TWAS
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Traits
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Forced expiratory volume in 1-second (FEV1), Best measure
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chr12:30,084,002-31,526,510
Best TWAS P=7.1e-09 · Best GWAS P=1.97e-09 conditioned to 1
30M
30.2M
30.4M
30.6M
30.8M
31M
31.2M
31.4M
31.6M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Nerve Tibial
IPO8
0.21
0.16
lasso
6
0.15
1.3e-10
-5.8
-5.8
7.1e-09
1.00
0.02
0.98
TRUE
2
GTEx
Skin Sun Exposed Lower leg
IPO8
0.23
0.08
lasso
10
0.13
1.1e-10
-5.9
-5.2
2.4e-07
0.87
0.03
0.97
FALSE