Best TWAS P=1.52e-24 · Best GWAS P=1.03e-22 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | RAD9A | 0.43 | 0.22 | lasso | 6 | 0.23 | 7.1e-19 | -9.8 | -9.4 | 6.7e-21 | 0.97 | 0.00 | 1.00 | FALSE |
| 2 | GTEx | Artery Tibial | RAD9A | 0.39 | 0.26 | lasso | 2 | 0.24 | 3.5e-19 | -9.8 | -9.8 | 1.2e-22 | 1.00 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Brain Cerebellar Hemisphere | ZDHHC24 | 0.22 | 0.11 | enet | 15 | 0.16 | 8.2e-05 | 4.7 | -5.1 | 2.9e-07 | 0.08 | 0.07 | 0.67 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | RAD9A | 0.24 | 0.16 | lasso | 3 | 0.16 | 3.6e-12 | -9.8 | -9.1 | 7.7e-20 | 0.92 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Colon Transverse | RAD9A | 0.40 | 0.16 | lasso | 8 | 0.16 | 7.2e-08 | -9.8 | -8.6 | 1.2e-17 | 0.88 | 0.00 | 1.00 | FALSE |
| 6 | GTEx | Esophagus Muscularis | TCIRG1 | 0.10 | 0.09 | lasso | 2 | 0.06 | 8.7e-05 | -4.4 | 5.8 | 5.5e-09 | -0.43 | 0.20 | 0.07 | FALSE |
| 7 | GTEx | Esophagus Muscularis | IGHMBP2 | 0.12 | 0.06 | enet | 17 | 0.06 | 9.4e-05 | 4.3 | 6.0 | 2.0e-09 | 0.05 | 0.60 | 0.31 | TRUE |
| 8 | GTEx | Esophagus Muscularis | RAD9A | 0.25 | 0.26 | lasso | 2 | 0.26 | 6.2e-16 | -9.8 | -10.2 | 1.5e-24 | 0.99 | 0.00 | 1.00 | TRUE |
| 9 | GTEx | Esophagus Muscularis | MRGPRF | 0.09 | 0.01 | lasso | 3 | 0.01 | 1.3e-01 | -4.9 | 5.8 | 7.7e-09 | 0.02 | 0.03 | 0.81 | FALSE |
| 10 | GTEx | Muscle Skeletal | RAD9A | 0.12 | 0.02 | lasso | 4 | 0.03 | 4.2e-04 | -9.8 | -7.5 | 4.2e-14 | 0.83 | 0.00 | 0.99 | FALSE |
| 11 | GTEx | Nerve Tibial | RAD9A | 0.53 | 0.24 | lasso | 10 | 0.23 | 5.6e-16 | -9.8 | -9.5 | 2.0e-21 | 0.99 | 0.00 | 1.00 | FALSE |
| 12 | GTEx | Testis | RAD9A | 0.72 | 0.50 | lasso | 4 | 0.49 | 1.1e-24 | -9.8 | -9.8 | 1.6e-22 | 1.00 | 0.00 | 1.00 | FALSE |
| 13 | GTEx | Thyroid | RAD9A | 0.27 | 0.07 | lasso | 6 | 0.20 | 1.8e-15 | -9.8 | -7.4 | 1.2e-13 | 0.70 | 0.00 | 1.00 | FALSE |
| 14 | NTR | Blood | MRPL21 | 0.06 | 0.07 | enet | 19 | 0.07 | 7.0e-23 | 4.4 | -5.4 | 7.1e-08 | -0.03 | 1.00 | 0.00 | FALSE |
| 15 | ROSMAP | Brain Pre-frontal Cortex | RAD9A | 0.34 | 0.17 | enet | 21 | 0.20 | 1.1e-25 | -9.8 | -9.2 | 5.7e-20 | 0.89 | 0.00 | 1.00 | FALSE |
| 16 | YFS | Blood | RAD9A | 0.08 | 0.02 | lasso | 7 | 0.04 | 5.4e-12 | -9.8 | -7.5 | 4.2e-14 | 0.78 | 0.00 | 1.00 | FALSE |
| 17 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CCDC87 | 0.03 | 0.02 | blup | 34 | 0.02 | 2.0e-03 | 5.2 | 6.2 | 4.7e-10 | -0.13 | 0.01 | 0.73 | TRUE |
| 18 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SAPS3 | 0.04 | 0.02 | blup | 84 | 0.04 | 2.5e-05 | -4.1 | 5.8 | 8.2e-09 | 0.00 | 0.19 | 0.80 | TRUE |