TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Forced vital capacity (FVC), Best measure
:
←
→
chr5:77,052,232-78,753,539
Best TWAS P=2.53e-17 · Best GWAS P=1.08e-20 conditioned to 5.58e-05
77M
77.2M
77.4M
77.6M
77.8M
78M
78.2M
78.4M
78.6M
78.8M
0
5
10
15
20
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
The Cancer Genome Atlas
Breast Invasive Carcinoma
AP3B1
0.02
0.00
blup
126
0.01
1.8e-02
-9.3
-8.5
2.5e-17
0.85
0.02
0.88
TRUE
5
The Cancer Genome Atlas
Prostate Adenocarcinoma
AP3B1
0.05
0.02
blup
126
0.03
5.0e-04
3.9
-7.7
1.7e-14
0.81
0.02
0.92
FALSE
1
GTEx
Pituitary
LHFPL2
0.38
0.02
lasso
9
0.04
4.0e-02
1.9
-6.5
8.4e-11
0.50
0.04
0.49
FALSE
4
The Cancer Genome Atlas
Head and Neck Squamous Cell Carcinoma
AP3B1
0.08
0.01
enet
20
0.02
9.7e-04
-9.1
-5.6
2.3e-08
0.60
0.01
0.84
FALSE
3
The Cancer Genome Atlas
Cervical Squamous Cell Carcinoma
AP3B1
0.16
0.06
enet
18
0.09
2.2e-05
3.5
-5.3
1.1e-07
0.52
0.05
0.46
FALSE