Best TWAS P=3.95e-11 · Best GWAS P=1.3e-09 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | LRPAP1 | 0.16 | 0.04 | lasso | 4 | 0.04 | 1.6e-04 | 5.9 | -6.3 | 3.1e-10 | -0.85 | 0.01 | 0.96 | FALSE |
| 2 | GTEx | Artery Aorta | LRPAP1 | 0.20 | 0.13 | lasso | 3 | 0.13 | 1.7e-07 | 5.8 | -6.4 | 1.5e-10 | -0.98 | 0.01 | 0.99 | TRUE |
| 3 | GTEx | Artery Coronary | LRPAP1 | 0.24 | 0.13 | lasso | 2 | 0.07 | 2.1e-03 | 6.1 | -6.0 | 1.6e-09 | -1.00 | 0.01 | 0.98 | FALSE |
| 4 | GTEx | Artery Tibial | LRPAP1 | 0.36 | 0.21 | lasso | 7 | 0.21 | 3.5e-16 | 6.1 | -6.2 | 4.9e-10 | -0.98 | 0.00 | 1.00 | FALSE |
| 5 | GTEx | Brain Cerebellar Hemisphere | LRPAP1 | 0.53 | 0.04 | lasso | 11 | 0.17 | 4.1e-05 | -2.8 | -5.9 | 2.8e-09 | -0.36 | 0.07 | 0.37 | FALSE |
| 6 | GTEx | Brain Cerebellum | LRPAP1 | 0.54 | 0.03 | lasso | 10 | 0.18 | 7.3e-06 | -3.0 | -5.3 | 9.2e-08 | -0.27 | 0.09 | 0.33 | FALSE |
| 7 | GTEx | Cells Transformed fibroblasts | LRPAP1 | 0.35 | 0.20 | lasso | 4 | 0.26 | 2.3e-19 | 4.8 | -5.7 | 1.6e-08 | -0.91 | 0.01 | 0.99 | FALSE |
| 8 | GTEx | Esophagus Muscularis | LRPAP1 | 0.22 | 0.03 | lasso | 7 | 0.02 | 1.1e-02 | 5.9 | -6.0 | 2.7e-09 | -0.93 | 0.01 | 0.99 | FALSE |
| 9 | GTEx | Muscle Skeletal | LRPAP1 | 0.16 | 0.04 | enet | 23 | 0.09 | 4.4e-09 | 5.9 | -5.7 | 1.4e-08 | -0.66 | 0.01 | 0.99 | FALSE |
| 10 | GTEx | Nerve Tibial | LRPAP1 | 0.29 | 0.11 | enet | 16 | 0.14 | 7.6e-10 | 5.8 | -6.3 | 3.7e-10 | -0.85 | 0.01 | 0.99 | FALSE |
| 11 | GTEx | Skin Sun Exposed Lower leg | LRPAP1 | 0.13 | 0.03 | enet | 12 | 0.08 | 3.6e-07 | -3.0 | -6.6 | 3.9e-11 | -0.42 | 0.35 | 0.56 | TRUE |
| 12 | GTEx | Thyroid | LRPAP1 | 0.28 | 0.07 | lasso | 8 | 0.15 | 2.6e-11 | 6.1 | -6.1 | 8.6e-10 | -0.82 | 0.00 | 1.00 | FALSE |
| 13 | METSIM | Adipose | LRPAP1 | 0.14 | 0.12 | lasso | 4 | 0.12 | 4.4e-17 | 4.8 | -5.2 | 2.2e-07 | -0.94 | 0.02 | 0.98 | FALSE |
| 14 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | LRPAP1 | 0.08 | 0.01 | blup | 52 | 0.04 | 2.9e-03 | -3.0 | -5.7 | 1.0e-08 | -0.57 | 0.02 | 0.47 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | LRPAP1 | 0.05 | 0.00 | blup | 52 | 0.02 | 2.8e-02 | -2.3 | -6.1 | 1.3e-09 | -0.38 | 0.04 | 0.17 | FALSE |
| 16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LRPAP1 | 0.12 | 0.09 | blup | 52 | 0.12 | 1.5e-12 | 5.9 | -6.3 | 2.8e-10 | -0.80 | 0.01 | 0.99 | FALSE |
| 17 | The Cancer Genome Atlas | Soft Tissue Sarcoma | LRPAP1 | 0.12 | 0.02 | blup | 52 | 0.05 | 6.6e-04 | 1.3 | -6.5 | 5.7e-11 | -0.42 | 0.04 | 0.25 | FALSE |
| 18 | The Cancer Genome Atlas | Thyroid Carcinoma | RGS12 | 0.08 | 0.01 | blup | 108 | 0.01 | 2.4e-02 | -5.5 | -5.8 | 7.0e-09 | -0.01 | 0.00 | 0.79 | TRUE |