Best TWAS P=5.36e-09 · Best GWAS P=8.7e-07 conditioned to 0.202
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | CRIPAK | 0.31 | 0.15 | enet | 34 | 0.26 | 1.2e-31 | -3.6 | -5.2 | 2.5e-07 | 0.60 | 0.21 | 0.42 | FALSE |
2 | GTEx | Adipose Visceral Omentum | CRIPAK | 0.47 | 0.24 | lasso | 12 | 0.31 | 1.3e-16 | -4.7 | -5.6 | 2.1e-08 | 0.76 | 0.01 | 0.98 | FALSE |
3 | GTEx | Brain Caudate basal ganglia | CRIPAK | 0.27 | 0.00 | lasso | 2 | 0.02 | 9.3e-02 | -4.6 | -5.3 | 1.4e-07 | 0.81 | 0.01 | 0.44 | FALSE |
4 | GTEx | Brain Cortex | CRIPAK | 0.34 | 0.10 | lasso | 6 | 0.18 | 9.5e-06 | -4.7 | -5.8 | 5.4e-09 | 0.68 | 0.01 | 0.85 | TRUE |
5 | GTEx | Brain Hippocampus | CRIPAK | 0.48 | 0.22 | lasso | 4 | 0.23 | 4.0e-06 | -3.4 | -5.3 | 1.3e-07 | 0.61 | 0.03 | 0.54 | FALSE |
6 | GTEx | Brain Hypothalamus | CRIPAK | 0.22 | 0.00 | lasso | 5 | 0.01 | 2.1e-01 | -4.6 | -5.5 | 5.1e-08 | 0.77 | 0.01 | 0.47 | FALSE |
7 | GTEx | Brain Nucleus accumbens basal ganglia | CRIPAK | 0.34 | 0.13 | lasso | 6 | 0.25 | 2.7e-07 | -4.7 | -5.2 | 2.5e-07 | 0.67 | 0.01 | 0.82 | FALSE |
8 | GTEx | Cells EBV-transformed lymphocytes | CRIPAK | 0.49 | 0.27 | lasso | 8 | 0.35 | 2.9e-12 | -4.7 | -5.2 | 2.4e-07 | 0.67 | 0.01 | 0.98 | FALSE |
9 | GTEx | Esophagus Mucosa | CRIPAK | 0.49 | 0.14 | enet | 28 | 0.40 | 6.8e-29 | -4.7 | -5.2 | 2.6e-07 | 0.66 | 0.01 | 0.98 | FALSE |
10 | GTEx | Lung | CRIPAK | 0.61 | 0.22 | enet | 46 | 0.41 | 1.1e-33 | -4.7 | -5.4 | 5.6e-08 | 0.67 | 0.01 | 0.98 | FALSE |
11 | GTEx | Muscle Skeletal | CRIPAK | 0.25 | 0.11 | enet | 32 | 0.18 | 7.6e-18 | -4.7 | -5.2 | 2.3e-07 | 0.62 | 0.01 | 0.98 | FALSE |
12 | GTEx | Ovary | CRIPAK | 0.43 | 0.27 | enet | 19 | 0.32 | 9.0e-09 | -4.7 | -5.1 | 2.8e-07 | 0.72 | 0.01 | 0.93 | FALSE |
13 | GTEx | Uterus | CRIPAK | 0.52 | 0.34 | lasso | 3 | 0.33 | 1.7e-07 | -4.6 | -5.3 | 1.3e-07 | 0.81 | 0.01 | 0.85 | FALSE |
14 | GTEx | Whole Blood | CRIPAK | 0.38 | 0.17 | lasso | 9 | 0.28 | 3.4e-26 | -3.4 | -5.3 | 1.1e-07 | 0.69 | 0.09 | 0.74 | FALSE |
15 | METSIM | Adipose | CRIPAK | 0.28 | 0.16 | bslmm | 335 | 0.25 | 2.7e-37 | -4.9 | -5.4 | 5.7e-08 | 0.71 | 0.00 | 0.99 | FALSE |
16 | METSIM | Adipose | UVSSA | 0.26 | 0.04 | bslmm | 366 | 0.12 | 9.0e-18 | 0.7 | -5.2 | 1.9e-07 | 0.56 | 0.02 | 0.96 | FALSE |
17 | NTR | Blood | CRIPAK | 0.13 | 0.09 | enet | 31 | 0.15 | 1.5e-46 | -4.0 | -5.5 | 3.1e-08 | 0.70 | 0.10 | 0.73 | FALSE |
18 | YFS | Blood | CRIPAK | 0.35 | 0.27 | bslmm | 301 | 0.33 | 6.0e-112 | -3.4 | -5.2 | 1.7e-07 | 0.72 | 0.25 | 0.29 | FALSE |
19 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | CRIPAK | 0.57 | 0.07 | enet | 9 | 0.23 | 6.7e-07 | -4.7 | -5.3 | 9.1e-08 | 0.54 | 0.00 | 0.76 | FALSE |