TWAS hub - KPNA3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0448	0.0153	5.3e-06	0.018	0.022	0.023	0.024	0.024	1.2e-06	6.2e-08	3e-08	1.4e-08	1.5e-08
2	TCGA	Prostate Adenocarcinoma	0.0499	0.0233	1.5e-04	0.022	0.040	0.026	NA	0.026	2.2e-03	4.6e-05	9e-04	NA	8.7e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Forced expiratory volume in 1-second (FEV1), Best measure	9.4	30.1	31.1	5.4	-5.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	9.1	19.2	21.6	4.1	-4.7
Lung FEV1/FVC ratio	8.7	44.4	52.3	6.0	-7.2
Forced expiratory volume in 1-second (FEV1)	7.2	24.4	25.7	4.8	-5.1
Angina	6.7	8.8	9.0	-3.0	2.9
Angina (self-reported)	6.5	8.6	8.6	-2.9	2.9
Had other major operations	6.3	7.7	10.4	3.2	-2.2
Mother’s age at death	5.8	7.3	10.0	2.1	-3.2
Lupus	5.5	8.3	10.6	-2.5	3.3
Peak expiratory flow (PEF)	5.4	12.6	13.3	3.4	-3.6
Qualifications: nursing, teaching	4.9	7.6	8.9	2.5	-3.0
Tinnitus: Yes, now most or all of the time	4.9	5.7	6.2	-2.3	2.5
LDL Cholesterol	4.2	6.7	8.2	-2.3	2.9
Forced vital capacity (FVC), Best measure	4.2	15.2	15.4	3.9	-3.9
Illnesses of siblings: Diabetes	4.2	5.2	5.8	2.1	-2.4
High cholesterol (Self-reported)	3.9	7.0	8.7	-2.3	3.0
Leg pain on walking	3.8	4.8	5.7	2.4	-2.0
Diabetes (mother)	3.6	4.6	5.1	2.3	-2.0
Verbal and Numeric Reasoning (VNR)	3.5	8.4	10.4	2.5	-3.2
Heel T-Score	3.5	27.9	38.3	-6.2	4.2
Medication: Ramipril	3.5	4.5	5.7	-2.4	1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	3.5	5.4	7.2	2.7	-1.9
Frequency of depressed mood in last 2 weeks	3.4	4.7	5.0	2.2	-2.1
Ever unenthusiastic/disinterested for a whole week	3.3	4.1	4.2	2.0	-2.0
Pack years adult smoking proportion	3.2	4.9	6.7	-1.8	2.6
Qualifications: A levels/AS levels or equivalent	3.2	7.2	7.2	2.7	-2.7
Birth weight	3.2	6.8	7.2	2.5	-2.7
Coronary Artery Disease (CAD)	3.1	3.7	3.8	1.9	-1.9
Pack years of smoking	3.1	4.5	6.8	-1.5	2.6
Hypothyroidism (self reported)	3.0	6.8	8.6	2.9	-2.2
Forced vital capacity (FVC)	2.9	11.1	11.3	3.4	-3.3
Eye problems/disorders: Diabetes related eye disease	2.8	3.1	3.8	1.5	-1.9
Depression (Nagel 2018)	2.7	4.1	5.4	2.3	-1.7
Prostate Cancer	2.6	3.6	4.1	-2.0	1.8
Tinnitus: Yes, but not now, but have in the past	2.6	2.8	3.7	1.9	-1.4
Weight	2.6	12.8	15.0	3.9	-3.2
Risk taking	2.6	3.8	5.7	1.4	-2.4
Fluid intelligence score	2.3	4.8	5.5	2.0	-2.3
Neuroticism (2016)	2.2	3.1	3.9	-1.5	2.0
Blood Eosinophil Count	2.2	16.6	17.7	4.2	-3.9
Multivitamins +/- minerals	2.1	2.6	3.2	1.4	-1.8
Worry too long after embarrassment	2.1	3.6	5.0	-1.5	2.2
Illnesses of father: Heart disease	2.1	2.9	3.0	1.7	-1.7
Primary Biliary Cirrhosis	2.0	2.9	3.8	-2.0	1.4
Average weekly fortified wine intake	2.0	2.3	4.4	2.1	-0.5
Leg predicted mass (left)	2.0	10.5	13.3	3.6	-2.8
Trunk fat mass	2.0	8.7	9.5	3.1	-2.8
Arm predicted mass (right)	2.0	10.1	13.2	3.6	-2.7
Basal metabolic rate	2.0	11.3	14.4	3.8	-2.9
Arm fat-free mass (left)	2.0	10.2	12.9	3.6	-2.7
Arm predicted mass (left)	2.0	10.2	13.3	3.7	-2.7
Height	1.9	36.5	53.7	7.3	-4.4
Severe depression (siblings)	1.9	2.1	2.4	1.6	-1.4
Leg fat-free mass (left)	1.9	10.2	13.0	3.6	-2.7
Number of children fathered	1.9	2.2	2.6	1.6	-1.3
Leg fat mass (left)	1.9	7.5	8.0	2.8	-2.6
Financial difficulties in last 2 years	1.8	2.4	4.1	0.9	-2.0
Illnesses of siblings	1.8	2.5	3.0	-1.4	1.7
Exposure to tobacco smoke outside home	1.8	2.4	2.7	1.5	-1.6
Whole body fat mass	1.8	7.4	8.0	2.8	-2.6
Leg fat mass (right)	1.8	7.2	7.3	2.7	-2.6
Leg fat-free mass (right)	1.8	9.4	12.0	3.5	-2.6
Mouth/teeth dental problems: Mouth ulcers	1.8	2.9	5.1	2.3	-0.8
Leg predicted mass (right)	1.8	9.6	12.3	3.5	-2.6
Average weekly champagne plus white wine intake	1.8	2.5	3.2	1.8	-1.3
Alcohol drinker status: Previous	1.8	2.0	2.8	1.7	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	2.8	1.7	-1.3
Trunk fat-free mass	1.7	9.6	13.2	3.6	-2.5
Arm fat mass (right)	1.7	6.8	7.2	2.7	-2.5
Trunk predicted mass	1.7	9.8	13.3	3.6	-2.5
Standing height	1.7	17.0	25.7	5.1	-2.9
Arm fat-free mass (right)	1.7	8.5	11.8	3.4	-2.3
Suffer from ‘nerves’	1.7	2.7	3.8	-1.3	2.0
Medication: Aspirin	1.7	2.2	3.5	-1.0	1.9
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.6	5.5	2.4	-1.3
Whole body fat-free mass	1.7	9.7	12.9	3.6	-2.5
Whole body water mass	1.7	9.4	12.4	3.5	-2.5
Cardiovascular Disease	1.6	5.2	6.1	-2.1	2.5
Bilateral oophorectomy (both ovaries removed)	1.6	1.9	3.2	1.8	-0.8
Medication: Atenolol	1.6	2.0	2.6	-1.1	1.6
Pain all over the body in last month	1.6	1.7	1.8	-1.3	1.3
Hip circumference	1.6	6.8	7.8	2.4	-2.8
Number of full brothers	1.6	2.0	2.9	-1.7	1.0
Unable to work because of sickness or disability	1.6	2.1	2.3	-1.3	1.5
Alzheimer’s Disease (in father)	1.5	1.7	2.0	-1.2	1.4
Allergy or Eczema	1.5	3.9	5.2	2.3	-1.6
Qualifications: None of the above	1.5	3.1	4.7	-1.2	2.2
Happiness	1.5	1.9	1.9	-1.3	1.4
Medication: Cholesterol lowering	1.5	2.4	2.8	-1.7	1.4
Illness, injury, bereavement, stress in last 2 years	1.5	1.9	3.5	-0.5	1.9
Ever had bowel cancer screening	1.5	1.8	3.0	1.7	-0.7
Arm fat mass (left)	1.5	6.0	6.0	2.4	-2.4
Age started oral contraceptive pill	1.5	1.9	2.5	1.2	-1.6
Rheumatoid Arthritis	1.4	2.0	3.3	0.8	-1.8
Relative age of first facial hair	1.4	2.9	3.6	1.5	-1.9
Nervous feelings	1.4	2.6	3.7	-1.2	1.9
Average weekly red wine intake	1.4	2.1	3.2	-1.8	1.0
Medication: Simvastatin	1.3	1.9	2.3	-1.2	1.5
Ever depressed for a whole week	1.3	1.6	1.8	1.3	-1.2
Cholesterol lowering medication	1.3	2.0	3.3	-0.8	1.8
Intelligence (Savage-Jansen 2018)	1.2	3.7	4.8	1.6	-2.2
Trunk fat percentage	1.2	4.9	4.9	2.2	-2.2
Qualifications: CSEs or equivalent	1.2	1.6	1.9	-1.1	1.4
Waist circumference	1.2	4.6	5.8	2.4	-1.8
Arm fat percentage (right)	1.2	4.9	5.7	2.0	-2.4
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.3	2.2	0.7	-1.5
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	2.2	1.0	-1.5
Medication: Paracetamol	1.2	1.9	2.1	1.3	-1.4
Pulse rate, automated reading	1.2	4.0	4.5	-2.1	1.9
Osteoporosis (self-reported)	1.2	1.5	2.8	0.4	1.7
Schizophrenia vs Biploar Disorder	1.1	1.4	1.6	1.1	-1.3
Worry (Nagel 2018)	1.1	2.4	3.3	-1.2	1.8
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	3.6	1.9	-0.9
Qualifications: College or University degree	1.1	3.3	5.2	1.2	-2.3
Eye problems/disorders: Cataract	1.1	1.3	1.5	1.2	-1.0
Medication: Ventolin 100micrograms inhaler	1.0	1.2	2.4	-0.3	1.5
Chronic bronchitis/emphysema (mother)	1.0	1.1	1.2	-1.1	1.1
Body fat percentage	1.0	3.9	4.2	1.9	-2.0
Medication: Blood pressure	1.0	1.8	2.1	-1.5	1.2
HbA1C	0.9	1.0	1.8	1.4	-0.4
Smoking Status	0.9	2.1	2.9	1.2	-1.7
Medication: Co-codamol	0.9	1.0	1.1	-1.0	1.0
High blood pressure	0.9	2.5	2.6	-1.5	1.6
Sitting height	0.9	6.1	8.5	2.9	-1.9
Body mass index (BMI)	0.9	3.8	4.5	1.7	-2.1
Hair/balding pattern: Pattern 3	0.9	1.4	2.1	-1.4	0.9
Exposure to tobacco smoke at home	0.9	1.0	1.4	1.2	-0.8
Leg fat percentage (right)	0.9	3.2	3.6	1.7	-1.9
Comparative height size at age 10	0.9	4.8	7.4	2.7	-1.5
Family relationship satisfaction	0.9	1.1	1.4	-1.2	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	1.9	-1.4	0.6
Hearing aid user	0.9	1.0	1.2	-0.9	1.1
Medication: Atorvastatin	0.9	1.2	1.3	-1.2	1.0
Illnesses of father: High blood pressure	0.9	1.1	1.2	-1.0	1.1
Leg fat percentage (left)	0.9	3.1	3.4	1.7	-1.8
Vascular/heart problems diagnosed by doctor	0.9	2.5	2.7	1.7	-1.5
Bipolar Disorder (2018)	0.8	1.3	1.6	1.3	-1.0
Neuroticism	0.8	1.9	3.1	-0.8	1.8
Maternal smoking around birth	0.8	1.2	1.9	-1.4	0.7
Past tobacco smoking	0.8	1.5	2.4	-1.5	0.8
Hair/balding pattern: Pattern 2	0.8	1.0	1.7	-0.6	1.3
Mouth/teeth dental problems	0.8	1.2	2.1	-1.4	0.6
Length of working week for main job	0.8	0.9	1.0	1.0	-0.9
Shortness of breath walking on level ground	0.8	0.9	1.3	1.1	-0.7
Supplements: Vitamin C	0.8	0.9	1.0	-1.0	0.9
Hypertension (Self-reported)	0.8	2.2	2.2	-1.5	1.5
Smoking status: Previous	0.8	1.2	2.1	1.4	-0.5
Arm fat percentage (left)	0.8	3.4	4.0	1.6	-2.0
Medication: Gliclazide	0.8	0.9	1.0	-1.0	0.9
Medication: Paracetamol	0.8	1.3	1.7	1.0	-1.3
Diastolic blood pressure, automated reading	0.8	2.6	3.4	1.8	-1.4
Alzheimer’s Disease (in mother)	0.7	0.8	1.0	0.8	-1.0
Mean Putamen Volume	0.7	0.8	1.1	-1.1	0.7
Chronotype (morning person)	0.7	1.7	2.7	-0.8	1.6
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	1.7	1.3	-0.1
Number of live births	0.7	1.0	2.0	0.2	-1.4
Loud music exposure frequency	0.7	0.7	0.8	-0.8	0.9
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.7	1.3	-0.3
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.4	-0.7	1.2
Neuroticism (Nagel 2018)	0.6	1.4	2.3	-0.7	1.5
Bipolar Disorder (2011)	0.6	0.6	1.0	-1.0	0.4
Sensitivity / hurt feelings	0.6	1.0	1.7	-0.5	1.3
Current tobacco smoking	0.6	1.0	1.7	-1.3	0.4
Neuroticism score	0.6	1.3	2.4	-0.5	1.5
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	1.7	0.6	-1.3
Medication: Amlodipine	0.6	0.8	1.0	-0.8	1.0
Medication: Aspirin	0.6	0.7	1.3	-0.5	1.1
Ever had prostate specific antigen (PSA) test	0.6	0.7	0.7	0.9	-0.8
Major Depression (MDD)	0.5	0.6	1.2	1.1	-0.3
Ulcerative Colitis	0.5	0.7	0.9	-0.7	-1.0
Type 2 Diabetes (T2D) (2018)	0.5	0.9	1.1	-1.1	0.9
Medication for hormone replacement therapy	0.5	0.5	0.8	-0.5	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	1.6	-1.3	-0.7
High blood pressure (mother)	0.5	0.7	1.1	-0.6	1.1
Falls in the last year	0.5	0.6	1.0	-0.5	1.0
Pulse rate	0.5	0.9	1.0	-1.0	0.9
Pulse wave Arterial Stiffness index	0.5	0.5	1.1	1.0	0.0
Pulse wave reflection index	0.5	0.6	0.8	-0.6	0.9
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.0	-0.3	1.0
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.0	-1.0	0.4
Commuting to job workplace: Walk	0.5	0.6	1.1	-0.1	1.1
Back pain experienced in last month	0.5	0.7	1.4	0.3	1.2
Supplements: Fish oil (including cod liver oil)	0.5	0.7	0.7	-0.8	0.8
Commuting to job workplace: Cycle	0.5	0.7	0.7	-0.8	0.8
Ovarian Cancer	0.4	0.5	0.8	0.9	0.5
Body Mass Index (BMI) (2010)	0.4	0.6	0.8	-0.7	0.9
Average weekly spirits intake	0.4	0.6	0.8	0.9	0.6
Ever had hysterectomy (womb removed)	0.4	0.4	0.8	0.9	-0.3
Medication: Metformin	0.4	0.5	0.5	-0.7	0.7
Hayfever, allergic rhinitis or eczema	0.4	0.8	1.1	1.1	-0.7
Impedance of leg (left)	0.4	1.9	2.0	-1.3	1.4
Number of incorrect matches in round	0.4	0.7	0.7	0.8	0.8
Alcohol usually taken with meals	0.4	0.6	1.0	-0.5	-1.0
Prospective memory result	0.4	0.5	0.6	0.8	-0.7
Illnesses of mother	0.4	0.5	0.9	0.2	-1.0
Breastfed as a baby	0.4	0.4	0.5	0.7	-0.6
Tense / ‘highly strung’	0.4	0.7	1.2	-0.3	1.1
Birth weight of first child	0.4	0.6	1.2	-0.3	-1.1
Ever highly irritable/argumentative for 2 days	0.4	0.4	0.5	0.6	-0.7
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	1.0	1.0	-0.2
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	0.8	0.9	-0.6
Gout (self-reported)	0.4	0.6	0.8	-0.9	0.6
Wheeze or whistling in the chest in last year	0.4	0.7	0.8	0.8	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	0.8	-0.3	0.9
Emphysema/chronic bronchitis	0.4	0.4	0.5	0.7	0.5
Heart disease (mother)	0.4	0.4	0.9	0.9	-0.0
Age at last live birth	0.4	0.5	1.1	-0.2	-1.0
Smoking status: Current	0.4	0.7	1.3	-1.2	0.1
Medication: Bendroflumethiazide	0.4	0.6	1.1	-0.4	1.0
Myopia	0.4	0.6	1.2	1.1	-0.3
Basal cell carcinoma (self-reported)	0.4	0.5	0.7	0.4	-0.9
Schizophrenia (2018)	0.3	0.6	1.1	-1.1	0.2
Crohns Disease (2017)	0.3	0.6	0.7	0.9	-0.7
Ulcerative Colitis (UC)	0.3	0.5	1.0	-1.0	0.1
Crohns Disease (2012)	0.3	0.4	0.5	-0.7	0.6
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.4	-0.5	0.6
Blood Platelet Count	0.3	3.6	5.8	2.4	-1.2
BMI	0.3	1.7	2.7	0.9	-1.6
Systolic blood pressure, automated reading	0.3	0.8	1.0	1.0	-0.8
Supplements: Zinc	0.3	0.4	0.6	0.8	-0.3
Fed-up feelings	0.3	0.5	0.9	1.0	0.1
Stomach or abdominal pain in last month	0.3	0.4	0.6	0.8	0.4
Supplements: Glucosamine	0.3	0.4	0.7	0.1	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.0	1.0	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.2	-0.5	-1.1
Heart attack	0.3	0.4	0.7	-0.4	0.9
Allergy	0.3	0.8	1.5	-1.2	0.0
Worrier / anxious feelings	0.3	0.5	0.8	-0.4	0.9
Noisy workplace	0.3	0.4	0.6	-0.5	0.8
Asthma	0.3	0.5	1.0	1.0	-0.1
Impedance of arm (left)	0.3	1.4	1.5	-1.2	1.2
Age at first live birth	0.3	0.5	0.8	-0.9	-0.3
Medication: Allopurinol	0.3	0.4	0.6	-0.8	0.4
Medication: Omeprazole	0.3	0.3	0.7	0.8	0.1
Medication: Seretide 50 evohaler	0.3	0.4	0.6	0.4	-0.8
Number of full sisters	0.3	0.3	0.4	0.6	-0.5
Chest pain or discomfort	0.3	0.4	0.4	0.6	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.7	0.8	-0.1
Medication for cholesterol	0.3	0.5	0.9	0.4	-0.9
Impedance of whole body	0.3	1.6	1.6	-1.3	1.3
Fasting Glucose	0.2	0.3	0.5	-0.3	-0.7
Blood White Count	0.2	1.2	2.0	1.4	-0.6
Waist Hip Ratio (WHR)	0.2	0.8	1.7	0.0	1.3
Respiratory disease	0.2	0.4	0.6	0.8	0.4
Lung FVC	0.2	1.1	1.9	0.5	-1.4
Tanning	0.2	2.4	3.6	-1.1	1.9
Hand grip strength (left)	0.2	0.6	1.0	1.0	-0.3
Impedance of leg (right)	0.2	1.1	1.1	-1.1	1.0
Taking other prescription medications	0.2	0.3	0.5	-0.4	0.7
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.3	0.3	0.5
Had menopause	0.2	0.3	0.4	0.4	0.6
Impedance of arm (right)	0.2	0.7	0.9	-0.9	0.7
Time employed in main current job	0.2	0.2	0.4	-0.1	0.7
Depression (self-reported)	0.2	0.2	0.5	-0.1	-0.7
Medication: Lansoprazole	0.2	0.2	0.3	-0.4	0.6
Lung cancer (father)	0.2	0.3	0.5	-0.3	0.7
Pulse wave peak to peak time	0.2	0.2	0.3	-0.6	-0.3
Health satisfaction	0.2	0.3	0.4	0.3	0.6
Medication for pain relief, constipation, heartburn	0.2	0.3	0.6	-0.8	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.4	-0.3	0.7
Overall health rating	0.2	0.4	0.8	0.1	0.9
Had major operations	0.2	0.2	0.3	0.4	-0.5
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.4	-0.7	-0.4
Knee pain experienced in last month	0.2	0.3	0.3	0.4	0.6
Mood swings	0.2	0.3	0.6	0.8	-0.1
Long-standing illness, disability or infirmity	0.2	0.4	0.7	-0.2	0.9
Friendships satisfaction	0.2	0.2	0.2	-0.4	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.3	-0.3	0.5
Breast cancer (self-reported)	0.2	0.2	0.4	0.7	0.1
Asthma (self-reported)	0.2	0.5	0.9	1.0	-0.1
Osteoarthritis (self-reported)	0.2	0.3	0.4	-0.7	-0.5
Number of self-reported non-cancer illnesses	0.2	0.4	0.7	-0.9	0.3
Miserableness	0.2	0.4	0.4	0.7	-0.5
Ever taken oral contraceptive pill	0.2	0.2	0.3	-0.3	-0.6
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.3	-0.5	0.4
Number of operations (self-reported)	0.2	0.4	0.7	0.9	0.0
Irritability	0.2	0.3	0.5	-0.7	0.3
Pain experienced in last month	0.2	0.3	0.7	0.2	-0.8
Supplements: Calcium	0.2	0.2	0.4	0.6	-0.0
Depressed Affect (Nagel 2018)	0.1	0.1	0.2	0.4	0.3
Reaction Time	0.1	0.2	0.2	-0.3	-0.5
Breast Cancer	0.1	0.2	0.3	0.5	-0.3
HDL Cholesterol	0.1	0.2	0.3	0.3	-0.5
Schizophrenia (2014)	0.1	0.3	0.5	-0.3	-0.7
Blood Red Count	0.1	0.6	0.8	0.6	-0.9
Systolic Blood Pressure	0.1	0.5	0.9	-0.4	1.0
Number of treatments/medications taken	0.1	0.1	0.2	-0.1	0.4
Hearing difficulty/problems: Yes	0.1	0.1	0.2	-0.5	0.1
Hand grip strength (right)	0.1	0.3	0.5	0.7	0.1
Relative age voice broke	0.1	0.2	0.3	-0.6	-0.2
Age when periods started (menarche)	0.1	0.1	0.3	-0.1	-0.5
Serious illness, injury or assault to yourself	0.1	0.1	0.1	-0.3	0.2
Medication: Levothyroxine sodium	0.1	0.2	0.3	0.6	-0.1
Chronic bronchitis/emphysema (father)	0.1	0.1	0.2	-0.5	-0.0
Diabetes (self-reported)	0.1	0.1	0.2	-0.5	0.1
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	0.0	0.4
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.3	0.6	-0.2
Headache pain in last month	0.1	0.1	0.2	-0.1	-0.5
High blood pressure (siblings)	0.1	0.2	0.2	0.4	-0.4
Comparative body size at age 10	0.1	0.2	0.3	0.3	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.3	0.6	0.0
Eye problems/disorders: None of the above	0.1	0.1	0.1	-0.2	0.4
Neck or shoulder pain in last month	0.1	0.1	0.2	0.0	0.4
Medication: Ibuprofen	0.1	0.1	0.1	0.1	-0.4
Mean time to correctly identify matches	0.1	0.2	0.3	0.1	-0.6
Alcohol intake frequency.	0.1	0.2	0.4	0.7	-0.2
Loneliness, isolation	0.1	0.2	0.2	0.4	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.1	0.1	-0.3
Mineral and other dietary supplements	0.1	0.1	0.2	0.5	-0.2
Illnesses of father: None of the above (group 1)	0.1	0.1	0.2	0.5	0.0
Guilty feelings	0.1	0.1	0.2	0.2	0.5
Wears glasses or contact lenses	0.1	0.2	0.2	0.3	0.5
Financial situation satisfaction	0.1	0.1	0.2	0.4	-0.3
Commuting to job workplace: Public transport	0.1	0.1	0.2	-0.2	0.4
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	0.1	-0.5
Medication: Blood pressure	0.1	0.2	0.3	-0.1	0.5
Medication: Lisinopril	0.1	0.2	0.3	0.6	-0.2
Ever smoked	0.1	0.3	0.5	0.7	0.1
Average weekly beer plus cider intake	0.1	0.1	0.2	0.4	0.1
Fractured/broken bones in last 5 years	0.1	0.1	0.2	-0.4	0.1
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	0.4	-0.1
Heart disease (siblings)	0.1	0.1	0.1	-0.2	-0.3
Bipolar Disorder or Schizophrenia	0.0	0.1	0.2	-0.0	-0.4
Alzheimer’s Disease (including proxy)	0.0	0.1	0.1	-0.3	0.2
Irritable Bowel Disease (IBD)	0.0	0.1	0.1	-0.3	-0.4
Age at First Birth	0.0	0.0	0.0	-0.0	-0.1
Triglycerides	0.0	0.0	0.1	-0.0	0.2
Hair Pigment	0.0	0.7	1.4	-0.0	-1.2
Ever used hormone-replacement therapy (HRT)	0.0	0.1	0.1	0.3	-0.0
Vitamin and mineral supplements	0.0	0.0	0.1	-0.3	0.1
Diabetes (father)	0.0	0.0	0.0	0.0	0.0
Townsend deprivation index at recruitment	0.0	0.0	0.0	-0.2	0.0
Hearing difficulty/problems with background noise	0.0	0.1	0.1	0.1	0.3
Alcohol intake versus 10 years previously	0.0	0.0	0.0	0.1	-0.1
Father’s age at death	0.0	0.0	0.0	0.1	-0.1
Mouth/teeth dental problems: Dentures	0.0	0.0	0.0	0.2	0.1
Hair/balding pattern: Pattern 4	0.0	0.1	0.1	0.2	0.3
Blood clot in the leg (DVT)	0.0	0.0	0.0	-0.0	-0.1
Glaucoma (self-reported)	0.0	0.0	0.0	0.0	0.1
Migraine (self-reported)	0.0	0.0	0.1	-0.1	-0.3
Diabetes diagnosed by doctor	0.0	0.1	0.1	-0.4	0.1
Alcohol drinker status: Never	0.0	0.0	0.0	0.1	0.2

Hub : Genes

KPNA3

Models

Trait associations