[Hub]/) : Traits : Forced vital capacity (FVC), Best measure :

chr6:129,638,583-132,080,991

Best TWAS P=4.17e-24 · Best GWAS P=7.14e-26 conditioned to 5.15e-14

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous L3MBTL3 0.20 0.08 lasso 4 0.09 1.1e-07 9.6 9.3 2.1e-20 -0.32 0.92 0.08 FALSE
2 GTEx Adipose Visceral Omentum L3MBTL3 0.14 0.12 lasso 2 0.15 2.8e-08 9.6 9.7 2.7e-22 -0.32 0.92 0.04 FALSE
3 GTEx Breast Mammary Tissue L3MBTL3 0.31 0.25 lasso 7 0.23 2.8e-12 9.6 9.7 4.3e-22 -0.29 0.93 0.07 FALSE
4 GTEx Breast Mammary Tissue RP11-73O6.3 0.27 0.22 lasso 9 0.22 1.5e-11 9.6 9.8 1.1e-22 -0.29 0.92 0.08 FALSE
5 GTEx Breast Mammary Tissue (Male) L3MBTL3 0.31 0.24 lasso 6 0.23 5.5e-06 9.6 9.4 4.8e-21 -0.33 0.27 0.06 FALSE
6 GTEx Breast Mammary Tissue (Male) RP11-73O6.3 0.33 0.17 lasso 4 0.12 1.3e-03 9.6 9.1 6.7e-20 -0.30 0.16 0.05 FALSE
7 GTEx Breast Mammary Tissue (Female) L3MBTL3 0.30 0.13 lasso 5 0.14 4.5e-05 7.2 9.6 1.1e-21 -0.28 0.36 0.13 FALSE
8 GTEx Breast Mammary Tissue (Female) RP11-73O6.3 0.29 0.08 lasso 5 0.10 5.7e-04 8.8 9.8 1.2e-22 -0.32 0.29 0.11 FALSE
9 GTEx Cells EBV-transformed lymphocytes L3MBTL3 0.28 0.08 lasso 10 0.03 4.4e-02 9.6 9.4 4.2e-21 -0.36 0.21 0.10 FALSE
10 GTEx Colon Transverse L3MBTL3 0.27 0.13 lasso 8 0.20 8.0e-10 9.6 9.8 1.7e-22 -0.35 0.97 0.03 FALSE
11 GTEx Colon Transverse RP11-73O6.3 0.19 0.09 lasso 2 0.06 1.2e-03 9.6 9.7 3.1e-22 -0.33 0.50 0.05 FALSE
12 GTEx Esophagus Mucosa L3MBTL3 0.26 0.18 lasso 2 0.23 2.7e-15 8.8 9.9 4.0e-23 -0.32 0.96 0.04 FALSE
13 GTEx Lung L3MBTL3 0.37 0.34 lasso 4 0.38 4.1e-30 9.6 9.8 6.9e-23 -0.32 0.90 0.10 FALSE
14 GTEx Lung RP11-73O6.3 0.15 0.08 lasso 5 0.12 2.2e-09 9.6 9.7 3.7e-22 -0.32 0.97 0.02 FALSE
15 GTEx Nerve Tibial L3MBTL3 0.30 0.23 lasso 4 0.22 2.3e-15 9.6 9.9 5.5e-23 -0.31 0.90 0.10 FALSE
16 GTEx Pancreas L3MBTL3 0.32 0.17 lasso 4 0.23 4.4e-10 9.6 9.8 7.7e-23 -0.32 0.90 0.09 FALSE
17 GTEx Pituitary L3MBTL3 0.45 0.31 lasso 8 0.29 5.1e-08 7.2 8.5 1.7e-17 -0.15 0.85 0.02 FALSE
18 GTEx Pituitary RP11-73O6.3 0.48 0.07 lasso 7 0.16 8.2e-05 7.2 7.3 2.9e-13 -0.09 0.42 0.04 FALSE
19 GTEx Prostate L3MBTL3 0.35 0.27 lasso 5 0.17 5.9e-05 9.6 9.5 2.0e-21 -0.30 0.26 0.05 FALSE
20 GTEx Skin Not Sun Exposed Suprapubic L3MBTL3 0.26 0.12 lasso 4 0.12 4.0e-07 7.9 9.5 1.4e-21 -0.34 0.86 0.10 FALSE
21 GTEx Skin Sun Exposed Lower leg L3MBTL3 0.25 0.25 lasso 9 0.24 1.4e-19 9.6 9.4 4.3e-21 -0.27 0.90 0.10 FALSE
22 GTEx Small Intestine Terminal Ileum L3MBTL3 0.37 0.20 lasso 4 0.17 1.3e-04 9.6 10.0 2.2e-23 -0.35 0.18 0.06 FALSE
23 GTEx Spleen L3MBTL3 0.64 0.34 enet 14 0.48 6.4e-14 8.8 9.7 3.7e-22 -0.33 0.98 0.01 FALSE
24 GTEx Spleen RP11-73O6.3 0.45 0.43 enet 21 0.42 7.7e-12 8.8 9.5 1.6e-21 -0.29 0.98 0.00 FALSE
25 GTEx Stomach L3MBTL3 0.36 0.18 enet 27 0.20 1.1e-09 8.6 8.8 1.2e-18 -0.40 0.99 0.01 FALSE
26 GTEx Stomach RP11-73O6.3 0.21 0.12 lasso 6 0.06 5.9e-04 8.6 7.7 2.0e-14 -0.39 0.27 0.04 FALSE
27 GTEx Testis L3MBTL3 0.41 0.22 lasso 8 0.30 9.2e-14 9.6 9.4 3.3e-21 -0.35 0.88 0.11 FALSE
28 GTEx Thyroid L3MBTL3 0.40 0.39 enet 9 0.43 2.8e-35 9.6 10.1 7.1e-24 -0.36 0.90 0.10 TRUE
29 GTEx Thyroid RP11-73O6.3 0.18 0.15 lasso 3 0.20 2.3e-15 8.1 9.6 8.6e-22 -0.32 0.98 0.02 FALSE
30 GTEx Whole Blood L3MBTL3 0.22 0.20 lasso 9 0.20 5.1e-18 9.6 9.9 3.7e-23 -0.33 0.90 0.10 FALSE
31 GTEx Whole Blood RP11-73O6.3 0.15 0.06 lasso 8 0.04 1.1e-04 9.6 10.1 4.2e-24 -0.34 0.42 0.14 FALSE
32 METSIM Adipose L3MBTL3 0.13 0.12 enet 22 0.12 4.8e-18 8.8 8.2 2.3e-16 -0.20 1.00 0.00 FALSE
33 ROSMAP Brain Pre-frontal Cortex EPB41L2 0.12 0.12 blup 522 0.10 6.5e-13 4.3 5.2 2.2e-07 0.01 0.99 0.01 FALSE
34 ROSMAP Brain Pre-frontal Cortex L3MBTL3 0.14 0.07 blup 609 0.08 3.8e-10 9.6 8.4 3.4e-17 -0.37 0.92 0.08 FALSE
35 YFS Blood L3MBTL3 0.28 0.22 blup 614 0.27 1.2e-88 8.8 7.3 2.2e-13 -0.22 1.00 0.00 FALSE
36 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma L3MBTL3 0.06 0.01 blup 114 0.04 4.0e-03 8.8 7.1 1.2e-12 -0.10 0.13 0.03 FALSE
37 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma LOC285733 0.22 0.19 enet 9 0.19 3.9e-11 6.0 6.1 8.7e-10 0.02 0.02 0.98 TRUE