TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Forced expiratory volume in 1-second (FEV1), Best measure
:
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→
chr19:10,068,513-11,873,382
Best TWAS P=1.15e-09 · Best GWAS P=3.27e-11 conditioned to 0.00276
10M
10.5M
11M
11.5M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
The Cancer Genome Atlas
Brain Lower Grade Glioma
LOC147727
0.07
0.02
lasso
2
0.02
5.4e-03
6.2
-6.1
1.1e-09
-0.79
0.01
0.84
TRUE
2
GTEx
Nerve Tibial
ILF3-AS1
0.14
0.04
lasso
3
0.08
3.8e-06
6.3
-5.7
1.4e-08
-0.46
0.03
0.94
FALSE
5
The Cancer Genome Atlas
Thyroid Carcinoma
SLC44A2
0.32
0.22
enet
14
0.25
3.8e-24
6.1
5.5
4.6e-08
0.74
0.03
0.97
FALSE
1
GTEx
Esophagus Mucosa
ILF3-AS1
0.11
0.00
lasso
4
0.00
2.5e-01
6.2
-5.2
1.5e-07
-0.42
0.04
0.70
FALSE
3
GTEx
Skin Sun Exposed Lower leg
SMARCA4
0.15
0.10
enet
25
0.15
1.4e-12
3.5
-5.2
2.2e-07
-0.70
0.69
0.31
FALSE