Best TWAS P=4.69e-26 · Best GWAS P=1.52e-30 conditioned to 0.0217
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Frontal Cortex BA9 | EFEMP1 | 0.19 | 0.10 | lasso | 8 | 0.08 | 3.7e-03 | -10.15 | -10.6 | 4.7e-26 | 0.78 | 0.04 | 0.70 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | EFEMP1 | 0.11 | 0.00 | enet | 22 | 0.05 | 1.1e-04 | -0.12 | -5.4 | 6.2e-08 | 0.39 | 0.16 | 0.57 | TRUE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | EFEMP1 | 0.29 | 0.14 | enet | 37 | 0.19 | 2.2e-24 | -7.60 | -7.2 | 4.1e-13 | 0.64 | 1.00 | 0.00 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | EFEMP1 | 0.02 | 0.01 | blup | 79 | 0.02 | 3.9e-05 | -11.49 | 7.5 | 6.9e-14 | -0.73 | 0.00 | 1.00 | FALSE |