4
Current tobacco smoking	7.67	1	0	0.0	1	PSMA4
Unable to work because of sickness or disability	7.33	1	0	0.0	1	PSMA4
Smoking status: Previous	7.16	1	0	0.0	1	PSMA4
Number of live births	7.15	1	0	0.0	1	PSMA4
Mouth/teeth dental problems: Loose teeth	7.14	1	0	0.0	1	PSMA4
Lung FVC	7.05	1	1	2.2	1	PSMA4
Qualifications: CSEs or equivalent	7.05	1	0	0.0	1	PSMA4
Wheeze or whistling in the chest in last year	7.02	1	0	0.0	1	PSMA4
Forced vital capacity (FVC), Best measure	6.90	1	0	0.0	1	PSMA4
Lung FEV1/FVC ratio	6.79	1	1	2.2	1	PSMA4
Peak expiratory flow (PEF)	6.68	1	0	0.0	1	PSMA4
Forced vital capacity (FVC)	6.67	1	0	0.0	1	PSMA4
Allergy or Eczema	6.15	1	0	0.0	1	PSMA4
Average weekly champagne plus white wine intake	5.89	1	0	0.0	1	PSMA4
Knee pain experienced in last month	5.75	1	0	0.0	1	PSMA4
Average weekly red wine intake	5.50	1	0	0.0	1	PSMA4
Age when periods started (menarche)	5.05	1	0	0.0	1	PSMA4
Hayfever, allergic rhinitis or eczema	5.02	1	0	0.0	1	PSMA4
Birth weight	4.63	1	0	0.0	1	PSMA4
Alcohol intake frequency.	4.63	1	0	0.0	1	PSMA4
Comparative body size at age 10	3.10	1	0	0.0	1	PSMA4
Blood White Count	1.22	1	0	0.0	1	PSMA4
Blood Red Count	0.85	1	0	0.0	1	PSMA4

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Brain Hypothalamus	0	0.000	1.3
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.3
GTEx	Pituitary	0	0.000	1.3
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.3
GTEx	Uterus	0	0.000	1.3
GTEx	Vagina	0	0.000	1.3
GTEx	Adipose Subcutaneous	0	0.000	1.2
GTEx	Adipose Visceral Omentum	0	0.000	1.2
GTEx	Artery Aorta	0	0.000	1.2
GTEx	Artery Coronary	0	0.000	1.2
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.2
GTEx	Brain Cerebellum	0	0.000	1.2
GTEx	Brain Cortex	0	0.000	1.2
GTEx	Brain Frontal Cortex BA9	0	0.000	1.2
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.2
GTEx	Brain Putamen basal ganglia	0	0.000	1.2
GTEx	Breast Mammary Tissue	0	0.000	1.2
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.2
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.2
GTEx	Cells Transformed fibroblasts	0	0.000	1.2
GTEx	Colon Sigmoid	0	0.000	1.2
GTEx	Colon Transverse	0	0.000	1.2
GTEx	Esophagus Mucosa	0	0.000	1.2
GTEx	Esophagus Muscularis	0	0.000	1.2
GTEx	Heart Atrial Appendage	0	0.000	1.2
GTEx	Heart Left Ventricle	0	0.000	1.2
GTEx	Liver	1	0.139	1.2
GTEx	Lung	0	0.000	1.2
GTEx	Muscle Skeletal	0	0.000	1.2
GTEx	Nerve Tibial	0	0.000	1.2
GTEx	Ovary	0	0.000	1.2
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.2
GTEx	Spleen	0	0.000	1.2
GTEx	Stomach	0	0.000	1.2
GTEx	Testis	1	0.032	1.2
GTEx	Thyroid	0	0.000	1.2
GTEx	Whole Blood	0	0.000	1.2
NTR	Blood	0	0.000	1.2
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Esophageal Carcinoma	2	0.292	1.2
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	1	0.090	1.2
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	1	0.075	1.2
The Cancer Genome Atlas	Prostate Adenocarcinoma	1	0.022	1.2
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.2
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.2
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.2
GTEx	Adrenal Gland	0	0.000	1.1
GTEx	Artery Tibial	0	0.000	1.1
GTEx	Brain Caudate basal ganglia	0	0.000	1.1
GTEx	Brain Hippocampus	0	0.000	1.1
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.1
GTEx	Pancreas	0	0.000	1.1
GTEx	Prostate	0	0.000	1.1
GTEx	Small Intestine Terminal Ileum	0	0.000	1.1
METSIM	Adipose	0	0.000	1.1
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.1
YFS	Blood	2	0.043	1.1
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.1
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.1
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.1
The Cancer Genome Atlas	Stomach Adenocarcinoma	1	0.059	1.1