Best TWAS P=1.23e-14 · Best GWAS P=1.25e-14 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | TRIM13 | 0.15 | 0.04 | lasso | 5 | 0.12 | 1.1e-14 | 7.6 | -6.6 | 4.0e-11 | -0.80 | 0.01 | 0.99 | FALSE |
2 | GTEx | Esophagus Gastroesophageal Junction | EBPL | 0.27 | 0.24 | enet | 14 | 0.26 | 4.6e-10 | 5.9 | -5.9 | 3.0e-09 | -0.30 | 0.94 | 0.06 | FALSE |
3 | GTEx | Nerve Tibial | DLEU2 | 0.11 | 0.05 | lasso | 3 | 0.02 | 7.8e-03 | 7.7 | 7.7 | 1.2e-14 | 0.99 | 0.01 | 0.98 | TRUE |
4 | GTEx | Pancreas | EBPL | 0.18 | 0.10 | enet | 5 | 0.09 | 1.6e-04 | 7.2 | -5.3 | 1.1e-07 | -0.23 | 0.19 | 0.51 | TRUE |
5 | GTEx | Pituitary | EBPL | 0.44 | 0.32 | enet | 29 | 0.37 | 3.1e-10 | 6.0 | -5.7 | 9.5e-09 | -0.37 | 0.67 | 0.28 | FALSE |
6 | GTEx | Skin Not Sun Exposed Suprapubic | EBPL | 0.34 | 0.26 | enet | 12 | 0.30 | 4.0e-17 | 6.0 | -6.0 | 1.8e-09 | -0.26 | 0.96 | 0.04 | FALSE |
7 | GTEx | Skin Sun Exposed Lower leg | EBPL | 0.28 | 0.21 | lasso | 5 | 0.20 | 2.5e-16 | 5.9 | -6.3 | 2.4e-10 | -0.32 | 1.00 | 0.00 | FALSE |
8 | GTEx | Testis | EBPL | 0.33 | 0.17 | lasso | 6 | 0.24 | 8.4e-11 | 5.9 | -7.3 | 2.5e-13 | -0.32 | 0.76 | 0.24 | TRUE |
9 | GTEx | Thyroid | EBPL | 0.36 | 0.14 | enet | 33 | 0.30 | 5.1e-23 | 5.9 | -5.2 | 2.4e-07 | -0.31 | 0.70 | 0.30 | TRUE |
10 | YFS | Blood | KPNA3 | 0.04 | 0.02 | bslmm | 427 | 0.02 | 1.4e-08 | 3.5 | 5.4 | 7.0e-08 | 0.34 | 1.00 | 0.00 | FALSE |
11 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | DLEU2 | 0.03 | 0.01 | blup | 61 | 0.02 | 2.4e-03 | 7.6 | 7.5 | 9.0e-14 | 0.90 | 0.01 | 0.96 | TRUE |
12 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | EBPL | 0.28 | 0.18 | blup | 59 | 0.19 | 4.3e-08 | 5.9 | -5.4 | 6.4e-08 | -0.23 | 0.01 | 0.98 | TRUE |
13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | EBPL | 0.08 | 0.01 | blup | 59 | 0.04 | 6.4e-05 | 5.9 | -6.5 | 7.6e-11 | -0.27 | 0.01 | 0.89 | FALSE |
14 | The Cancer Genome Atlas | Prostate Adenocarcinoma | KPNA3 | 0.05 | 0.02 | blup | 75 | 0.04 | 4.6e-05 | -4.9 | -5.6 | 2.4e-08 | -0.25 | 0.47 | 0.05 | FALSE |