Best TWAS P=4.94e-10 · Best GWAS P=3.53e-09 conditioned to 0.282
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | SERPINF1 | 0.19 | 0.05 | lasso | 6 | 0.02 | 6.3e-03 | 5.3 | -5.5 | 4.7e-08 | 0.57 | 0.06 | 0.70 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | SERPINF1 | 0.20 | 0.11 | lasso | 3 | 0.16 | 5.6e-12 | 5.3 | -6.2 | 4.9e-10 | 0.86 | 0.01 | 0.99 | TRUE |
| 3 | GTEx | Skin Not Sun Exposed Suprapubic | SMYD4 | 0.28 | 0.06 | enet | 36 | 0.12 | 5.8e-07 | 4.5 | -5.2 | 1.8e-07 | 0.67 | 0.01 | 0.98 | FALSE |
| 4 | GTEx | Testis | SERPINF1 | 0.29 | 0.14 | lasso | 6 | 0.13 | 3.0e-06 | -5.4 | -5.3 | 1.1e-07 | 0.93 | 0.01 | 0.98 | FALSE |
| 5 | GTEx | Thyroid | SMYD4 | 0.32 | 0.13 | enet | 11 | 0.23 | 1.5e-17 | 4.5 | -5.4 | 7.9e-08 | 0.81 | 0.21 | 0.79 | FALSE |
| 6 | YFS | Blood | WDR81 | 0.17 | 0.16 | enet | 22 | 0.18 | 1.3e-57 | 5.3 | 5.5 | 3.7e-08 | -0.77 | 0.04 | 0.96 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SERPINF1 | 0.06 | 0.03 | blup | 68 | 0.05 | 8.8e-06 | 4.4 | -5.4 | 8.0e-08 | 0.75 | 0.01 | 0.97 | FALSE |