[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1), Best measure : ← →

chr11:61,627,881-63,110,149

Best TWAS P=2.44e-11 · Best GWAS P=1.04e-10 conditioned to 0.506

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
54	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	EEF1G	0.08	0.00	blup	27	0.04	1.3e-02	6.2	-6.7	2.4e-11	-0.93	0.01	0.85	TRUE
44	The Cancer Genome Atlas	Brain Lower Grade Glioma	EML3	0.03	0.04	blup	28	0.03	7.6e-05	6.2	6.6	3.1e-11	0.97	0.01	0.99	FALSE
60	The Cancer Genome Atlas	Stomach Adenocarcinoma	EEF1G	0.05	0.07	blup	27	0.07	1.7e-05	6.0	-6.6	3.1e-11	-0.98	0.02	0.98	FALSE
52	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	EEF1G	0.08	0.08	blup	27	0.05	3.6e-03	6.2	-6.6	3.2e-11	-0.98	0.01	0.95	FALSE
19	GTEx	Skin Sun Exposed Lower leg	ROM1	0.13	0.11	lasso	4	0.10	9.7e-09	6.5	-6.6	4.7e-11	-0.99	0.01	0.99	FALSE
63	The Cancer Genome Atlas	Thyroid Carcinoma	EML3	0.11	0.10	blup	28	0.12	2.3e-11	6.2	6.5	6.4e-11	0.90	0.06	0.94	FALSE
50	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EML3	0.04	0.05	blup	27	0.05	3.5e-06	6.2	6.5	6.6e-11	0.94	0.01	0.99	FALSE
2	GTEx	Adipose Visceral Omentum	ROM1	0.29	0.16	lasso	8	0.23	3.7e-12	6.3	-6.5	7.3e-11	-0.96	0.02	0.98	FALSE
43	The Cancer Genome Atlas	Brain Lower Grade Glioma	EEF1G	0.06	0.07	blup	27	0.07	8.1e-09	6.2	-6.5	7.6e-11	-0.96	0.01	0.99	FALSE
47	The Cancer Genome Atlas	Lung Adenocarcinoma	EML3	0.03	0.03	blup	28	0.03	8.4e-05	6.2	6.5	7.6e-11	0.98	0.01	0.99	FALSE
36	The Cancer Genome Atlas	Colon Adenocarcinoma	EML3	0.07	0.03	blup	29	0.05	6.5e-04	5.8	6.5	8.5e-11	0.93	0.01	0.91	FALSE
12	GTEx	Lung	ROM1	0.25	0.18	enet	13	0.20	2.2e-15	6.5	-6.5	9.9e-11	-0.99	0.01	0.99	FALSE
22	GTEx	Stomach	EML3	0.11	0.04	enet	5	0.03	2.1e-02	6.0	6.5	1.0e-10	0.96	0.02	0.86	FALSE
61	The Cancer Genome Atlas	Stomach Adenocarcinoma	ROM1	0.05	0.08	lasso	3	0.08	3.1e-06	6.4	-6.4	1.2e-10	-0.97	0.01	0.99	FALSE
57	The Cancer Genome Atlas	Rectum Adenocarcinoma	EML3	0.36	0.08	blup	27	0.19	3.7e-05	6.2	6.4	1.3e-10	0.85	0.01	0.83	FALSE
25	GTEx	Thyroid	EML3	0.10	0.11	lasso	4	0.10	5.9e-08	6.4	6.4	1.4e-10	0.97	0.01	0.99	FALSE
10	GTEx	Esophagus Mucosa	MTA2	0.29	0.34	lasso	5	0.33	6.9e-23	6.4	6.4	1.5e-10	1.00	0.01	0.99	FALSE
40	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EML3	0.04	0.06	lasso	3	0.06	1.7e-07	6.4	6.4	1.5e-10	0.98	0.01	0.99	FALSE
13	GTEx	Lung	EML3	0.07	0.04	lasso	3	0.01	2.5e-02	6.4	6.4	1.7e-10	0.99	0.01	0.96	FALSE
24	GTEx	Thyroid	ROM1	0.17	0.16	lasso	8	0.16	3.6e-12	6.4	-6.4	1.8e-10	-0.98	0.01	0.99	FALSE
3	GTEx	Artery Aorta	ROM1	0.18	0.17	lasso	7	0.16	3.3e-09	6.2	-6.3	2.1e-10	-0.99	0.01	0.99	FALSE
16	GTEx	Ovary	ROM1	0.25	0.00	lasso	5	0.00	3.3e-01	5.8	-6.3	2.2e-10	-0.94	0.02	0.76	FALSE
6	GTEx	Breast Mammary Tissue (Female)	ROM1	0.16	0.02	lasso	4	0.04	2.9e-02	6.3	-6.3	2.7e-10	-0.95	0.02	0.86	FALSE
23	GTEx	Testis	EML3	0.27	0.22	enet	15	0.29	2.7e-13	6.4	6.3	2.7e-10	0.98	0.01	0.99	FALSE
1	GTEx	Adipose Subcutaneous	ROM1	0.25	0.17	lasso	3	0.18	1.5e-14	6.2	-6.3	2.8e-10	-0.96	0.02	0.98	FALSE
5	GTEx	Breast Mammary Tissue	ROM1	0.10	0.09	lasso	5	0.06	5.4e-04	6.2	-6.3	3.4e-10	-0.99	0.02	0.98	FALSE
9	GTEx	Cells Transformed fibroblasts	EML3	0.19	0.16	lasso	9	0.18	7.3e-14	5.8	6.3	3.5e-10	0.96	0.02	0.98	FALSE
26	GTEx	Whole Blood	EML3	0.17	0.09	lasso	7	0.08	6.3e-08	6.2	6.3	3.6e-10	0.99	0.02	0.98	FALSE
46	The Cancer Genome Atlas	Lung Adenocarcinoma	EEF1G	0.06	0.08	lasso	8	0.08	5.9e-10	6.2	-6.3	3.6e-10	-0.97	0.02	0.98	FALSE
4	GTEx	Artery Tibial	ROM1	0.14	0.05	lasso	6	0.03	2.5e-03	6.5	-6.3	3.9e-10	-0.98	0.02	0.98	FALSE
29	YFS	Blood	EML3	0.20	0.31	lasso	12	0.33	1.3e-110	6.2	6.3	3.9e-10	0.98	0.02	0.98	FALSE
48	The Cancer Genome Atlas	Lung Adenocarcinoma	ROM1	0.04	0.04	blup	23	0.04	9.5e-06	6.2	-6.2	4.1e-10	-0.97	0.01	0.99	FALSE
11	GTEx	Esophagus Mucosa	EML3	0.40	0.43	lasso	8	0.46	1.8e-33	6.2	6.2	4.5e-10	0.99	0.01	0.99	FALSE
33	The Cancer Genome Atlas	Breast Invasive Carcinoma	EML3	0.02	0.02	lasso	4	0.02	2.5e-05	6.2	6.2	4.8e-10	0.96	0.01	0.99	FALSE
15	GTEx	Nerve Tibial	EML3	0.17	0.10	lasso	4	0.09	3.9e-07	6.4	6.2	4.9e-10	0.95	0.01	0.99	FALSE
32	The Cancer Genome Atlas	Breast Invasive Carcinoma	EEF1G	0.02	0.04	lasso	2	0.03	6.3e-07	6.2	-6.2	5.1e-10	-0.99	0.01	0.99	FALSE
58	The Cancer Genome Atlas	Soft Tissue Sarcoma	ROM1	0.06	0.05	blup	24	0.03	8.1e-03	6.2	-6.2	5.1e-10	-0.98	0.01	0.88	FALSE
17	GTEx	Skin Not Sun Exposed Suprapubic	EML3	0.20	0.19	lasso	3	0.24	2.7e-13	6.4	6.2	5.4e-10	0.95	0.01	0.99	FALSE
55	The Cancer Genome Atlas	Prostate Adenocarcinoma	EEF1G	0.08	0.13	lasso	2	0.12	1.8e-12	6.2	-6.2	5.4e-10	-0.99	0.02	0.98	FALSE
31	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	EEF1G	0.04	0.05	lasso	1	0.04	1.1e-04	6.2	-6.2	5.8e-10	-0.95	0.01	0.97	FALSE
56	The Cancer Genome Atlas	Prostate Adenocarcinoma	EML3	0.09	0.14	lasso	1	0.14	3.4e-14	6.2	6.2	5.8e-10	0.95	0.03	0.97	FALSE
39	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EEF1G	0.11	0.12	blup	27	0.13	5.5e-14	6.5	-6.2	6.5e-10	-0.97	0.01	0.99	FALSE
49	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EEF1G	0.08	0.13	lasso	4	0.12	3.1e-13	6.2	-6.2	6.5e-10	-0.99	0.02	0.98	FALSE
28	YFS	Blood	EEF1G	0.30	0.45	lasso	6	0.45	3.6e-166	6.2	-6.2	6.7e-10	-0.99	0.03	0.97	FALSE
51	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	EML3	0.03	0.02	blup	27	0.03	3.5e-03	6.2	6.1	1.3e-09	0.96	0.01	0.78	FALSE
7	GTEx	Cells EBV-transformed lymphocytes	EML3	0.33	0.22	lasso	8	0.21	1.6e-07	6.0	6.0	1.7e-09	0.95	0.02	0.98	FALSE
35	The Cancer Genome Atlas	Colon Adenocarcinoma	EEF1G	0.07	0.11	lasso	1	0.11	9.2e-07	6.0	-6.0	1.8e-09	-0.97	0.02	0.98	FALSE
62	The Cancer Genome Atlas	Thyroid Carcinoma	EEF1G	0.15	0.27	blup	27	0.28	3.6e-27	6.5	-5.9	3.0e-09	-0.94	0.01	0.99	FALSE
20	GTEx	Skin Sun Exposed Lower leg	EML3	0.32	0.25	enet	19	0.26	8.0e-22	6.4	5.9	3.1e-09	0.95	0.01	0.99	FALSE
64	The Cancer Genome Atlas	Thyroid Carcinoma	ROM1	0.03	0.02	blup	23	0.02	1.1e-02	6.4	-5.9	3.3e-09	-0.96	0.01	0.94	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	ROM1	0.01	0.02	enet	4	0.02	2.4e-04	6.2	-5.9	4.2e-09	-0.93	0.01	0.97	FALSE
37	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	EEF1G	0.10	0.09	blup	26	0.09	9.8e-11	6.0	-5.9	4.3e-09	-0.88	0.02	0.98	FALSE
45	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	EEF1G	0.06	0.03	blup	27	0.04	4.5e-03	5.4	-5.9	4.3e-09	-0.96	0.01	0.71	FALSE
8	GTEx	Cells Transformed fibroblasts	MTA2	0.06	0.09	lasso	1	0.07	3.0e-06	5.8	5.8	5.1e-09	0.87	0.02	0.97	FALSE
21	GTEx	Spleen	GANAB	0.35	-0.01	lasso	9	0.01	1.3e-01	6.4	5.7	1.0e-08	0.90	0.03	0.67	FALSE
38	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ROM1	0.04	0.02	blup	22	0.02	6.2e-03	5.8	-5.7	1.2e-08	-0.92	0.01	0.85	FALSE
42	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	EML3	0.06	0.09	lasso	2	0.08	1.6e-05	5.4	5.6	2.2e-08	0.85	0.05	0.94	FALSE
14	GTEx	Nerve Tibial	ROM1	0.15	0.06	lasso	7	0.06	2.9e-05	6.2	-5.5	3.1e-08	-0.88	0.02	0.98	FALSE
41	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	EEF1G	0.07	0.04	blup	28	0.07	9.8e-05	5.8	-5.5	4.4e-08	-0.93	0.02	0.91	FALSE
30	YFS	Blood	INTS5	0.09	0.12	lasso	4	0.12	1.9e-38	4.7	5.4	5.5e-08	0.79	0.99	0.01	FALSE
18	GTEx	Skin Not Sun Exposed Suprapubic	B3GAT3	0.18	0.11	lasso	3	0.11	9.8e-07	4.7	5.4	6.8e-08	0.78	0.33	0.66	FALSE
53	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ROM1	0.16	0.08	blup	23	0.07	5.7e-04	6.4	-5.3	1.4e-07	-0.78	0.01	0.88	FALSE
59	The Cancer Genome Atlas	Skin Cutaneous Melanoma	ROM1	0.35	0.12	blup	24	0.14	1.1e-04	6.4	-5.3	1.4e-07	-0.75	0.01	0.91	FALSE
27	METSIM	Adipose	EEF1G	0.08	0.05	bslmm	375	0.06	4.5e-09	6.2	-5.1	3.0e-07	-0.89	0.02	0.98	FALSE