Best TWAS P=2.53e-17 · Best GWAS P=1.08e-20 conditioned to 5.58e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Pituitary | LHFPL2 | 0.38 | 0.02 | lasso | 9 | 0.04 | 4.0e-02 | 1.9 | -6.5 | 8.4e-11 | 0.50 | 0.04 | 0.49 | FALSE |
| 2 | The Cancer Genome Atlas | Breast Invasive Carcinoma | AP3B1 | 0.02 | 0.00 | blup | 126 | 0.01 | 1.8e-02 | -9.3 | -8.5 | 2.5e-17 | 0.85 | 0.02 | 0.88 | TRUE |
| 3 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | AP3B1 | 0.16 | 0.06 | enet | 18 | 0.09 | 2.2e-05 | 3.5 | -5.3 | 1.1e-07 | 0.52 | 0.05 | 0.46 | FALSE |
| 4 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | AP3B1 | 0.08 | 0.01 | enet | 20 | 0.02 | 9.7e-04 | -9.1 | -5.6 | 2.3e-08 | 0.60 | 0.01 | 0.84 | FALSE |
| 5 | The Cancer Genome Atlas | Prostate Adenocarcinoma | AP3B1 | 0.05 | 0.02 | blup | 126 | 0.03 | 5.0e-04 | 3.9 | -7.7 | 1.7e-14 | 0.81 | 0.02 | 0.92 | FALSE |