TWAS hub - SNAI3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Lung	0.1976	0.0542	1.6e-04	0.109	NA	0.068	NA	0.097	1.1e-08	NA	6.3e-06	NA	7.0e-08
2	NTR	Blood	0.0514	0.0136	1.5e-07	0.043	0.032	0.032	0.040	0.040	1.2e-13	1.7e-10	1.4e-10	5.0e-13	5.3e-13
3	YFS	Blood	0.1860	0.0256	0.0e+00	0.165	0.167	0.206	0.217	0.211	1.4e-51	3.6e-52	2.7e-65	2.5e-69	3.0e-67
4	TCGA	Glioblastoma Multiforme	0.1900	0.0760	2.2e-03	0.055	0.114	0.121	NA	0.116	9.0e-03	2.6e-04	1.6e-04	NA	2.2e-04
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0479	0.0231	4.2e-03	0.020	0.013	0.011	NA	0.013	2.3e-03	1.1e-02	1.8e-02	NA	1.0e-02
6	TCGA	Brain Lower Grade Glioma	0.0543	0.0227	3.3e-04	0.059	0.022	0.042	NA	0.045	3.0e-07	1.4e-03	1.5e-05	NA	7.0e-06
7	TCGA	Soft Tissue Sarcoma	0.0880	0.0460	9.3e-03	0.047	0.019	0.020	NA	0.024	8.5e-04	2.5e-02	2.1e-02	NA	1.4e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Hair Pigment	9.2	263.2	571.2	10.0	19.5	-3.8	23.9	17.7	18.9	10.3
Ever taken oral contraceptive pill	5.9	6.5	9.9	3.1	2.8	2.7	2.8	2.0	2.7	1.2
Tanning	5.4	65.9	158.8	-5.3	-9.5	0.7	-12.6	-9.0	-9.4	-3.6
Medication: Ibuprofen (e.g. Nurofen)	5.4	6.9	11.0	2.1	2.5	2.4	3.2	3.3	2.5	2.0
Medication: Bendroflumethiazide	5.2	7.8	14.5	2.7	3.0	1.5	3.8	2.3	3.2	2.5
Neuroticism score	5.0	10.3	20.6	3.3	3.6	2.8	4.5	2.2	3.3	2.1
Loneliness, isolation	5.0	6.9	15.0	2.5	3.0	1.5	3.9	1.7	2.8	2.4
Worry (Nagel 2018)	4.9	10.4	13.9	3.2	3.7	2.5	3.7	2.3	3.4	3.4
Medication: Ventolin 100micrograms inhaler	4.9	6.3	9.8	2.5	2.9	1.9	3.1	2.1	2.8	1.9
Neuroticism	4.8	11.6	23.2	3.2	3.8	2.3	4.8	3.1	3.5	2.7
Leg fat-free mass (right)	4.8	25.9	46.5	-3.9	-5.5	-2.3	-6.8	-5.5	-5.7	-4.6
Leg predicted mass (right)	4.8	25.7	46.6	-3.9	-5.5	-2.3	-6.8	-5.5	-5.7	-4.5
Leg predicted mass (left)	4.6	24.2	41.5	-3.8	-5.4	-2.1	-6.4	-5.2	-5.6	-4.7
Leg fat-free mass (left)	4.5	24.1	40.7	-3.8	-5.3	-2.2	-6.4	-5.2	-5.6	-4.7
Medication: Ibuprofen	4.5	5.4	8.9	1.8	2.3	2.2	3.0	2.7	2.3	1.7
Commuting to job workplace: Public transport	4.4	5.3	12.6	2.0	2.4	1.7	3.6	1.2	2.7	1.7
Osteoporosis (self-reported)	4.3	5.4	8.2	-2.3	-2.5	-1.6	-2.9	-2.2	-2.6	-1.9
Worrier / anxious feelings	4.0	7.5	11.3	2.9	3.4	1.6	3.0	1.9	3.2	2.8
Medication for hormone replacement therapy	3.9	4.4	6.0	2.3	2.1	2.0	2.4	2.0	2.1	1.6
Blood clot in the leg (DVT)	3.7	4.8	8.9	-2.0	-1.9	-1.9	-3.0	-2.3	-2.4	-1.5
Number of children fathered	3.7	4.2	8.3	-1.5	-1.5	-2.5	-2.9	-2.4	-1.8	-1.4
Forced expiratory volume in 1-second (FEV1)	3.6	12.2	31.2	-2.3	-3.5	-2.0	-5.6	-4.0	-3.9	-1.6
Wheeze or whistling in the chest in last year	3.6	6.5	12.5	2.4	2.6	1.8	3.5	2.8	2.5	1.7
Illness, injury, bereavement, stress in last 2 years	3.6	4.4	6.3	-2.4	-2.1	-2.5	-2.4	-2.0	-2.1	-0.1
Height	3.5	67.7	153.8	-5.2	-8.6	-2.6	-12.4	-9.5	-9.1	-6.3
Forced expiratory volume in 1-second (FEV1), Best measure	3.5	11.2	29.4	-2.2	-3.1	-2.1	-5.4	-3.8	-3.5	-1.6
Whole body fat-free mass	3.5	20.2	39.7	-3.1	-4.8	-1.6	-6.3	-4.9	-5.1	-4.2
Deep venous thrombosis (DVT) (self-reported)	3.5	4.5	8.0	-1.9	-1.9	-1.9	-2.8	-2.1	-2.3	-1.5
Respiratory disease	3.4	7.7	19.9	2.4	2.5	1.4	4.5	2.3	2.9	2.5
Whole body water mass	3.4	19.7	38.9	-3.0	-4.7	-1.5	-6.2	-4.8	-5.0	-4.1
Miserableness	3.4	5.8	9.6	2.2	2.6	2.5	3.1	2.5	2.4	1.4
Basal metabolic rate	3.3	18.4	34.8	-3.0	-4.6	-1.4	-5.9	-4.6	-4.9	-4.1
Neuroticism (2016)	3.2	4.7	9.3	2.1	2.3	2.0	3.0	1.8	2.1	1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.2	3.7	5.2	-2.3	-2.2	-1.3	-2.1	-1.6	-2.1	-1.6
Depressed Affect (Nagel 2018)	3.1	6.6	16.7	1.6	2.2	0.9	4.1	3.1	2.1	2.6
Hearing difficulty/problems: Yes	3.1	4.7	7.6	2.5	2.8	1.2	2.0	1.3	2.6	2.2
Trunk predicted mass	3.1	17.5	36.2	-2.7	-4.3	-1.3	-6.0	-4.7	-4.7	-3.8
Neuroticism (Nagel 2018)	3.0	7.0	17.1	2.1	2.6	1.4	4.1	2.7	2.4	2.3
Average weekly fortified wine intake	2.9	3.4	5.1	2.3	2.2	1.3	1.0	1.9	2.0	1.8
Trunk fat-free mass	2.9	16.7	34.6	-2.6	-4.3	-1.2	-5.9	-4.6	-4.6	-3.7
Suffer from ‘nerves’	2.9	4.6	6.6	2.4	2.5	2.6	2.0	1.2	2.2	1.8
Number of full brothers	2.8	3.6	7.1	-1.7	-1.9	-1.3	-2.2	-1.4	-1.7	-2.7
Impedance of leg (right)	2.7	12.8	25.1	3.3	3.5	2.8	5.0	3.7	3.7	2.6
Sitting height	2.7	18.9	41.5	-2.9	-4.8	-2.6	-6.4	-4.5	-4.9	-2.9
Weight	2.7	13.3	19.5	-2.9	-4.2	-1.1	-4.4	-3.7	-4.3	-3.8
Standing height	2.7	26.5	58.8	-3.0	-5.5	-1.4	-7.7	-6.2	-5.7	-3.9
Guilty feelings	2.7	4.0	5.6	2.4	2.2	2.3	2.2	1.5	2.0	1.0
Impedance of leg (left)	2.6	12.4	22.8	3.4	3.6	2.8	4.8	3.3	3.7	2.7
Arm fat-free mass (left)	2.6	13.2	25.6	-2.3	-3.7	-1.1	-5.1	-4.0	-4.1	-3.7
Age started oral contraceptive pill	2.6	3.3	8.9	-1.8	-1.8	-1.6	-3.0	-0.9	-1.9	-0.7
Arm predicted mass (left)	2.6	13.1	26.2	-2.3	-3.7	-1.1	-5.1	-4.0	-4.0	-3.6
High blood pressure (mother)	2.5	3.5	5.7	1.7	2.2	1.0	2.4	1.3	2.2	1.8
Forced vital capacity (FVC), Best measure	2.5	9.2	25.1	-1.9	-2.9	-2.3	-5.0	-3.4	-3.1	-0.7
Average weekly spirits intake	2.3	2.8	5.6	2.3	1.7	2.4	1.3	-0.0	1.8	0.9
Forced vital capacity (FVC)	2.3	9.0	26.3	-1.7	-3.0	-1.9	-5.1	-3.3	-3.2	-0.8
Arm predicted mass (right)	2.3	11.9	24.2	-2.2	-3.7	-0.9	-4.9	-3.7	-3.9	-3.3
Leg pain on walking	2.3	2.9	4.3	-1.8	-1.4	-2.1	-1.1	-2.1	-1.5	-1.8
Age when periods started (menarche)	2.2	5.2	8.8	-2.6	-2.3	-3.0	-1.7	-2.6	-2.1	-1.0
Irritability	2.2	3.8	10.8	1.8	2.0	0.8	3.3	1.2	2.1	1.4
Hayfever/allergic rhinitis (self-reported)	2.1	2.8	5.0	1.7	1.5	1.3	1.9	1.4	1.5	2.2
Arm fat-free mass (right)	2.1	10.9	22.8	-2.0	-3.5	-0.8	-4.8	-3.5	-3.8	-3.1
Forced expiratory volume in 1-second (FEV1), predicted	2.1	4.4	12.2	-0.8	-2.2	-0.1	-3.5	-2.0	-2.3	-2.0
Wears glasses or contact lenses	2.1	2.4	5.8	1.6	1.7	1.1	2.4	0.6	2.0	0.6
Financial situation satisfaction	2.1	2.6	6.6	1.3	1.1	1.3	1.8	2.6	1.4	1.4
Alzheimer’s Disease (including proxy)	2.0	2.9	4.5	-1.6	-1.7	-2.0	-2.1	-1.9	-1.6	-0.6
Time employed in main current job	2.0	2.3	3.5	-1.8	-1.5	-1.4	-0.1	-1.8	-1.3	-1.9
Medication for cholesterol	2.0	3.0	4.7	-2.2	-2.0	-1.6	-1.3	-1.5	-1.7	-1.7
Breastfed as a baby	1.9	2.3	4.8	-1.0	-1.4	-0.5	-2.1	-2.2	-1.3	-1.5
Pulse rate, automated reading	1.9	6.2	11.7	3.1	2.4	3.4	1.9	2.4	2.4	0.9
Handedness (chirality/laterality): Left-handed	1.9	2.3	4.9	-1.8	-1.5	-2.2	-1.3	-0.8	-1.7	-0.7
Smoking status: Current	1.9	3.1	6.0	2.1	2.1	2.4	1.0	0.3	1.9	1.4
Medication: Blood pressure	1.9	3.7	5.7	2.1	2.1	0.8	1.1	2.4	2.0	2.3
Pack years of smoking	1.9	2.8	4.4	-2.0	-1.8	-1.1	-1.3	-1.2	-2.1	-2.0
Tense / ‘highly strung’	1.8	3.0	5.4	2.3	2.3	1.7	1.4	-0.7	2.1	0.6
Alzheimer’s Disease (in mother)	1.7	1.9	4.2	-1.2	-1.3	-1.5	-1.4	-2.0	-1.1	-0.8
Trunk fat mass	1.7	7.2	10.0	-2.1	-3.2	-0.5	-2.9	-2.8	-3.2	-3.0
Financial difficulties in last 2 years	1.7	2.3	4.9	1.3	1.6	1.0	1.8	2.2	1.4	0.9
Pulse rate	1.7	2.8	6.0	2.0	1.4	2.4	1.4	1.8	1.5	0.4
Migraine (self-reported)	1.7	2.1	4.7	1.3	1.4	1.2	0.8	2.2	1.3	1.6
Asthma (self-reported)	1.7	3.3	9.9	1.5	1.3	1.3	3.1	1.3	1.5	1.9
Pain type(s) experienced in last month: Hip pain	1.7	2.1	3.0	-1.4	-1.7	-0.5	-1.7	-1.2	-1.7	-1.7
Medication: Lisinopril	1.7	2.2	4.7	1.5	1.4	1.0	1.6	0.9	1.4	2.2
Asthma	1.6	3.1	9.5	1.5	1.3	1.3	3.1	1.1	1.5	1.7
Commuting to job workplace: Car/motor vehicle	1.6	1.9	3.6	-1.5	-1.2	-1.1	-1.5	-1.9	-1.3	-1.0
Mood swings	1.6	2.8	9.3	1.1	1.6	0.6	3.1	1.7	1.5	1.0
Lung FVC	1.5	7.9	24.1	-2.2	-2.3	-2.5	-4.9	-2.9	-2.6	-0.2
Medication: Ramipril	1.5	1.9	5.2	-0.7	-1.0	-0.4	-1.3	-1.7	-1.3	-2.3
Worry too long after embarrassment	1.5	2.5	4.5	1.7	1.7	1.6	2.1	1.4	1.4	0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.7	2.8	-1.4	-1.1	-1.4	-1.0	-1.7	-1.3	-1.1
Medication: Seretide 50 evohaler	1.5	1.7	3.7	-1.7	-1.4	-1.9	-0.7	-0.3	-1.5	-0.4
Average weekly beer plus cider intake	1.5	2.1	4.5	1.3	1.0	2.0	0.2	1.8	0.7	2.1
Frequency of depressed mood in last 2 weeks	1.4	1.9	4.5	1.3	1.4	1.3	2.1	0.8	1.3	1.1
Pack years adult smoking proportion	1.4	2.1	3.4	-1.8	-1.5	-0.9	-1.1	-0.8	-1.9	-1.8
Current tobacco smoking	1.4	2.3	4.2	1.7	1.8	2.1	0.9	0.3	1.6	1.4
Prospective memory result	1.4	1.7	4.4	-1.3	-1.5	-0.2	-0.9	-0.9	-1.4	-2.1
Length of working week for main job	1.4	1.6	2.6	-1.3	-1.6	-0.1	-1.3	-1.3	-1.6	-0.9
Whole body fat mass	1.4	5.7	8.1	-2.0	-2.8	-0.5	-2.4	-2.5	-2.9	-2.8
Arm fat mass (left)	1.4	5.9	8.4	-1.9	-2.7	-0.5	-2.8	-2.4	-2.8	-2.9
Smoking Status	1.3	3.1	5.2	1.9	2.1	2.3	0.7	0.8	1.7	2.2
Allergy or Eczema	1.3	3.4	6.2	1.5	2.0	0.1	2.5	1.8	2.0	2.0
Cardiovascular Disease	1.3	4.4	12.0	1.9	2.2	0.9	3.5	2.0	2.1	1.1
Ever had hysterectomy (womb removed)	1.3	1.5	2.9	1.4	1.1	1.3	0.1	1.7	1.0	1.4
Multivitamins +/- minerals	1.3	1.7	3.1	-1.5	-1.8	-0.7	-0.3	-0.7	-1.6	-1.6
Father’s age at death	1.3	1.8	3.5	-0.8	-1.1	0.4	-1.8	-1.2	-1.6	-1.9
Commuting to job workplace: Walk	1.3	1.4	2.6	1.5	1.1	1.1	0.9	1.6	0.9	0.8
Hearing aid user	1.3	1.5	2.0	1.2	1.3	1.0	1.4	0.8	1.4	1.2
Alzheimer’s Disease (in father)	1.2	1.3	2.3	-1.5	-1.4	-1.1	-1.0	-0.6	-1.3	-0.5
Hayfever, allergic rhinitis or eczema	1.2	2.5	5.3	1.4	1.7	0.3	1.4	1.7	1.6	2.3
Hip circumference	1.2	5.0	7.7	-2.0	-2.8	-0.7	-2.4	-1.7	-2.8	-2.6
Breast cancer (self-reported)	1.2	1.4	2.2	-1.3	-1.2	-1.0	-0.8	-1.1	-1.2	-1.5
Blood Red Count	1.1	10.2	34.5	-1.5	-3.3	-0.1	-5.9	-3.2	-3.0	-1.9
Chronotype (morning person)	1.1	2.4	5.7	-1.6	-1.6	-1.3	-1.5	0.1	-1.6	-2.4
Vitamin and mineral supplements	1.1	1.5	3.6	1.9	1.6	1.1	-0.3	0.6	1.4	0.8
Nervous feelings	1.1	2.0	4.1	1.8	1.6	2.0	1.2	0.1	1.3	0.8
Arm fat mass (right)	1.1	4.7	6.8	-1.8	-2.5	-0.3	-2.4	-2.1	-2.6	-2.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	2.0	-1.4	-1.2	-1.3	-0.5	-1.4	-1.2	-1.0
Age at last live birth	1.1	1.6	2.5	-1.6	-1.2	-1.4	-1.2	-1.1	-1.3	-1.0
Average weekly red wine intake	1.1	1.6	3.1	1.8	1.5	1.0	0.8	1.2	1.4	1.0
Medication: Gliclazide	1.1	1.2	2.4	-1.0	-1.5	-0.3	-1.4	-0.6	-1.4	-0.9
Illnesses of father: High blood pressure	1.1	1.4	4.8	0.2	0.6	-0.0	1.1	1.7	0.5	2.2
Primary Biliary Cirrhosis	1.0	1.4	1.8	-1.3	-1.3	-1.0	-1.0	-1.2	-1.3	-1.2
Hand grip strength (left)	1.0	2.8	6.7	-0.9	-1.2	-0.8	-2.4	-2.6	-1.4	-1.4
Medication: Co-codamol	1.0	1.2	4.1	-0.9	-0.7	-1.4	-0.1	-0.6	-0.7	-2.0
Hand grip strength (right)	1.0	2.7	6.9	-0.5	-1.1	-0.4	-2.4	-2.6	-1.2	-1.7
Fed-up feelings	1.0	1.8	5.4	0.5	1.0	-0.3	2.3	1.6	0.7	1.7
Medication: Atenolol	1.0	1.2	5.2	-0.8	0.1	-2.3	1.4	-0.4	0.2	-0.6
Had menopause	1.0	1.3	1.9	-1.3	-1.1	-0.7	-1.4	-0.7	-1.2	-1.3
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	1.6	1.3	1.3	1.2	1.2	1.1	1.2	-0.2
Allergy	1.0	2.2	4.1	-1.3	-1.5	-0.7	-1.9	-1.3	-1.4	-2.0
Alcohol intake frequency.	1.0	2.3	7.4	-2.0	-1.5	-2.7	-0.1	-0.0	-1.2	-1.2
Illnesses of father: Heart disease	1.0	1.4	2.6	-1.6	-1.3	-1.3	-1.2	0.6	-1.1	-0.5
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.3	-0.3	-0.6	1.5	-1.2	-1.2	-0.7	-0.7
Serious illness, injury or assault to yourself	0.9	1.1	2.8	1.2	0.9	1.7	0.7	0.2	1.1	-0.8
Lung cancer (father)	0.9	1.1	5.3	0.3	-0.0	0.8	0.5	-1.0	0.2	-2.3
Age at first live birth	0.9	1.6	2.9	-1.5	-1.2	-1.7	-0.5	-1.6	-1.1	-0.2
Arm fat percentage (left)	0.9	3.4	5.8	-1.9	-2.3	-0.4	-1.6	-1.4	-2.3	-2.4
Ever had bowel cancer screening	0.9	1.0	2.0	-0.9	-0.9	-0.7	-0.6	-1.4	-0.9	-1.4
Back pain experienced in last month	0.9	1.3	2.0	1.3	1.4	0.5	1.3	-0.6	1.1	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.8	2.8	-1.3	-1.1	-1.7	-1.6	-1.5	-1.3	-0.7
Bipolar Disorder or Schizophrenia	0.8	1.8	2.9	1.4	1.5	1.7	1.6	1.1	1.4	0.4
Trunk fat percentage	0.8	3.4	5.2	-1.6	-2.2	-0.1	-1.7	-1.8	-2.2	-2.3
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.8	-1.2	-0.5	-1.1	1.1	-1.3	-0.5	-0.3
Hearing difficulty/problems with background noise	0.8	1.3	4.2	0.9	1.4	-0.8	0.4	0.3	1.2	2.1
Arm fat percentage (right)	0.8	3.1	5.3	-1.7	-2.1	-0.3	-1.5	-1.4	-2.1	-2.3
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.2	4.3	0.6	0.9	1.2	2.1	0.8	1.0	0.4
Falls in the last year	0.8	1.1	2.1	-1.1	-1.3	-0.7	-0.7	-0.6	-1.5	-1.2
Peak expiratory flow (PEF)	0.8	1.8	3.5	-0.9	-1.1	-0.8	-1.9	-1.7	-1.4	-1.1
Loud music exposure frequency	0.8	0.8	3.1	0.5	0.4	-0.0	1.8	1.2	0.5	0.7
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	4.4	0.3	1.1	0.3	2.1	-0.3	1.0	-0.1
Comparative height size at age 10	0.8	4.2	11.8	0.1	-1.8	0.9	-3.4	-2.8	-2.0	-1.3
Supplements: Vitamin C	0.8	1.0	1.9	-1.4	-1.2	-1.0	-0.3	-1.3	-1.0	-0.1
Osteoarthritis (self-reported)	0.8	1.1	2.6	-1.6	-1.1	-1.5	-0.1	-0.1	-1.1	0.4
Supplements: Fish oil (including cod liver oil)	0.8	1.1	2.2	-1.5	-1.0	-1.4	-0.1	-0.8	-1.0	0.8
Medication: Atorvastatin	0.8	1.0	2.4	-1.5	-1.3	-1.2	0.5	0.5	-0.9	0.2
Pain experienced in last month	0.8	1.4	3.2	-0.9	-1.6	-0.9	-1.8	-1.1	-1.1	-0.4
Leg fat mass (left)	0.8	3.0	6.5	-1.4	-2.0	-0.2	-1.2	-1.7	-2.0	-2.5
Schizophrenia (2018)	0.7	1.4	1.8	1.2	1.3	1.2	1.3	1.3	1.2	0.2
Blood White Count	0.7	4.9	10.8	-2.3	-3.3	0.0	-2.5	-2.1	-2.6	-0.5
Heel T-Score	0.7	5.2	8.2	-1.1	-2.6	0.3	-2.8	-2.9	-2.4	-2.6
Lung FEV1/FVC ratio	0.7	3.6	7.7	-1.2	-1.7	0.3	-2.2	-2.8	-1.9	-2.2
Hair/balding pattern: Pattern 2	0.7	0.8	3.5	-0.1	0.6	-0.0	1.9	0.9	0.7	0.8
Birth weight of first child	0.7	1.3	4.5	1.2	0.8	2.1	1.0	0.3	1.1	-0.7
Leg fat mass (right)	0.7	2.7	5.7	-1.4	-1.9	-0.2	-1.0	-1.5	-1.9	-2.4
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	1.5	0.4	0.8	1.0	1.2	0.2	0.8	1.2
Friendships satisfaction	0.7	0.9	2.1	-1.1	-0.7	-1.2	1.4	-0.8	-0.1	0.3
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.7	-0.6	-0.9	-0.3	-1.4	-0.7	-1.1	-1.6
Number of self-reported non-cancer illnesses	0.7	1.2	3.0	0.4	0.9	0.3	1.7	1.7	0.7	0.8
Ever smoked	0.7	1.3	2.6	1.4	1.3	1.6	0.5	0.9	1.1	0.6
Ever depressed for a whole week	0.7	0.8	1.5	1.1	1.2	0.7	0.8	0.7	1.1	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.5	-0.9	-1.0	-1.2	-0.9	-0.6	-1.0	-0.4
Supplements: Calcium	0.7	0.7	2.1	1.1	0.9	1.4	0.3	0.5	0.6	0.7
Depression (Nagel 2018)	0.6	0.8	3.2	0.5	0.7	0.4	1.8	0.5	0.8	0.9
Irritable Bowel Disease (IBD)	0.6	1.5	3.6	1.1	1.0	1.2	1.9	1.0	1.1	1.1
HbA1C	0.6	0.7	1.2	1.1	1.0	0.0	0.8	0.6	0.7	1.0
Angina	0.6	0.8	1.9	-1.2	-0.7	-1.4	0.7	-0.8	-0.6	-0.4
Severe depression (siblings)	0.6	0.7	1.8	0.5	0.9	0.0	1.4	0.8	0.9	-0.6
Stomach or abdominal pain in last month	0.6	0.7	2.5	0.7	0.8	1.6	0.8	-0.4	0.7	-0.3
Waist circumference	0.6	2.3	5.0	-1.0	-1.7	0.5	-1.5	-1.4	-1.8	-2.2
Happiness	0.6	0.7	3.3	0.3	0.0	1.1	1.8	0.6	0.4	0.0
Depression (self-reported)	0.6	0.7	1.8	0.6	0.7	0.8	1.3	0.7	0.5	-0.7
Mineral and other dietary supplements	0.6	0.8	1.9	1.4	1.1	0.9	-0.0	0.4	0.8	-0.9
Risk taking	0.6	0.9	2.4	1.0	0.9	1.6	1.0	-0.2	0.9	-0.4
Crohns Disease (2017)	0.5	1.1	1.9	1.0	0.9	1.0	1.4	0.8	1.1	1.1
Lupus	0.5	0.8	2.1	1.0	1.0	0.5	0.2	1.4	0.6	1.0
Type 2 Diabetes (T2D) (2018)	0.5	1.0	2.3	0.7	0.8	1.5	1.2	0.9	0.8	0.8
Number of treatments/medications taken	0.5	0.9	3.0	0.4	0.7	0.4	1.7	1.2	0.7	0.4
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.0	0.6	1.0	0.7	0.9	0.2	1.0	0.8
Supplements: Zinc	0.5	0.6	1.2	-0.7	-0.8	0.1	-0.5	-0.8	-0.9	-1.1
Diabetes (mother)	0.5	0.6	1.5	-0.9	-0.4	-0.9	1.2	-0.1	-0.2	-0.9
Maternal smoking around birth	0.5	0.7	1.1	-0.9	-0.9	-0.7	-0.3	-1.1	-0.8	-0.8
High blood pressure	0.5	1.4	4.5	0.9	1.1	0.1	2.1	1.1	1.2	0.6
Supplements: Glucosamine	0.5	0.6	1.8	-1.3	-1.0	-0.9	-0.1	-0.0	-0.8	-0.1
Body mass index (BMI)	0.5	2.3	4.5	-1.6	-1.8	-0.5	-1.1	-1.1	-1.8	-2.1
Noisy workplace	0.5	0.6	3.7	-0.2	-0.2	-0.2	-0.3	-0.6	-0.0	-1.9
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.6	0.9	0.6	1.0	0.3	0.0	0.4	-1.2
Medication: Lansoprazole	0.5	0.6	1.5	-1.0	-0.5	-1.2	1.1	-0.3	-0.5	-0.1
Body fat percentage	0.5	1.9	4.3	-1.2	-1.7	0.0	-0.8	-1.1	-1.6	-2.1
Emphysema/chronic bronchitis	0.5	0.5	1.1	-0.6	-0.5	-0.7	-0.7	-1.0	-0.6	-0.9
Angina (self-reported)	0.5	0.7	1.4	-1.0	-0.6	-1.2	0.9	-0.7	-0.5	-0.5
Heart disease (mother)	0.5	0.6	2.0	0.4	0.6	1.1	-0.1	1.4	0.4	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.3	0.5	0.8	-0.3	1.1	0.4	0.9	1.0
Number of full sisters	0.5	0.6	2.0	-0.3	0.2	-0.8	-0.3	-1.3	-0.1	-1.4
Overall health rating	0.5	1.1	3.1	0.5	1.1	0.1	1.8	0.7	0.9	1.4
Hypertension (Self-reported)	0.5	1.4	4.4	0.8	1.1	0.1	2.1	1.1	1.2	0.7
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.7	-0.6	-0.1	-1.6	0.4	0.6	-0.0	0.5
Alcohol drinker status: Never	0.5	0.6	3.5	-0.8	-0.4	-1.9	0.4	0.2	-0.1	-0.1
Fractured/broken bones in last 5 years	0.5	0.7	1.8	0.7	0.8	0.3	0.8	1.3	0.8	0.7
Vascular/heart problems diagnosed by doctor	0.5	1.4	4.9	-0.9	-1.0	-0.3	-2.2	-1.1	-1.2	-0.4
Cholesterol lowering medication	0.5	0.8	1.6	-1.0	-0.8	-0.5	-1.2	-0.7	-1.2	-0.3
Alcohol drinker status: Previous	0.5	0.6	2.4	0.3	0.5	-0.0	0.9	1.5	0.6	0.1
Impedance of whole body	0.5	2.4	4.5	1.4	1.4	1.2	2.1	1.4	1.6	1.5
Breast Cancer	0.4	1.0	1.9	1.2	1.4	1.0	0.0	0.2	1.4	0.9
Ovarian Cancer	0.4	0.5	1.6	0.3	0.5	-0.1	0.3	1.3	0.3	1.2
Mean Putamen Volume	0.4	0.5	0.9	-0.7	-0.7	-0.0	-0.7	-0.5	-0.8	-1.0
Blood Platelet Count	0.4	4.3	16.7	2.2	0.5	4.1	1.8	-0.6	1.6	-1.4
Systolic Blood Pressure	0.4	2.2	5.3	0.9	1.5	-0.8	2.3	1.6	1.5	1.1
Relative age of first facial hair	0.4	0.9	1.8	-1.4	-1.0	-0.9	-0.1	-0.8	-0.8	-1.1
Chronic bronchitis/emphysema (father)	0.4	0.5	1.4	-0.9	-0.5	-1.2	-0.8	-0.1	-0.7	-0.3
Number of incorrect matches in round	0.4	0.7	1.4	-0.8	-0.6	-0.8	0.4	-1.1	-0.6	-1.2
Heart attack	0.4	0.5	1.3	-0.8	-0.6	-1.2	0.2	0.7	-0.7	-0.6
Fluid intelligence score	0.4	0.8	2.6	0.6	0.7	0.6	0.4	0.9	0.6	1.6
Alcohol intake versus 10 years previously	0.4	0.6	2.1	0.6	0.8	0.6	1.4	0.2	0.7	-0.1
Illnesses of mother	0.4	0.4	1.9	0.2	-0.4	-0.2	-1.4	-0.6	-0.5	-0.6
Ever highly irritable/argumentative for 2 days	0.4	0.5	3.1	0.1	0.1	0.0	0.2	-0.5	0.1	-1.8
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.1	0.9	0.6	1.0	-0.7	1.1	0.4	1.0
Medication: Blood pressure	0.4	0.7	2.5	-0.7	-0.1	-1.3	1.6	-0.5	0.2	0.2
Medication: Omeprazole	0.4	0.4	1.3	-0.6	-0.5	-1.1	-0.7	-0.2	-0.5	-0.6
Chest pain or discomfort	0.4	0.6	2.5	-0.1	0.2	-0.4	1.6	1.0	0.2	0.6
Illnesses of father: None of the above (group 1)	0.4	0.4	1.7	0.7	0.2	0.6	0.4	-1.3	0.2	-0.6
Commuting to job workplace: Cycle	0.4	0.5	1.8	0.4	0.3	0.1	1.1	1.3	0.5	0.3
Basal cell carcinoma (self-reported)	0.4	0.5	1.2	-0.3	-0.3	-1.1	-0.6	-1.1	-0.7	-0.2
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.0	-0.8	-0.5	-1.0	0.3	0.7	-0.6	-0.7
Ulcerative Colitis (UC)	0.3	0.6	1.8	0.6	0.5	0.7	1.3	0.7	0.6	0.5
Reaction Time	0.3	0.6	2.6	0.6	0.2	1.6	0.8	0.5	0.2	-0.1
Schizophrenia (2014)	0.3	0.8	1.4	0.6	1.0	0.4	1.2	1.1	1.0	0.3
Sensitivity / hurt feelings	0.3	0.5	2.3	-0.2	0.4	0.0	1.5	0.3	0.2	-0.9
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.9	0.4	0.3	0.6	0.6	0.9	0.4	0.3
Medication: Metformin	0.3	0.4	0.9	0.3	0.2	0.9	0.6	-0.1	0.5	0.9
Taking other prescription medications	0.3	0.4	0.9	-0.8	-0.5	-1.0	-0.2	-0.7	-0.6	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	2.6	-0.5	-1.0	-0.4	-0.9	-1.6	-0.8	-0.1
Had other major operations	0.3	0.4	1.3	0.5	0.7	0.3	0.5	0.0	0.6	1.1
Diabetes (self-reported)	0.3	0.4	1.3	-0.6	-0.5	0.4	-0.6	-1.2	-0.5	-0.4
Medication: Cholesterol lowering	0.3	0.5	1.0	-0.9	-0.6	-1.0	0.5	-1.0	-0.4	-0.2
Exposure to tobacco smoke at home	0.3	0.3	1.1	0.1	-0.3	0.6	0.5	-1.0	0.2	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	2.1	0.1	0.3	-0.0	1.4	0.8	0.3	0.0
Hair/balding pattern: Pattern 4	0.3	0.7	1.9	-0.3	0.0	-0.6	-1.0	-1.0	-0.6	-1.4
Pulse wave reflection index	0.3	0.4	1.2	0.3	0.6	-0.3	0.4	0.6	0.6	1.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	2.7	0.8	0.4	1.6	-0.4	-0.6	0.3	-0.2
Birth weight	0.3	0.7	1.6	-0.7	-1.1	-1.1	-0.3	-1.3	-0.7	0.0
High blood pressure (siblings)	0.3	0.4	1.1	0.2	0.5	-0.1	0.2	1.0	0.5	1.0
Health satisfaction	0.3	0.4	2.1	-0.3	-0.1	-0.6	1.4	0.1	0.3	-0.7
Eye problems/disorders: None of the above	0.3	0.4	0.9	-0.5	-0.4	-0.9	0.4	0.9	-0.2	0.6
Medication for pain relief, constipation, heartburn	0.3	0.4	1.5	0.3	-0.1	0.3	-1.0	-1.2	0.0	-0.6
Family relationship satisfaction	0.3	0.4	1.6	-0.3	-0.4	0.4	1.3	-0.3	-0.1	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.4	-0.6	-0.2	-1.0	-0.2	-1.2	0.1	0.2
Eye problems/disorders: Cataract	0.3	0.3	1.2	0.2	0.4	-0.3	1.1	-0.8	0.5	-0.2
High cholesterol (Self-reported)	0.3	0.5	1.2	-1.1	-0.6	-1.0	-0.1	-0.9	-0.6	-0.2
Ever had prostate specific antigen (PSA) test	0.3	0.4	2.2	-0.4	-0.2	-1.5	-0.1	0.4	0.1	-0.2
Bipolar Disorder (2018)	0.2	0.3	1.4	0.2	0.2	1.2	0.6	0.4	0.0	0.0
Prostate Cancer	0.2	0.3	0.6	0.4	0.8	-0.2	0.6	-0.1	0.7	-0.4
HDL Cholesterol	0.2	0.4	1.2	-0.6	-0.3	-0.6	-0.8	0.0	-0.2	1.1
Triglycerides	0.2	0.3	1.2	-0.5	-0.5	-0.5	-0.2	0.0	-0.4	-1.1
Ulcerative Colitis	0.2	0.3	0.9	0.2	0.1	0.0	0.9	0.2	0.3	0.8
BMI	0.2	1.1	3.7	-1.0	-1.0	-0.3	-0.1	-0.5	-1.2	-1.9
Waist Hip Ratio (WHR)	0.2	0.8	3.3	1.0	0.6	1.8	-0.2	-0.9	0.3	0.4
Hypothyroidism (self reported)	0.2	0.4	1.4	0.5	0.2	1.2	-0.3	-0.5	0.1	-1.0
Diabetes (father)	0.2	0.2	0.5	-0.5	-0.2	-0.4	-0.7	-0.7	-0.3	0.0
Townsend deprivation index at recruitment	0.2	0.3	1.0	-0.2	-0.1	0.6	1.0	0.9	0.2	-0.3
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.8	0.5	0.5	0.3	0.5	0.9	0.4	0.2
Medication: Levothyroxine sodium	0.2	0.3	1.2	0.1	0.3	0.7	-0.1	-1.1	0.1	-0.7
Past tobacco smoking	0.2	0.3	0.6	-0.5	-0.7	-0.5	0.0	-0.6	-0.6	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.2	0.6	0.7	0.5	0.8	0.3	0.1	0.3	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.9	0.3	-0.3	0.6	-1.0	-0.9	-0.3	0.7
Pain all over the body in last month	0.2	0.3	1.0	0.1	0.2	0.3	1.0	0.6	0.4	-0.4
Illnesses of siblings	0.2	0.2	0.3	-0.1	-0.5	0.6	-0.4	-0.3	-0.6	-0.6
Hair/balding pattern: Pattern 3	0.2	0.3	0.7	0.6	0.2	0.8	0.7	0.1	0.5	0.4
Number of live births	0.2	0.2	1.4	-0.1	-0.0	0.1	0.2	-0.3	-0.0	1.2
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.9	0.2	0.2	-0.8	-0.6	-0.1	0.2	1.4
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	1.2	0.4	0.1	1.1	0.3	0.4	0.1	0.9
Medication: Paracetamol	0.2	0.3	1.2	0.0	-0.1	0.4	0.8	1.1	-0.2	0.1
Glaucoma (self-reported)	0.2	0.2	1.0	0.2	0.1	1.0	0.4	0.3	0.4	0.3
Medication: Amlodipine	0.2	0.3	0.8	0.3	0.6	0.3	0.9	-0.0	0.7	-0.1
Chronic bronchitis/emphysema (mother)	0.2	0.3	1.4	0.2	0.2	0.2	0.6	-0.1	0.2	-1.2
Leg fat percentage (right)	0.2	0.7	2.9	0.2	0.2	1.0	1.7	0.7	0.3	-0.8
Exposure to tobacco smoke outside home	0.2	0.2	1.3	-0.1	-0.0	-0.0	-0.2	-0.4	-0.1	-1.1
Comparative body size at age 10	0.2	0.5	1.3	-0.8	-1.1	-0.1	-0.6	-0.5	-1.0	-0.3
Mouth/teeth dental problems: Loose teeth	0.2	0.3	1.1	-0.1	-0.2	0.3	-1.1	-0.0	-0.5	-0.5
Medication: Allopurinol	0.2	0.2	0.9	-0.3	0.1	-0.1	0.9	0.5	0.2	0.6
Knee pain experienced in last month	0.2	0.3	0.7	-0.4	-0.4	0.6	-0.8	-0.7	-0.6	-0.5
Smoking status: Previous	0.2	0.3	0.6	-0.6	-0.4	-0.8	-0.7	0.6	-0.5	0.3
Diabetes diagnosed by doctor	0.2	0.3	1.3	-0.2	-0.4	1.1	-0.1	-0.7	-0.3	-0.4
Qualifications: nursing, teaching	0.2	0.3	0.7	-0.5	-0.3	-0.8	-0.1	0.6	-0.2	0.7
Mother’s age at death	0.2	0.2	0.8	0.2	0.2	0.1	0.2	0.9	0.2	0.6
Eye problems/disorders: Glaucoma	0.2	0.2	0.9	0.4	0.1	1.0	-0.5	-0.5	0.1	0.2
Leg fat percentage (left)	0.2	0.6	2.2	0.3	0.2	0.9	1.5	0.5	0.2	-0.9
Diastolic blood pressure, automated reading	0.2	0.7	2.6	0.8	0.7	0.7	0.6	1.6	0.6	0.3
Unable to work because of sickness or disability	0.2	0.2	0.5	0.6	0.2	0.7	0.5	-0.0	0.4	-0.6
Heart disease (siblings)	0.2	0.3	0.6	0.7	0.8	-0.4	-0.1	0.3	0.6	-0.5
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.9	-0.7	-0.9	-0.4	-0.6	0.4	-0.9	0.2
Verbal and Numeric Reasoning (VNR)	0.1	0.3	1.1	-0.1	-0.1	-0.6	-0.6	0.5	-0.2	1.1
Age at First Birth	0.1	0.2	0.5	0.2	-0.4	-0.1	-0.2	-0.7	-0.4	-0.7
Body Mass Index (BMI) (2010)	0.1	0.1	0.3	0.1	0.5	-0.2	-0.4	0.0	0.3	-0.6
Fasting Glucose	0.1	0.1	0.3	0.4	-0.1	-0.0	-0.1	0.5	-0.2	0.5
Rheumatoid Arthritis	0.1	0.1	0.3	0.1	-0.2	0.5	-0.3	0.1	-0.4	-0.4
Blood Eosinophil Count	0.1	0.6	1.7	-0.8	-1.1	-0.3	-0.1	-1.3	-0.5	-0.2
Systolic blood pressure, automated reading	0.1	0.2	0.9	-0.1	0.1	-1.0	-0.5	0.3	-0.1	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.8	0.2	0.2	0.2	0.6	-0.9	0.1	-0.3
Relative age voice broke	0.1	0.2	0.6	0.2	0.4	0.3	0.4	0.8	0.6	0.3
Qualifications: CSEs or equivalent	0.1	0.1	0.4	0.0	0.3	0.2	0.3	-0.2	0.3	0.6
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.7	0.2	0.1	0.1	-0.6	-0.9	0.2	0.2
Alcohol usually taken with meals	0.1	0.1	0.3	0.5	0.2	0.4	-0.5	-0.0	0.1	-0.2
Qualifications: None of the above	0.1	0.1	0.4	0.1	0.4	-0.4	0.3	0.5	0.0	-0.6
Mouth/teeth dental problems	0.1	0.1	0.3	-0.1	-0.6	-0.3	-0.4	0.0	-0.2	0.5
Medication: Simvastatin	0.1	0.2	0.6	-0.6	0.0	-0.7	0.1	-0.8	-0.2	0.2
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	-0.3	-0.2	-0.1	-0.2	0.4	-0.3	-0.0
Headache pain in last month	0.1	0.2	0.3	0.5	0.4	0.4	0.2	0.5	0.1	0.5
Gout (self-reported)	0.1	0.1	0.6	-0.1	0.2	0.2	0.8	-0.3	0.3	0.4
Pulse wave peak to peak time	0.1	0.1	0.5	0.2	-0.1	0.1	-0.5	-0.7	-0.1	-0.3
Shortness of breath walking on level ground	0.1	0.2	0.6	-0.1	0.3	-0.6	-0.0	0.8	0.0	-0.1
Qualifications: College or University degree	0.1	0.2	0.6	0.0	0.0	-0.4	-0.8	-0.6	-0.0	0.4
Neck or shoulder pain in last month	0.1	0.2	0.6	-0.7	-0.2	-0.1	0.3	0.3	-0.5	-0.6
Mean time to correctly identify matches	0.1	0.1	0.3	0.1	0.0	0.2	0.5	-0.3	0.1	-0.6
Had major operations	0.1	0.1	0.4	0.3	0.3	0.1	-0.1	-0.5	0.5	0.6
Medication: Aspirin	0.1	0.1	0.3	0.0	0.2	-0.5	0.1	0.3	0.2	0.6
Illnesses of siblings: Diabetes	0.1	0.2	0.5	-0.1	0.1	0.5	0.7	0.5	0.1	0.4
Long-standing illness, disability or infirmity	0.1	0.1	0.5	-0.4	-0.1	-0.7	-0.1	-0.5	-0.2	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.5	0.1	-0.2	-0.1	-0.3	-0.7	-0.1	0.2
Medication: Aspirin	0.1	0.1	0.2	0.1	0.3	-0.4	0.1	0.0	0.3	0.5
Average weekly champagne plus white wine intake	0.1	0.1	0.4	0.4	0.3	0.1	0.2	0.3	0.3	-0.6
Medication: Paracetamol	0.1	0.1	0.3	-0.1	-0.3	0.3	0.2	0.5	-0.4	-0.3
Number of operations (self-reported)	0.1	0.1	0.3	0.2	0.2	-0.2	-0.5	0.1	0.2	0.4
Myopia	0.1	0.1	0.3	0.5	-0.3	0.5	-0.4	0.4	-0.1	0.3
Schizophrenia vs Biploar Disorder	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.0	0.0	0.0	0.0	0.0	0.1	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.1	0.2	0.4	-0.3	0.1	0.1	0.0	-0.4	0.2
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Impedance of arm (right)	0.0	0.0	0.1	-0.3	-0.3	-0.0	0.1	-0.3	-0.2	-0.2
Mouth/teeth dental problems: Dentures	0.0	0.1	0.2	0.1	0.4	-0.1	0.0	0.2	0.3	0.3
Impedance of arm (left)	0.0	0.1	0.2	-0.3	-0.5	0.0	-0.1	-0.1	-0.2	0.2

Hub : Genes

SNAI3

Models

Trait associations