Best TWAS P=4.3e-10 · Best GWAS P=1.63e-09 conditioned to 0.18
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | RP1-93H18.7 | 0.11 | 0.08 | lasso | 3 | 0.08 | 8.1e-07 | -5.9 | -6.0 | 2.7e-09 | 0.88 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Cells EBV-transformed lymphocytes | FAM26F | 0.34 | 0.10 | enet | 32 | 0.32 | 5.8e-11 | 4.7 | 6.0 | 2.7e-09 | -0.68 | 0.03 | 0.97 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | DSE | 0.07 | 0.01 | enet | 7 | 0.01 | 4.1e-02 | -5.8 | -6.1 | 1.3e-09 | 0.80 | 0.02 | 0.97 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | FAM26F | 0.29 | 0.19 | enet | 26 | 0.23 | 1.9e-17 | -6.0 | 6.2 | 5.7e-10 | -0.76 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | RP1-93H18.7 | 0.08 | 0.06 | enet | 8 | 0.07 | 3.9e-06 | -5.9 | -6.2 | 4.3e-10 | 0.86 | 0.01 | 0.99 | TRUE |
| 6 | GTEx | Esophagus Gastroesophageal Junction | RP1-93H18.7 | 0.16 | 0.06 | lasso | 3 | 0.05 | 5.3e-03 | -5.8 | -5.9 | 3.6e-09 | 0.84 | 0.02 | 0.93 | FALSE |
| 7 | GTEx | Lung | RP1-93H18.7 | 0.06 | 0.07 | lasso | 4 | 0.04 | 4.4e-04 | -5.7 | -5.7 | 1.1e-08 | 0.80 | 0.02 | 0.96 | FALSE |
| 8 | GTEx | Nerve Tibial | RP1-93H18.7 | 0.14 | 0.08 | lasso | 6 | 0.08 | 1.7e-06 | -4.6 | -5.2 | 2.6e-07 | 0.73 | 0.29 | 0.68 | FALSE |
| 9 | GTEx | Skin Sun Exposed Lower leg | RP1-93H18.7 | 0.07 | 0.04 | enet | 5 | 0.03 | 1.1e-03 | -5.9 | -5.9 | 3.3e-09 | 0.86 | 0.02 | 0.97 | FALSE |
| 10 | GTEx | Whole Blood | DSE | 0.09 | 0.05 | lasso | 5 | 0.04 | 1.8e-04 | -5.9 | -5.3 | 1.4e-07 | 0.70 | 0.02 | 0.98 | FALSE |
| 11 | GTEx | Whole Blood | RP1-93H18.7 | 0.19 | 0.17 | lasso | 3 | 0.16 | 3.1e-14 | -5.7 | -6.0 | 2.0e-09 | 0.81 | 0.02 | 0.98 | FALSE |
| 12 | NTR | Blood | DSE | 0.04 | 0.02 | bslmm | 437 | 0.02 | 1.7e-08 | -5.9 | -5.6 | 2.2e-08 | 0.69 | 0.02 | 0.98 | FALSE |