TWAS
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Traits
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Forced expiratory volume in 1-second (FEV1), Best measure
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chr18:8,010,444-9,532,097
Best TWAS P=4.57e-09 · Best GWAS P=2.16e-09 conditioned to 0.0319
8M
8.2M
8.4M
8.6M
8.8M
9M
9.2M
9.4M
9.6M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
3
ROSMAP
Brain Pre-frontal Cortex
SOGA2
0.09
0.04
lasso
6
0.04
2.1e-06
-5.9
5.9
4.6e-09
-0.80
0.01
0.99
TRUE
2
GTEx
Nerve Tibial
SOGA2
0.17
0.08
lasso
7
0.05
1.5e-04
-5.9
5.7
1.3e-08
-0.84
0.02
0.97
FALSE
1
GTEx
Lung
SOGA2
0.14
0.09
lasso
5
0.08
1.2e-06
-5.1
-5.2
1.8e-07
0.79
0.11
0.88
FALSE