Best TWAS P=1.62e-10 · Best GWAS P=7.67e-11 conditioned to 0.0921
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Caudate basal ganglia | CCDC171 | 0.30 | 0.18 | lasso | 4 | 0.23 | 2.4e-07 | -5.0 | 5.8 | 6.5e-09 | 0.95 | 0.09 | 0.91 | FALSE |
2 | GTEx | Brain Cerebellar Hemisphere | CCDC171 | 0.46 | 0.19 | lasso | 7 | 0.23 | 1.3e-06 | 6.2 | 6.4 | 1.6e-10 | 0.91 | 0.15 | 0.82 | TRUE |
3 | GTEx | Brain Cerebellum | CCDC171 | 0.46 | 0.22 | lasso | 7 | 0.15 | 3.4e-05 | 6.1 | 6.2 | 4.3e-10 | 0.98 | 0.06 | 0.94 | FALSE |
4 | GTEx | Brain Cortex | CCDC171 | 0.26 | 0.15 | lasso | 2 | 0.16 | 2.8e-05 | 5.7 | 5.9 | 3.8e-09 | 0.93 | 0.09 | 0.86 | FALSE |
5 | GTEx | Nerve Tibial | CCDC171 | 0.25 | 0.16 | lasso | 6 | 0.14 | 2.1e-10 | 6.2 | 6.1 | 1.1e-09 | 0.99 | 0.06 | 0.94 | FALSE |
6 | GTEx | Pituitary | CCDC171 | 0.28 | 0.16 | enet | 29 | 0.12 | 5.2e-04 | -5.0 | 5.4 | 7.0e-08 | 0.92 | 0.19 | 0.74 | FALSE |
7 | ROSMAP | Brain Pre-frontal Cortex | CCDC171 | 0.14 | 0.11 | enet | 21 | 0.11 | 8.3e-14 | -5.2 | 5.3 | 1.5e-07 | 0.83 | 0.82 | 0.18 | FALSE |