TWAS
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Models
Genes
Traits
[Hub]/) :
Traits
:
Forced expiratory volume in 1-second (FEV1), Best measure
:
←
→
chr2:55,401,562-56,843,605
Best TWAS P=4.69e-26 · Best GWAS P=1.52e-30 conditioned to 0.0217
55.4M
55.6M
55.8M
56M
56.2M
56.4M
56.6M
56.8M
0
5
10
15
20
25
30
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Brain Frontal Cortex BA9
EFEMP1
0.19
0.10
lasso
8
0.08
3.7e-03
-10.15
-10.6
4.7e-26
0.78
0.04
0.70
TRUE
2
GTEx
Cells Transformed fibroblasts
EFEMP1
0.11
0.00
enet
22
0.05
1.1e-04
-0.12
-5.4
6.2e-08
0.39
0.16
0.57
TRUE
4
The Cancer Genome Atlas
Breast Invasive Carcinoma
EFEMP1
0.02
0.01
blup
79
0.02
3.9e-05
-11.49
7.5
6.9e-14
-0.73
0.00
1.00
FALSE
3
ROSMAP
Brain Pre-frontal Cortex
EFEMP1
0.29
0.14
enet
37
0.19
2.2e-24
-7.60
-7.2
4.1e-13
0.64
1.00
0.00
FALSE