Best TWAS P=2.26e-08 · Best GWAS P=9.83e-07 conditioned to 0.00481
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | LRPAP1 | 0.16 | 0.04 | lasso | 4 | 0.04 | 1.6e-04 | 4.8 | -5.2 | 1.9e-07 | -0.85 | 0.01 | 0.92 | FALSE |
| 2 | GTEx | Artery Aorta | LRPAP1 | 0.20 | 0.13 | lasso | 3 | 0.13 | 1.7e-07 | 4.6 | -5.1 | 3.0e-07 | -0.98 | 0.01 | 0.98 | FALSE |
| 3 | GTEx | Nerve Tibial | LRPAP1 | 0.29 | 0.11 | enet | 16 | 0.14 | 7.6e-10 | 4.6 | -5.4 | 6.7e-08 | -0.85 | 0.01 | 0.98 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | LRPAP1 | 0.13 | 0.03 | enet | 12 | 0.08 | 3.6e-07 | -2.9 | -5.6 | 2.3e-08 | -0.42 | 0.24 | 0.35 | TRUE |
| 5 | GTEx | Thyroid | LRPAP1 | 0.28 | 0.07 | lasso | 8 | 0.15 | 2.6e-11 | 4.9 | -5.2 | 1.7e-07 | -0.82 | 0.00 | 0.99 | FALSE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LRPAP1 | 0.12 | 0.09 | blup | 52 | 0.12 | 1.5e-12 | 4.8 | -5.1 | 2.9e-07 | -0.80 | 0.01 | 0.98 | FALSE |
| 7 | The Cancer Genome Atlas | Soft Tissue Sarcoma | LRPAP1 | 0.12 | 0.02 | blup | 52 | 0.05 | 6.6e-04 | 1.1 | -5.4 | 6.7e-08 | -0.42 | 0.02 | 0.13 | FALSE |