TWAS
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Models
Genes
Traits
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Traits
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Forced expiratory volume in 1-second (FEV1), Best measure
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chr16:88,030,355-89,448,663
Best TWAS P=4.46e-09 · Best GWAS P=2.53e-08 conditioned to 0.00595
88M
88.2M
88.4M
88.6M
88.8M
89M
89.2M
89.4M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Whole Blood
SNAI3-AS1
0.15
0.04
enet
21
0.10
6.7e-10
1.8
5.9
4.5e-09
-0.56
0.06
0.93
TRUE
3
The Cancer Genome Atlas
Glioblastoma Multiforme
SNAI3
0.19
0.06
enet
7
0.12
1.6e-04
2.6
-5.4
5.8e-08
0.68
0.00
0.62
FALSE
1
GTEx
Uterus
SNAI3-AS1
0.47
0.00
enet
13
0.04
5.3e-02
-2.7
5.4
7.2e-08
-0.59
0.03
0.40
FALSE