[Hub]/) : Traits : Forced expiratory volume in 1-second (FEV1), Best measure : ← →

chr11:46,010,847-48,360,648

Best TWAS P=1.39e-09 · Best GWAS P=9.24e-10 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
34	The Cancer Genome Atlas	Esophageal Carcinoma	C1QTNF4	0.39	0.33	blup	15	0.35	6.1e-12	-6.0	6.1	1.4e-09	0.25	0.00	1.00	TRUE
29	ROSMAP	Brain Pre-frontal Cortex	C1QTNF4	0.05	0.06	blup	281	0.06	1.7e-08	-4.7	6.0	2.1e-09	0.39	0.06	0.94	TRUE
28	ROSMAP	Brain Pre-frontal Cortex	ACP2	0.03	0.00	blup	295	0.02	1.5e-03	-4.7	-5.9	2.8e-09	-0.64	0.18	0.59	TRUE
30	YFS	Blood	PSMC3	0.02	0.01	blup	289	0.01	2.8e-05	-6.0	-5.9	4.5e-09	-0.36	0.00	0.99	TRUE
16	GTEx	Heart Left Ventricle	ARHGAP1	0.06	0.03	lasso	2	0.02	2.1e-02	6.1	-5.6	2.0e-08	-0.96	0.02	0.90	TRUE
8	GTEx	Cells Transformed fibroblasts	C1QTNF4	0.13	0.11	enet	19	0.12	5.2e-09	-5.4	5.2	1.5e-07	0.30	0.02	0.98	TRUE
2	GTEx	Adipose Subcutaneous	ACP2	0.08	0.03	enet	18	0.03	3.5e-03	4.4	-5.2	1.7e-07	-0.49	0.20	0.45	TRUE
41	The Cancer Genome Atlas	Lung Adenocarcinoma	C1QTNF4	0.03	0.02	blup	15	0.02	1.3e-03	-6.0	6.0	1.8e-09	0.27	0.00	0.97	FALSE
19	GTEx	Muscle Skeletal	C1QTNF4	0.09	0.14	lasso	3	0.13	9.9e-13	-6.0	6.0	1.9e-09	0.26	0.00	1.00	FALSE
4	GTEx	Artery Aorta	C1QTNF4	0.09	0.10	lasso	1	0.08	3.2e-05	-6.0	6.0	2.3e-09	0.27	0.00	0.99	FALSE
11	GTEx	Esophagus Mucosa	C1QTNF4	0.10	0.11	lasso	1	0.10	5.0e-07	-6.0	6.0	2.3e-09	0.27	0.00	1.00	FALSE
15	GTEx	Heart Left Ventricle	C1QTNF4	0.10	0.11	lasso	1	0.09	1.1e-05	-6.0	6.0	2.3e-09	0.27	0.00	0.99	FALSE
32	The Cancer Genome Atlas	Colon Adenocarcinoma	C1QTNF4	0.12	0.12	lasso	1	0.12	1.6e-07	-6.0	6.0	2.3e-09	0.27	0.00	1.00	FALSE
9	GTEx	Cells Transformed fibroblasts	NDUFS3	0.08	0.01	lasso	2	0.01	3.3e-02	-6.0	6.0	2.7e-09	0.23	0.01	0.97	FALSE
10	GTEx	Colon Transverse	C1QTNF4	0.07	0.02	lasso	6	0.03	2.0e-02	-6.0	6.0	2.7e-09	0.25	0.01	0.96	FALSE
14	GTEx	Heart Left Ventricle	MADD	0.14	0.01	enet	17	0.05	7.0e-04	4.0	-5.9	3.1e-09	-0.57	0.07	0.86	FALSE
36	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C1QTNF4	0.12	0.14	enet	4	0.16	6.5e-18	-5.3	5.8	9.1e-09	0.24	0.02	0.98	FALSE
3	GTEx	Adipose Subcutaneous	C1QTNF4	0.16	0.22	lasso	4	0.22	2.5e-18	-6.0	5.7	9.4e-09	0.24	0.00	1.00	FALSE
12	GTEx	Esophagus Muscularis	C1QTNF4	0.10	0.05	enet	23	0.06	1.4e-04	-6.0	5.7	9.7e-09	0.19	0.01	0.99	FALSE
18	GTEx	Muscle Skeletal	MTCH2	0.05	0.03	enet	15	0.04	1.5e-04	-4.7	-5.7	9.8e-09	-0.37	0.04	0.95	FALSE
20	GTEx	Nerve Tibial	C1QTNF4	0.20	0.23	enet	12	0.23	1.7e-16	-6.0	5.7	1.2e-08	0.34	0.00	1.00	FALSE
31	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C1QTNF4	0.06	0.07	lasso	2	0.06	4.9e-06	-5.4	5.7	1.2e-08	0.24	0.00	0.99	FALSE
13	GTEx	Heart Atrial Appendage	C1QTNF4	0.26	0.14	lasso	9	0.17	3.9e-08	-6.0	5.6	1.7e-08	0.20	0.01	0.99	FALSE
42	The Cancer Genome Atlas	Stomach Adenocarcinoma	C1QTNF4	0.06	0.04	lasso	4	0.03	4.3e-03	-5.4	5.6	1.7e-08	0.24	0.00	0.92	FALSE
1	CommonMind	Brain Pre-frontal Cortex	FAM180B	0.07	0.08	lasso	3	0.08	9.1e-10	-6.0	-5.6	2.2e-08	-0.24	0.02	0.98	FALSE
7	GTEx	Cells Transformed fibroblasts	PSMC3	0.07	0.00	enet	13	0.02	2.3e-02	4.0	-5.6	2.6e-08	-0.34	0.03	0.75	FALSE
39	The Cancer Genome Atlas	Brain Lower Grade Glioma	PSMC3	0.10	0.05	blup	39	0.08	3.7e-09	-4.8	-5.6	2.6e-08	-0.22	0.02	0.96	FALSE
33	The Cancer Genome Atlas	Colon Adenocarcinoma	KBTBD4	0.14	0.01	blup	13	0.02	1.6e-02	4.3	-5.5	2.8e-08	-0.26	0.00	0.50	FALSE
27	ROSMAP	Brain Pre-frontal Cortex	MTCH2	0.35	0.40	enet	9	0.40	4.7e-56	-5.3	-5.5	3.0e-08	-0.22	0.08	0.92	FALSE
22	GTEx	Spleen	C1QTNF4	0.31	0.28	enet	29	0.34	1.8e-09	-5.4	5.5	3.5e-08	0.12	0.04	0.95	FALSE
5	GTEx	Brain Cerebellar Hemisphere	ACP2	0.29	0.05	enet	16	0.12	5.9e-04	5.1	-5.5	3.6e-08	-0.84	0.03	0.72	FALSE
23	GTEx	Whole Blood	C1QTNF4	0.09	0.05	lasso	3	0.03	1.4e-03	-5.5	5.5	3.6e-08	0.22	0.06	0.91	FALSE
43	The Cancer Genome Atlas	Thyroid Carcinoma	C1QTNF4	0.04	0.01	blup	15	0.03	7.9e-04	-6.0	5.5	3.9e-08	0.37	0.00	0.94	FALSE
37	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C1QTNF4	0.13	0.16	lasso	1	0.16	3.1e-09	-5.4	5.4	5.7e-08	0.22	0.02	0.98	FALSE
26	NTR	Blood	MTCH2	0.02	0.04	lasso	1	0.04	1.3e-11	-5.4	5.4	5.8e-08	0.22	0.07	0.93	FALSE
21	GTEx	Skin Sun Exposed Lower leg	C1QTNF4	0.25	0.22	lasso	12	0.23	4.2e-19	-6.0	5.4	6.5e-08	0.16	0.00	1.00	FALSE
17	GTEx	Lung	C1QTNF4	0.18	0.15	lasso	6	0.13	3.2e-10	-4.7	5.4	8.3e-08	0.22	0.06	0.94	FALSE
24	METSIM	Adipose	C1QTNF4	0.24	0.31	lasso	7	0.31	1.2e-46	-5.3	5.4	8.5e-08	0.23	0.09	0.91	FALSE
35	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C1QTNF4	0.06	0.08	lasso	3	0.08	7.5e-09	-5.3	5.3	8.6e-08	0.21	0.02	0.98	FALSE
38	The Cancer Genome Atlas	Brain Lower Grade Glioma	MTCH2	0.11	0.11	lasso	2	0.10	6.4e-12	-5.3	-5.3	9.3e-08	-0.21	0.02	0.98	FALSE
40	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C1QTNF4	0.19	0.19	lasso	3	0.19	3.2e-09	-5.3	5.3	9.3e-08	0.21	0.02	0.97	FALSE
25	NTR	Blood	DDB2	0.01	0.00	lasso	7	0.01	2.2e-03	5.6	-5.3	1.0e-07	-0.91	0.04	0.89	FALSE
6	GTEx	Brain Cortex	MTCH2	0.21	0.19	lasso	6	0.16	4.0e-05	-5.4	-5.1	3.0e-07	-0.26	0.07	0.84	FALSE
44	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	ZNF408	0.27	0.01	blup	27	0.09	1.5e-03	6.0	-5.1	3.0e-07	-0.81	0.00	0.79	FALSE