Best TWAS P=4.81e-32 · Best GWAS P=1.92e-34 conditioned to 0.00064
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CENPW | 0.04 | 0.06 | lasso | 10 | 0.06 | 2.4e-07 | 11.6 | -11.8 | 4.8e-32 | -0.93 | 0.32 | 0.68 | TRUE |
| 2 | GTEx | Heart Atrial Appendage | CENPW | 0.17 | 0.01 | enet | 15 | 0.06 | 1.8e-03 | 11.5 | -7.6 | 2.5e-14 | -0.66 | 0.04 | 0.32 | FALSE |
| 3 | GTEx | Vagina | CENPW | 0.24 | -0.01 | lasso | 8 | -0.01 | 7.9e-01 | 4.9 | 5.8 | 6.4e-09 | 0.39 | 0.04 | 0.07 | FALSE |
| 4 | METSIM | Adipose | CENPW | 0.02 | 0.02 | blup | 189 | 0.01 | 8.3e-03 | 11.5 | -9.4 | 3.4e-21 | -0.71 | 0.07 | 0.28 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CENPW | 0.04 | 0.05 | lasso | 5 | 0.05 | 2.6e-06 | 11.5 | -11.3 | 1.1e-29 | -0.90 | 0.02 | 0.98 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CENPW | 0.04 | 0.06 | blup | 35 | 0.05 | 9.2e-07 | 11.5 | -11.4 | 3.8e-30 | -0.91 | 0.02 | 0.98 | FALSE |