TWAS
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Traits
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Traits
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Forced vital capacity (FVC), Best measure
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chr8:56,269,387-57,683,880
Best TWAS P=1.29e-14 · Best GWAS P=9.57e-24 conditioned to 8.82e-11
56.2M
56.4M
56.6M
56.8M
57M
57.2M
57.4M
57.6M
0
5
10
15
20
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
4
GTEx
Skin Not Sun Exposed Suprapubic
RPS20
0.18
0.03
enet
12
0.07
1.5e-04
-6.9
-7.7
1.3e-14
0.81
0.11
0.60
TRUE
3
GTEx
Esophagus Muscularis
RPS20
0.12
0.04
lasso
6
0.05
7.2e-04
-7.0
-6.9
4.2e-12
0.76
0.22
0.64
FALSE
2
GTEx
Brain Cerebellum
RPS20
0.26
0.07
enet
17
0.10
5.4e-04
-7.1
-5.8
5.2e-09
0.60
0.31
0.21
FALSE
5
The Cancer Genome Atlas
Brain Lower Grade Glioma
RPS20
0.33
0.07
enet
8
0.07
1.7e-08
-4.7
-5.4
5.5e-08
0.49
0.96
0.03
FALSE
1
GTEx
Artery Tibial
RP11-446E9.1
0.07
0.00
lasso
6
0.00
6.6e-01
-4.1
5.2
1.9e-07
-0.76
0.02
0.75
FALSE