Best TWAS P=4.22e-08 · Best GWAS P=7.09e-08 conditioned to 0.0234
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | INPP5B | 0.21 | 0.13 | lasso | 3 | 0.21 | 5.5e-12 | -4.9 | 5.2 | 1.5e-07 | -0.76 | 0.02 | 0.98 | FALSE |
2 | GTEx | Artery Aorta | RP11-109P14.10 | 0.26 | 0.17 | lasso | 3 | 0.16 | 3.9e-09 | -5.2 | 5.5 | 4.2e-08 | -0.68 | 0.01 | 0.99 | TRUE |
3 | GTEx | Artery Tibial | INPP5B | 0.35 | 0.12 | lasso | 6 | 0.25 | 6.0e-20 | 2.8 | 5.1 | 2.7e-07 | -0.65 | 0.01 | 0.98 | FALSE |
4 | GTEx | Artery Tibial | RP11-109P14.10 | 0.21 | 0.13 | lasso | 6 | 0.15 | 1.7e-11 | -5.2 | 5.4 | 5.4e-08 | -0.67 | 0.01 | 0.99 | FALSE |
5 | GTEx | Esophagus Muscularis | FHL3 | 0.10 | 0.02 | enet | 2 | 0.00 | 4.3e-01 | 3.8 | 5.1 | 3.0e-07 | -0.80 | 0.02 | 0.75 | FALSE |
6 | GTEx | Esophagus Muscularis | RP11-109P14.10 | 0.17 | 0.11 | lasso | 6 | 0.13 | 3.6e-08 | -5.0 | 5.4 | 7.7e-08 | -0.76 | 0.01 | 0.99 | FALSE |
7 | GTEx | Lung | RP11-109P14.10 | 0.15 | 0.03 | enet | 14 | 0.12 | 9.2e-10 | 2.8 | 5.1 | 2.9e-07 | -0.45 | 0.04 | 0.96 | FALSE |
8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | INPP5B | 0.05 | 0.03 | blup | 68 | 0.05 | 6.7e-06 | 4.2 | 5.2 | 2.0e-07 | -0.82 | 0.08 | 0.90 | FALSE |
9 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | FHL3 | 0.08 | 0.08 | lasso | 2 | 0.08 | 1.4e-09 | -5.2 | 5.2 | 1.8e-07 | -0.97 | 0.00 | 1.00 | FALSE |
10 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | C1orf122 | 0.07 | 0.07 | blup | 32 | 0.05 | 3.8e-03 | -5.0 | -5.2 | 1.8e-07 | 0.75 | 0.00 | 0.80 | FALSE |
11 | The Cancer Genome Atlas | Stomach Adenocarcinoma | FHL3 | 0.10 | 0.05 | lasso | 2 | 0.03 | 2.2e-03 | -5.2 | 5.2 | 2.5e-07 | -0.98 | 0.00 | 0.93 | FALSE |